WO2010047515A2 - 바이포달 펩타이드 바인더 - Google Patents

바이포달 펩타이드 바인더 Download PDF

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Publication number
WO2010047515A2
WO2010047515A2 PCT/KR2009/006059 KR2009006059W WO2010047515A2 WO 2010047515 A2 WO2010047515 A2 WO 2010047515A2 KR 2009006059 W KR2009006059 W KR 2009006059W WO 2010047515 A2 WO2010047515 A2 WO 2010047515A2
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WO
WIPO (PCT)
Prior art keywords
peptide binder
bipodal peptide
present
target
antiparallel
Prior art date
Application number
PCT/KR2009/006059
Other languages
English (en)
French (fr)
Other versions
WO2010047515A3 (ko
WO2010047515A9 (ko
Inventor
전상용
김성현
박세호
Original Assignee
광주과학기술원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 광주과학기술원 filed Critical 광주과학기술원
Priority to US12/999,717 priority Critical patent/US10131693B2/en
Priority to EP09822191.4A priority patent/EP2360172B1/en
Priority to CA2741040A priority patent/CA2741040C/en
Priority to AU2009307249A priority patent/AU2009307249B2/en
Priority to CN200980146415.7A priority patent/CN102224162B/zh
Priority to JP2011533100A priority patent/JP5390621B2/ja
Publication of WO2010047515A2 publication Critical patent/WO2010047515A2/ko
Publication of WO2010047515A9 publication Critical patent/WO2010047515A9/ko
Publication of WO2010047515A3 publication Critical patent/WO2010047515A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

본 발명은 (a) 가닥간(interstrand) 비공유결합이 형성된 패러럴(parallel), 안티패러럴(antiparallel) 또는 패러럴(parallel)과 안티패러럴(antiparallel) 아미노산 가닥들을 포함하는 구조 안정화 부위(structure stabilizing region); 및 (b) 상기 구조 안정화 부위의 양 말단에 결합되어 있고 무작위적으로 선택된 각각 n 및 m개의 아미노산을 포함하는 타겟 결합 부위 I(target binding region I) 및 타겟 결합 부위 Ⅱ(target binding region Ⅱ)를 포함하는 타겟에 특이적으로 결합하는 바이포달 펩타이드 바인더, 그리고 그의 제조방법에 관한 것으로서, 본 발명의 바이포달 펩타이드 바인더는 매우 낮은 수준(예컨대, nM 수준)의 KD 값(해리상수)을 나타내어, 타겟에 매우 높은 친화도를 나타낸다. 본 발명의 바이포달 펩타이드 바인더는 의약으로서의 용도를 가질 뿐만 아니라, 인 비보 분자 이미징, 인 비트로 세포 이미징 및 약물전달용 타겟팅을 하는 데 이용될 수 있으며, 에스코트 분자로도 매우 유용하게 이용될 수 있다.
PCT/KR2009/006059 2008-10-20 2009-10-20 바이포달 펩타이드 바인더 WO2010047515A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US12/999,717 US10131693B2 (en) 2008-10-20 2009-10-20 Bipodal-peptide binder
EP09822191.4A EP2360172B1 (en) 2008-10-20 2009-10-20 Bipodal peptide binder
CA2741040A CA2741040C (en) 2008-10-20 2009-10-20 Bipodal-peptide binder
AU2009307249A AU2009307249B2 (en) 2008-10-20 2009-10-20 Bipodal peptide binder
CN200980146415.7A CN102224162B (zh) 2008-10-20 2009-10-20 双齿肽结合物
JP2011533100A JP5390621B2 (ja) 2008-10-20 2009-10-20 二座ペプチドバインダー

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0102648 2008-10-20
KR20080102648 2008-10-20

Publications (3)

Publication Number Publication Date
WO2010047515A2 true WO2010047515A2 (ko) 2010-04-29
WO2010047515A9 WO2010047515A9 (ko) 2010-06-17
WO2010047515A3 WO2010047515A3 (ko) 2010-07-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/006059 WO2010047515A2 (ko) 2008-10-20 2009-10-20 바이포달 펩타이드 바인더

Country Status (8)

