WO2010038634A1 - Stent delivery system - Google Patents

Stent delivery system Download PDF

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Publication number
WO2010038634A1
WO2010038634A1 PCT/JP2009/066448 JP2009066448W WO2010038634A1 WO 2010038634 A1 WO2010038634 A1 WO 2010038634A1 JP 2009066448 W JP2009066448 W JP 2009066448W WO 2010038634 A1 WO2010038634 A1 WO 2010038634A1
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WO
WIPO (PCT)
Prior art keywords
stent
portion
proximal
delivery system
end
Prior art date
Application number
PCT/JP2009/066448
Other languages
French (fr)
Japanese (ja)
Inventor
杉本 良太
北岡 孝史
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2008254742 priority Critical
Priority to JP2008-254742 priority
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Publication of WO2010038634A1 publication Critical patent/WO2010038634A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9505Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9505Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument
    • A61F2002/9511Instruments specially adapted for placement or removal of stents or stent-grafts having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument the retaining means being filaments or wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
    • A61F2002/9665Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod with additional retaining means

Abstract

A stent delivery system (1) is provided with a self-expanding stent (10), a shaft section (3) having a guide wire lumen (61), and a sheath (2) having the stent (10) contained in a distal end section thereof.  The stent (10) is located at a position which is on the shaft section (3) and near the distal end thereof.  The stent delivery system (1) has a wire member (5) and a breaking member (7).  The wire member (5) has one end (5a) and the other end (5b) which are fixed to the shaft section (3), and also has an intermediate section (5c) engaged with a proximal end section of the stent (10).  The breaking member (7) breaks the wire member (5) to release the stent from the engagement.

Description

The stent delivery system

The present invention is a blood vessel, bile duct, trachea, esophagus, stenosis occurs in a body lumen such as a urethra, or a stent delivery system that is used to improve occlusion.

Vivo indwelling stent, to treat a variety of diseases caused by blood vessel or other body passageway lumen is constricted or occluded, there to extend that stenosis or occlusion site, ensuring that the lumen generally a medical device tubular to be placed in.
Hereinafter will be described a blood vessel as an example, but not limited thereto.

Stents, for insertion from the outside into the body, when inserted small diameter to increase the diameter is expanded stenotic or occluded region of interest, and is to hold the lumen as it is.
The stent, metal wire, or hollow cylindrical shape formed by processing a metal tube is generally used. Mounted in thin state like a catheter is inserted into a living body, it is extended in some manner in the target site, close contact with the lumen wall to maintain the tube 腔形 shape by fixing. Stents, depending on the function and indwelling method is classified into a self-expanding stent and balloon expandable stents. Balloon expandable stents are not extensions to the stent itself, after insertion of the stent mounted on the balloon to a target site, to expand the balloon, the desired lumen stent is expanded (plastic deformation) of the expansion force of the balloon brought into close contact with the inner surface and fixed. In this type of stent, expansion work of the stent as described above it is required. On the other hand, self-expanding stents are those which gave the extensions stent itself, thin shrink was inserted into a living body as a state, his original expanded state on the return lumen wall by releasing at the target site adhesion, to maintain a fixed to the tube 腔形 shape.

The purpose of the current stenting is to return the stenosed vessel for some reason the original patency, mainly the prevention of restenosis that occurs after performing procedures such as PTCA, the aims of the reduction it is almost. In recent years, in order to suppress the probability of more restenosis, drug-eluting stents equipped with agents such as immunosuppressive agents and anticancer drugs have also been used, the effect is generally known.
Self-expanding stents many of which are used in peripheral regions such as the lower limbs of the vessel and the carotid artery, for example, there is provided a form as shown in Japanese Patent Kohyo 11-505441 (Patent Document 1).

Kohyo 11-505441 JP

The stent delivery system using a self-expanding stents as described in Patent Document 1, the self-expanding with the stent, difficult positioning during deployment is compared to the balloon expandable stent, the jumping phenomenon in which the stent jumps out from the expander may occur, the stent when this phenomenon occurs, is arranged at a position shifted from the expected position. Further, during the stenting procedure, after a certain extent discharged stent, sometimes readjustment of indwelling position is required. However, those such as described in Patent Document 1, re-storage of the stent of the stent delivery system is difficult.

An object of the present invention, there is provided a stent delivery system using a self-expanding stent, when releasing the stent from the expander, there is no pop-out due to the self-expanding stent, and, to some extent expanding the stent even after being exposed from the instrument, to provide a stent delivery system that can be housed in the dilator again.

Order to attain the above object is as follows.
Is formed in a substantially cylindrical shape, at the time of insertion into a living body is compressed in the central axis direction, and recoverable stent shape before compression by expanding outward during indwelling, a shaft portion having a guide wire lumen, said stent the a sheath housed in the distal end portion, and wherein the stent is a stent delivery system which is located near the tip on the shaft portion, the stent delivery system, one and the other ends are fixed to the shaft portion is has a stent proximal portion fixing wire intermediate portion is anchored to the proximal end of the stent, and a breaking member for broken the stent proximal portion fixing wire to release the anchoring of the stent The stent delivery system.

