WO2006103638A3 - Topical pharmaceutical compositions of terbinafine and processes for their preparation - Google Patents

Topical pharmaceutical compositions of terbinafine and processes for their preparation Download PDF

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Publication number
WO2006103638A3
WO2006103638A3 PCT/IB2006/050991 IB2006050991W WO2006103638A3 WO 2006103638 A3 WO2006103638 A3 WO 2006103638A3 IB 2006050991 W IB2006050991 W IB 2006050991W WO 2006103638 A3 WO2006103638 A3 WO 2006103638A3
Authority
WO
WIPO (PCT)
Prior art keywords
terbinafine
processes
preparation
pharmaceutical compositions
topical pharmaceutical
Prior art date
Application number
PCT/IB2006/050991
Other languages
French (fr)
Other versions
WO2006103638A2 (en
Inventor
Swati Aggarwal
Romi Barat Singh
Vishnubhotla Nagaprasad
Tarun Vijan
Original Assignee
Ranbaxy Lab Ltd
Swati Aggarwal
Romi Barat Singh
Vishnubhotla Nagaprasad
Tarun Vijan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Swati Aggarwal, Romi Barat Singh, Vishnubhotla Nagaprasad, Tarun Vijan filed Critical Ranbaxy Lab Ltd
Publication of WO2006103638A2 publication Critical patent/WO2006103638A2/en
Publication of WO2006103638A3 publication Critical patent/WO2006103638A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to topical pharmaceutical compositions of terbinafine,one or more non-ionic surfactants, and one or more fatty acids or fatty alcohols, and processes for their preparation.
PCT/IB2006/050991 2005-03-31 2006-03-31 Topical pharmaceutical compositions of terbinafine and processes for their preparation WO2006103638A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN713DE2005 2005-03-31
IN713/DEL/2005 2005-03-31

Publications (2)

Publication Number Publication Date
WO2006103638A2 WO2006103638A2 (en) 2006-10-05
WO2006103638A3 true WO2006103638A3 (en) 2007-02-15

Family

ID=37053767

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/050991 WO2006103638A2 (en) 2005-03-31 2006-03-31 Topical pharmaceutical compositions of terbinafine and processes for their preparation

Country Status (1)

Country Link
WO (1) WO2006103638A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2120870A2 (en) * 2007-02-21 2009-11-25 Power Paper Ltd. Terbinafine formulation for iontophoresis
PE20110642A1 (en) * 2008-07-23 2011-08-31 Tdt Ltd TOPIC ANTIFUNGAL FORMULATIONS BASED ON TERBINAFINE AND TERBINAFINE-SIMILAR COMPOUNDS AND METHODS OF USE
JP5832302B2 (en) 2009-02-26 2015-12-16 ビー．アール．エイ．アイ．エヌ．バイオテクノロジー リサーチ アンド インフォメーション ネットワーク アクチエンゲゼルシャフトＢ．Ｒ．Ａ．Ｉ．Ｎ． Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ ａｎｄ Ｉｎｆｏｒｍａｔｉｏｎ Ｎｅｔｗｏｒｋ ＡＧ Compositions, uses and methods of use of surface active proteins in topical drug delivery to keratin
DK2672962T3 (en) * 2011-02-11 2015-04-20 Moberg Pharma Ab Novel anti-fungal composition
CN106474051B (en) * 2011-03-21 2022-07-08 博任达生化科技（上海）有限公司 Reverse temperature-sensitive reversible hydrogel composition
CN114981379B (en) * 2019-10-08 2024-05-14 哈尔卢克斯股份有限公司 Compositions and methods for treating onychomycosis
JP2023553574A (en) 2020-12-08 2023-12-22 モバーグ ファーマ アーベー Treatment plan for onychomycosis using antifungal allylamine compositions

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681849A (en) * 1991-05-20 1997-10-28 Novartis Ag Ltd. Pharmaceutical composition for topical applications
WO1999020250A1 (en) * 1997-10-17 1999-04-29 Soltec Research Pty. Ltd. Topical antifungal composition
WO2001060345A2 (en) * 2000-02-18 2001-08-23 Novartis Ag Pharmaceutical composition comprising squalene epoxidase inhibitor and macrolide immunomodulator
US6455592B1 (en) * 1991-03-08 2002-09-24 Novartis Ag Use of hydrophilic penetration agents in dermatological compositions for the treatment of onychomycoses, and corresponding compositions
WO2005013955A2 (en) * 2003-08-12 2005-02-17 Novartis Consumer Health S.A. Topical composition comprising terbinafine and hydrocortisone
WO2006012146A2 (en) * 2004-06-24 2006-02-02 Idexx Laboratories, Inc. Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455592B1 (en) * 1991-03-08 2002-09-24 Novartis Ag Use of hydrophilic penetration agents in dermatological compositions for the treatment of onychomycoses, and corresponding compositions
US5681849A (en) * 1991-05-20 1997-10-28 Novartis Ag Ltd. Pharmaceutical composition for topical applications
WO1999020250A1 (en) * 1997-10-17 1999-04-29 Soltec Research Pty. Ltd. Topical antifungal composition
WO2001060345A2 (en) * 2000-02-18 2001-08-23 Novartis Ag Pharmaceutical composition comprising squalene epoxidase inhibitor and macrolide immunomodulator
WO2005013955A2 (en) * 2003-08-12 2005-02-17 Novartis Consumer Health S.A. Topical composition comprising terbinafine and hydrocortisone
WO2006012146A2 (en) * 2004-06-24 2006-02-02 Idexx Laboratories, Inc. Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALBERTI I ET AL: "In vivo assessment of enhanced topical delivery of terbinafine to human stratum corneum", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 71, no. 3, 28 April 2001 (2001-04-28), pages 319 - 327, XP004234529, ISSN: 0168-3659 *
BUNDESVERBAND DER PHARMAZEUTISCHEN INDUSTRIE E.V.: "Rote Liste 1995", 1995, ECV-EDITIO CANTOR, AUKLENDORF, GERMANY, XP002404962 *

Also Published As

Publication number Publication date
WO2006103638A2 (en) 2006-10-05

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