WO2010001119A3 - Use of glucosinolates from cruciferous plants in modifying extracellular signalling proteins - Google Patents

Use of glucosinolates from cruciferous plants in modifying extracellular signalling proteins Download PDF

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Publication number
WO2010001119A3
WO2010001119A3 PCT/GB2009/001648 GB2009001648W WO2010001119A3 WO 2010001119 A3 WO2010001119 A3 WO 2010001119A3 GB 2009001648 W GB2009001648 W GB 2009001648W WO 2010001119 A3 WO2010001119 A3 WO 2010001119A3
Authority
WO
WIPO (PCT)
Prior art keywords
phytochemicals
signalling proteins
extracellular signalling
modifying
glucosinolates
Prior art date
Application number
PCT/GB2009/001648
Other languages
French (fr)
Other versions
WO2010001119A2 (en
Inventor
Richard Mithen
Maria Traka
Original Assignee
Plant Bioscience Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plant Bioscience Limited filed Critical Plant Bioscience Limited
Publication of WO2010001119A2 publication Critical patent/WO2010001119A2/en
Publication of WO2010001119A3 publication Critical patent/WO2010001119A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The invention relates to methods and compositions for the post-translational modification of extracellular signalling proteins by dietary phytochemicals and related compounds, including,, but not limited to one or more of the following phytochemicals: sulforaphane, erucin, sativin, iberin, β-phenylethylisothiocyanate (PE-ITC)5 3- methylthiopropyl isothiocyanate. The invention further relates to assays for determining suitable phytochemicals for modifying extracellular signalling proteins. In addition the present invention relates to use of combinations of the phytochemicals isothiocyanataes and procyanidins, as well as methods of modifying plants to increase the levels of 3-methylthiopropyl glucosinolate therein.
PCT/GB2009/001648 2008-07-01 2009-07-01 Use WO2010001119A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0812012.3 2008-07-01
GBGB0812012.3A GB0812012D0 (en) 2008-07-01 2008-07-01 Use

Publications (2)

Publication Number Publication Date
WO2010001119A2 WO2010001119A2 (en) 2010-01-07
WO2010001119A3 true WO2010001119A3 (en) 2011-01-06

Family

ID=39707821

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/001648 WO2010001119A2 (en) 2008-07-01 2009-07-01 Use

Country Status (2)

Country Link
GB (1) GB0812012D0 (en)
WO (1) WO2010001119A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0811992D0 (en) * 2008-07-01 2008-08-06 Mithen Richard Treatment
GB0922505D0 (en) 2009-12-23 2010-02-10 Plant Bioscience Ltd Use
NZ615098A (en) 2012-09-13 2015-05-29 Seminis Vegetable Seeds Inc Genetic markers for myb28
NZ615094A (en) 2012-09-13 2015-05-29 Seminis Vegetable Seeds Inc Brassica oleracea plants with improved nutritional value
WO2014049044A1 (en) * 2012-09-26 2014-04-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of ulcerative colitis
ES2818179T3 (en) 2015-06-26 2021-04-09 Plant Bioscience Ltd Glucoraphanin for use in the treatment and / or prevention of diabetes mellitus
FR3127863A1 (en) * 2021-08-09 2023-04-14 Elicir USE OF A PLANT PART EXTRACT TO BOOST PLANT DEFENSES AGAINST VIRUSES, COMPOSITION AND ASSOCIATED METHODS
FR3127864B1 (en) * 2021-10-11 2024-01-19 Elicir USE OF SATIVINE TO STIMULATE PLANT DEFENSES AGAINST PATHOGENS, COMPOSITION AND ASSOCIATED METHODS
WO2023062025A1 (en) * 2021-10-11 2023-04-20 Elicir Use of an extract of part of a plant for stimulating plant defenses against viruses, and associated composition and methods

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089065A1 (en) * 2003-04-14 2004-10-21 Bejo Zaden B.V. Brassica plants with high levels of anticarcinogenic glucosinolates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089065A1 (en) * 2003-04-14 2004-10-21 Bejo Zaden B.V. Brassica plants with high levels of anticarcinogenic glucosinolates

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "BroccoMax", 12 January 2006 (2006-01-12), XP002609437, Retrieved from the Internet <URL:http://www.willner.com/desc/50465.pdf> [retrieved on 20101111] *
CONAWAY C CLIFFORD ET AL: "Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli", NUTRITION AND CANCER, LONDON, GB, vol. 38, no. 2, 1 January 2000 (2000-01-01), pages 168 - 178, XP009121867, ISSN: 0163-5581, DOI: DOI:10.1207/S15327914NC382_5 *
DATABASE GNPD [Online] Mintel; 1 August 2005 (2005-08-01), "Decaf Black Tea with SGS", XP002609438, Database accession no. 10228399 *
HÄNSEL, STICHER: "Pharmakognosie Phytopharmazie", 1 January 2010, SPRINGER MEDIZIN VERLAG, Heidelberg, ISBN: 978-3-642-00962-4, article "Teeblätter", pages: 1176 - 1178, XP002609439 *
KIM JUNG-HWAN ET AL: "Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin", CARCINOGENESIS (OXFORD), vol. 27, no. 3, March 2006 (2006-03-01), pages 475 - 482, XP009141103, ISSN: 0143-3334 *
THORNALLEY PAUL J: "Isothiocyanates: Mechanism of cancer chemopreventive action", ANTI-CANCER DRUGS, LIPPINCOTT WILLIAMS & WILKINS, US; NL LNKD- DOI:10.1097/00001813-200204000-00001, vol. 13, no. 4, 1 April 2002 (2002-04-01), pages 331 - 338, XP009122474, ISSN: 0959-4973 *
TRAKA MARIA ET AL: "Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, SAN FRANCISCO, CA, US LNKD- DOI:10.1371/JOURNAL, vol. 3, no. 7 (e2568), 2 July 2008 (2008-07-02), pages 1 - 14, XP009121849, ISSN: 1932-6203 *

Also Published As

Publication number Publication date
GB0812012D0 (en) 2008-08-06
WO2010001119A2 (en) 2010-01-07

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