WO2010062057A2 - Composition for promoting implantation of embryo or pregnancy - Google Patents

Composition for promoting implantation of embryo or pregnancy Download PDF

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Publication number
WO2010062057A2
WO2010062057A2 PCT/KR2009/006419 KR2009006419W WO2010062057A2 WO 2010062057 A2 WO2010062057 A2 WO 2010062057A2 KR 2009006419 W KR2009006419 W KR 2009006419W WO 2010062057 A2 WO2010062057 A2 WO 2010062057A2
Authority
WO
WIPO (PCT)
Prior art keywords
composition
pregnancy
embryo
implantation
rate
Prior art date
Application number
PCT/KR2009/006419
Other languages
French (fr)
Korean (ko)
Other versions
WO2010062057A3 (en
Inventor
김철호
강승우
Original Assignee
주식회사 베네비오
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 베네비오 filed Critical 주식회사 베네비오
Publication of WO2010062057A2 publication Critical patent/WO2010062057A2/en
Publication of WO2010062057A3 publication Critical patent/WO2010062057A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24035—Gelatinase B (3.4.24.35), i.e. matrix metalloprotease 9 or MMP9

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to a composition for promoting implantation of an embryo or pregnancy of an animal, containing MMP-9(metalloproteinase-9) as active ingredients. The composition of the present invention significantly increases an embryo implantation rate, or remarkably increases a pregnancy rate. As proved in the following embodiment, the composition of the present invention leads to a 25% increase in pregnancy rate and embryo implantation rate.
PCT/KR2009/006419 2008-11-03 2009-11-03 Composition for promoting implantation of embryo or pregnancy WO2010062057A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0108199 2008-11-03
KR1020080108199A KR20100049153A (en) 2008-11-03 2008-11-03 Compositions for enhancing embryo implantation or pregnancy

Publications (2)

Publication Number Publication Date
WO2010062057A2 true WO2010062057A2 (en) 2010-06-03
WO2010062057A3 WO2010062057A3 (en) 2010-08-19

Family

ID=42226212

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/006419 WO2010062057A2 (en) 2008-11-03 2009-11-03 Composition for promoting implantation of embryo or pregnancy

Country Status (2)

Country Link
KR (1) KR20100049153A (en)
WO (1) WO2010062057A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101897896B1 (en) 2017-02-03 2018-09-12 고려대학교 산학협력단 Composition comprising Coumestrol for improving pregnancy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100570501B1 (en) * 2003-03-20 2006-04-12 김철호 A pregnancy predicting Kit and Method thereof
KR20080072353A (en) * 2007-02-02 2008-08-06 주식회사 베네비오 Uses of mmp-9 activities present in blood

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100570501B1 (en) * 2003-03-20 2006-04-12 김철호 A pregnancy predicting Kit and Method thereof
KR20080072353A (en) * 2007-02-02 2008-08-06 주식회사 베네비오 Uses of mmp-9 activities present in blood

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BAI SX ET AL.: 'Dynamic expression of matrix metalloproteinases (MMP-2, -9 and -14) and the tissue inhibitors of MMPs (TIMP-1, -2 and -3) at the implantation site during tubal pregnancy.' REPRODUCTION. vol. 192, no. 1, January 2005, pages 103 - 113 *
BANY BM ET AL.: 'Expression of matrix metalloproteinases 2 and 9 in the mouse uterus during implantation and oil-induced decidualization.' J REPROD FERTIL. vol. 120, no. 1, September 2000, pages 125 - 134 *
HULBOY DL ET AL.: 'Matrix metalloproteinases as mediators of reproductive function.' MOL HUM REPROD. vol. 3, no. 1, January 1997, pages 27 - 45 *
LEE DM ET AL.: 'The expression of matrix metalloproteinase-9 in human follicular fluid is associated with in vitro fertilisation pregnancy.' BJOG. vol. 112, no. 7, July 2005, pages 946 - 951 *
ZHAO YG ET AL.: 'Expression of matrix metalloproteinase -2, -9 and tissue inhibitors of metalloproteinase -1, -2, -3 mRNAs in rat uterus during early pregnancy.' MOL REPROD DEV. vol. 62, no. 2, June 2002, pages 149 - 158 *

Also Published As

Publication number Publication date
WO2010062057A3 (en) 2010-08-19
KR20100049153A (en) 2010-05-12

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