WO2009146124A1

WO2009146124A1 - Natural antigingivitis and antiplaque mouth rinses, and methods of use thereof

Info

Publication number: WO2009146124A1
Application number: PCT/US2009/039426
Authority: WO
Inventors: Connie J. Gregson
Original assignee: The Natural Dentist
Priority date: 2008-04-04
Filing date: 2009-04-03
Publication date: 2009-12-03

Abstract

One aspect of the invention relates to an anti-gingivitis or anti-plaque composition, comprising water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and at least one natural betaine. Another aspect of the invention relates to an oral hygiene composition, comprising water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate, grapefruit seed extract; at least one natural flavor; at least one natural colorant; and at least one natural betaine. Another aspect of the invention relates to treating and/or preventing one or more of dental caries, oral microbial infections, gingivitis and plaque formation, comprising applying to the oral cavity of a mammal a composition of the invention.

Description

Natural Antigingivitis and Antiplaque Mouth Rinses, and Methods of Use Thereof

RELATED APPLICATIONS

This application claims the benefit of priority to United States Provisional Patent

Application serial number 61/042,429, filed April 4, 2008; the entirety of which is hereby incorporated by reference.

BACKGROUND OF THE INVENTION

According to the National Institutes of Health, about 80 percent of U.S. adults currently have some form of gum or periodontal disease. It begins when the bacteria in plaque causes the gums to become inflamed and bleed easily. Periodontal disease often reflects serious health risks. The disease ranges from simple gum inflammation (gingivitis) to serious disease that results in tooth loss and damage to the bone structures that support the teeth (periodontitis). Periodonitis may be associated with heart disease, stroke, and systemic infections. There is also evidence that premature births happen more often to women who have gum disease before or during their pregnancies.

There has been a significant increase in the last decade in the use of alternative medicine, including use of natural or herbal oral health care products. An estimated one- third to one -half of all Americans practice some form of alternative medicine, including use of natural or herbal oral hygiene products. The use of these products has increased significantly in the last decade. American consumers who gravitate toward using natural or herbal products often view these products as being safer than conventional products. Consumers are also interested in natural oral hygiene products because they can be produced from renewable resources. Oral hygiene products labeled as "natural" typically do not include synthetic ingredients, such as synthetic sweeteners, artificial colors, preservatives, additives, and synthetic flavors and fragrances. The term "herbal" on the label implies that most of a product's active ingredients are plant-based. It is highly desirable to this consumer group that oral hygiene compositions consist essentially of herbal agents, and do not have undesirable materials, such as those that are primarily stimulants, depressants, or the like, as active ingredients. Moreover, certain herbal ingredients have been shown to have antimicrobial properties. Certain herbs (e.g., some of those used in traditional Chinese medicine for colds, virus, infection, cancer, mumps, hepatovirus, and chronic fatigue) have been shown clinically to be effective as antimicrobials. Further, herbal ingredients have been used to treat bone and joint inflammation, especially in eastern countries, and they are increasingly used for this purpose in western countries. For example, a number of compositions composed of natural ingredients and said to be useful in reducing inflammation have been disclosed. U.S. Pat. No. 5,494,668 (Patwardhan, incorporated herein by reference) discloses a method of treating degenerative musculoskeletal diseases such as rheumatoid arthritis and osteoarthritis in an animal, typically a human, involving administering (typically enterally) extracts of the ashwagandha, sallai Guggul, turmeric, and ginger plants, in a predetermined proportion relative to each other with or without other biologically active inorganic ingredients. U.S. Pat. No. 5,683,698 (Chavali et al., incorporated herein by reference) discloses an orally administered herbal formulation for reducing or alleviating symptoms associated with rheumatoid arthritis, osteoarthritis, and reactive arthritis and for reducing the production of pro-inflammatory cytokines, wherein the formulation contains herbal extracts taken from Alpinia, Smilax, Tinospora, Tribulus, Withania, and Zingiber plants. U.S. Pat. No. 5,916,565 (Rose et al., incorporated herein by reference) discloses an orally administered composition for prophylaxis and therapy of joint and connective tissue disorders in vertebrates, wherein the composition contains metabolic precursors, herbal phytochemicals, and palatability agents. Specific herbal phytochemicals disclosed include cayenne, ginger, turmeric, yucca, Devil's claw, nettle leaf, Black Cohosh, alfalfa and celery seeds. U.S. Pat. No. 5,854,291 (Laughlin et al., incorporated herein by reference) discloses a topically- applied pain reliever composition for treating such discomforts as arthritis pain, the composition being composed of capsaicin and, optionally, a plant extract selected from the group consisting of nettle extract, yarrow extract, coltsfoot extract, birch extract, rosemary extract, horsetail extract, ginger extract, chamomile extract, comfrey extract, lavender extract, and bergamot extract. U.S. Pat. No. 5,910,307 (Kwak, et al., incorporated herein by reference) discloses a combined medicinal plant composition for alleviating acute/chronic inflammation, composed of Clematis Radix, Trichosanthes root, and Prunella Herba (which contains oleanolic acid ursolic acid) in a certain ratio. SUMMARY OF THE INVENTION

