WO2010098549A2 - Dispositif automatique pour aspirer des cellules à l'aide d'une aiguille fine - Google Patents

Dispositif automatique pour aspirer des cellules à l'aide d'une aiguille fine Download PDF

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Publication number
WO2010098549A2
WO2010098549A2 PCT/KR2010/000968 KR2010000968W WO2010098549A2 WO 2010098549 A2 WO2010098549 A2 WO 2010098549A2 KR 2010000968 W KR2010000968 W KR 2010000968W WO 2010098549 A2 WO2010098549 A2 WO 2010098549A2
Authority
WO
WIPO (PCT)
Prior art keywords
motor
syringe
cylinder
cells
aspirator
Prior art date
Application number
PCT/KR2010/000968
Other languages
English (en)
Korean (ko)
Other versions
WO2010098549A3 (fr
Inventor
김동석
Original Assignee
Kim Dong Seok
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kim Dong Seok filed Critical Kim Dong Seok
Publication of WO2010098549A2 publication Critical patent/WO2010098549A2/fr
Publication of WO2010098549A3 publication Critical patent/WO2010098549A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0283—Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/50—Instruments, other than pincettes or toothpicks, for removing foreign bodies from the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0208—Biopsy devices with actuators, e.g. with triggered spring mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3148—Means for causing or aiding aspiration or plunger retraction

