WO2010020307A3 - Dérivés d'acide indazol-5-carboxylique - Google Patents

Dérivés d'acide indazol-5-carboxylique Download PDF

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Publication number
WO2010020307A3
WO2010020307A3 PCT/EP2009/005023 EP2009005023W WO2010020307A3 WO 2010020307 A3 WO2010020307 A3 WO 2010020307A3 EP 2009005023 W EP2009005023 W EP 2009005023W WO 2010020307 A3 WO2010020307 A3 WO 2010020307A3
Authority
WO
WIPO (PCT)
Prior art keywords
indazole
carboxylic acid
acid hydrazide
hydrazide derivatives
derivatives
Prior art date
Application number
PCT/EP2009/005023
Other languages
German (de)
English (en)
Other versions
WO2010020307A2 (fr
Inventor
Markus Klein
Norbert Beier
Florian Lang
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of WO2010020307A2 publication Critical patent/WO2010020307A2/fr
Publication of WO2010020307A3 publication Critical patent/WO2010020307A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux dérivés d'indazol de formule (I) dans laquelle Ar, G, R, X1, X2, X3, Y et n ont les correspondances indiquées dans la revendication 1, qui sont des inhibiteurs de kinase et peuvent être utilisés pour traiter des maladies et des affections telles que le diabète, l'obésité, le syndrome métabolique (dyslipidémie), l'hypertonie systémique et pulmonaire, les troubles cardio-vasculaires et les troubles rénaux, de manière générale du type fibroses, phénomènes inflammatoires, tumeurs et troubles tumoraux.
PCT/EP2009/005023 2008-08-18 2009-07-10 Dérivés d'acide indazol-5-carboxylique WO2010020307A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008038222.1 2008-08-18
DE102008038222A DE102008038222A1 (de) 2008-08-18 2008-08-18 Indazol-5-carbonsäurehydrazid-derivate

Publications (2)

Publication Number Publication Date
WO2010020307A2 WO2010020307A2 (fr) 2010-02-25
WO2010020307A3 true WO2010020307A3 (fr) 2010-07-29

Family

ID=41557422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/005023 WO2010020307A2 (fr) 2008-08-18 2009-07-10 Dérivés d'acide indazol-5-carboxylique

Country Status (2)

Country Link
DE (1) DE102008038222A1 (fr)
WO (1) WO2010020307A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020103229A1 (en) * 2000-07-31 2002-08-01 Bhagwat Shripad S. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
WO2004078924A2 (fr) * 2003-02-28 2004-09-16 Rheogene, Inc. Ligands diacylhydrazine biodisponibles pour moduler l'expression des genes exogenes via un complexe recepteur d'ecdysone
DE102006005179A1 (de) * 2006-02-06 2007-08-09 Merck Patent Gmbh Aminoindazolderivate

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227841A (en) 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
DE19917990A1 (de) 1999-04-20 2000-11-02 Florian Lang Arzneimittel enthaltend Hemmstoffe der zellvolumenregulierten humanen Kinase h-sgk
DE10042137A1 (de) 2000-08-28 2002-03-14 Florian Lang sgk2 und sgk3 als diagnostische und therapeutische Targets
WO2002072549A1 (fr) 2001-03-12 2002-09-19 Millennium Pharmaceuticals, Inc. Heterocycles fonctionnalises en tant que modulateurs de la fonction du recepteur de chimiokines et procedes de mise en oeuvre
AU2002353186A1 (en) 2001-12-19 2003-06-30 Smithkline Beecham P.L.C. (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors
TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
BR0311291A (pt) 2002-05-17 2005-03-29 Pharmacia Italia Spa Derivados de aminoindazol ativos como inibidores da cinase, processo para sua preparação e composições farmacêuticas compreendendo os mesmos
JP4414881B2 (ja) 2002-05-31 2010-02-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾール化合物およびこれを含んでなる医薬組成物
WO2004052280A2 (fr) 2002-12-10 2004-06-24 Imclone Systems Incorporated Composes anti-angiogenique et utilisations de ceux-ci dans le traitement du cancer
US20050019366A1 (en) 2002-12-31 2005-01-27 Zeldis Jerome B. Drug-coated stents and methods of use therefor
WO2005000813A1 (fr) 2003-05-30 2005-01-06 Imclone Systems Incorporated Derives d'heteroarylamino-phenylcetone et leur utilisation en tant qu'inhibiteurs de kinases
US20050090529A1 (en) 2003-07-31 2005-04-28 Pfizer Inc 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
TW200524601A (en) 2003-12-05 2005-08-01 Bristol Myers Squibb Co Heterocyclic anti-migraine agents
JP2007533753A (ja) 2004-04-23 2007-11-22 タケダ サン ディエゴ インコーポレイテッド インドール誘導体及びキナーゼ阻害剤としてのその使用
NZ553492A (en) 2004-08-25 2010-11-26 Targegen Inc Triazole derivatives and methods of use
US7354944B2 (en) 2004-10-18 2008-04-08 Amgen Inc. Thiadiazole compounds and methods of use
EP1833806A1 (fr) 2004-12-14 2007-09-19 AstraZeneca AB Dérivés d'oxadiazole en tant qu'inhibiteurs de dgat
WO2006064375A2 (fr) 2004-12-16 2006-06-22 Ab Science Composes heterocycliques a noyau a cinq elements a substitution aminoaryle pour le traitement de maladies
CA2630884A1 (fr) 2005-11-30 2007-06-07 Vertex Pharmaceuticals Incorporated Inhibiteurs de c-met et leurs utilisations
EA015754B1 (ru) 2005-12-21 2011-12-30 Янссен Фармацевтика, Н.В. Триазолопиридазины в качестве модуляторов тирозинкиназы
EP2032578A2 (fr) 2006-05-30 2009-03-11 Pfizer Products Incorporated Dérivés de la triazolopyridazine
PE20080403A1 (es) 2006-07-14 2008-04-25 Amgen Inc Derivados heterociclicos fusionados y metodos de uso
KR101083177B1 (ko) 2006-10-23 2011-11-11 에스지엑스 파마슈티컬스, 인코포레이티드 트리아졸로-피리다진 단백질 키나제 조정제
EA200900613A1 (ru) 2006-11-29 2009-10-30 Пфайзер Продактс Инк. Спирокетоновые ингибиторы ацетил-коа-карбоксилаз

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020103229A1 (en) * 2000-07-31 2002-08-01 Bhagwat Shripad S. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
WO2004078924A2 (fr) * 2003-02-28 2004-09-16 Rheogene, Inc. Ligands diacylhydrazine biodisponibles pour moduler l'expression des genes exogenes via un complexe recepteur d'ecdysone
DE102006005179A1 (de) * 2006-02-06 2007-08-09 Merck Patent Gmbh Aminoindazolderivate

Also Published As

Publication number Publication date
DE102008038222A1 (de) 2010-02-25
WO2010020307A2 (fr) 2010-02-25

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