Figure 1 is a partial omitted front view of the stent delivery system according to an embodiment of the present invention. Figure 2 is a longitudinal sectional view of the stent delivery system shown in FIG. Figure 3 is a partial omitted front view of the sheath of the stent delivery system shown in FIG. Figure 4 is a partial omitted front view of the shaft of the stent delivery system shown in FIG. Figure 5 is an enlarged longitudinal sectional view of the vicinity of the leading end portion of the stent delivery system shown in FIG. Figure 6 is an enlarged longitudinal sectional view of the vicinity of the middle portion of the stent delivery system shown in FIG. Figure 7 is an enlarged longitudinal sectional view of the vicinity of a sheath proximal end portion of the stent delivery system shown in FIG. Figure 8 is an enlarged longitudinal sectional view of the vicinity of the shaft portion proximal end of the stent delivery system shown in FIG. Figure 9 is an explanatory view for explaining the vicinity of the stent proximal end of the stent delivery system shown in FIG. Figure 10 is a front view of an example of the in-vivo indwelling stent for use in a stent delivery system of the present invention. Figure 11 is a developed view of the indwelling stent of Figure 10. Figure 12 is an enlarged view of the vicinity of the base end portion pores of the stent shown in FIG. 10. Figure 13 is an A-A line enlarged sectional view of FIG. 12. Figure 14 is an enlarged longitudinal sectional view of the vicinity of the stent delivery system distal portion of another embodiment of the present invention. Figure 15 is an enlarged perspective view of the vicinity of the base end portion pores of the stent used in the stent delivery system of the present invention. Figure 16 is an explanatory view for explaining the operation of the stent delivery system of the present invention. Figure 17 is an explanatory view for explaining the operation of the stent delivery system of the present invention. Figure 18 is an explanatory view for explaining the operation of the stent delivery system of the present invention.

For stent delivery system of the present invention will be described with reference to the preferred embodiments which follow. The stent delivery system, in other words, a living organ dilator.

The stent delivery system 1 of the present invention is formed in a substantially cylindrical shape, at the time of insertion into a living body is compressed in the axial direction, and recoverable stent 10 to the shape before compression by expanding outward during the indwelling guide a shaft portion 3 having a wire lumen 61, and a sheath 2 in which housing a stent 10 in the distal end portion, and the stent 10 is a stent delivery system which is located near the tip on the shaft portion 3. Furthermore, the stent delivery system 1 is fixed one end 5a and the other end 5b is the shaft portion 3, the intermediate portion 5c has a stent proximal portion fixing wire 5, which is anchored to the proximal end of the stent 10, the stent group cutaway end fixing wire 5, and a breaking member 7 for releasing the anchoring of the stent.
Further, the stent delivery system 1 of the illustrated embodiment includes a recoverable stent 10 to the shape before compression by expanding outward during indwelling, and the sheath 2 accommodating the stent 10 in the distal end portion, the sheath 2 slidably inserted, and a shaft portion 3 for discharging the stent 10 from the distal end of the sheath 2. The stent 10 includes a proximal end facing the tip and base end facing the distal end side of the sheath 2, further not substantially free of bending a free end which projects at least on the proximal side except the proximal end portion, the sheath by moving the sheath 2 after exposure of the tip of the 2, those reusable housing the exposed tip sheath 2 is used. The stent delivery system 1 has one end open at the distal end of the stent delivery system, the other end has a guide wire lumen 61 which opens at the proximal side of the stent-containing part of the sheath 2. Shaft 3 is fixed one end 5a and the other end 5b is the shaft portion 3, the intermediate portion 5c has a stent proximal portion fixing wire 5, which is anchored to the proximal end of the stent 10, the stent proximal portion fixing broken the use wire 5, and a breaking member 7 for releasing the anchoring of the stent 10.

The stent delivery system 1 of the present invention includes a stent 10, and sheath 2 accommodating the stent 10 in the distal end portion is constituted by a shaft portion 3 for inserting the sheath 2 slidably.
The sheath 2, as shown in FIGS. 1 to 7, comprising a sheath tube 21, a sheath hub 22 fixed to the proximal end of the sheath tube 21.
Sheath tube 21, as shown in FIGS. 1 to 7, a tubular body, front and rear ends are open. Tip opening, when placing the stent 10 into the stenosis in a body cavity, which functions as an outlet of the stent 10. The stent 10, stress loading by being pushed out from the distal end opening to expand is released to restore the shape before compression. Distal end portion of the sheath tube 21 has a stent-containing part 21a for accommodating the stent 10 therein. Moreover, the sheath tube 21 is provided with a side hole 23 provided on the proximal side of the stent housing portion 21a. Side hole 23 is for deriving a guide wire to the outside.
The outer diameter of the sheath tube 21 is preferably about 0.5 ~ 4.0 mm, particularly preferably 0.8 ~ 2.0 mm. As the inner diameter of the sheath tube 21, preferably about 0.2 ~ 1.8 mm. The length of the sheath tube 21, 300 ~ 2500 mm, particularly preferably about 300 ~ 2000 mm.
As the material for forming the sheath tube 21, the physical properties required of the sheath tube (flexibility, hardness, strength, sliding property, kink resistance, stretchability) in consideration of, for example, polyethylene, polypropylene, nylon, polyethylene terephthalate, PTFE , fluorine-based polymer ETFE or the like, a thermoplastic elastomer is preferred. The thermoplastic elastomer, nylon-based (e.g., polyamide elastomer), urethane-based (e.g., polyurethane elastomer), polyester-based appropriately selected from (e.g., polyethylene terephthalate elastomer), an olefinic (e.g., polyethylene elastomer, polypropylene elastomer) It is.