Country Link
US (1) US10131693B2 (ko)
EP (1) EP2360172B1 (ko)
JP (1) JP5390621B2 (ko)
KR (2) KR101151805B1 (ko)
CN (1) CN107011415A (ko)
AU (1) AU2009307249B2 (ko)
CA (1) CA2741040C (ko)
WO (1) WO2010047515A2 (ko)

Cited By (5)

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WO2011132939A2 (ko) * 2010-04-20 2011-10-27 광주과학기술원 Rtk에 특이적으로 결합하는 rtk-bpb
WO2011132940A2 (ko) * 2010-04-20 2011-10-27 광주과학기술원 Rtk에 특이적으로 결합하는 rtk-bpb
US20140296479A1 (en) * 2011-04-08 2014-10-02 Gwangju Institute Of Science And Technology D-aptide and retro-inverso aptide with maintained target affinity and improved stability
WO2018087232A1 (en) 2016-11-11 2018-05-17 University Of Copenhagen Binding peptides
RU2793935C2 (ru) * 2018-12-26 2023-04-10 Скинмед Ко., Лтд. Пептиды, ингибирующие ацетилхолиновые рецепторы, и их применение

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KR20130103301A (ko) * 2010-04-20 2013-09-23 광주과학기술원 전사인자에 특이적으로 결합하는 ｔｆ-ｂｐｂ
KR20130103300A (ko) * 2010-04-20 2013-09-23 광주과학기술원 Ｇｐｃｒ에 특이적으로 결합하는 ｇｐｃｒ-ｂｐｂ
KR101347833B1 (ko) * 2011-12-29 2014-01-16 광주과학기술원 Ｃｄ7 특이적으로 결합하는 ｃｄ7 -ｂｐｂ
KR101443839B1 (ko) * 2012-07-27 2014-09-26 광주과학기술원 펩타이드의 타겟 친화도 개선방법
EP2909226A4 (en) * 2012-10-19 2016-04-13 Nat Res Council Canada PEPTIDE DERIVATIVES IN HAIR PINS BINDERING COLLAGEN
WO2014071234A1 (en) * 2012-11-02 2014-05-08 The Governing Council Of The University Of Toronto Gb1 peptidic compounds and methods for making and using the same
JP5904565B2 (ja) * 2012-12-27 2016-04-13 国立研究開発法人産業技術総合研究所 微小タンパク質の骨格構造に基づく分子ライブラリ
KR101531944B1 (ko) * 2013-12-24 2015-06-29 광주과학기술원 Ｖｅｇｆ에 특이적으로 결합하는 ｖｅｇｆ－ｂｐｂ
KR20150118252A (ko) * 2014-04-11 2015-10-22 한국과학기술원 환형의 β-헤어핀 기반 펩타이드 바인더 및 이의 제조방법
KR101971092B1 (ko) * 2017-06-28 2019-04-23 한국세라믹기술원 아세틸콜린수용체 결합 펩타이드
WO2019233605A1 (en) * 2018-06-08 2019-12-12 BioNTech SE Compositions and methods for diagnosis and treatment of cancer
KR20200080179A (ko) 2018-12-26 2020-07-06 아미코젠주식회사 아세틸콜린 수용체 저해 펩타이드 및 이의 용도
WO2020138948A2 (ko) * 2018-12-26 2020-07-02 아미코젠주식회사 아세틸콜린 수용체 저해 펩타이드 및 이의 용도
KR20230017747A (ko) 2021-07-27 2023-02-06 주식회사 스킨메드 아세틸콜린 수용체 결합 최적화 단축 펩타이드 및 이의 용도
WO2023008913A1 (ko) 2021-07-27 2023-02-02 주식회사 스킨메드 아세틸콜린 수용체 결합 최적화 단축 펩타이드 및 이의 용도