Definitions

  • the present invention relates to an automatic fine needle cell aspirator, and more particularly, uniformly and reliably regardless of the individual's skill of the operator in a series of processes of aspirating and extracting cells by puncturing tissue of the body with a needle coupled to a syringe body.
  • the present invention relates to an automatic fine needle cell aspirator configured to be able to automatically suction extract cells and to accurately discharge the extracted cells by a required amount.
  • a syringe is used as a means for performing a cell test.
  • a needle is attached to the body of the body with a needle coupled to the syringe body, and the cells are sucked and extracted and smeared on a slide glass to perform a cell test.
  • the cells are sucked and extracted by puncturing the tissue of the body with a needle coupled to the syringe body.
  • the preliminary work for sucking and extracting the cells is performed by using a needle coupled to the syringe body to poke and rotate the body tissue. Repeat this several times to make the cells easier to aspirate.
  • the plunger constituting the syringe is retracted to generate negative pressure inside the syringe cylinder, and the cells are sucked out.
  • the plunger loaded in the syringe cylinder is pushed to discharge the cells extracted by the suction.
  • the discharge since the discharge is determined by the senses and habits of the hand, the discharge varies with each test, such that the discharge becomes inconsistent.
  • the automatic fine needle cell aspirator of the present invention for solving the above problems is a series of processes in which the needle is coupled to the aspirator main body, and the needle and the needle are rotated and pulled out several times by using the needle.
  • the purpose of the present invention is to provide an automatic fine needle cell aspirator that can reliably suck and extract cells irrespective of the individual skill of the operator.
  • the syringe holder portion to which the syringe is mounted in a state in which the hub is exposed from the body so that the cells are aspirated through the hub of the syringe and connected thereto A suction unit body having a suction unit cap for fixing a syringe inserted into the syringe holder unit; A cylinder handle groove is formed at the front end to engage the cylinder handle of the syringe. A rear screw is formed at the outer end of the rear end to form a male screw coupled to a female screw formed at a rear side of the inner circumferential surface of the syringe.
  • An operating tool which is rotated and moved back and forth within the space part;
  • a plunger handle groove is formed to which the plunger handle of the syringe is coupled, and is installed in a space provided inside the operating port together with a plunger handle detection sensor, and is discharged through an internal and external screw gear to a second motor installed in the space.
  • An operating tool ; And a controller for controlling the operation of the first motor and the second motor, and a first switch and a second switch for operating the first motor and the second motor.
  • the automatic fine needle cell aspirator of the present invention configured as described above, since a series of suction operations are performed automatically by the aspirator, using a needle of a syringe coupled to the aspirator body, the needle is turned and pulled out. Irrespective of the level of skill, there is an effect of uniformly and reliably aspirating cells.
  • the automatic fine needle cell aspirator of the present invention even when the cells are aspirated and extracted by a syringe cylinder, the cells can be discharged accurately and reliably in a necessary amount, thereby increasing the reliability of the cytology. It is effective in increasing the reliability of the aspiration extraction and discharge of cells, and the overall results of cytology.
  • Figure 1 is a perspective view showing the overall configuration of the automatic fine needle cell aspirator according to the present invention
  • Figure 2 is a perspective view showing the internal configuration of the automatic fine needle cell aspirator according to the present invention
  • Figure 3 is a cross-sectional view showing the internal configuration of the automatic fine needle cell aspirator according to the present invention
  • Figure 4 is an exploded cross-sectional view of the internal structure of the automatic fine needle cell aspirator according to the present invention
  • aspirator main body 2 syringe holder
  • FIG. 1 is a perspective view showing the overall configuration of the automatic fine needle cell aspirator according to the present invention
  • Figure 2 is a perspective view showing the internal structure of an automatic fine needle cell aspirator according to the present invention
  • Figure 3 is an internal configuration of an automatic fine needle cell aspirator according to the present invention 4 is a cross-sectional view showing the internal structure of the automatic fine cell aspirator according to the present invention.
  • the automatic fine needle cell aspirator includes a syringe (with the hub 46 exposed from the main body) to confirm that the cells are sucked through the hub 46 of the syringe 41 to which the needle 40 is connected.
  • a syringe holder portion (2) on which 41 is mounted and a space portion (3) connected thereto are formed, and an aspirator provided with an aspirator cap (30) for fixing the syringe (41) inserted into the syringe holder portion (2)
  • a cylinder handle groove 5 is formed at the distal end of which the cylinder handle 43 of the syringe 41 is coupled, and a male screw coupled to the female screw screw 4 formed at the inner circumferential side of the space portion 3 at the rear end outer circumferential surface thereof.
  • the plunger handle groove 11 to which the plunger handle 45 of the syringe 41 is coupled is formed, and together with the plunger handle detection sensor 12 in the space portion 10 provided inside the operating port 7. It is installed, and the discharge operation port 13 connected to the second motor 14 installed in the space portion 10 through the inner and outer screw gears (16) (17);
  • 2 switch 21 comprises a.
  • the first switch 20 drives the first motor 8 and the second motor 14 at the same time, so that a negative pressure is generated inside the syringe cylinder 42, and the syringe 41 of the syringe 41.