Further, on the outer surface of the sheath tube 21, it is preferably subjected to processing in order to exhibit lubricity. Such processing, for example, poly (2-hydroxyethyl methacrylate), polyhydroxyethyl acrylate, hydroxypropyl cellulose, methyl vinyl ether-maleic anhydride copolymer, polyethylene glycol, polyacrylamide, hydrophilic polymers such as polyvinyl pyrrolidone coating or the like fixing method of the like. Further, the inner surface of the sheath tube 21, to the sliding of the stent 10 and the shaft portion 3 to obtain favorable coating those described above or may be fixed.
Further, the proximal end portion of the sheath tube 21, as shown in FIGS. 1 to 3 and 7, the sheath hub 22 is fixed. The sheath hub 22, as shown in FIG. 7, a sealing member 25 for holding the shaft portion 3 can slide, and fluid-tightly. In addition, the sheath hub 22 is provided with a side port 24.
The constituent material of the sheath hub 22, a rigid or semi-rigid material is used. The rigid or semi-rigid material, polycarbonate, polyolefins (e.g., polyethylene, polypropylene, ethylene - propylene copolymer), a styrene-based resin [e.g., polystyrene, MS resin (methacrylate - styrene copolymer), MBS resin (methacrylate - butylene - styrene copolymer)], synthetic resins such as polyester, stainless steel, metals such as aluminum or an aluminum alloy can be used.
Further, as the material of the seal member 25 and the later-described elastic ring 69, the elastic materials used. As the elastic material, urethane rubber, silicone rubber, such as natural rubber and synthetic rubber, latex rubber, such as butadiene rubber, olefin-based elastomer (e.g., polyethylene elastomer, polypropylene elastomer), polyamide elastomers, styrene elastomers (e.g. , styrene - butadiene - styrene copolymer, styrene - isoprene - styrene copolymer, styrene - ethylene butylene - styrene copolymer), polyurethane, urethane elastomers, synthetic resin elastomer, such as a fluorine resin-based elastomer is used.
Further, the distal end portion of the sheath hub 22, the reinforcing member 26, 27 is provided which extends distally from the distal end of the sheath hub.

Shaft 3, as shown in FIGS. 1-8, the shaft body 33, provided at the front end of the shaft body 33, the tip tube 31 projecting from the distal end of the sheath 2, fixed to a proximal portion of the shaft main body 33 includes a shaft hub 30 which is a stent proximal portion fixing wire 5 fixed to the shaft body 33, and a breaking member 7 for breaking the stent proximal portion fixing wire 5 provided on the shaft body 33 ing.
In this embodiment, the stent proximal portion fixing wire 5 is a heat rupturable stent proximal portion fixing wire, breaking member 7 has a thermal break member. It is not limited to such, the stent proximal portion fixing wire 5 and the breaking member 7 is electrically stent, broken by such as mechanical or hydraulic, which is detached from the shaft portion 3 it may be.
Then, in this embodiment, the shaft portion 3 is provided with a base end opening of the guidewire lumen which opens at the side of the proximal side of the stent-containing part of the sheath 2, the sheath 2, the proximal end than the stent-containing part comprising a sheath side hole provided on the side, from the sheath side hole and the proximal-side opening, it has a guide wire can be inserted.

Tip tube 31, as shown in FIG. 5, projects from the distal end of the sheath 2. Further, the distal end tube 31, a stopper 32 for preventing the distal movement of the sheath 2 is provided. Proximal end of the distal tube 31, as shown in FIG. 6, curved, penetrates into the side hole 23 of the sheath tube 21 is detachably engaged. The outer diameter of the distal tube 31 is preferably 0.2 mm ~ 1.8 mm. The tip portion of the distal side stopper 32, as shown in FIG. 5, it is preferable that the diameter decreases toward the distal end side. The outer diameter of the maximum diameter portion of the stopper 32 is preferably 0.5 ~ 4.0 mm. The base end portion of the stopper 32 as shown in FIG. 5, it is preferable that the diameter is reduced toward the proximal side. The tip tube 31 has a guidewire lumen 61 extending to the proximal end than the distal end, the position of the proximal end opening 62, from the tip of the distal tube 31, to be located in 10 ~ 400 mm proximal side preferably, particularly preferably 50 ~ 350 mm. The position of the proximal end opening 62 (in other words, the rear end of the stent-containing part) the rear end of the stent 10 disposed from, is preferably 50 ~ 250 mm about the base end side.
Shaft body 33, the tip portion has a been tip fixed to a proximal portion of the distal tube 31, a body portion extending in a predetermined length base end side and a proximal end projecting from the shaft hub 30 . Then, in this embodiment, the shaft body 33, the tip portions of the fixed portion to the distal end tube 31, has a small diameter portion, the body portion and a proximal end, from the small diameter portion, and the outer diameter is larger going on. Then, in this embodiment, the distal end portion of the shaft body 33, the heat shrinkable tube 63 is fixed to a side surface of the distal end tube 31.
Length of the shaft portion 3 is preferably about 400 ~ 2500 mm, particularly preferably 400 ~ 2200 mm. The outside diameter of the body portion of the shaft body 33, preferably about 1.0 ~ 2.5 mm, particularly preferably 1.0 ~ 2.0 mm. The length of the tip tube 31 is preferably about 10 ~ 400 mm, particularly preferably 50 ~ 350 mm, the outer diameter is preferably about 0.2 ~ 2.0 mm. As the inner diameter of the lumen 61, preferably about 0.2 ~ 2.0 mm, particularly preferably 0.3 ~ 1.0 mm.