Citations (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
WO1992000091A1 (en) 1990-07-02 1992-01-09 Bioligand, Inc. Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5186800A (en) 1988-04-18 1993-02-16 Bio-Rad Laboratories, Inc. Electroporation of prokaryotic cells
US5422272A (en) 1993-07-14 1995-06-06 Andrew A. Papp Improvements to apparatus and method for electroporation
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5432018A (en) 1990-06-20 1995-07-11 Affymax Technologies N.V. Peptide library and screening systems
WO1995034683A1 (en) 1994-06-10 1995-12-21 Symbiotech, Inc. Method of detecting compounds utilizing genetically modified lambdoid bacteriophage
US5498530A (en) 1991-10-16 1996-03-12 Affymax Technologies, N.V. Peptide library and screening method
US5627024A (en) 1994-08-05 1997-05-06 The Scripps Research Institute Lambdoid bacteriophage vectors for expression and display of foreign proteins
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
US5723323A (en) 1985-03-30 1998-03-03 Kauffman; Stuart Alan Method of identifying a stochastically-generated peptide, polypeptide, or protein having ligand binding property and compositions thereof
US5734018A (en) 1988-05-02 1998-03-31 The Regents Of The University Of California Peptide mixtures
US5750373A (en) 1990-12-03 1998-05-12 Genentech, Inc. Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
US5763192A (en) 1986-11-20 1998-06-09 Ixsys, Incorporated Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
US5766905A (en) 1996-06-14 1998-06-16 Associated Universities Inc. Cytoplasmic bacteriophage display system
US5770434A (en) 1990-09-28 1998-06-23 Ixsys Incorporated Soluble peptides having constrained, secondary conformation in solution and method of making same
US5807979A (en) 1988-04-08 1998-09-15 The Scripps Research Institute Synthetic, three-dimensionally stabilized polypeptide mimics of HIV
US5990275A (en) 1992-11-20 1999-11-23 Enzon, Inc. Linker and linked fusion polypeptides
WO2005047503A1 (en) 2003-11-15 2005-05-26 Polyphor Ltd. Template fixed βετα-hairpin loop mimetics and their use in phage display
US6914123B2 (en) 2001-04-17 2005-07-05 Genentech, Inc. Hairpin peptides with a novel structural motif and methods relating thereto

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5720937A (en) * 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
US5885577A (en) * 1994-09-21 1999-03-23 Cytogen Corporation Antigen binding peptides (abtides) from peptide libraries
AU4499499A (en) * 1999-04-01 2000-10-23 Innogenetics N.V. A polypeptide structure for use as a scaffold
US20030103978A1 (en) 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
WO2001081379A2 (en) 2000-04-21 2001-11-01 Corixa Corporation Compounds and methods for treatment and diagnosis of chlamydial infection
US20080181886A1 (en) 2004-11-04 2008-07-31 Genentech, Inc. Polypeptides That Bind Baff And/Or April
JP5677454B2 (ja) 2009-12-11 2015-02-25 グワンジュ・インスティテュート・オブ・サイエンス・アンド・テクノロジー 細胞内ターゲット結合用二座ペプチドバインダー
US20120321697A1 (en) 2009-12-11 2012-12-20 Gwangju Institute Of Science And Technology Bpb-based cargo delivery system

Patent Citations (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US5723323A (en) 1985-03-30 1998-03-03 Kauffman; Stuart Alan Method of identifying a stochastically-generated peptide, polypeptide, or protein having ligand binding property and compositions thereof
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5763192A (en) 1986-11-20 1998-06-09 Ixsys, Incorporated Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
US5807979A (en) 1988-04-08 1998-09-15 The Scripps Research Institute Synthetic, three-dimensionally stabilized polypeptide mimics of HIV
US5186800A (en) 1988-04-18 1993-02-16 Bio-Rad Laboratories, Inc. Electroporation of prokaryotic cells
US5734018A (en) 1988-05-02 1998-03-31 The Regents Of The University Of California Peptide mixtures
US5580717A (en) 1990-05-01 1996-12-03 Affymax Technologies N.V. Recombinant library screening methods
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5432018A (en) 1990-06-20 1995-07-11 Affymax Technologies N.V. Peptide library and screening systems
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
WO1992000091A1 (en) 1990-07-02 1992-01-09 Bioligand, Inc. Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5770434A (en) 1990-09-28 1998-06-23 Ixsys Incorporated Soluble peptides having constrained, secondary conformation in solution and method of making same
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
US5750373A (en) 1990-12-03 1998-05-12 Genentech, Inc. Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
US5498530A (en) 1991-10-16 1996-03-12 Affymax Technologies, N.V. Peptide library and screening method
US5990275A (en) 1992-11-20 1999-11-23 Enzon, Inc. Linker and linked fusion polypeptides
US5422272A (en) 1993-07-14 1995-06-06 Andrew A. Papp Improvements to apparatus and method for electroporation
WO1995034683A1 (en) 1994-06-10 1995-12-21 Symbiotech, Inc. Method of detecting compounds utilizing genetically modified lambdoid bacteriophage
US5627024A (en) 1994-08-05 1997-05-06 The Scripps Research Institute Lambdoid bacteriophage vectors for expression and display of foreign proteins
US5766905A (en) 1996-06-14 1998-06-16 Associated Universities Inc. Cytoplasmic bacteriophage display system
US6914123B2 (en) 2001-04-17 2005-07-05 Genentech, Inc. Hairpin peptides with a novel structural motif and methods relating thereto
WO2005047503A1 (en) 2003-11-15 2005-05-26 Polyphor Ltd. Template fixed βετα-hairpin loop mimetics and their use in phage display

