WO2010068037A2 - 4-헥실레조르시놀-1,3-디올을 유효성분으로 포함하는 항암용 조성물 - Google Patents
4-헥실레조르시놀-1,3-디올을 유효성분으로 포함하는 항암용 조성물 Download PDFInfo
- Publication number
- WO2010068037A2 WO2010068037A2 PCT/KR2009/007361 KR2009007361W WO2010068037A2 WO 2010068037 A2 WO2010068037 A2 WO 2010068037A2 KR 2009007361 W KR2009007361 W KR 2009007361W WO 2010068037 A2 WO2010068037 A2 WO 2010068037A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cancer
- hexylresorcinol
- diol
- active ingredient
- cancer cells
- Prior art date
Links
- WFJIVOKAWHGMBH-UHFFFAOYSA-N CCCCCCc(ccc(O)c1)c1O Chemical compound CCCCCCc(ccc(O)c1)c1O WFJIVOKAWHGMBH-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
본 발명은 4-헥실레조르시놀-1,3-디올을 유효성분으로 포함하는 항암용 조성물에 관한 것이다. 본 발명의 항암용 조성물의 유효성분인 4-헥실레조르시놀-1,3-디올(4-hexylresorcinol-1,3-diol)은 세포 수준에서 암세포의 증식을 억제하고 암세포의 아폽토시스 및 분화를 촉진할 뿐만 아니라, 암세포가 이식된 이종이식 동물모델 및 암환자 대상 임상실험에서 종양의 성장을 현저히 억제하는 효능을 나타낸다. 본 발명의 항암용 조성물은 다양한 암세포에 대해 현저한 증식억제 활성을 나타냄으로써 매우 우수한 성능의 항암제로 개발될 수 있다.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2008-0125087 | 2008-12-10 | ||
KR1020080125087A KR20100066675A (ko) | 2008-12-10 | 2008-12-10 | 4-헥실레조르시놀-1,3-디올을 유효성분으로 포함하는 항암용 조성물 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2010068037A2 true WO2010068037A2 (ko) | 2010-06-17 |
WO2010068037A9 WO2010068037A9 (ko) | 2010-09-02 |
WO2010068037A3 WO2010068037A3 (ko) | 2010-10-14 |
Family
ID=42243218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2009/007361 WO2010068037A2 (ko) | 2008-12-10 | 2009-12-09 | 4-헥실레조르시놀-1,3-디올을 유효성분으로 포함하는 항암용 조성물 |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR20100066675A (ko) |
WO (1) | WO2010068037A2 (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210086463A (ko) * | 2019-12-30 | 2021-07-08 | 경북대학교 산학협력단 | 4-헥실레소르시놀을 유효성분으로 포함하는 골질환 예방 또는 치료용 약학조성물 |
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2008
- 2008-12-10 KR KR1020080125087A patent/KR20100066675A/ko not_active Application Discontinuation
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2009
- 2009-12-09 WO PCT/KR2009/007361 patent/WO2010068037A2/ko active Application Filing
Non-Patent Citations (3)
Title |
---|
BARBINI, L. ET AL.: 'Induction of apoptosis on human hepatocarcinoma cell lines by an alkyl resorcinol isolated from Lithraea molleoides' WORLD JOURNAL OF GASASTROENTEROLOGY vol. 12, no. 37, 2006, pages 5959 - 5963 * |
CHHABRA, R.S.: 'Inhibition of some spontaneous tumors by 4-hexylresorcinol F344/N rats and B6C3F1 mice' FUNDAMENTAL AND APPLIED TOXICOLOGY vol. 11, no. 4, 1988, pages 685 - 690 * |
KIM, SEONG GON ET AL.: '4-Hexylresorcinol Induced an Apoptosis and Differentiation of Oral Cancer Cells' JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY vol. 65, no. 9, 2007, page 41E * |
Also Published As
Publication number | Publication date |
---|---|
KR20100066675A (ko) | 2010-06-18 |
WO2010068037A9 (ko) | 2010-09-02 |
WO2010068037A3 (ko) | 2010-10-14 |
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