Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
  • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
  • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/31—Details
  • A61M5/3129—Syringe barrels
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/31—Details
  • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
  • A61M5/31533—Dosing mechanisms, i.e. setting a dose
  • A61M5/31545—Setting modes for dosing
  • A61M5/31548—Mechanically operated dose setting member
  • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
  • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/31—Details
  • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
  • A61M5/31533—Dosing mechanisms, i.e. setting a dose
  • A61M5/31545—Setting modes for dosing
  • A61M5/31548—Mechanically operated dose setting member
  • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals

Definitions

• Certain drugs or medicaments are preferably provided in powder or dry form (such as a lyophilized form), and require reconstitution prior to administration.
• Lyophilized drugs typically are supplied in a freeze-dried form that needs to be mixed with a diluent to reconstitute the substance into a form that is suitable for injection.
• Medicaments may also be provided in other dry or powder form that require reconstitution.
• drugs may be provided as multipart systems which require mixing prior to administration.
• one or more liquid (e.g., flowable (slurry or liquid)) components, and/or dry (e.g., powdered or granular) components may be provided in a drug container or delivery device which require mixing prior to administration.
• the components can be mixed and used to form various administratable drugs, such as insulin.
• a medical injector having a body; a reservoir containing first and second mixable components, a stopper associated with the reservoir, a predetermined extent of advancement of the stopper causing mixing of the first and second mixable components; a displaceable plunger disposed in the body; a spring disposed to advance the plunger; a first releasable retainer for releasably retaining the plunger in a first state against force of the spring; a first trigger for causing the first releasable retainer to release the plunger; a second releasable retainer for releasably retaining the plunger in a second state against force of the spring; and, a second trigger for causing the second releasable retainer to release the plunger.
• Figure 1 is a perspective view of a medical injector formed in accordance with the subject invention
• One or more by-pass channels 46 are formed in the wall of the reservoir 34.
• the secondary stopper 38 is located at least partially proximally of the by-pass channels 46 so as to define a seal between the first and second chambers 40, 42 and to define a seal between the second chamber 42 and the by-pass channels 46.
• the second chamber 42 comes into communication with the by-pass channels 46, thus allowing the second mixable component 30 to be urged into the first chamber 40 with further distal movement of the stopper 36.
• the second chamber 42 is collapsed with none or substantially none of the second mixable component 32 remaining therein.
• the secondary stopper 38 is located so as to define a seal between the first chamber 40 and the by -pass channels 46.
• the first and second mixable components 30, 32 are mixed within the first chamber 40, such as through agitation of the medical injector 10, so as to produce an injectable solution, ready for injection.
• a trigger 60 may be slidably disposed in the body 24, and the plunger 58 may include one or more deflectable latch tabs 62.
• the latch tabs 62 In the initial first state of Figure 2, the latch tabs 62 have free ends 64 which interferingly engage ledges 66. Interengagement between the latch tabs 66 and the ledges 66 retains the plunger 58 in the first state against force of movement of the spring 56.
• the trigger 60 includes one or more arms 68 which define a smaller diameter than the latch tabs 62. With sufficient distal advancement of the trigger 60, e.g. being caused by force being applied to proximal end 70 thereof, the arms 68 engage the latch tabs 62 and cause inward deflection thereof. With inward deflection of the latch tabs 62, the spring 56 is free to drive the plunger 58 distally and engage the stopper 36 in causing autoreconstitution.
• the stop member 78 is axially spaced from the stop block 72.
• the plunger 58 With the plunger 58 being released from the first state, the plunger 58 axially advances with the plunger stem 76 passing through the opening 74. During this movement, the plunger 58 advances the stopper 36 at least a sufficient distance to achieve reconstitution.
• the stop block 72 is initially in the blocking state. Eventual distal advancement of the plunger 58 causes the stop member 78 to engage the stop block 72, as shown in Figure 3. The point of engagement between the stop member 78 and the stop block 72 is reached prior to the entire predetermined extent of movement of the plunger 58 for which the spring 56 is configured.
• This secondary distal advancement may assist in priming a needle for use. It is preferred that autoreconstitution be completed prior to the stop member 78 coming into engagement with the stop block 72. With subsequent mounting of the needle 12 onto the medical injector 10, the reservoir 34 is vented, thus reducing the trapped volume therein. This permits the stopper 36 to be further advanced under force of movement of the spring 56 till trapped gases are purged. It is preferred that the stop member 78 come into engagement with the stop block 72 upon this secondary distal advancement.

Landscapes

• Health & Medical Sciences (AREA)
• Vascular Medicine (AREA)
• Engineering & Computer Science (AREA)
• Anesthesiology (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Hematology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Infusion, Injection, And Reservoir Apparatuses (AREA)

Priority Applications (6)

Applications Claiming Priority (4)

Related Child Applications (2)

Publications (2)

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ID=42040160

Family Applications (1)

Country Status (6)

Cited By (2)

Families Citing this family (8)

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• 2009
  • 2009-09-18 EP EP09815269.7A patent/EP2328640B1/en active Active
  • 2009-09-18 WO PCT/US2009/057485 patent/WO2010033808A2/en not_active Ceased
  • 2009-09-18 CN CN2009801415112A patent/CN102186520B/zh active Active
  • 2009-09-18 JP JP2011527999A patent/JP2012502765A/ja active Pending
  • 2009-09-18 US US13/119,266 patent/US8500682B2/en active Active
  • 2009-09-18 ES ES09815269.7T patent/ES2619526T3/es active Active
• 2013
  • 2013-06-12 US US13/916,101 patent/US10034980B2/en active Active

Non-Patent Citations (2)

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