EP2341941A4 - Polymères d'héparosane et leurs procédés de fabrication et d'utilisation destinés à l'amélioration de composés thérapeutiques - Google Patents

Polymères d'héparosane et leurs procédés de fabrication et d'utilisation destinés à l'amélioration de composés thérapeutiques

Info

Publication number
EP2341941A4
EP2341941A4 EP09813350.7A EP09813350A EP2341941A4 EP 2341941 A4 EP2341941 A4 EP 2341941A4 EP 09813350 A EP09813350 A EP 09813350A EP 2341941 A4 EP2341941 A4 EP 2341941A4
Authority
EP
European Patent Office
Prior art keywords
therapeutics
enhancement
making
methods
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09813350.7A
Other languages
German (de)
English (en)
Other versions
EP2341941A2 (fr
Inventor
Paul L Deangelis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oklahoma
Original Assignee
University of Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oklahoma filed Critical University of Oklahoma
Publication of EP2341941A2 publication Critical patent/EP2341941A2/fr
Publication of EP2341941A4 publication Critical patent/EP2341941A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP09813350.7A 2008-09-09 2009-09-09 Polymères d'héparosane et leurs procédés de fabrication et d'utilisation destinés à l'amélioration de composés thérapeutiques Withdrawn EP2341941A4 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9557208P 2008-09-09 2008-09-09
US38304609A 2009-03-19 2009-03-19
US17927509P 2009-05-18 2009-05-18
PCT/US2009/005050 WO2010030342A2 (fr) 2008-09-09 2009-09-09 Polymères d'héparosane et leurs procédés de fabrication et d'utilisation destinés à l'amélioration de composés thérapeutiques

Publications (2)

Publication Number Publication Date
EP2341941A2 EP2341941A2 (fr) 2011-07-13
EP2341941A4 true EP2341941A4 (fr) 2014-12-10

Family

ID=44123336

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09813350.7A Withdrawn EP2341941A4 (fr) 2008-09-09 2009-09-09 Polymères d'héparosane et leurs procédés de fabrication et d'utilisation destinés à l'amélioration de composés thérapeutiques

Country Status (3)

Country Link
EP (1) EP2341941A4 (fr)
CA (1) CA2773755C (fr)
WO (1) WO2010030342A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8580290B2 (en) 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
US9925209B2 (en) 2008-03-19 2018-03-27 The Board Of Regents Of The University Of Oklahoma Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en) 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
WO2013149161A1 (fr) 2012-03-30 2013-10-03 Deangelis Paul L Polymères d'héparosane de poids moléculaire élevé et procédés de production et d'utilisation de ceux-ci
CA2884896C (fr) 2012-09-17 2017-07-04 Technip France Amortissement de vibrations induites par un tourbillon de plateforme de haute mer a entretoises comportant des plaques verticales
WO2014060397A1 (fr) * 2012-10-15 2014-04-24 Novo Nordisk Health Care Ag Conjugués de facteur vii
WO2014060401A1 (fr) * 2012-10-15 2014-04-24 Novo Nordisk Health Care Ag Polypeptides de facteur vii de coagulation
CN105637088A (zh) * 2013-10-15 2016-06-01 诺和诺德保健股份有限公司 凝固因子vii多肽
AR099340A1 (es) * 2014-02-12 2016-07-13 Novo Nordisk As Conjugados del factor de coagulación ix
AR101060A1 (es) * 2014-02-12 2016-11-23 Novo Nordisk As Conjugados de fviii

