WO2010056048A2 - 아릴옥시아세틸계 화합물을 유효성분으로 포함하는 dna 메틸트랜스퍼레이즈 억제용 약학적 조성물 - Google Patents

아릴옥시아세틸계 화합물을 유효성분으로 포함하는 dna 메틸트랜스퍼레이즈 억제용 약학적 조성물 Download PDF

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Publication number
WO2010056048A2
WO2010056048A2 PCT/KR2009/006643 KR2009006643W WO2010056048A2 WO 2010056048 A2 WO2010056048 A2 WO 2010056048A2 KR 2009006643 W KR2009006643 W KR 2009006643W WO 2010056048 A2 WO2010056048 A2 WO 2010056048A2
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WIPO (PCT)
Prior art keywords
aryloxyacetyl
dna
based compounds
present
pharmaceutical composition
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PCT/KR2009/006643
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English (en)
French (fr)
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WO2010056048A3 (ko
Inventor
이경
원미선
이정준
정경숙
박성규
권병목
임남희
강정은
김영란
하연
김보연
안종석
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한국생명공학연구원
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Publication of WO2010056048A2 publication Critical patent/WO2010056048A2/ko
Publication of WO2010056048A3 publication Critical patent/WO2010056048A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 화학식 1로 표시되는 아릴옥시아세틸계 화합물을 유효성분으로 함유하는 DNA 메틸렌트랜스퍼레이즈 억제용 약학적 조성물에 관한 것으로, 본 발명에 의한 조성물은 DNA 과메틸화(DNA hypermethylation)에 의해 유발되는 질환 인항종양, 뇌신경 질환, 혈액질환, 후생유전 질환의 치료제로 사용될 수 있다. 또한, 본 발명은 DNA 메틸트랜스퍼레이즈 억제제 또는 DNA 메틸레이션 억제제를 제조하기 위해 하기 화학식(1)로 표시되는 아릴옥시아세틸계 화합물 또는 이의 약학적으로 허용가능한 염을 사용하는 용도 제공한다. 본 발명은 화학식 1로 표시되는 아릴옥시아세틸계 화합물 (LW6) 또는 이의 약학적으로 허용되는 염을 DNA 메틸트랜스퍼레이즈 억제 또는 DNA 메틸레이션 억제를 필요로 하는 포유류(인간 포함)에게 투여함으로서 DNA 과메틸화에 의해 유발되는 질환을 치료하는 방법을 제공한다.
PCT/KR2009/006643 2008-11-12 2009-11-12 아릴옥시아세틸계 화합물을 유효성분으로 포함하는 dna 메틸트랜스퍼레이즈 억제용 약학적 조성물 WO2010056048A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0112141 2008-11-12
KR1020080112141A KR20100053150A (ko) 2008-11-12 2008-11-12 아릴옥시아세틸계 유도체를 유효성분으로 포함하는 ｄｎａ 메틸트렌스퍼레이즈 억제용 약학적 조성물

Publications (2)

Publication Number Publication Date
WO2010056048A2 true WO2010056048A2 (ko) 2010-05-20
WO2010056048A3 WO2010056048A3 (ko) 2010-08-26

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PCT/KR2009/006643 WO2010056048A2 (ko) 2008-11-12 2009-11-12 아릴옥시아세틸계 화합물을 유효성분으로 포함하는 dna 메틸트랜스퍼레이즈 억제용 약학적 조성물

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KR (1) KR20100053150A (ko)
WO (1) WO2010056048A2 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2760823A4 (en) * 2011-09-27 2015-05-20 Univ Dongguk Ind Acad Coop NEW COMPOUNDS AS A HIF-1 INHIBITOR AND METHOD OF MANUFACTURING THEREOF

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020060991A (ko) * 1999-12-09 2002-07-19 아스트라제네카 아베 아다만탄 유도체
KR20050101559A (ko) * 2003-02-21 2005-10-24 아스트라제네카 아베 아다만탄 유도체, 이의 제조 방법 및 이를 함유하는 제약조성물
KR100787131B1 (ko) * 2006-07-04 2007-12-21 한국생명공학연구원 Ｈｉｆ―１ 활성을 저해하는 화합물, 이의 제조방법 및이를 유효성분으로 함유하는 약학적 조성물

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020060991A (ko) * 1999-12-09 2002-07-19 아스트라제네카 아베 아다만탄 유도체
KR20050101559A (ko) * 2003-02-21 2005-10-24 아스트라제네카 아베 아다만탄 유도체, 이의 제조 방법 및 이를 함유하는 제약조성물
KR100787131B1 (ko) * 2006-07-04 2007-12-21 한국생명공학연구원 Ｈｉｆ―１ 활성을 저해하는 화합물, 이의 제조방법 및이를 유효성분으로 함유하는 약학적 조성물

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2760823A4 (en) * 2011-09-27 2015-05-20 Univ Dongguk Ind Acad Coop NEW COMPOUNDS AS A HIF-1 INHIBITOR AND METHOD OF MANUFACTURING THEREOF
AU2012316941B2 (en) * 2011-09-27 2016-02-25 Dongguk University Industry-Academic Cooperation Foundation Novel compounds as HIF-1alphainhibitors and manufacturing process thereof
US9315507B2 (en) 2011-09-27 2016-04-19 Dongguk University Industry-Academic Cooperation Foundation Compounds as HIF-1alphainhibitors and manufacturing process thereof

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KR20100053150A (ko) 2010-05-20
WO2010056048A3 (ko) 2010-08-26

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