WO2010006286A3 - Constructions et bibliothèques comprenant des séquences à chaîne légère de kappa succédané d'anticorps - Google Patents

Constructions et bibliothèques comprenant des séquences à chaîne légère de kappa succédané d'anticorps Download PDF

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Publication number
WO2010006286A3
WO2010006286A3 PCT/US2009/050290 US2009050290W WO2010006286A3 WO 2010006286 A3 WO2010006286 A3 WO 2010006286A3 US 2009050290 W US2009050290 W US 2009050290W WO 2010006286 A3 WO2010006286 A3 WO 2010006286A3
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WO
WIPO (PCT)
Prior art keywords
light chain
libraries
constructs
chain sequences
kappa light
Prior art date
Application number
PCT/US2009/050290
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English (en)
Other versions
WO2010006286A2 (fr
Inventor
Lawrence Horowitz
Ramesh R. Bhatt
Original Assignee
Sea Lane Biotechnologies, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sea Lane Biotechnologies, Llc filed Critical Sea Lane Biotechnologies, Llc
Priority to CA2729181A priority Critical patent/CA2729181A1/fr
Priority to AU2009268352A priority patent/AU2009268352A1/en
Priority to JP2011517662A priority patent/JP2011527707A/ja
Priority to BRPI0915512A priority patent/BRPI0915512A2/pt
Priority to MX2011000230A priority patent/MX2011000230A/es
Priority to CN2009801348404A priority patent/CN102149727A/zh
Priority to EP09790293A priority patent/EP2300498A2/fr
Publication of WO2010006286A2 publication Critical patent/WO2010006286A2/fr
Publication of WO2010006286A3 publication Critical patent/WO2010006286A3/fr
Priority to IL210052A priority patent/IL210052A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des constructions et bibliothèques comprenant des séquences à chaîne légère de K succédané d'anticorps. En particulier, l'invention concerne des constructions contenant des séquences à chaîne légère de kappa succédané d'anticorps, facultativement liés avec un autre polypeptide, comme par exemple des séquences de domaine à chaîne légère et/ou lourde d'anticorps, et des bibliothèques les contenant.
PCT/US2009/050290 2008-07-11 2009-07-10 Constructions et bibliothèques comprenant des séquences à chaîne légère de kappa succédané d'anticorps WO2010006286A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2729181A CA2729181A1 (fr) 2008-07-11 2009-07-10 Constructions et bibliotheques comprenant des sequences a chaine legere de kappa succedane d'anticorps
AU2009268352A AU2009268352A1 (en) 2008-07-11 2009-07-10 Constructs and libraries comprising antibody surrogate kappa light chain sequences
JP2011517662A JP2011527707A (ja) 2008-07-11 2009-07-10 抗体代替κ軽鎖配列を含む構築物及びライブラリー
BRPI0915512A BRPI0915512A2 (pt) 2008-07-11 2009-07-10 construtos e bibliotecas compreendendo sequências substitutas de cadeia leve kappa de anticorpo
MX2011000230A MX2011000230A (es) 2008-07-11 2009-07-10 Construcciones y bibliotecas que comprenden secuencias de cadena ligera kappa surrogadas de anticuerpo.
CN2009801348404A CN102149727A (zh) 2008-07-11 2009-07-10 包含抗体替代卡帕轻链序列的构建体和文库
EP09790293A EP2300498A2 (fr) 2008-07-11 2009-07-10 Constructions et bibliothèques comprenant des séquences à chaîne légère de kappa succédané d'anticorps
IL210052A IL210052A0 (en) 2008-07-11 2010-12-16 Constructs and libraries comprising antibody surrogate kappa light chain sequences

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13492908P 2008-07-11 2008-07-11
US61/134,929 2008-07-11

Publications (2)

Publication Number Publication Date
WO2010006286A2 WO2010006286A2 (fr) 2010-01-14
WO2010006286A3 true WO2010006286A3 (fr) 2010-05-27

Family

ID=41507761

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/050290 WO2010006286A2 (fr) 2008-07-11 2009-07-10 Constructions et bibliothèques comprenant des séquences à chaîne légère de kappa succédané d'anticorps

Country Status (11)

