WO2010059711A1 - Ligands de récepteur sigma-1 et leurs procédés d'utilisation - Google Patents

Ligands de récepteur sigma-1 et leurs procédés d'utilisation Download PDF

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Publication number
WO2010059711A1
WO2010059711A1 PCT/US2009/064970 US2009064970W WO2010059711A1 WO 2010059711 A1 WO2010059711 A1 WO 2010059711A1 US 2009064970 W US2009064970 W US 2009064970W WO 2010059711 A1 WO2010059711 A1 WO 2010059711A1
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WO
WIPO (PCT)
Prior art keywords
sigma
receptor
compound
compounds
alkyl
Prior art date
Application number
PCT/US2009/064970
Other languages
English (en)
Inventor
Arnold E. Ruoho
Abdol R. Hajipour
Uyen B. Chu
Dominique A. Fontanilla
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of WO2010059711A1 publication Critical patent/WO2010059711A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton

Abstract

L'invention porte sur des composés de formule I et des compositions contenant lesdits composés. L'invention porte également sur des procédés d'utilisation des composés et des compositions. Les composés de l'invention peuvent créer une liaison à haute affinité avec les récepteurs sigma-1 chez un mammifère. Les composés peuvent présenter une sélectivité pour le récepteur sigma-1 par rapport au récepteur sigma-2. Les composés et compositions de l'invention peuvent également être utilisés pour traiter des affections qui impliquent le récepteur sigma-1, tels que l'accoutumance, les affections cardiovasculaires, et le cancer, par exemple le cancer du sein, du poumon, de la prostate, le cancer ovarien, colorectal, ou des troubles du système nerveux central.
PCT/US2009/064970 2008-11-18 2009-11-18 Ligands de récepteur sigma-1 et leurs procédés d'utilisation WO2010059711A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11564108P 2008-11-18 2008-11-18
US61/115,641 2008-11-18

Publications (1)

Publication Number Publication Date
WO2010059711A1 true WO2010059711A1 (fr) 2010-05-27

Family

ID=41460114

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/064970 WO2010059711A1 (fr) 2008-11-18 2009-11-18 Ligands de récepteur sigma-1 et leurs procédés d'utilisation

Country Status (2)

Country Link
US (2) US8349898B2 (fr)
WO (1) WO2010059711A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2615111A1 (fr) 2012-01-10 2013-07-17 Laboratorios del Dr. Esteve S.A. Procédés pour identifier les ligands de récepteurs de sigma-1
CN103483209A (zh) * 2013-09-13 2014-01-01 陕西嘉禾植物化工有限责任公司 一种大麦碱的合成方法
WO2016094821A3 (fr) * 2014-12-11 2016-08-25 Beta Pharma, Inc. Dérivés de 2-anilinopyrimidine substitués utilisés comme modulateurs de l'egfr
KR101724541B1 (ko) * 2016-04-29 2017-04-07 제주대학교 산학협력단 페닐아세트알데히드를 포함하는, 유방암 줄기세포 성장 억제용 조성물

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2771341A4 (fr) * 2011-10-28 2015-09-23 Univ Texas Nouvelles compositions et procédés pour traiter le cancer
US20200087730A1 (en) * 2016-12-16 2020-03-19 Drexel University Methods of identifying and treating tumors with sigma1 inhibitors
CN113620821A (zh) * 2021-09-01 2021-11-09 广汉市派瑞林科技有限责任公司 一种大麦芽碱盐酸盐的制备方法
WO2024033399A1 (fr) * 2022-08-10 2024-02-15 Institut National de la Santé et de la Recherche Médicale Ligand sigmar1 pour traitement du cancer du pancréas

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1109924A (en) * 1965-11-29 1968-04-18 Roche Products Ltd Novel substituted diphenylalkyl amines and a process for the manufacture thereof
WO1993000313A2 (fr) * 1991-06-27 1993-01-07 Virginia Commonwealth University Ligands de recepteurs sigma et leur utilisation
EP0697407A1 (fr) * 1994-08-19 1996-02-21 MITSUI TOATSU CHEMICALS, Inc. Dérivés de pyrimidinedione et compositions antiarrhythmiques les contenant
WO2000050377A1 (fr) * 1999-02-26 2000-08-31 University Of South Florida Synthese efficace d'amines secondaires par alkylation selective d'amines primaires
US6482986B1 (en) * 1999-06-11 2002-11-19 Sanofi-Synthelabo Benzene derivatives, preparation method and pharmaceutical compositions containing same
FR2846882A1 (fr) * 2002-09-05 2004-05-14 Oreal Utilisation d'une amine phenylee secondaire ou tertiaire pour lisser les rides et ridules
WO2006013048A1 (fr) * 2004-08-05 2006-02-09 F.Hoffmann-La Roche Ag Derives d'indole, d'indazole ou d'indoline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277501A (en) * 1977-12-19 1981-07-07 Eli Lilly And Company Para-nitrophenylalkylamines and pharmaceutical compositions
NL8105170A (nl) * 1980-12-10 1982-07-01 Thomae Gmbh Dr K Nieuwe fenylalkylaminen, werkwijze ter bereiding daarvan en de toepassing daarvan als geneesmiddelen.