The shaft body 33 may be either a solid one tubular ones. In addition, it may be a coil shaft. As the material of the shaft portion 3 is preferably a material which has and some flexibility there hardness, for example, stainless steel, metal wire or metal pipe, such as a super elastic metal, polyethylene, polypropylene, nylon, polyethylene terephthalate, fluorine-based polymer ETFE, etc., PEEK (polyether ether ketone), rod-like member or an annular member such as polyimide can be preferably used. Note that the outer surface of the shaft portion 3, biocompatible, may be coated with a resin having a particular anti-thrombotic. The antithrombotic material, such as poly-hydroxyethyl methacrylate, a copolymer of hydroxyethyl methacrylate and styrene (e.g., HEMA-St-HEMA block copolymer), etc. can be preferably used.
Furthermore, of the shaft portion 3, the outer surface of the portion that may protrude from the sheath 2, preferably has lubricity. For this, for example, poly (2-hydroxyethyl methacrylate), polyhydroxyethyl acrylate, hydroxypropyl cellulose, methyl vinyl ether-maleic anhydride copolymer, polyethylene glycol, polyacrylamide, coating a hydrophilic polymer such as polyvinylpyrrolidone or, it may be fixed. Also, coating those described above the entire outer surface of the shaft portion 3 or may be fixed. Furthermore, in order to improve the slidability of the guide wire, coating those in the inner surface of the shaft portion 3 of the above or may be fixed.
The shaft body 33 penetrates the sheath 2, and protrudes from the rear end opening of the sheath 2. The proximal end of the shaft body 33, as shown in FIGS. 1 to 3 and 8, the shaft hub 30 is secured. In this embodiment, the shaft body 33, as shown in FIG. 7, the fixing ring 66 is fixed. Further, the shaft hub 30, proximal tube 34 extending distally from the shaft hub 30 is fixed. The distal end of the proximal tube 34 is fixed to the fixing ring 66. Further, the proximal end of the proximal tube 34 (inside of the shaft hub 30), the elastic ring 69 is fixed. Further, in this embodiment, the second fixing ring 68 is provided in a predetermined length distal to the fixing ring 66. Then, a fixing ring 66 between the second fastening ring 68, the intermediate tube 67 is disposed. Intermediate tube 67 is not also fixed to one of the shaft body 33 and sheath tube 21, and has become a thing capable of contacting and fixing ring 66 and the second fixing ring 68. By providing such an intermediate tube, sliding of the sheath is improved. The intermediate tube 67, which has a low friction surface is preferred. Specifically, for example, polyethylene, polypropylene, nylon, polyethylene terephthalate, PTFE, is a tube which is formed by a fluorine-based polymer ETFE or the like.

Further, FIG. 5 and FIG. 9 (specifically, near the proximal end of a portion stent of the tip tube 31 is located) the tip portion of the shaft portion 3, the proximally of the stent 10 proximal side stopper 70 for restricting the movement of is provided. In particular, in this embodiment, the proximal side stopper 70 has a spring-like stopper wound around the shaft portion. The proximal side stopper 70, FIG. 5, as shown in FIG. 9, the proximal end side coil portion 70a wound around the distal tube 31, extends distally from the proximal side coil portion 70a, the distal end tube 31 and a distal coil portion 70b having a partial non-contact portion. Distal coil portion 70b of this embodiment is fixed eccentrically to the tip tube 31, and a portion separated from the portion contacting with the tip tube 31. The stent proximal portion fixing wire 5 extends through the non-contact portion between the distal end tube 31 of the distal end side coil portion 70b. Further, the wire 5 of the portion extending from one end 5a of the wire in the stent direction may be fixed to the tip-side coil portion 70b. Fixed to the distal end side coil portion 70b of the wire 5 is gripped by the inter-coil is preferred. Further, the distal end side coil section 70b functions as a stopper of the stent 10. Further, as the distal end side coil portion 70b, as in the embodiment shown in FIG. 14, or may be a substantially entirely tip tube 31 is separated.

Further, the base end side coil portion 70a is a spring-like, without damage to the base end portion of the stent, has become what lockable. Further, the stopper 70 may be formed by X-ray contrast material. This makes it possible to grasp the position near the proximal end of the stent under X-ray contrast media, the procedure is made more easily. The X-ray contrast material, for example, gold, platinum, platinum - iridium alloy, silver, stainless steel, platinum, or alloys thereof are preferred. Then, the stopper 70 is formed by winding the distal end tube 31 outer surface to form a wire by X-ray contrast material.
Furthermore, as shown in FIGS. 4 to 6 and 9, the shaft portion 3, one end portion 5a and the other end 5b is fixed to the shaft portion, the intermediate portion 5c is anchored to the proximal end of the stent 10 a heat rupturable stent proximal portion fixing wire 5, the stent proximal portion cutaway fixing wire 5, and a thermal break member 7 for releasing the anchoring of the stent 10.
In particular, in this embodiment, as shown in FIG. 9, which comprises as a stent 10, a plurality of small holes 18 of the stent proximal portion fixing wire insertion provided in the coupling portion 16 of the base end side in a substantially annular and is used, further, the intermediate portion 5c of the stent proximal portion fixing wire 5, and that a plurality of small holes 18 of the stent 10 through the order, as a whole, through which the plurality of small holes 18 in an annular going on. Thus, the stent 10, the stent proximal portion fixing wire 5, which is anchored (fixed) to the shaft portion 3, as long as the stent proximal portion fixing wire 5 is not broken (cut), not separated from the shaft portion 3 It has become a thing.

In particular, in this embodiment, one end portion 5a of the stent proximal portion fixing wire 5, around and at some base end of the stopper 70, wound around the outer surface of the distal tube 31, and is secured by adhesive 51 there. The other end portion 5b of the stent proximal portion fixing wire 5 is fixed wound around the outer surface of the shaft body 33. Incidentally, one end portion 5a and the other end portion 5b of the stent proximal portion fixing wire 5 are not limited to those fixed wound to the outer surface of the distal tube 31 and the shaft body 33. The stent proximal portion end portion 5a and the other end portion 5b of the fixing wire 5, by caulking ring, may be fixed to the outer surface of the distal tube 31 and the shaft body 33. Further, in this embodiment, the stent proximal portion fixing wire 5, from one end 5a and the other end portion 5b fixed to the shaft portion, the stent direction through the gap between coils of the spring-like stopper 70 It has become a thing that extends to. Specifically, the portion extending from one end 5a of the portion extending from the stent proximal portion fixing wire 5 and the other end portion 5b stent proximal portion fixing wire 5, the proximal side coil portion 70a of the stopper 70 together It passes over, and is intended to extend through between the distal end side coil portion 70b and the tip tube 31. By thus forming the stopper exerts an effect as a stopper for the stent proximal portion, also, by the guide (through) the stent fixing wire, fixed stent is ensured by the wire, also, the wire to prevent the entanglement of the wire of the stent at the time of release from the stent, it is possible to carry out the release reliably.