One aspect of the present invention relates to oral hygiene compositions comprising a betaine derived from renewable natural resources as a natural flavor emulsifϊer and surfactant. One aspect of the present invention relates to an oral hygiene composition, comprising water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate, grapefruit seed extract; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

Another aspect of the present invention relates to an oral hygiene composition, consisting essentially of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

One aspect of the present invention relates to an oral hygiene composition, consisting of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

In addition, the present invention relates to an oral hygiene composition comprising water, vegetable glycerin, witch hazel, aloe vera gel, sodium bicarbonate, xylitol, at least one natural flavor; and at least one natural betaine. The present invention also relates to an oral hygiene composition consisting of water, vegetable glycerin, witch hazel, aloe vera gel, sodium bicarbonate, xylitol, at least one natural flavor; and at least one natural betaine.

One aspect of the present invention relates to an oral hygiene composition consisting essentially of water, vegetable glycerin, witch hazel, aloe vera gel, sodium bicarbonate, xylitol, at least one natural flavor; and at least one natural betaine.

Another aspect of the present invention relates to an oral hygiene composition comprising water, vegetable glycerin, witch hazel, aloe vera gel, at least one natural flavor, at least one natural betaine; and ascorbic acid.

Yet another aspect of the present invention relates to an oral hygiene composition consisting of water, vegetable glycerin, witch hazel, aloe vera gel, at least one natural flavor, at least one natural betaine; and ascorbic acid. One aspect of the present invention relates to an oral hygiene composition consisting essentially of water, vegetable glycerin, witch hazel, aloe vera gel, sodium bicarbonate, xylitol, at least one natural flavor; and at least one natural betaine.

The present invention also relates to an anti-gingivitis or anti-plaque composition comprising water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal;

Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

Another aspect of the invention relates to an anti-gingivitis or anti-plaque composition consisting essentially of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

Yet another aspect of the invention relates to an anti-gingivitis or anti-plaque composition consisting of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

The present invention also relates to the use of a composition of the invention to treat or prevent dental caries, oral microbial infections, oral inflammation, dentine hypersensitivity, or any of combination thereof.

The present invention also relates to a kit, comprising a composition of the invention; and instructions for use thereof.