Country Link
US (1) US20100062950A1 (fr)
EP (1) EP2300498A2 (fr)
JP (1) JP2011527707A (fr)
KR (1) KR20110028543A (fr)
CN (1) CN102149727A (fr)
AU (1) AU2009268352A1 (fr)
BR (1) BRPI0915512A2 (fr)
CA (1) CA2729181A1 (fr)
IL (1) IL210052A0 (fr)
MX (1) MX2011000230A (fr)
WO (1) WO2010006286A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2680237C (fr) 2007-03-27 2018-11-06 Sea Lane Biotechnologies, Llc Constructions et bibliotheques comprenant des sequences de chaines legeres de substitution d'anticorps
AU2010249046A1 (en) 2009-05-13 2011-12-01 Sea Lane Biotechnologies, Llc Neutralizing molecules to influenza viruses
US8969082B2 (en) 2009-06-26 2015-03-03 Sea Lane Biotechnologies, Llc Expression of surrogate light chains
US20120269830A1 (en) * 2009-12-07 2012-10-25 Lawrence Horowitz Conjugates with improved pharmacokinetic properties
WO2013003652A1 (fr) 2011-06-28 2013-01-03 Sea Lane Biotechnologies, Llc Protéines de liaison à domaines variables empilés polyvalentes
CA2842860A1 (fr) 2011-07-28 2013-01-31 Sea Lane Biotechnologies, Llc Proteines se liant a sur dirigees contre erbb3
EP2793940B1 (fr) 2011-12-22 2018-11-14 i2 Pharmaceuticals, Inc. Protéines substitutives de liaison
US20150011736A1 (en) 2012-01-20 2015-01-08 Sea Lane Biotechnologies, Llc Binding molecule conjugates
PT3126383T (pt) 2014-04-03 2019-03-22 Igm Biosciences Inc Cadeia j modificada
WO2016126488A1 (fr) 2015-02-02 2016-08-11 Sea Lane Biotechnologies, Llc Anticorps anti-chaînes légères de substitution
CA2999284C (fr) 2015-09-30 2023-06-13 Igm Biosciences A/S Molecules de liaison a chaine j modifiee
CN108463472A (zh) 2015-09-30 2018-08-28 Igm生物科学有限公司 具有修饰的j-链的结合分子

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068696A1 (fr) * 2000-03-15 2001-09-20 Incyte Genomics, Inc. Proteines de reponse immunitaire humaines
WO2008118970A2 (fr) * 2007-03-27 2008-10-02 Sea Lane Biotechnologies, Llc Constructions et bibliothèques comprenant des séquences de chaînes légères de substitution d'anticorps

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476198B1 (en) * 1993-07-13 2002-11-05 The Scripps Research Institute Multispecific and multivalent antigen-binding polypeptide molecules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068696A1 (fr) * 2000-03-15 2001-09-20 Incyte Genomics, Inc. Proteines de reponse immunitaire humaines
WO2008118970A2 (fr) * 2007-03-27 2008-10-02 Sea Lane Biotechnologies, Llc Constructions et bibliothèques comprenant des séquences de chaînes légères de substitution d'anticorps

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 7 November 1985 (1985-11-07), "Human germ line gene for immunoglobulin kappa light chain leader peptide and variable region (subgroup V kappa I)", XP002570437, retrieved from EBI accession no. EMBL:V01577 Database accession no. V01577 *
FRANCES VERONIQUE ET AL: "A surrogate 15 kDa JC-kappa protein is expressed in combination with mu heavy chain by human B cell precursors", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 13, no. 24, 1 August 1994 (1994-08-01), pages 5937 - 5943, XP009130092, ISSN: 0261-4189 *
MCKELLER M R ET AL: "The kappa-like pre-B receptor: Surplus biology or a missing link?", SEMINARS IN IMMUNOLOGY, W.B. SAUNDERS COMPANY, PA, US, vol. 18, no. 1, 1 February 2006 (2006-02-01), pages 40 - 43, XP024907985, ISSN: 1044-5323, [retrieved on 20060201] *
MORSTADT LUCIA ET AL: "Engineering and characterization of a single chain surrogate light chain variable domain", PROTEIN SCIENCE, CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, GB, vol. 17, no. 3, 1 March 2008 (2008-03-01), pages 458 - 465, XP009106641, ISSN: 0961-8368 *
RANGEL ROBERTO ET AL: "Assembly of the kappa PreB receptor requires a V kappa-like protein encoded by a germline transcript", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US, vol. 280, no. 18, 1 May 2005 (2005-05-01), pages 17807 - 17814, XP009130089, ISSN: 0021-9258 *
THOMPSON ALLAN ET AL: "A pro-B-cell stage characterized by germline lg transcription without surrogate light chain expression", IMMUNOGENETICS, SPRINGER VERLAG, BERLIN, DE, vol. 48, no. 5, 1 October 1998 (1998-10-01), pages 305 - 311, XP009130088, ISSN: 0093-7711 *
XU LI ET AL: "Combinatorial surrobody libraries", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 105, no. 31, 5 August 2008 (2008-08-05), pages 10756 - 10761, XP002498064, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
IL210052A0 (en) 2011-02-28
KR20110028543A (ko) 2011-03-18
CN102149727A (zh) 2011-08-10
BRPI0915512A2 (pt) 2017-06-20
MX2011000230A (es) 2011-03-02
CA2729181A1 (fr) 2010-01-14
US20100062950A1 (en) 2010-03-11
EP2300498A2 (fr) 2011-03-30
AU2009268352A1 (en) 2010-01-14
JP2011527707A (ja) 2011-11-04
WO2010006286A2 (fr) 2010-01-14

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