Thermal break stent proximal portion fixing wire 5 is preferably a thermoplastic resin fiber. As the thermoplastic resin, polyethylene, polypropylene, nylon, preferably a synthetic resin such as polyethylene terephthalate, in particular, is preferably a low melting point. The thermal break stent proximal portion fixing wire is only around portions to be thermally broken may be constituted by a low-melting resin. The thermal break stent proximal portion fixing wire is a single thermoplastic resin fiber alone, or may be formed such as by a thermoplastic resin fiber that a plurality of bundled ones or twisted .
Then, the shaft portion 3, the stent proximal portion cutaway fixing wire 5, and a thermal break member 7 for releasing the anchoring of the stent 10. In this embodiment, the thermal break element 7, the fracturing heating portion 36, the distal end portion is connected to the heat generating portion, and an electrical cable 64, 65 extending to the proximal end portion of the shaft main body 33, the electric cables 64, 65 connected, and includes a connecting portion 35 of a power supply formed in the proximal end portion of the shaft main body 33. In particular, the shaft in this embodiment, fracturing heating portion 36 of the heat breaking member 7 is fixed to the distal end of the shaft body 33, the electrical cables 64 and 65, in a state fixed to the outer surface of the shaft body 33 It extends to the proximal end of the body 33.
Then, the proximal end portion of the shaft body 33 connecting portion 35 of the power supply (not shown) is formed. Connecting portion 35 is formed on the outer surface of the proximal portion of the shaft main body 33 includes a first electrode portion 37 connected to the cable 64 and electrically, and a second electrode 38 connected to the cable 65. Further, in this embodiment, it includes an insulating portion 39 for the first electrode 37 to insulate the second electrode 38. Some of the heat rupturable stent proximal portion fixing wire 5, in this embodiment, the portion of the predetermined length middle portion from the other end portion 5b, which is encapsulated in breaking the heating portion 36, the connector 35 the power applied to the first electrode portion 37 to the second electrode 38, the heating portion 36 is heated for breaking the 5 thermal break stent proximal portion fixing wire to melt fracture at that portion.

Then, stent 10 for use in the present invention, at the time of the indwelling restorable in shape before compression by expanding outward, so-called self-expanding stents. Further, stent 10 includes a proximal end facing the tip and base end facing the distal end side of the sheath 2, further not substantially free of bending a free end which projects at least on the proximal side, except the proximal end portion by moving the sheath 2 after exposure of the distal portion of the sheath 2, those reusable housing the exposed tip sheath 2 is used.
The stent used, by the vicinity of the top or apex of the base end side bent portion to bind with other linear elements, may be one which is assumed having no free ends. As the stent to be used may be such as shown in FIGS. 10 and 11. Figure 10 is a front view of an example of the in-vivo indwelling stent for use in a stent delivery system of the present invention. Figure 11 is a developed view of the indwelling stent of Figure 10.
The stent 10 includes a wavy strut 13, 14 which are arrayed in the circumferential direction of the extending and stent in the axial direction until the other end from one end of the stent, extending in a predetermined axial direction with connecting undulating struts mutually the next and a one or more connecting struts 15, further, an end portion of the wavy strut 13 and 14 are coupled with the end of the undulating strut adjacent.

In particular, the stent 10 shown in FIGS. 10 and 11, the first undulating strut 13 which are arrayed in the circumferential direction of the extending and stent axially from one end of the stent 10 to the other side, between the first undulating strut 13 located in a second undulating strut 14 which are arrayed in the circumferential direction of the extending and stent in the axial direction from one end of the stent to the other end, the first undulating strut 13 mutually each adjacent second wavy strut 14 and a one or more connecting struts 15 extending in a predetermined longitudinal direction as well as connections. The apex of the second undulating strut 14, to the apex of the first undulating strut 13 which is curved in proximity to and in the same direction in the circumferential direction of the stent 10, which is what was shifted by a predetermined length in the axial direction of the stent . The end portion 13a of the first undulating strut 13, 13b, the end portion 14a of the second undulating strut adjacent, coupled with 14b.
The stent 10 of this embodiment is formed in a substantially cylindrical shape, at the time of insertion into a living body is compressed in the axial direction, at the time of indwelling a so-called self-expanding stent to restore the shape before compression by expanding outward ing.

First undulating strut 13 has a one axially extending substantially parallel to the central axis of the stent. The first undulating strut 13 are a plurality of arranged in the circumferential direction of the stent. The number of first undulating strut 13, preferably three or more, in particular, about the present 3-8 are preferred. Furthermore, the first undulating strut 13 of the plurality of, it is preferably arranged so as to be substantially regular angular with respect to the central axis of the stent.
The second undulating strut 14 has a one axially extending substantially parallel to the central axis of the stent. The second undulating strut 14, in the circumferential direction of the stent are a plurality of sequences, each of the second undulating strut 14 is arranged between the first undulating strut. The number of second undulating strut 14, preferably three or more, in particular, about the present 3-8 are preferred. Further, the second undulating strut 14 of the plurality of, it is preferably arranged so as to be substantially regular angular with respect to the central axis of the stent. The number of second undulating strut 14 is made the same as the number of first undulating strut.
Then, the stent 10 is provided with one or more connecting struts 15 extending in a predetermined longitudinal direction as well as connected with the first wave strut 13 mutually each adjacent a second corrugated strut 14. In particular, the stent 10 of this embodiment, connecting strut 15 has one end near an inflection point of one of the wavy strut, the other end to slightly beyond the apex from the vicinity of the apex of the other adjacent undulating strut region has, curved extending and in the same direction as the apex of the other undulating strut in the axial direction. Vertex Specifically, as shown in FIG. 11, connecting struts 15, toward the other circumferential side of the first connecting strut 15a and the stent 10 that is curved with an apex toward the one side in the circumferential direction of the stent 10 and a second connecting strut 15b curved having. The connection strut 15, as well as curved in an arc shape, and is assumed to have substantially the same radius as the first undulating strut 13 or arc of the curved portion of the second undulating strut 14 adjacent in the circumferential direction of the stent 10.

