WO2009157739A3 - 전도성 그라핀을 이용한 바이오센서 및 그 제조방법 - Google Patents

전도성 그라핀을 이용한 바이오센서 및 그 제조방법 Download PDF

Info

Publication number
WO2009157739A3
WO2009157739A3 PCT/KR2009/003482 KR2009003482W WO2009157739A3 WO 2009157739 A3 WO2009157739 A3 WO 2009157739A3 KR 2009003482 W KR2009003482 W KR 2009003482W WO 2009157739 A3 WO2009157739 A3 WO 2009157739A3
Authority
WO
WIPO (PCT)
Prior art keywords
conductive
biosensor
preparation
present
graphenes
Prior art date
Application number
PCT/KR2009/003482
Other languages
English (en)
French (fr)
Other versions
WO2009157739A2 (ko
Inventor
이상엽
박태정
홍원희
정희태
박호석
최봉길
Original Assignee
한국과학기술원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국과학기술원 filed Critical 한국과학기술원
Publication of WO2009157739A2 publication Critical patent/WO2009157739A2/ko
Publication of WO2009157739A3 publication Critical patent/WO2009157739A3/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B32/00—Carbon; Compounds thereof
    • C01B32/15—Nano-sized carbon materials
    • C01B32/182—Graphene
    • C01B32/194—After-treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/308—Electrodes, e.g. test electrodes; Half-cells at least partially made of carbon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333—Ion-selective electrodes or membranes
    • G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Cell Biology (AREA)
  • Composite Materials (AREA)
  • Biophysics (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Carbon And Carbon Compounds (AREA)

Abstract

본 발명은 전도성 그라핀(graphene)을 이용한 바이오센서 및 그 제조방법에 관한 것으로, 보다 상세하게는 화학작용기를 이용하여 제조된 전도성 그라핀 또는 상기 전도성 그라핀을 기질상에 높은 표면 밀도를 가지도록 반복 적층시킨 전도성 그라핀 필름에 표적 바이오물질과 선택적으로 결합하는 바이오 리셉터가 부착되어 있는 전도성 그라핀을 이용하는 바이오센서 및 그 제조방법에 관한 것이다. 본 발명에 따른 전도성 그라핀 바이오센서는 표면적이 넓고, 전기전도도 성질이 우수하여 DNA와 같은 생물분자의 고정화 양을 높일 수 있고, 생물분자에 대한 검출 민감도를 증대시키는 것이 가능하다. 또한, 다양한 표적 바이오분자들을 직접 검출하거나, 전기화학적 신호를 측정함으로써, 바이오 물질과 바이오 리셉터의 반응을 정확히 한번에 대량으로 검출할 수 있을 뿐만 아니라, 소량의 원료(source)만으로도 정확한 측정치를 얻을 수 있는 검출법을 도입하는 것이 가능하다.
PCT/KR2009/003482 2008-06-26 2009-06-26 전도성 그라핀을 이용한 바이오센서 및 그 제조방법 WO2009157739A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0060813 2008-06-26
KR1020080060813A KR101440542B1 (ko) 2008-06-26 2008-06-26 전도성 그라핀을 이용한 바이오센서 및 그 제조방법

Publications (2)

Publication Number Publication Date
WO2009157739A2 WO2009157739A2 (ko) 2009-12-30
WO2009157739A3 true WO2009157739A3 (ko) 2010-04-01

Family

ID=41445122

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/003482 WO2009157739A2 (ko) 2008-06-26 2009-06-26 전도성 그라핀을 이용한 바이오센서 및 그 제조방법

Country Status (2)

Country Link
KR (1) KR101440542B1 (ko)
WO (1) WO2009157739A2 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9304130B2 (en) 2010-12-16 2016-04-05 International Business Machines Corporation Trenched sample assembly for detection of analytes with electromagnetic read-write heads

