WO2010030342A3 - Polymères d'héparosane et leurs procédés de fabrication et d'utilisation destinés à l'amélioration de composés thérapeutiques - Google Patents

Polymères d'héparosane et leurs procédés de fabrication et d'utilisation destinés à l'amélioration de composés thérapeutiques Download PDF

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Publication number
WO2010030342A3
WO2010030342A3 PCT/US2009/005050 US2009005050W WO2010030342A3 WO 2010030342 A3 WO2010030342 A3 WO 2010030342A3 US 2009005050 W US2009005050 W US 2009005050W WO 2010030342 A3 WO2010030342 A3 WO 2010030342A3
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WO
WIPO (PCT)
Prior art keywords
methods
therapeutics
enhancement
making
same
Prior art date
Application number
PCT/US2009/005050
Other languages
English (en)
Other versions
WO2010030342A2 (fr
Inventor
Paul L. Deangelis
Original Assignee
The Board Of Regents Of The University Of Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Regents Of The University Of Oklahoma filed Critical The Board Of Regents Of The University Of Oklahoma
Priority to CA2773755A priority Critical patent/CA2773755C/fr
Priority to EP09813350.7A priority patent/EP2341941A4/fr
Publication of WO2010030342A2 publication Critical patent/WO2010030342A2/fr
Publication of WO2010030342A3 publication Critical patent/WO2010030342A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des compositions, des procédés, et des systèmes destinés au développement et à l'utilisation de l'héparosane, un polymère naturel apparenté à l'héparine, comme nouvel agent ou support de modification thérapeutique qui peut moduler les comportements pharmacocinétiques de la charge de médicaments et le comportement d'un patient mammifère.
PCT/US2009/005050 2008-09-09 2009-09-09 Polymères d'héparosane et leurs procédés de fabrication et d'utilisation destinés à l'amélioration de composés thérapeutiques WO2010030342A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA2773755A CA2773755C (fr) 2008-09-09 2009-09-09 Polymeres d'heparosane et leurs procedes de fabrication et d'utilisation destines a l'amelioration de composes therapeutiques
EP09813350.7A EP2341941A4 (fr) 2008-09-09 2009-09-09 Polymères d'héparosane et leurs procédés de fabrication et d'utilisation destinés à l'amélioration de composés thérapeutiques

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US9557208P 2008-09-09 2008-09-09
US61/095,572 2008-09-09
US38304609A 2009-03-19 2009-03-19
US12/383,046 2009-03-19
US17927509P 2009-05-18 2009-05-18
US61/179,275 2009-05-18

Publications (2)

Publication Number Publication Date
WO2010030342A2 WO2010030342A2 (fr) 2010-03-18
WO2010030342A3 true WO2010030342A3 (fr) 2010-06-17

Family

ID=44123336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/005050 WO2010030342A2 (fr) 2008-09-09 2009-09-09 Polymères d'héparosane et leurs procédés de fabrication et d'utilisation destinés à l'amélioration de composés thérapeutiques

Country Status (3)

Country Link
EP (1) EP2341941A4 (fr)
CA (1) CA2773755C (fr)
WO (1) WO2010030342A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8580290B2 (en) 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
US9925209B2 (en) 2008-03-19 2018-03-27 The Board Of Regents Of The University Of Oklahoma Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en) 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
BR112014024291B1 (pt) 2012-03-30 2022-07-05 The Board Of Regents Of The University Of Oklahoma Método para a produção de forma recombinante de um polímero de heparosan com alto peso molecular, uso do referido polímero para aumento de tecido, polinucleotídeo isolado e composição de material biológico compreendendo o referido polímero
MX345548B (es) 2012-09-17 2017-02-03 Technip France Amortiguación de vibración inducida por vórtice de viga de mástil con placas verticales.
US20150307865A1 (en) * 2012-10-15 2015-10-29 Novo Nordisk Health Care Ag Coagulation factor vii polypeptides
US20150259665A1 (en) * 2012-10-15 2015-09-17 Novo Nordisk Health Care Ag Factor vii conjugates
MX2016004702A (es) 2013-10-15 2016-07-22 Novo Nordisk Healthcare Ag Polipeptidos del factor vii de coagulacion.
AR101060A1 (es) * 2014-02-12 2016-11-23 Novo Nordisk As Conjugados de fviii
AR099340A1 (es) * 2014-02-12 2016-07-13 Novo Nordisk As Conjugados del factor de coagulación ix

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470911A (en) * 1988-11-21 1995-11-28 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US20020193516A1 (en) * 2001-03-30 2002-12-19 Bucevschi Mircea Dan Biocompatible, Biodegradable, water-absorbent material and methods for its preparation
US20030017131A1 (en) * 2001-07-09 2003-01-23 Park Tae Gwan Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer
US20040087488A1 (en) * 2002-07-02 2004-05-06 Genzyme Corporation Hydrophilic biopolymer-drug conjugates, their preparation and use
US20050255562A1 (en) * 2003-11-12 2005-11-17 Rosenberg Robert D Methods for synthesis of sulfated saccharides
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US20080109236A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
US20080226690A1 (en) * 2001-05-08 2008-09-18 Deangelis Paul L Heparosan-based biomaterials and coatings and methods of production and use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9112212D0 (en) * 1991-06-06 1991-07-24 Gregoriadis Gregory Pharmaceutical compositions
US6562781B1 (en) * 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6309646B1 (en) * 1996-05-09 2001-10-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates
US20060105431A1 (en) * 1998-11-11 2006-05-18 Deangelis Paul L Polymer grafting by polysaccharide synthases using artificial sugar acceptors
US20040197868A1 (en) * 2001-05-08 2004-10-07 Deangelis Paul L. Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same
US20020192205A1 (en) * 2001-05-11 2002-12-19 Francis Michon Immunogenic compositions of low molecular weight hyaluronic acid and methods to prevent, treat and diagnose infections and diseases caused by group A and group C streptococci
ITPD20020271A1 (it) * 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
CA2434668A1 (fr) * 2003-07-04 2005-01-04 Laurence Mulard Nouvelle approche pour concevoir des glycopeptides a base de o-specifique polysaccharide de shigella flexneri serotype 2a
US7842500B2 (en) * 2005-03-31 2010-11-30 Seikagaku Corporation Anti-heparan sulfate antibody, method for detection of heparan sulfate, and kit for detection of heparan sulfate
JP5279269B2 (ja) * 2005-06-28 2013-09-04 生化学工業株式会社 酵素活性の測定方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470911A (en) * 1988-11-21 1995-11-28 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US20080109236A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US20020193516A1 (en) * 2001-03-30 2002-12-19 Bucevschi Mircea Dan Biocompatible, Biodegradable, water-absorbent material and methods for its preparation
US20080226690A1 (en) * 2001-05-08 2008-09-18 Deangelis Paul L Heparosan-based biomaterials and coatings and methods of production and use thereof
US20030017131A1 (en) * 2001-07-09 2003-01-23 Park Tae Gwan Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer
US20040087488A1 (en) * 2002-07-02 2004-05-06 Genzyme Corporation Hydrophilic biopolymer-drug conjugates, their preparation and use
US20050255562A1 (en) * 2003-11-12 2005-11-17 Rosenberg Robert D Methods for synthesis of sulfated saccharides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2341941A4 *

Also Published As

Publication number Publication date
EP2341941A4 (fr) 2014-12-10
EP2341941A2 (fr) 2011-07-13
CA2773755A1 (fr) 2010-03-18
CA2773755C (fr) 2017-04-25
WO2010030342A2 (fr) 2010-03-18

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