WO2010098625A2 - 약제학적 제제 - Google Patents

약제학적 제제 Download PDF

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Publication number
WO2010098625A2
WO2010098625A2 PCT/KR2010/001244 KR2010001244W WO2010098625A2 WO 2010098625 A2 WO2010098625 A2 WO 2010098625A2 KR 2010001244 W KR2010001244 W KR 2010001244W WO 2010098625 A2 WO2010098625 A2 WO 2010098625A2
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical preparation
calcium channel
channel blocker
active ingredient
compartment containing
Prior art date
Application number
PCT/KR2010/001244
Other languages
English (en)
French (fr)
Other versions
WO2010098625A3 (ko
Inventor
김성욱
전성수
구자성
김진욱
Original Assignee
한올바이오파마 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한올바이오파마 주식회사 filed Critical 한올바이오파마 주식회사
Priority to CN2010800080129A priority Critical patent/CN102316856A/zh
Publication of WO2010098625A2 publication Critical patent/WO2010098625A2/ko
Publication of WO2010098625A3 publication Critical patent/WO2010098625A3/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 약리학적 활성성분으로 레닌억제제를 포함하는 선방출성 구획, 및 약리학적 활성성분으로 디히드로피리딘계 칼슘채널차단제를 포함하는 지연방출성 구획을 포함하는 약제학적 제제를 제공한다. 본 발명의 약제학적 제제는 레닌 억제 제 및 디히드로피리딘계 칼슘채널차단제의 생체내 약물동태학적 상호작용을 회피할 수 있고, 각 활성성분의 체내 흡수 능력에 따른 최적의 약리효과를 유도하며, 각 활성성분의 약리효과를 발현하는 시간대에 약물을 방출케하여 임상적인 상승효과까 지 얻을 수 있어 대사증후군, 심혈관계 질환, 신장 질환의 예방 또는 치료에 효과 적이다.
PCT/KR2010/001244 2009-02-27 2010-02-26 약제학적 제제 WO2010098625A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2010800080129A CN102316856A (zh) 2009-02-27 2010-02-26 药物制剂

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15619509P 2009-02-27 2009-02-27
US61/156,195 2009-02-27

Publications (2)

Publication Number Publication Date
WO2010098625A2 true WO2010098625A2 (ko) 2010-09-02
WO2010098625A3 WO2010098625A3 (ko) 2011-01-06

Family

ID=42666086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/001244 WO2010098625A2 (ko) 2009-02-27 2010-02-26 약제학적 제제

Country Status (3)

Country Link
KR (1) KR20110129405A (ko)
CN (1) CN102316856A (ko)
WO (1) WO2010098625A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2740492A1 (en) * 2012-12-07 2014-06-11 Ceva Sante Animale Triazine formulations with a second active ingredient and surfactant(s)
CN113081991B (zh) * 2015-06-03 2022-07-15 南京三迭纪医药科技有限公司 药品剂型及其使用
CN107550881B (zh) * 2017-09-28 2020-08-28 南京易亨制药有限公司 一种非洛地平缓释片及其制备工艺

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070078625A (ko) * 2006-01-27 2007-08-01 씨제이 주식회사 멀티플 유닛 타입 서방성 경구 제제 및 그 제조방법
KR20080000624A (ko) * 2005-04-27 2008-01-02 노파르티스 아게 아테롬성동맥경화증의 치료 방법
KR20080018841A (ko) * 2006-08-24 2008-02-28 한올제약주식회사 방출성이 제어된 디히드로피리딘계 칼슘길항제/스타틴계지질저하제의 복합제제

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080000624A (ko) * 2005-04-27 2008-01-02 노파르티스 아게 아테롬성동맥경화증의 치료 방법
KR20070078625A (ko) * 2006-01-27 2007-08-01 씨제이 주식회사 멀티플 유닛 타입 서방성 경구 제제 및 그 제조방법
KR20080018841A (ko) * 2006-08-24 2008-02-28 한올제약주식회사 방출성이 제어된 디히드로피리딘계 칼슘길항제/스타틴계지질저하제의 복합제제

Also Published As

Publication number Publication date
WO2010098625A3 (ko) 2011-01-06
KR20110129405A (ko) 2011-12-01
CN102316856A (zh) 2012-01-11

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