WO2010003443A2 - Implant d'ostéosynthèse destiné à être implanté dans le corps d'un être humain ou d'un animal - Google Patents

Implant d'ostéosynthèse destiné à être implanté dans le corps d'un être humain ou d'un animal Download PDF

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Publication number
WO2010003443A2
WO2010003443A2 PCT/EP2008/006307 EP2008006307W WO2010003443A2 WO 2010003443 A2 WO2010003443 A2 WO 2010003443A2 EP 2008006307 W EP2008006307 W EP 2008006307W WO 2010003443 A2 WO2010003443 A2 WO 2010003443A2
Authority
WO
WIPO (PCT)
Prior art keywords
magnesium alloy
implant
implant according
osteosynthetic
strength
Prior art date
Application number
PCT/EP2008/006307
Other languages
German (de)
English (en)
Other versions
WO2010003443A3 (fr
Inventor
Volkmar Neubert
Original Assignee
Syntellix Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntellix Ag filed Critical Syntellix Ag
Priority to DE202008018000U priority Critical patent/DE202008018000U1/de
Publication of WO2010003443A2 publication Critical patent/WO2010003443A2/fr
Publication of WO2010003443A3 publication Critical patent/WO2010003443A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425

Definitions

  • Osteosynthetic implant for implantation in the human or animal body
  • the invention relates to an osteosynthetic implant referred to in the preamble of claim 1 for implantation in the human or animal body.
  • osteosynthetic implants are well known, for example in the form of screws, plates or nails. They are used in particular in the treatment of bone fractures and serve to stabilize and / or hold together bone parts. Because of its excellent strength, Titanium is often used as the material for the implants. The disadvantage here, however, is that the implant must be removed after a healing of a bone fracture and for this purpose a surgical procedure is required.
  • EP 1 835 042 A1 discloses an osteosynthetic implant of the type in question for implantation in the human or animal body, which has a base body which consists at least partially of an in vivo degradable magnesium alloy.
  • the document proposes in particular magnesium alloys, which contain aluminum to a considerable extent.
  • the invention has for its object to provide an osteosynthetic implant, which has an optimized compatibility with respect to the organism into which the implant is introduced.
  • the invention provides an implant which, on the one hand, meets the requirements of strength and, on the other hand, has optimized compatibility with the organism in which it is incorporated.
  • the magnesium alloy is substantially free of aluminum and essentially free of scandium. Due to the fact that the magnesium alloy according to the invention, which is also referred to below as alloy for short, is substantially free of aluminum, the compatibility with respect to the organism into which the implant has been introduced is substantially increased. This is particularly the case because, according to the current state of science, aluminum is suspected of being toxic in the human or animal body and in particular of causing or promoting neurological damage. For example, aluminum is suspected of causing or promoting Alzheimer's disease. Due to the fact that the magnesium alloy used according to the invention does not contain aluminum or only in low mass contents contains, corresponding effects are avoided.
  • a magnesium alloy which is free of an element is understood according to the invention to mean a magnesium alloy whose mass content at the relevant element is substantially less than 1%. Under an aluminum-free magnesium alloy is thus understood according to the invention a magnesium alloy, the mass content of aluminum is substantially less than 1%.
  • a magnesium alloy, which is free of an element in the sense of the invention means a magnesium alloy, in the production of which the element in question is not added but, for example and in particular due to impurities, enters the alloy.
  • corresponding impurities are usually present in such a low mass content in the magnesium alloy that they do not adversely affect the properties of the magnesium alloy, in particular its mechanical properties and its compatibility with respect to the human or animal organism.
  • the magnesium alloy according to the invention contains yttrium and / or rare earths and / or zirconium.
  • yttrium and / or rare earths and / or zirconium are present in the magnesium alloy simply or in combination with one another.
  • the fact that these elements are present in the magnesium alloy simply or in combination with one another improves the strength properties of the magnesium alloy, in particular with regard to the yield strength and the tensile strength, which increase, so that the implant consisting of the magnesium alloy according to the invention readily meets the requirements meets mechanical requirements that are to be placed on such an implant.
  • the invention thus provides an implant made of an in vivo degradable material. which meets the requirements of its strength as well as the requirements for an optimized compatibility with respect to an organism in which the implant is incorporated.
  • the mass content of yttrium or rare earth or zirconium in the magnesium alloy according to the invention can be selected within wide limits.
  • the mass content of yttrium in the alloy about 2 to 3% and / or the mass content of rare earths in the alloy about 3 to 4% and / or the mass content of zirconium in the magnesium alloy is about 0..4 to 0.7%, in particular greater than 0.5%.
  • the magnesium alloy contains calcium and / or calcium phosphate or the body consists at least partially of calcium or calcium phosphate or is coated therewith.
  • the use of calcium has the
  • Calcium phosphate has the advantage that it promotes healing or healing. It accelerates as it dissolves, creating voids. As the bone seeks to fill these cavities, calcium phosphate promotes bone growth. By adjusting the calcium content in the magnesium alloy, the rate at which the implant degrades in vivo can be adjusted.
  • the respective rare earth metal can be selected according to the respective requirements within wide limits.
  • the magnesium alloy contains rare-earth metal neodymium or a NeodymvGrbin- tion, in particular a Neodymmischmetall.
  • particularly favorable material properties result, in particular with regard to the strength of the implant. This is especially true when a neodymium mischmetal consisting of, for example, neodymium (2 to 2.5%), terbium, erbium, dysprosium and gadolinium is used.
  • the magnesium alloy contains as rare earth metal terbium and / or erbium and / or dysprosium and / or gadolinium. Shape, size and intended use of the implant according to the invention can be selected within wide limits.
  • An advantageous development of the invention provides insofar as the implant is an osteosynthetic support or holding part for insertion into a bone part, for example a screw, a plate or a nail.
  • magnesium alloy contains lithium.
  • the decomposition accelerate the speed of the implant in the organism.
  • the implant consists completely or substantially completely of the magnesium alloy. It is also possible that the main body partially consists entirely of the magnesium alloy, for example, in that the shaft of a screw in an axial region consists entirely of the magnesium alloy, while it consists of a different material in other axial regions.
  • An advantageous development of the invention provides that the implant is at least partially coated with the magnesium alloy.
  • FIGURE of the drawing is a schematic side view of an embodiment of an inventive osteosynthetic implant 2 for implantation in the human or animal body.
  • the implant 2 is formed in this embodiment as an osteosynthetic screw and has a base 4, which in the illustrated embodiment completely made of an in vivo degradable magnesium alloy.
  • the magnesium alloy is aluminum-free and scandium-free and has strength-reducing properties. inducing elements in the embodiment of yttrium and rare earths and zirconium.
  • the mass contents of the individual elements are as follows: yttrium 2 to 3% rare earth 3 to 4% zirconium 0.4 to 0.7% magnesium balance
  • the invention provides an implant which not only meets the requirements of its strength properties, but also has an optimized compatibility with respect to an organism in which it is implanted.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un implant d'ostéosynthèse (2) destiné à être implanté dans le corps d'un être humain ou d'un animal, cet implant d'ostéosynthèse comprenant un corps de base (4) composé au moins partiellement d'un alliage de magnésium résorbable in vivo. Selon l'invention, l'alliage de magnésium est sensiblement sans aluminium et sensiblement sans scandium et contient comme éléments renforçateurs de l'yttrium et/ou des terres rares et/ou du zirconium.
PCT/EP2008/006307 2008-07-07 2008-07-31 Implant d'ostéosynthèse destiné à être implanté dans le corps d'un être humain ou d'un animal WO2010003443A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE202008018000U DE202008018000U1 (de) 2008-07-07 2008-07-31 Osterosynthetisches Implantat zur Implantation in den menschlichen oder tierischen Körper