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101006488B1 (ko) * 2009-03-13 2011-01-07 한국표준과학연구원 그래핀의 전기적 특성 제어 방법
GB2471672B (en) * 2009-07-07 2015-12-09 Swansea Innovations Ltd Graphene biosensor
JP5904734B2 (ja) 2010-09-16 2016-04-20 三星電子株式会社Ｓａｍｓｕｎｇ Ｅｌｅｃｔｒｏｎｉｃｓ Ｃｏ．，Ｌｔｄ． グラフェン発光素子及びその製造方法
US8395774B2 (en) 2010-09-21 2013-03-12 International Business Machines Corporation Graphene optical sensor
KR20120063164A (ko) 2010-12-07 2012-06-15 삼성전자주식회사 그래핀 구조물 및 그 제조방법
WO2012087065A2 (ko) * 2010-12-24 2012-06-28 성균관대학교산학협력단 그래핀을 이용한 압력 및 위치 동시감지 터치센서
US9040311B2 (en) 2011-05-03 2015-05-26 International Business Machines Corporation Calibration assembly for aide in detection of analytes with electromagnetic read-write heads
US8855957B2 (en) 2011-05-03 2014-10-07 International Business Machines Corporation Method for calibrating read sensors of electromagnetic read-write heads
KR101890703B1 (ko) 2012-03-23 2018-08-22 삼성전자주식회사 무선 주파수를 이용한 센싱 장치 및 이의 제조 방법
KR101462903B1 (ko) * 2012-07-12 2014-11-20 성균관대학교산학협력단 그래핀의 패턴 형성 방법
US9435800B2 (en) 2012-09-14 2016-09-06 International Business Machines Corporation Sample assembly with an electromagnetic field to accelerate the bonding of target antigens and nanoparticles
KR101878747B1 (ko) 2012-11-05 2018-07-16 삼성전자주식회사 나노갭 소자 및 이로부터의 신호를 처리하는 방법
KR101594524B1 (ko) * 2014-10-30 2016-02-16 전남대학교산학협력단 고안정성 콜로이드형태의 그래핀용액, 상기 그래핀용액으로 형성된 막을 포함하는 전도성필름, 에너지저장장치, 센서 및 상기 그래핀용액을 유효성분으로 포함하는 부식방지용 코팅조성물
KR101837579B1 (ko) 2016-09-08 2018-03-13 연세대학교 산학협력단 향상된 형광 특성을 갖는 금을 포함하는 그래핀 양자점 나노 복합체 및 그 제조방법, 이를 이용하는 금속 이온 검출기
KR101929901B1 (ko) 2016-09-09 2018-12-18 한국과학기술연구원 센싱 원점 회복이 가능한 생분자 감지 장치 및 방법
KR101875595B1 (ko) * 2016-11-11 2018-07-09 한국과학기술연구원 효소 필름 및 그를 포함하는 고감도 및 선택성을 갖는 바이오 센서
KR102006651B1 (ko) * 2017-06-12 2019-08-02 한국표준과학연구원 나노역학적 바이오센서 및 이의 제조방법
CN113008967A (zh) * 2020-06-29 2021-06-22 山东大学 一种无标记石墨烯场效应晶体管柔性生物传感器及其制备方法和应用
CN115092918B (zh) * 2022-07-28 2023-03-24 广东工业大学 一种高比表面积微纳多孔石墨烯薄膜的加工方法及装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040115232A1 (en) * 2002-06-06 2004-06-17 Franck Giroud Cosmetic composition for volumizing keratin fibers and cosmetic use of nanotubes for volumizing keratin fibers
US6869581B2 (en) * 2001-11-27 2005-03-22 Fuji Xerox Co., Ltd. Hollow graphene sheet structure, electrode structure, process for the production thereof, and device thus produced
US20050265914A1 (en) * 2002-03-18 2005-12-01 Honeywell International, Inc. Carbon nanotube-based glucose sensor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6869581B2 (en) * 2001-11-27 2005-03-22 Fuji Xerox Co., Ltd. Hollow graphene sheet structure, electrode structure, process for the production thereof, and device thus produced
US20050265914A1 (en) * 2002-03-18 2005-12-01 Honeywell International, Inc. Carbon nanotube-based glucose sensor
US20040115232A1 (en) * 2002-06-06 2004-06-17 Franck Giroud Cosmetic composition for volumizing keratin fibers and cosmetic use of nanotubes for volumizing keratin fibers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHONGFAN LIU ET AL., LANGMUIR, vol. 16, 18 April 2000 (2000-04-18), pages 3569 - 4144 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9304130B2 (en) 2010-12-16 2016-04-05 International Business Machines Corporation Trenched sample assembly for detection of analytes with electromagnetic read-write heads