  • the forward and backward rotation and the left and right rotations are repeated, and the second switch 21 drives the second motor 14 to perform a discharge function.
  • the cylinder handle groove 5 and the plunger handle groove 11 are both formed in the inlet wider than the width of the cylinder handle 43 and the plunger handle 45, the cylinder handle 43 and the plunger handle 45 ) So that it can be easily mounted.
  • the syringe cylinder 42 to which the needle 40 is coupled is mounted on the syringe holder 2 formed in the aspirator main body 1.
  • the cylinder handle 43 is coupled to the cylinder handle groove 5 formed in the operating port 7 and the plunger handle 45 is coupled to the plunger handle groove 11 of the discharge operation port 13.
  • the hub 46 portion of the syringe cylinder 42 is exposed from the aspirator body 1 so that the suction state of the cells can be seen.
  • the plunger handle detecting sensor 12 installed in the plunger handle groove 11 detects the mounting of the syringe 41 and sends a signal to the controller 15.
  • the controller 15 operates the second motor 14 to cause the plunger 44 to be slightly retracted by the internal and external screw gears 16 and 17.
  • a space of about 1 ms is created in the syringe cylinder 42. This preparation process is very difficult to push out if there is no space secured in advance when the amount of aspirated cells is too small, so that even a small amount of sample can be easily pushed out using the space secured in advance.
  • the syringe 41 is suction-extracted from the cells of the body in the state mounted on the aspirator main body (1). That is, after the syringe 41 is mounted on the aspirator main body 1, the plunger 44 moves backward to suck and extract the cells of the body in a state where a space of about 1 mm is secured inside the syringe cylinder 42. .
  • the plunger handle 45 is moved backward by the second motor 14 so that a negative pressure is applied to the inside of the syringe cylinder 42.
  • the operating tool 7 holding the cylinder handle 43 is moved by the first motor 8. That is, as the first motor 8 repeats the forward rotation and the reverse rotation, the operating port 7 also repeats the forward rotation and the reverse rotation and moves forward and backward by engaging the male and female screws 4 and 6. Will be repeated.
  • the needle 40 repeats the action of stabbing and spinning while rotating the tissue of the body, so that the cells in the tissue can be suctioned and reliably and reliably extracted.
  • the controller 15 controls the first motor 8 and the second motor 14 to continuously perform the operation until the first switch 20 is pressed once again.
  • the aspirating operation is stopped by pressing the first switch 20, and then the needle 40 is removed from the body, and then the aspirated and extracted cells are pressed by pressing the second switch 21. Discharge by amount.
  • the second motor 14 When the second switch 21 is pressed, the second motor 14 is operated to slightly advance the plunger 44 to discharge the cells sucked into the syringe cylinder 42. In this case, since the controller 15 controls to discharge only the proper amount every time the second switch 21 is pressed, when the amount of suction is large, the second switch 21 is sucked by pressing the second switch 21 several times. Divide out the cells several times.
  • the suction was started in the initial state with a free space of about 1 mm in the syringe cylinder 42, the aspirated cells can be discharged cleanly without leaving even a small amount of aspirated cells.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • External Artificial Organs (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne un dispositif automatique pour aspirer des cellules à l'aide d'une aiguille fine, permettant d'aspirer automatiquement des cellules de manière régulière et fiable indépendamment des compétences personnelles de l'utilisateur du dispositif, pendant des processus d'aspiration et d'extraction de cellules d'un tissu, et permettant de vider avec précision la quantité voulue de cellules aspirées et extraites. Le dispositif automatique pour aspirer des cellules à l'aide d'une aiguille fine selon l'invention comprend : un corps d'aspiration (1) présentant une partie support de seringue (2) servant de support à un cylindre de seringue (42), à un logement relié à la partie support de seringue (2), et à un capuchon (30) de corps d'aspiration; un élément fonctionnel (7) qui présente une rainure (5) de collerette de préhension de cylindre servant à l'accouplement d'une collerette (43) de préhension de cylindre, la surface extérieure de l'élément fonctionnel (7) présentant une vis mâle (6) à fixer dans un filetage femelle (4) formé sur une surface intérieure de l'élément fonctionnel (7), let ledit élément (7) tournant et se déplaçant dans les directions avant et arrière au moyen d'un premier moteur (8); un élément fonctionnel de vidage de seringue (13) qui présente une rainure (11) d'élément de préhension de plongeur pour un accouplement à un élément de préhension de plongeur (45) de la seringue, qui est monté conjointement à un capteur (12) d'élément de préhension de plongeur dans un logement (10) formé dans l'élément fonctionnel (7), et qui est relié à un second moteur (14) par des engrenages hélicoïdaux (16, 17); un contrôleur (15) permettant de contrôler le fonctionnement du premier moteur (8) et du second moteur (14); et un premier commutateur (20) et un second commutateur (21) permettant de faire fonctionner le premier moteur (8) et le second moteur (14). Le dispositif automatique pour aspirer des cellules à l'aide d'une aiguille fine selon l'invention effectue automatiquement une série d'opérations d'aspiration dans lesquelles les cellules sont aspirées et extraites de manière régulière et fiable indépendamment des compétences personnelles de l'utilisateur, et sont vidées avec précision, dans la quantité voulue, ce qui permet d'augmenter la fiabilité d'une cytoscopie. Le dispositif automatique d'aspiration de cellules selon l'invention permet d'augmenter la fiabilité du processus dans son ensemble, à savoir l'aspiration et l'extraction de cellules, le vidage de la seringue et la cytoscopie.
PCT/KR2010/000968 2009-02-24 2010-02-17 Dispositif automatique pour aspirer des cellules à l'aide d'une aiguille fine WO2010098549A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0015113 2009-02-24
KR1020090015113A KR101079155B1 (ko) 2009-02-24 2009-02-24 자동세침세포흡인기

