WO2009149053A3 - Naproxcinod process and solid dispersion - Google Patents

Naproxcinod process and solid dispersion Download PDF

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Publication number
WO2009149053A3
WO2009149053A3 PCT/US2009/045920 US2009045920W WO2009149053A3 WO 2009149053 A3 WO2009149053 A3 WO 2009149053A3 US 2009045920 W US2009045920 W US 2009045920W WO 2009149053 A3 WO2009149053 A3 WO 2009149053A3
Authority
WO
WIPO (PCT)
Prior art keywords
naproxcinod
solid dispersion
processes
preparation
dispersions
Prior art date
Application number
PCT/US2009/045920
Other languages
French (fr)
Other versions
WO2009149053A2 (en
Inventor
Naveen Kumar Kolla
Srinivas Gangula
Anitha Naredla
Sudhakar Reddy Baddam
Sumeet Vishwasrao Patil
Ashok Sigala
Raghunath Babu Venkata Chittapathina
Rama Krishna Venkata Medisetti
Kushal Surajmal Manudhane
Santosh Reddy Narra
Vijaya Kumar Kotagiri
Original Assignee
Dr. Reddy's Laboratories Ltd.
Dr. Reddy's Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Laboratories Ltd., Dr. Reddy's Laboratories, Inc. filed Critical Dr. Reddy's Laboratories Ltd.
Publication of WO2009149053A2 publication Critical patent/WO2009149053A2/en
Publication of WO2009149053A3 publication Critical patent/WO2009149053A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Processes for the preparation of naproxcinod and its purification, solid dispersions of naproxcinod with a pharmaceutically acceptable carrier, and processes for making dispersions. Also provided is crystalline 2-(S)-(4-chlorobutyl)-2-(6-methoxy-2-naphthyl)-propanoate and methods for its preparation.
PCT/US2009/045920 2008-06-02 2009-06-02 Naproxcinod process and solid dispersion WO2009149053A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
IN1344/CHE/2008 2008-06-02
IN1344CH2008 2008-06-02
US8123608P 2008-07-16 2008-07-16
US61/081,236 2008-07-16
IN2217CH2008 2008-09-12
IN2217/CHE/2008 2008-09-12
US12095108P 2008-12-09 2008-12-09
US61/120,951 2008-12-09

Publications (2)

Publication Number Publication Date
WO2009149053A2 WO2009149053A2 (en) 2009-12-10
WO2009149053A3 true WO2009149053A3 (en) 2010-05-14

Family

ID=41398813

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/045920 WO2009149053A2 (en) 2008-06-02 2009-06-02 Naproxcinod process and solid dispersion

Country Status (1)

Country Link
WO (1) WO2009149053A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102442908A (en) * 2010-10-14 2012-05-09 天津药物研究院 Intermediate and method for preparing naproxcinod
TWI417276B (en) 2011-03-01 2013-12-01 Everlight Chem Ind Corp Anhydride derivatives of 2-(s)-(6-methoxy-2-naphtyl)-propanoic acid, preparation method and use thereof
WO2012152438A1 (en) * 2011-05-11 2012-11-15 Nicox S.A. Process for the preparation of nitrate acid ester of organic compounds
CN103599547B (en) * 2012-12-06 2016-09-07 河北医科大学 NO-donating NSAID beta-schardinger dextrin or derivatives thereof inclusion compound and its production and use
CN103058861B (en) * 2013-01-08 2015-03-18 安徽赛诺医药化工有限公司 New synthetic method of naproxcinod intermediate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700947A (en) * 1993-10-06 1997-12-23 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
US6700011B1 (en) * 1999-08-04 2004-03-02 Nicox S.A. Process for the preparation of naproxene nitroxyalkylesters
US20050129774A1 (en) * 2002-03-22 2005-06-16 Astrazeneca Ab Non-donating nsaids adsorbed into carrier particles
KR20060076136A (en) * 2002-06-25 2006-07-04 니콕스 에스. 에이. Oral pharmaceutical forms of liquid drugs having improved bioavailability
US7199258B2 (en) * 2002-08-29 2007-04-03 Nicox S.A. Process for preparing nitrooxyderivatives of naproxen

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700947A (en) * 1993-10-06 1997-12-23 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
US6700011B1 (en) * 1999-08-04 2004-03-02 Nicox S.A. Process for the preparation of naproxene nitroxyalkylesters
US20050129774A1 (en) * 2002-03-22 2005-06-16 Astrazeneca Ab Non-donating nsaids adsorbed into carrier particles
KR20060076136A (en) * 2002-06-25 2006-07-04 니콕스 에스. 에이. Oral pharmaceutical forms of liquid drugs having improved bioavailability
US7199258B2 (en) * 2002-08-29 2007-04-03 Nicox S.A. Process for preparing nitrooxyderivatives of naproxen

Also Published As

Publication number Publication date
WO2009149053A2 (en) 2009-12-10

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