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008031547.8 2008-07-07
DE102008031547 2008-07-07

Publications (2)

Publication Number Publication Date
WO2010003443A2 true WO2010003443A2 (fr) 2010-01-14
WO2010003443A3 WO2010003443A3 (fr) 2010-10-14

Family

ID=40466937

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2008/006307 WO2010003443A2 (fr) 2008-07-07 2008-07-31 Implant d'ostéosynthèse destiné à être implanté dans le corps d'un être humain ou d'un animal
PCT/EP2008/006306 WO2010003442A2 (fr) 2008-07-07 2008-07-31 Endoprothèse destinée à être implantée dans le corps d'un être humain ou d'un animal

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/006306 WO2010003442A2 (fr) 2008-07-07 2008-07-31 Endoprothèse destinée à être implantée dans le corps d'un être humain ou d'un animal

Country Status (2)

Country Link
DE (2) DE202008018000U1 (fr)
WO (2) WO2010003443A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011115884A1 (de) * 2011-10-14 2013-04-18 Geb-Vet Ug Milchdrüseneinlage zur Behandlung vonMastitiden
DE102015107056B4 (de) 2015-05-06 2021-04-01 Syntellix Ag Arthrodesen-Implantat

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10128100A1 (de) * 2001-06-11 2002-12-19 Hannover Med Hochschule Medizinisches Implantat für den menschlichen und tierischen Körper
WO2003055537A2 (fr) * 2001-12-24 2003-07-10 Universität Hannover Implants medicaux, protheses, parties de protheses, instruments medicaux, appareils et accessoires medicaux constitues de matiere de magnesium modifiee par halogenures
WO2007035791A2 (fr) * 2005-09-19 2007-03-29 Cook Incorporated Greffon avec structure de maintien bioabsorbable
WO2007125532A2 (fr) * 2006-04-28 2007-11-08 Biomagnesium Systems Ltd. Alliages de magnésium biodégradables et utilisations de ceux-ci

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4137383C2 (de) 1991-11-14 1994-01-13 S & G Implants Gmbh Endoprothese
DE19731021A1 (de) 1997-07-18 1999-01-21 Meyer Joerg In vivo abbaubares metallisches Implantat
DE10241572B4 (de) 2002-09-07 2007-02-08 Werner Scholz Stütz- oder Halteteil zum Einbringen in ein Knochenteil
EP1835042A1 (fr) 2006-03-18 2007-09-19 Acrostak Corp. Alliage à base de magnesium avec une combinaison améliorée de la résistance mécanique et de la résistance à la corrosion

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10128100A1 (de) * 2001-06-11 2002-12-19 Hannover Med Hochschule Medizinisches Implantat für den menschlichen und tierischen Körper
WO2003055537A2 (fr) * 2001-12-24 2003-07-10 Universität Hannover Implants medicaux, protheses, parties de protheses, instruments medicaux, appareils et accessoires medicaux constitues de matiere de magnesium modifiee par halogenures
WO2007035791A2 (fr) * 2005-09-19 2007-03-29 Cook Incorporated Greffon avec structure de maintien bioabsorbable
WO2007125532A2 (fr) * 2006-04-28 2007-11-08 Biomagnesium Systems Ltd. Alliages de magnésium biodégradables et utilisations de ceux-ci

Also Published As

Publication number Publication date
WO2010003442A2 (fr) 2010-01-14
DE202008018002U1 (de) 2011-04-21
WO2010003442A3 (fr) 2010-10-07
WO2010003443A3 (fr) 2010-10-14
DE202008018000U1 (de) 2011-04-21

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