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WO2010098549A2 true WO2010098549A2 (fr) 2010-09-02
WO2010098549A3 WO2010098549A3 (fr) 2010-11-25

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KR (1) KR101079155B1 (fr)
WO (1) WO2010098549A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9222953B2 (en) 2013-04-11 2015-12-29 Rarecyte, Inc. Device, system, and method for selecting a target analyte or fluid
US9227188B2 (en) 2013-04-11 2016-01-05 Rarecyte, Inc. Device, system, and method for selecting a target analyte or fluid
CN107595327A (zh) * 2017-10-20 2018-01-19 中国人民解放军第四军医大学 术中甲状旁腺准确识别方法及其检测装置
US10416046B2 (en) 2013-04-11 2019-09-17 Rarecyte, Inc. Device, system, and method for selecting a target analyte
CN111281441A (zh) * 2020-03-13 2020-06-16 北京大学深圳医院 肝病穿刺肝脏标本抽吸辅助装置
CN111643201A (zh) * 2020-07-02 2020-09-11 西安交通大学口腔医院 一种口腔牙齿种植使用的夹持装置

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101524501B1 (ko) * 2013-11-25 2015-06-01 김동주 세침검사용 주사기 제어장치
KR102604528B1 (ko) * 2020-08-12 2023-11-20 인하대학교 산학협력단 극소량의 체액 수집 또는 체액 내 세균/바이오마커 검출을 위한 의료용 이동형 흡인장치

Citations (4)

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US5662612A (en) * 1993-11-24 1997-09-02 Liebel Flarsheim Company Controlling plunger drives for fluid injections in animals
JP2003220136A (ja) * 2002-01-30 2003-08-05 Nemoto Kyorindo:Kk 薬液注入装置、シリンジアダプタ、注入ヘッド
KR200423667Y1 (ko) * 2006-05-31 2006-08-09 양희철 채혈용 주사기 자동보조장치
US20070167920A1 (en) * 2004-08-11 2007-07-19 Edgar Hommann Automatic Injector

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MXPA02011395A (es) 2000-05-18 2003-04-25 Dentsply Int Inc Jeringa surtidora de material fluido.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5662612A (en) * 1993-11-24 1997-09-02 Liebel Flarsheim Company Controlling plunger drives for fluid injections in animals
JP2003220136A (ja) * 2002-01-30 2003-08-05 Nemoto Kyorindo:Kk 薬液注入装置、シリンジアダプタ、注入ヘッド
US20070167920A1 (en) * 2004-08-11 2007-07-19 Edgar Hommann Automatic Injector
KR200423667Y1 (ko) * 2006-05-31 2006-08-09 양희철 채혈용 주사기 자동보조장치

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9222953B2 (en) 2013-04-11 2015-12-29 Rarecyte, Inc. Device, system, and method for selecting a target analyte or fluid
US9227188B2 (en) 2013-04-11 2016-01-05 Rarecyte, Inc. Device, system, and method for selecting a target analyte or fluid
US10416046B2 (en) 2013-04-11 2019-09-17 Rarecyte, Inc. Device, system, and method for selecting a target analyte
US11231344B2 (en) 2013-04-11 2022-01-25 Rarecyte, Inc. Device, system, and method for selecting a target analyte
CN107595327A (zh) * 2017-10-20 2018-01-19 中国人民解放军第四军医大学 术中甲状旁腺准确识别方法及其检测装置
CN111281441A (zh) * 2020-03-13 2020-06-16 北京大学深圳医院 肝病穿刺肝脏标本抽吸辅助装置
CN111643201A (zh) * 2020-07-02 2020-09-11 西安交通大学口腔医院 一种口腔牙齿种植使用的夹持装置

Also Published As

Publication number Publication date
KR20100096305A (ko) 2010-09-02
WO2010098549A3 (fr) 2010-11-25
KR101079155B1 (ko) 2011-11-02

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