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022331A1 (fr) * 1991-06-06 1992-12-23 The School Of Pharmacy Compositions pharmaceutiques
WO1997041897A1 (fr) * 1996-05-09 1997-11-13 Virion Systems, Inc. Vaccins a base de conjugues proteine/polysaccharide prepares a l'aide de vinylsulfones homobifonctionnelles et heterobifonctionnelles
US20020192205A1 (en) * 2001-05-11 2002-12-19 Francis Michon Immunogenic compositions of low molecular weight hyaluronic acid and methods to prevent, treat and diagnose infections and diseases caused by group A and group C streptococci
US6562781B1 (en) * 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US20040087488A1 (en) * 2002-07-02 2004-05-06 Genzyme Corporation Hydrophilic biopolymer-drug conjugates, their preparation and use
US20040197868A1 (en) * 2001-05-08 2004-10-07 Deangelis Paul L. Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same
US20060105431A1 (en) * 1998-11-11 2006-05-18 Deangelis Paul L Polymer grafting by polysaccharide synthases using artificial sugar acceptors
US20060116346A1 (en) * 2002-10-18 2006-06-01 Fidia Farmaceutici S.P.A. Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives
EP1870421A1 (fr) * 2005-03-31 2007-12-26 Seikagaku Corporation Anticorps original de sulfate d'anti-héparane, procédé pour la détection du sulfate d'héparane, et nécessaire pour la détection du sulfate d'héparane
US20080109236A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
US20080112951A1 (en) * 2003-07-04 2008-05-15 Armelle Phalipon Glycoconjugates and Their Use as Potential Vaccines Against Infection by Shigella Flexneri
EP1923402A1 (fr) * 2005-06-28 2008-05-21 Seikagaku Corporation Procédé de détermination de l'activité enzymatique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6833488B2 (en) * 2001-03-30 2004-12-21 Exotech Bio Solution Ltd. Biocompatible, biodegradable, water-absorbent material and methods for its preparation
US8580290B2 (en) * 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
US6623729B2 (en) * 2001-07-09 2003-09-23 Korea Advanced Institute Of Science And Technology Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer
US7655445B2 (en) * 2003-11-12 2010-02-02 Massachusetts Institute Of Technology Methods for synthesis of sulfated saccharides

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022331A1 (fr) * 1991-06-06 1992-12-23 The School Of Pharmacy Compositions pharmaceutiques
US6562781B1 (en) * 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
WO1997041897A1 (fr) * 1996-05-09 1997-11-13 Virion Systems, Inc. Vaccins a base de conjugues proteine/polysaccharide prepares a l'aide de vinylsulfones homobifonctionnelles et heterobifonctionnelles
US20080109236A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
US20060105431A1 (en) * 1998-11-11 2006-05-18 Deangelis Paul L Polymer grafting by polysaccharide synthases using artificial sugar acceptors
US20040197868A1 (en) * 2001-05-08 2004-10-07 Deangelis Paul L. Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same
US20020192205A1 (en) * 2001-05-11 2002-12-19 Francis Michon Immunogenic compositions of low molecular weight hyaluronic acid and methods to prevent, treat and diagnose infections and diseases caused by group A and group C streptococci
US20040087488A1 (en) * 2002-07-02 2004-05-06 Genzyme Corporation Hydrophilic biopolymer-drug conjugates, their preparation and use
US20060116346A1 (en) * 2002-10-18 2006-06-01 Fidia Farmaceutici S.P.A. Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives
US20080112951A1 (en) * 2003-07-04 2008-05-15 Armelle Phalipon Glycoconjugates and Their Use as Potential Vaccines Against Infection by Shigella Flexneri
EP1870421A1 (fr) * 2005-03-31 2007-12-26 Seikagaku Corporation Anticorps original de sulfate d'anti-héparane, procédé pour la détection du sulfate d'héparane, et nécessaire pour la détection du sulfate d'héparane
EP1923402A1 (fr) * 2005-06-28 2008-05-21 Seikagaku Corporation Procédé de détermination de l'activité enzymatique

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. E. SISMEY-RAGATZ ET AL: "Chemoenzymatic Synthesis with Distinct Pasteurella Heparosan Synthases: MONODISPERSE POLYMERS AND UNNATURAL STRUCTURES", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 39, 11 July 2007 (2007-07-11), pages 28321 - 28327, XP055116675, ISSN: 0021-9258, DOI: 10.1074/jbc.M701599200 *
KIYOSHI SUZUKI ET AL: "Generation and characterization of a series of monoclonal antibodies that specifically recognize [HexA(Ã Â+-2S)-GlcNAc]n epitopes in heparan sulfate", GLYCOCONJUGATE JOURNAL, KLUWER ACADEMIC PUBLISHERS, BO, vol. 25, no. 8, 7 May 2008 (2008-05-07), pages 703 - 712, XP019642419, ISSN: 1573-4986, DOI: 10.1007/S10719-008-9130-Z *

Also Published As

Publication number Publication date
CA2773755A1 (fr) 2010-03-18
CA2773755C (fr) 2017-04-25
EP2341941A2 (fr) 2011-07-13
WO2010030342A2 (fr) 2010-03-18
WO2010030342A3 (fr) 2010-06-17

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RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 9/10 20060101ALI20141104BHEP

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