Also Published As

Publication number Publication date
KR101440542B1 (ko) 2014-09-16
KR20100001062A (ko) 2010-01-06
WO2009157739A2 (ko) 2009-12-30

Similar Documents

Publication Publication Date Title
WO2009157739A3 (ko) 전도성 그라핀을 이용한 바이오센서 및 그 제조방법
Hassani et al. Novel label-free electrochemical aptasensor for determination of Diazinon using gold nanoparticles-modified screen-printed gold electrode
Ferrari et al. Recent advances in portable heavy metal electrochemical sensing platforms
Uniyal et al. Technological advancement in electrochemical biosensor based detection of Organophosphate pesticide chlorpyrifos in the environment: A review of status and prospects
Cinti et al. Graphene-based screen-printed electrochemical (bio) sensors and their applications: Efforts and criticisms
kholafazad Kordasht et al. Biosensing of microcystins in water samples; recent advances
Privett et al. Electrochemical sensors
Tang et al. Internal calibration potentiometric aptasensors for simultaneous detection of Hg2+, Cd2+, and As3+ based on a screen-printed carbon electrodes array
Hughes et al. Development of a novel reagentless, screen-printed amperometric biosensor based on glutamate dehydrogenase and NAD+, integrated with multi-walled carbon nanotubes for the determination of glutamate in food and clinical applications
Pichetsurnthorn et al. Nanoporous impedemetric biosensor for detection of trace atrazine from water samples
Malhotra et al. Nanomaterials based biosensors for cancer biomarker detection
Xu et al. Analysis of interactions between proteins and small-molecule drugs by a biosensor based on a graphene field-effect transistor
WO2012145270A3 (en) Luminescent polymer cyclic amplification
Tam et al. Facile preparation of a DNA sensor for rapid herpes virus detection
Karuppiah et al. Ultrasensitive and low-cost paper-based graphene oxide nanobiosensor for monitoring water-borne bacterial contamination
Beduk et al. A portable molecularly imprinted sensor for on-site and wireless environmental bisphenol A monitoring
Song et al. Laser-cut polymer tape templates for scalable filtration fabrication of user-designed and carbon-nanomaterial-based electrochemical sensors
Ozkan-Ariksoysal Current perspectives in graphene oxide-based electrochemical biosensors for cancer diagnostics
Mandli et al. Impedimetric genosensor for miRNA-34a detection in cell lysates using polypyrrole
Ren et al. The construction and application of a new PPY-MSPQC for l-asparaginase activity assay
Cancelliere et al. An inverse-designed electrochemical platform for analytical applications
SG159463A1 (en) Method for detecting biomolecules and use thereof
Feier et al. Development of a novel flow sensor for copper trace analysis by electrochemical reduction of 4-methoxybenzene diazonium salt
Kongkaew et al. Studying the preparation, electrochemical performance testing, comparison and application of a cost-effective flexible graphene working electrode
Zeng et al. Interfacially super-assembled tyramine-modified mesoporous silica-alumina oxide heterochannels for label-free tyrosinase detection

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09770411

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09770411

Country of ref document: EP

Kind code of ref document: A2