Non-Patent Citations (48)

* Cited by examiner, † Cited by third party
Title
"Glossary of Biochemistry and Molecular Biology", 1997, PORTLAND PRESS, article "Leucine scissors"
ANDREA ET AL., PROC. NATL. ACAD. SCI., vol. 98, 2001, pages 5578 - 5583
ANDREA G. COCHRAN ET AL., PNAS, vol. 98, no. 10, pages 5578 - 5583
B. L. SIBANDA ET AL., J. MOL. BIOL., vol. 206, no. 4, 1989, pages 759 - 777
B. L. SIBANDA ET AL., METHODS ENZYMOL., vol. 202, 1991, pages 59 - 82
BLANCO ET AL., J. AM. CHEM. SOC., vol. 115, 1993, pages 5887 - 5888
BLANCO ET AL., NAT. STRUCT. BIOL., vol. 1, 1994, pages 584 - 590
CHOU; FASSMAN, ANNU. REV. BIOCHEM., vol. 47, 1978, pages 251 - 276
CLACKSON; LOWMAN: "Phage Display", 2004, OXFORD UNIVERSITY PRESS
COHEN, S.N. ET AL., PROC. NATL. ACAC. SCI. USA, vol. 9, 1973, pages 2110 - 2114
DE ALBA ET AL., FOLD. DES., vol. 1, 1996, pages 133 - 144
DE ALBA ET AL., PROTEIN SCI., vol. 6, 1997, pages 2548 - 2560
GRIFFITHS-JONES ET AL., CHEM. COMMUN., 1998, pages 789 - 790
H. JANE DYSON ET AL., EUR. J. BIOCHEM., vol. 255, 1998, pages 462 - 471
HANAHAN, D., J. MOL. BIOL., vol. 166, 1983, pages 557 - 580
HAQUE; GELLMAN, J. AM. CHEM. SOC., vol. 119, 1997, pages 2303 - 2304
KIM; BERG, NATURE, vol. 362, 1993, pages 267 - 270
LAM ET AL., NATURE, vol. 354, 1991, pages 82
LANDSCHULZ WH ET AL., SCIENCE, vol. 240, 1988, pages 1759 - 1764
LEWIS PN ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 303, 1973, pages 211 - 229
MARATEA ET AL., GENE, vol. 40, 1985, pages 39 - 46
MAYNARD ET AL., J. AM. CHEM. SOC., vol. 120, 1998, pages 1996 - 2007
MAYNARD; SEARLE, CHEM. COMMUN., 1997, pages 1297 - 1298
MILNER-WHITE EJ., J. MOL. BIOL., vol. 216, 1990, pages 385 - 397
MILNER-WHITE EJ; POET R., TIBS, vol. 12, 1987, pages 189 - 192
MINOR; KIM, NATURE, vol. 367, 1994, pages 660 - 663
MINOR; KIM, NATURE, vol. 371, 1993, pages 264 - 267
MURPHY ET AL., PROC. NATL. ACAD SCI. USA, vol. 83, 1986, pages 8258 - 8562
NEMETHY G; PRINTZ MP, MACROMOLECULES, vol. 5, 1972, pages 755 - 758
PAVONE V ET AL., BIOPOLYMERS, vol. 38, 1996, pages 705 - 721
RAJASHANKAR KR; RAMAKUMAR S., PROTEIN SCI., vol. 5, 1996, pages 932 - 946
RAMIREZ-ALVARADO ET AL., NAT. STRUCT. BIOL., vol. 3, 1996, pages 604 - 612
REN ET AL., GENE, vol. 215, 1998, pages 439
RICHARDSON JS., ADV. PROTEIN CHEM., vol. 34, 1981, pages 167 - 339
ROSE GD ET AL., ADV. PROTEIN CHEM., vol. 37, 1985, pages 1 - 109
SAMBROOK, J. ET AL.: "Molecular Cloning. A Laboratory Manual", 2001, COLD SPRING HARBOR PRESS
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
SCOTT, J. K.; SMITH, G. P.: "Science", vol. 249, 1990, pages: 386
SEARLE ET AL., NAT. STRUCT. BIOL., vol. 2, 1995, pages 999 - 1006
See also references of EP2360172A4
SMITH ET AL., BIOCHEMISTRY, vol. 33, 1994, pages 5510 - 5517
SMITH; REGAN, SCIENCE, vol. 270, 1995, pages 980 - 982
STANGER; GELLMAN, J. AM. CHEM. SOC., vol. 120, 1998, pages 4236 - 4237
TONIOLO C., CRC CRIT. REV. BIOCHEM., vol. 9, 1980, pages 1 - 44
UHLMAN; PEYMAN: "Chemical Reviews", vol. 90, 1990, pages: 543 - 584
VENKATACHALAM CM, BIOPOLYMERS, vol. 6, 1968, pages 1425 - 1436
WILMOT CM; THORNTON JM., J. MOL. BIOL., vol. 203, 1988, pages 221 - 232
ZHU, CAN, vol. 33, 1997, pages 534