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1109924A (en) * 1965-11-29 1968-04-18 Roche Products Ltd Novel substituted diphenylalkyl amines and a process for the manufacture thereof
WO1993000313A2 (fr) * 1991-06-27 1993-01-07 Virginia Commonwealth University Ligands de recepteurs sigma et leur utilisation
EP0697407A1 (fr) * 1994-08-19 1996-02-21 MITSUI TOATSU CHEMICALS, Inc. Dérivés de pyrimidinedione et compositions antiarrhythmiques les contenant
WO2000050377A1 (fr) * 1999-02-26 2000-08-31 University Of South Florida Synthese efficace d'amines secondaires par alkylation selective d'amines primaires
US6482986B1 (en) * 1999-06-11 2002-11-19 Sanofi-Synthelabo Benzene derivatives, preparation method and pharmaceutical compositions containing same
FR2846882A1 (fr) * 2002-09-05 2004-05-14 Oreal Utilisation d'une amine phenylee secondaire ou tertiaire pour lisser les rides et ridules
WO2006013048A1 (fr) * 2004-08-05 2006-02-09 F.Hoffmann-La Roche Ag Derives d'indole, d'indazole ou d'indoline

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAIR K W ET AL: "(1-Pyrenylmethyl)amino Alcohols, a New Class of Antitumor DNA Intercalators. Discovery and Initial Amine Side Chain Structure-Activity Studies", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 33, no. 9, 1 January 1990 (1990-01-01), pages 2385 - 2393, XP002099784, ISSN: 0022-2623 *
FONTANILLA, DOMINIQUE ET AL: "Probing the Steroid Binding Domain-like I (SBDLI) of the Sigma -1 Receptor Binding Site Using N-Substituted Photoaffinity Labels", BIOCHEMISTRY , 47(27), 7205-7217 CODEN: BICHAW; ISSN: 0006-2960, 12 June 2008 (2008-06-12), XP002562248 *
WILKERSON W ET AL: "Anti-inflammatory phospholipase-A2 inhibitors. II. Design, synthesis and structure-activity relationship", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 27, no. 6, 1 September 1992 (1992-09-01), pages 595 - 610, XP023870773, ISSN: 0223-5234, [retrieved on 19920901] *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2615111A1 (fr) 2012-01-10 2013-07-17 Laboratorios del Dr. Esteve S.A. Procédés pour identifier les ligands de récepteurs de sigma-1
WO2013104648A1 (fr) 2012-01-10 2013-07-18 Laboratorios Del Dr. Esteve, S.A. Procédé pour identifier des ligands pour des récepteurs sigma -1
CN103483209A (zh) * 2013-09-13 2014-01-01 陕西嘉禾植物化工有限责任公司 一种大麦碱的合成方法
US10590111B2 (en) 2014-12-11 2020-03-17 Beta Pharma, Inc. Substituted 2-anilinopyrimidine derivatives as EGFR modulators
WO2016094821A3 (fr) * 2014-12-11 2016-08-25 Beta Pharma, Inc. Dérivés de 2-anilinopyrimidine substitués utilisés comme modulateurs de l'egfr
AU2015360360B2 (en) * 2014-12-11 2020-06-25 Beta Pharma (Shanghai) Co., Ltd. Substituted 2-anilinopyrimidine derivatives as EGFR modulators
EA036453B1 (ru) * 2014-12-11 2020-11-12 Бета Фарма, Инк. Замещенные производные 2-анилинпиримидина в качестве модуляторов egfr
CN112457298A (zh) * 2014-12-11 2021-03-09 贝达医药公司 取代的2-苯胺基嘧啶衍生物及其作为表皮生长因子受体调节剂
US11414401B2 (en) 2014-12-11 2022-08-16 Beta Pharma Inc. Substituted 2-anilinopyrimidine derivatives as EGFR modulators
CN112457298B (zh) * 2014-12-11 2024-05-07 贝达医药公司 取代的2-苯胺基嘧啶衍生物及其作为表皮生长因子受体调节剂
KR101724541B1 (ko) * 2016-04-29 2017-04-07 제주대학교 산학협력단 페닐아세트알데히드를 포함하는, 유방암 줄기세포 성장 억제용 조성물
WO2017188690A1 (fr) * 2016-04-29 2017-11-02 제주대학교 산학협력단 Composition permettant d'inhiber la croissance des cellules souches cancéreuses mammaires, comprenant du phénylacétaldéhyde
US11324706B2 (en) 2016-04-29 2022-05-10 Jeju National University-Academic Cooperation Foundation Composition for inhibiting growth of breast cancer stem cells containing phenylacetaldehyde

Also Published As

Publication number Publication date
US8349898B2 (en) 2013-01-08
US20100179111A1 (en) 2010-07-15
US8946302B2 (en) 2015-02-03
US20130102571A1 (en) 2013-04-25

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