The stent 10 of this embodiment includes a coupling portion 16 for coupling with the end of one of the second undulating strut adjacent the one end portion and the other end of all the first wave strut . Specifically, one end portion 13a of the first undulating strut of the stent 10, the second undulating strut 14 (specifically while proximity, second undulating strut located on the other side of the adjacent and circumferentially It is coupled by the coupling portion 16 and one end side of the end portion 14a of the 14). The other end portion 13b of the first undulating strut, the other end of the second undulating strut 14 while adjacent (second undulating strut 14 Specifically, positioned on one side of adjacent and circumferentially) It is coupled by the coupling portion 16 to the side of the end portion 14b. That is, in one end side of the coupling portion 16 and the other end side of the coupling portion 16, the combination of the first undulating strut 13 and second undulating strut 14 to be combined has made different (one shift).
Then, the coupling portion 16, as shown in FIGS. 10 to 12, radiopaque marker 17 is attached. In this embodiment, the coupling portion 16, as shown in FIG. 12, the two frame portions 16a that endwise extending parallel with a predetermined distance therebetween has a 16b, radiopaque markers 17, the two frame portions 16a, substantially the entire or part of 16b has been assumed that the encapsulation. Further, radiopaque markers 17, those of the thin rectangular parallelepiped shape, the two frame parts 16a, 16b to the housing inside, and by the central portion recessed, fixed two frame portions 16a, 16b, It is. As the material for forming the radiopaque marker, iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, and those of one selected from the group of elements consisting of hafnium (alone) or two seed or more of (alloy) can be suitably used.
Further, stent 10, each joint 16 serving as a base end, and a small hole 18 for a stent proximal portion fixing wire insertion. The small hole 18 is made as extending toward the center of the stent. Incidentally, the small hole 18 of the stent proximal portion fixing wire insertion, it preferably has a low friction inner surface or the easily releasable form for enhancing the detachment of the wire 5. Low friction inner surface can be formed such as by coating the or low friction material to the inner surface a smooth surface.

Further, as the easily releasable form of small holes, it can be considered as shown in FIG. 15. Small hole 18 formed in the coupling portion 16 shown in FIG. 15, has assumed that the opening edge of the small hole 18 is expanded in diameter chamfered or tapered. Incidentally, the small hole 18, the opening edge portions of both the outer surface and inner surface of the stent may be configured to enlarged chamfered or tapered. This facilitates insertion and withdrawal of the stent fixing wire.
As a constituent material of the stent 10, super elastic metal is preferred. The superelastic metal, superelastic alloys are preferably used. This superelastic alloys referred to is generally called shape memory alloy shows a superelasticity at least vivo temperature (around 37 ° C.). Particularly preferably, 49 Ti-Ni alloy to 53 atomic% Ni, Cu-Zn alloy of 38.5 to 41.5 wt% Zn, 1 ~ 10 wt% X of Cu-Zn-X alloy (X = Be, Si, Sn, Al, Ga), super elastic metal material such as Ni-Al alloy of 36-38 atom% Al is preferably used. Particularly preferred are the above Ti-Ni alloy. Also, part of Ti-Ni alloy 0.01 ~ 10.0% X with substituted Ti-Ni-X alloy (X = Co, Fe, Mn, Cr, V, Al, Nb, W, B, etc.) be with or Ti-Ni was part of the alloy was replaced with 0.01 to 30.0 percent atomic Ti-Ni-X alloy (X = Cu, Pb, Zr) to be, also, the cold working ratio or / and the conditions of the final heat treatment by selecting, can alter the mechanical properties appropriate. Further, by selecting the conditions of cold working ratio and / or final heat treatment using the above-described Ti-Ni-X alloy, it is possible to alter the mechanical properties appropriate. Buckling strength of superelastic alloys used (yield stress under load) is, 5 ~ 200kg / mm 2 ( 22 ℃), more preferably, 8 ~ 150kg / mm 2, restoring stress (yield stress upon unloading ) is, 3 ~ 180kg / mm 2 ( 22 ℃), more preferably 5 ~ 130kg / mm 2. The superelastic here, modified to a region ordinary metal at the use temperature is plastically deformed (bending, tension, compression) be allowed to, after release of the deformation, recovery substantially uncompressed shape without the need for heating It means that.
Then, the stent diameter during compression is preferably set at about 0.5 ~ 1.8 mm, particularly, more preferably 0.6 ~ 1.4 mm. The length of the uncompressed stent is preferably about 5 ~ 200 mm, particularly preferably 8.0 ~ 100.0 mm. The diameter of the uncompressed stent is preferably about 1.5 ~ 6.0 mm, particularly, more preferably 2.0 ~ 5.0 mm. Further, as the thickness of the stent is preferably about 0.05 ~ 0.40 mm, in particular, 0.05 ~ 0.15 mm is preferred. The width of undulating strut is suitably 0.01 ~ 1.00 mm, particularly preferably 0.05 ~ 0.2 mm. Preferably the surface of the wavy strut are smoothly machined, smooth by electrolytic polishing is more preferable. Also, radial strength of the stent is preferably 0.1 ~ 30.0 N / cm, particularly preferably 0.5 ~ 5.0N / cm.