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011132939A2 (ko) * 2010-04-20 2011-10-27 광주과학기술원 Rtk에 특이적으로 결합하는 rtk-bpb
WO2011132940A2 (ko) * 2010-04-20 2011-10-27 광주과학기술원 Rtk에 특이적으로 결합하는 rtk-bpb
WO2011132939A3 (ko) * 2010-04-20 2012-04-05 광주과학기술원 Rtk에 특이적으로 결합하는 rtk-bpb
WO2011132940A3 (ko) * 2010-04-20 2012-04-05 광주과학기술원 Rtk에 특이적으로 결합하는 rtk-bpb
US20140296479A1 (en) * 2011-04-08 2014-10-02 Gwangju Institute Of Science And Technology D-aptide and retro-inverso aptide with maintained target affinity and improved stability
WO2018087232A1 (en) 2016-11-11 2018-05-17 University Of Copenhagen Binding peptides
RU2793935C2 (ru) * 2018-12-26 2023-04-10 Скинмед Ко., Лтд. Пептиды, ингибирующие ацетилхолиновые рецепторы, и их применение

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Publication number Publication date
AU2009307249A1 (en) 2010-04-29
KR20100044128A (ko) 2010-04-29
EP2360172A2 (en) 2011-08-24
KR101151805B1 (ko) 2012-06-01
CN102224162A (zh) 2011-10-19
WO2010047515A3 (ko) 2010-07-29
KR20110117038A (ko) 2011-10-26
EP2360172B1 (en) 2017-10-18
AU2009307249B2 (en) 2012-11-01
KR101216008B1 (ko) 2012-12-28
US20110152500A1 (en) 2011-06-23
CA2741040C (en) 2015-09-22
CN107011415A (zh) 2017-08-04
JP2012505929A (ja) 2012-03-08
EP2360172A4 (en) 2012-03-07
CA2741040A1 (en) 2010-04-29
WO2010047515A9 (ko) 2010-06-17
JP5390621B2 (ja) 2014-01-15
US10131693B2 (en) 2018-11-20

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