WO2010090498A3 - 이고들빼기 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 간 기능 개선용 약학적 조성물 및 간 기능 개선용 건강기능 식품조성물 - Google Patents

이고들빼기 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 간 기능 개선용 약학적 조성물 및 간 기능 개선용 건강기능 식품조성물 Download PDF

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Publication number
WO2010090498A3
WO2010090498A3 PCT/KR2010/000796 KR2010000796W WO2010090498A3 WO 2010090498 A3 WO2010090498 A3 WO 2010090498A3 KR 2010000796 W KR2010000796 W KR 2010000796W WO 2010090498 A3 WO2010090498 A3 WO 2010090498A3
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WO
WIPO (PCT)
Prior art keywords
fraction
isolated therefrom
liver function
active ingredient
extract
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PCT/KR2010/000796
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English (en)
French (fr)
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WO2010090498A2 (ko
Inventor
노주원
이샛별
윤지호
정상훈
이희주
강경수
유지혜
김명수
안수용
김종환
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한국과학기술연구원
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Priority to CN201080002926.4A priority Critical patent/CN102186488B/zh
Publication of WO2010090498A2 publication Critical patent/WO2010090498A2/ko
Publication of WO2010090498A3 publication Critical patent/WO2010090498A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 이고들빼기(Youngia denticulata) 추출물, 이의 분획물 또는 이로부터 분리한 화합물인 클로로제닉엑시드(Chlorogenic acid), 3,5-다이-오-카페오일퀴닉엑시드(3,5-Di-O-caffeoylquinic acid), 영지아사이드 A(Youngiaside A), 영지아사이드 B(Youngiaside B), 영지아사이드 C(Youngiaside C)로 구성되는 군으로부터 선택되는 하나 이상의 화합물을 유효성분으로 함유하는 암 예방용 약학적 조성물 또는 간 기능 개선용 약학적 조성물에 관한 것으로, 본 발명에 따른 이고들빼기 추출물, 이의 분획물 또는 이로부터 분리된 화합물은 암 예방 지표효소인 퀴논 리덕타아제(Quinone reductase, QR)와 항산화 반응인자인 항산화반응인자(Antioxidant response element, ARE)를 비롯한 간의 해독효소의 활성을 증진시키고, 세포 독성이 없을 뿐만 아니라, 에탄올과 아세트아미노펜에 의해 유도되는 간손상으로부터 간을 보호하므로, 본 발명에 따른 조성물은 암 예방 또는 간 기능 개선을 위한 의약품, 건강기능식품에 유용하게 사용될 수 있다.
PCT/KR2010/000796 2009-02-09 2010-02-09 이고들빼기 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 간 기능 개선용 약학적 조성물 및 간 기능 개선용 건강기능 식품조성물 WO2010090498A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201080002926.4A CN102186488B (zh) 2009-02-09 2010-02-09 齿裂黄鹌菜提取物用于制备肝功能改善用药物组合物及用于制备肝功能改善用健康功能食品组合物的用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20090010055 2009-02-09
KR10-2009-0010055 2009-02-09

Publications (2)

Publication Number Publication Date
WO2010090498A2 WO2010090498A2 (ko) 2010-08-12
WO2010090498A3 true WO2010090498A3 (ko) 2011-01-06

Family

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Application Number Title Priority Date Filing Date
PCT/KR2010/000796 WO2010090498A2 (ko) 2009-02-09 2010-02-09 이고들빼기 추출물, 이의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 간 기능 개선용 약학적 조성물 및 간 기능 개선용 건강기능 식품조성물

Country Status (3)

Country Link
KR (2) KR101236233B1 (ko)
CN (1) CN102186488B (ko)
WO (1) WO2010090498A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101404036B1 (ko) * 2011-10-05 2014-06-10 한국과학기술연구원 망막질환 예방 및 치료에 유용한 이고들빼기 추출물
CN102754832A (zh) * 2012-07-12 2012-10-31 赵四海 用酚和醌融解肿瘤和改造癌细胞的治病方法
KR101758144B1 (ko) 2014-08-22 2017-07-17 한국과학기술연구원 이고들빼기 추출물을 포함하는 항노화 조성물
EP3287136A1 (en) * 2016-08-18 2018-02-28 Incospharm Corporation Composition for preventing or treating cell damage including youngia denticulata extract
KR101963644B1 (ko) 2017-03-09 2019-04-01 한국과학기술연구원 기내배양을 통한 이고들빼기 대량생산방법 및 이고들빼기 캘러스 또는 현탁배양액으로부터 추출된 추출물을 유효성분으로 포함하는 화장품 조성물

Citations (4)

* Cited by examiner, † Cited by third party
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KR20040018733A (ko) * 2002-08-27 2004-03-04 주식회사 바이오원 고들빼기 추출물을 함유한 바이러스성 간질환 치료용 조성물
KR20050078917A (ko) * 2004-02-03 2005-08-08 주식회사 바이오원 마과, 씀바귀 및 고들빼기의 추출물을 함유한 복합생약을포함하는 바이러스성 간질환의 예방 및 치료용 조성물
KR100553982B1 (ko) * 2002-08-27 2006-02-22 주식회사 바이오원 마과, 씀바귀 및 고들빼기의 추출물을 함유한 복합생약바이러스성 간질환 치료용 조성물
KR100844161B1 (ko) * 2006-10-12 2008-07-04 문제학 고들빼기 뿌리와 줄기 및 잎으로부터 분리한천연항산화물질 및 그의 분리방법

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JP4644500B2 (ja) 2005-02-03 2011-03-02 アピ株式会社 細胞分化誘導剤及びその製造方法
JP2007131604A (ja) 2005-11-14 2007-05-31 Toyama Prefecture 癌転移抑制剤及び機能性食品

Patent Citations (4)

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KR20040018733A (ko) * 2002-08-27 2004-03-04 주식회사 바이오원 고들빼기 추출물을 함유한 바이러스성 간질환 치료용 조성물
KR100553982B1 (ko) * 2002-08-27 2006-02-22 주식회사 바이오원 마과, 씀바귀 및 고들빼기의 추출물을 함유한 복합생약바이러스성 간질환 치료용 조성물
KR20050078917A (ko) * 2004-02-03 2005-08-08 주식회사 바이오원 마과, 씀바귀 및 고들빼기의 추출물을 함유한 복합생약을포함하는 바이러스성 간질환의 예방 및 치료용 조성물
KR100844161B1 (ko) * 2006-10-12 2008-07-04 문제학 고들빼기 뿌리와 줄기 및 잎으로부터 분리한천연항산화물질 및 그의 분리방법

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Also Published As

Publication number Publication date
WO2010090498A2 (ko) 2010-08-12
KR101236233B1 (ko) 2013-02-22
KR101209574B1 (ko) 2012-12-18
CN102186488A (zh) 2011-09-14
KR20100091131A (ko) 2010-08-18
KR20120031041A (ko) 2012-03-29
CN102186488B (zh) 2014-05-14

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