Next, the operation of the stent delivery system of the present invention will be described with reference to FIG. 9, FIGS. 16 to 18.
Entire stent 10, in a state of being housed in the sheath 2, in the state shown in FIG. Then, by sliding the sheath 2 to the proximal side, the stent 10, as shown in FIG. 16, exposed from the distal end opening of the sheath 2. The stent 10 exposed from the sheath 2 expands by self-expansion force, it tries to restore the form before compression. However, in this stent delivery system, the proximal portion of the stent 10, because it is anchored to the shaft portion 3 by thermal rupture stent proximal portion fixing wire 5, can not be extended, the state of FIG. 16. If readjustment of the arrangement position of the stent 10 is required, by sliding the sheath 2 in the distal direction, it is possible to re-accommodating the stent 10 in the sheath. Then, after the stent 10 has confirmed that it is located in the target site, the power supply which is connected to the shaft portion 3 (not shown) is operated, by heating the fracturing heating unit 36, breaking the stent proximal portion fixing wire 5. Thus, the proximal portion of the stent 10, anchored by heat rupturable stent proximal portion fixing wire 5 is released, as shown in FIG. 17, be extended base end portion. Thereafter, the stent is moved stent delivery system 1 is released (sheath 2 and the shaft portion 3) in the proximal direction, as shown in FIG. 18, the stent proximal portion fixing wire has been anchored stent 10 the intermediate portion 5c of 5, disengaged from the stent. Incidentally, the stent proximal portion fixing wire 5 is broken and an intermediate portion 5c, since one end is fixed to the shaft portion 3, and the fact that there is no remaining stents release in vivo.

The stent delivery system of the present invention are the following.
(1) is formed in a substantially cylindrical shape, at the time of insertion into a living body is compressed in the central axis direction, and recoverable stent shape before compression by expanding outward during indwelling, a shaft portion having a guide wire lumen the stent and a sheath which is accommodated in the distal end portion, and wherein the stent is a stent delivery system which is located near the tip on the shaft portion, the stent delivery system, one end and the other end the shaft It is fixed to the section, and an intermediate portion is a stent proximal portion fixing wire is anchored to the proximal end of the stent, to break the stent proximal portion fixing wire, breaking member for releasing the anchoring of the stent the stent delivery system with a door.
Therefore, the stent until it breaks the stent proximal portion fixing wire, since the base end portion is anchored to the shaft portion, never jump out at the time of discharge from the sheath. Further, even after discharge of the stent from the sheath, but before breaking the stent proximal portion fixing wire is re housed in the sheath, it is possible to correct the position of the stent, an object of the stent certainly positionable site.
Furthermore, the stent proximal portion fixing wire is from one and the other ends fixed to the shaft section, as long as it extends in the stent direction through the gap between the coils of the spring-like stopper, the position of the wire since the stable, fixed stent is ensured by the wire, also becomes good departure from the stent wire.

The embodiments of the present invention may be the following.
(2) the stent is provided with a plurality of small holes for the stent proximal portion fixing wire insertion provided on the proximal end portion in a substantially annular, the middle portion of the stent proximal portion fixing wire, the the stent delivery system according to the above (1) to the plurality of small holes of the stent is inserted into the annular.
(3) The stent comprises a plurality of proximal direction bent portions located at the proximal end, the intermediate portion of the stent proximal portion fixing wire is ring a plurality of proximal direction bent portions of the stent the stent delivery system according to the above (1) which is inserted into.
(4) the shaft portion includes a distal tube having the guide wire lumen, and a shaft body distal end portion is fixed to the base end side of the tip tube, the breaking member, the distal end of said shaft body the stent delivery system according to any one of the provided by which said (1) through (3).
(5) The stent has a proximal end facing the tip and base end facing the distal end side of the sheath, further, the bent free ends substantially projecting at least a base end side, except the proximal end portion have not, by moving the sheath after exposure of the tip portion from the sheath, the above items (1) to those reusable housing the exposed tip into the sheath of any one of (4) The stent delivery system.

(6) the stent proximal portion fixing wire is a heat rupturable stent proximal portion fixing wire, the break member, to the above (1) to a thermal break member according to any one of (5) The stent delivery system.
(7) the heat rupture member may include a fracturing heating portion, the tip portion is connected to the heat generating portion, and an electrical cable extending to a proximal end portion of the shaft body, is connected to the electrical cable, and wherein the shaft the stent delivery system according to (6) which has a connecting portion between the power supply that is formed on the proximal end of the body.
(8) The shaft portion includes a proximal end side opening of the guidewire lumen which opens at the side of the stent-containing part from the base end of the sheath, the sheath is provided on the proximal side of the stent-containing part comprising a was sheath side hole, the stent delivery system according to any one of from the sheath side hole and the proximal-side opening, the above (1) which is capable of being inserted a guide wire (7).
(9) The stent, the stent proximal portion fixing wire is broken, according to any of the up to mooring of the stent is released, the above items (1) to be re-accommodated in the sheath (8) the stent delivery system of.
(10) The stent delivery system according to any of the stent proximal portion fixing wire is to the above (1) to a thermoplastic resin fiber (9).

(11) the shaft portion is positioned near the proximal end of a portion the stent is placed, the above (1) which has a proximal side stopper for restricting the movement in the proximal direction of the stent ( the stent delivery system according to any one of 10).
(12) the proximal-side stopper, the stent delivery system according to the above (11) is a spring-like stopper wound around the said shaft portion.
(13) the stent proximal portion fixing wire, from the one end and fixed to the shaft portion and the other end portion passes through the gap between the coils of the spring-like stopper that extends in the stent direction the stent delivery system according to the above (12) is.
(14) the stent proximal end ostium of the fixing wire for insertion of the stent, to be that the (2) no has low friction inner surface or the easily releasable form for enhancing the detachment of the wire ( the stent delivery system according to any one of 13).
(15) The stent, either by the vicinity of the top or apex of the base end side bent portion to bind with other linear elements, to be that (1) no a having no free ends (14) the stent delivery system as claimed in.
(16) said stent has a predetermined axial direction with connecting the wavy struts arrayed in a circumferential direction of the extending and the stent in the axial direction to the other side, the undulating strut mutually the next from one end of the stent and a one or more connecting struts extending further the ends of said undulating strut stent according to any one of (1) coupled with the end of the undulating strut adjacent (15) delivery system.
(17) the connecting strut, the stent delivery system according to the above (16) which is curved in an arc shape.
(18) said stent is provided with a coupling portion for coupling the end of the undulating strut adjacent an end of one side and the other side of all of the undulating strut, the other end a coupling portion of said one end in the coupling portion, the stent delivery system according to the combination of the undulating strut for coupling becomes different from (16) or (17).

Claims (18)

  1. Is formed in a substantially cylindrical shape, at the time of insertion into a living body is compressed in the central axis direction, and recoverable stent shape before compression by expanding outward during indwelling, a shaft portion having a guide wire lumen, said stent the a sheath housed in the distal end portion, and wherein the stent is a stent delivery system which is located near the tip on the shaft portion,
    The stent delivery system, one and the other ends are fixed to the shaft portion, and the stent proximal portion fixing wire intermediate portion is anchored to the proximal end of the stent, the stent proximal portion fixing wire broken away, stent delivery system characterized by having a breaking member for releasing the anchoring of the stent.
  2. The stent comprises a plurality of small holes for the stent proximal portion fixing wire insertion provided on the proximal end portion in a substantially annular, the middle portion of the stent proximal portion fixing wire, the said stent the stent delivery system according to a plurality of small holes in claim 1 which is inserted into the annular.
  3. The stent comprises a plurality of proximal direction bent portions located at the proximal end, the intermediate portion of the stent proximal portion fixing wire is a plurality of proximal direction bent portions of the stent is inserted into the annular and stent delivery system of claim 1 has.
  4. Said shaft portion, the guide includes a tip tube having a wire lumen, and a shaft body distal end portion is fixed to the base end side of the tip tube, the breaking member is provided at the tip portion of the shaft body the stent delivery system according to any one of claims 1 to 3 there.
  5. The stent has a proximal end facing the tip and base end facing the distal end side of the sheath, nor substantially free of bending a free end which projects at least on the proximal side, except the proximal end portion, wherein by moving the sheath after exposure of the tip, the stent delivery system according to the exposed tip in any one of the four claims 1 and is capable of re-accommodated in the sheath from the sheath.
  6. The stent proximal portion fixing wire is a heat rupturable stent proximal portion fixing wire, the break member, the stent delivery system according to any one of claims 1 to 5, which is a thermal break member.
  7. The heat break member includes a fracturing heating portion, the tip portion is connected to the heat generating portion, and an electrical cable extending to a proximal end portion of the shaft body, is connected to the electrical cable, and groups of said shaft body the stent delivery system of claim 6, and a connecting portion of a power supply formed in the end.
  8. Sheath said shaft portion includes a proximal end side opening of the guidewire lumen which opens at the side of the stent-containing part from the base end of the sheath, the sheath is provided on the proximal side of the stent-containing part comprises a side hole, the stent delivery system according to any one of from the sheath side hole and the proximal-side opening, claims 1 and has a possible insert a guide wire 7.
  9. The stent, the stent proximal portion fixing wire is broken, until said anchoring of the stent is released, the stent delivery system according to any one of claims 1 to 8 can be re-housed in the sheath.
  10. The stent proximal portion fixing wire is a stent delivery system according to any one of claims 1 to 9 which is a thermoplastic resin fiber.
  11. The shaft portion is located near the proximal end of a portion the stent is placed, in any of 10 claims 1 comprises a proximal side stopper for restricting the movement in the proximal direction of the stent the stent delivery system as claimed.
  12. The proximal-side stopper, the stent delivery system according to claim 11 which is a spring-like stopper wound around the said shaft portion.
  13. Wherein the stent proximal portion fixing wire, from the one end and fixed to the shaft portion and the other end portion, in which through the gaps of the coil constituting the spring-like stopper extending in the stent direction the stent delivery system according to claim 12.
  14. The stent proximal portion ostium of the fixing wire for insertion of the stent, to any one of claims 2 to 13 have a low friction inner surface or the easily releasable form for enhancing the detachment of the wire the stent delivery system as claimed.
  15. The stent, stent delivery system according to any one the vicinity of the apex or vertex of the base end side bent portion by binding to other linear elements, claims 1 and has a having no free ends 14 of the .
  16. The stent, 1 extending in a predetermined longitudinal direction as well as connected to the wave-like struts arrayed in a circumferential direction of the extending and the stent in the axial direction from one end of the stent to the other end, the undulating strut mutually the next one or a plurality of connecting struts, furthermore, the ends of the corrugated struts, the stent delivery system according to any one of claims 1 to 15 coupled with the end of the undulating strut adjacent.
  17. The connecting struts, the stent delivery system according to claim 16 which is curved in an arc shape.
  18. The stent is provided with a coupling portion for coupling the end of the undulating strut adjacent an end of one side and the other side of all of the undulating strut, the a coupling portion of the one end the other end of the coupling portion in stent delivery system according to claim 16 or 17 combination of the undulating strut for coupling becomes different.
PCT/JP2009/066448 2008-09-30 2009-09-18 Stent delivery system WO2010038634A1 (en)

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JP2010531813A JP5432912B2 (en) 2008-09-30 2009-09-18 The stent delivery system
EP20090817670 EP2322120B1 (en) 2008-09-30 2009-09-18 Stent delivery system
CN 200980128344 CN102098988B (en) 2008-09-30 2009-09-18 Stent delivery system
US13/074,519 US20110196472A1 (en) 2008-09-30 2011-03-29 Stent delivery system

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EP2322120A4 (en) 2011-08-31
US20110196472A1 (en) 2011-08-11
CN102098988B (en) 2014-05-14
EP2322120A1 (en) 2011-05-18
EP2322120B1 (en) 2013-04-24
CN102098988A (en) 2011-06-15
JPWO2010038634A1 (en) 2012-03-01
JP5432912B2 (en) 2014-03-05

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