DETAILED DESCRIPTION OF THE INVENTION

Anti-gingivitis/ Anti-plaque Agent

Many commercially available oral rinses claim antigingivitis/antiplaque efficacy based on cetylpyridinium chloride or an essential oil blend consisting of menthol, methyl salicylate, thymol and eucalyptol. Cetylpyridinium chloride, while recognized as effective, may cause side effects including teeth-staining and taste impairment. The essential oil blend used in many mouth rinses is also effective, however, it requires upwards of 27% alcohol to solubilize the essential oils. Consumers who want to avoid alcohol and cetylpyridium chloride have limited choices. The Antigingivitis/Antiplaque monograph is currently a Tentative Final Monograph at the FDA. Aloe vera gel at a minimum of 20% is recognized as a Category III active for antigingivitis/antiplaque function. Currently, there are no oral rinses on the market which apply aloe vera gel at 20% for an antigingivitis/antiplaque use. Possible reasons for not using aloe vera include limitations of using aloe vera gel IX which may include off-taste and odor. One aspect of the present invention relates to the use of an aloe vera gel powder which has been freeze-dried and concentrated to about 200X. As a result of the concentration process, the aloe vera gel is cleaner in taste and economically feasible to use in the final formulation. We have been able to quantify the aloe vera gel in both fresh and aged samples of the product, thereby establishing that the aloe vera concentration is 20% in the finished product over the recommended shelf- life of the oral rinse product.

Surfactants

Surfactants make it possible for oil-based ingredients to dissolve in a water-based solution. A surfactant molecule is characterized by its two distinct functional properties: a polar, hydrophilic property and a nonpolar, hydrophobic property. This dual receptivity allows oils to be dissolved into solution with water. Surfactants are added to the oral rinse compositions to serve as natural flavor emulsifϊers to allow the natural oil flavoring agents to mix with the aqueous ingredients of the composition. While some manufacturers of natural oral rinse compositions use surfactants derived from petroleum products (e.g., Poloxomer 335 and 407), the compositions of the present invention use betaines derived from renewable natural resources. Examples of natural betaines for use in the invention include, but are not limited to cocamidopropyl betaine, olivamidopropyl betaine or soyamidopropyl betaine.

Demulcents A demulcent is an agent, such as an oil, that forms a soothing film when administered onto the surface of a mucous membrane. A demulcent is meant to relieve the irritation of an inflamed mucous membrane. Demulcent herbs often have a high content of mucilage, and they have often been used to soothe and protect irritated or inflamed internal tissues of the body. The FDA recognizes glycerin as an oral demulcent that soothes sore gums and mouth irritations. Natural Flavors

The term "natural flavor" or "natural flavoring" means the essential oil, oleoresin, essence or extractive, protein hydro lysate, distillate, or any product of roasting, heating or enzymolysis, which contains the flavoring constituents derived from a spice, fruit or fruit juice, vegetable or vegetable juice, edible yeast, herb, bark, bud, root, leaf or similar plant material, meat, seafood, poultry, eggs, dairy products, or fermentation products thereof, whose significant function in food is flavoring rather than nutritional. Natural flavors include the natural essence or extractives obtained from the plants listed in 21 CFR §§ 182.10, 182.20, 182.40, and 182.50; the direct food substances listed in 21 CFR § 184; and the substances listed in 21 CFR § 172.510, "Natural flavoring substances and natural substances used in conjunction with flavors"; all of the preceding sections of the Code of Federal Regulations are hereby incorporated in their entirety by reference.

According to 21 CFR § 172.510, natural flavoring substances and natural adjuvants may be safely used in food in accordance with two conditions. First, they are used in the minimum quantity required to produce their intended physical or technical effect and in accordance with all the principles of good manufacturing practice. Second, in the appropriate forms (plant parts, fluid and solid extracts, concretes, absolutes, oils, gums, balsams, resins, oleoresins, waxes, and distillates) they consist of material from an approved source, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, previously sanctioned for such use, or regulated in any section of 21 CFR. Listed below are examples of approved sources.

Aloe

Althea root and flowers Amyris (West Indian sandalwood)

Angola weed

Arnica flowers

Artemisia (wormwood)

Artichoke leaves Benzoin resin

Blackberry bark

Boldus (boldo) leaves

Boronia flowers

Bryonia root Buchu leaves

Buckbean leaves

Cajeput Calumba root

Camphor tree

Cascara sagrada

Cassie flowers Castor oil

Catechu, black

Cedar, white (aborvitae), leaves and twigs

Centuary

Cherry pits Cherry-laurel leaves

Chestnut leaves

Chirata

Cinchona, red, bark

Cinchona, yellow, bark Copaiba

Cork, oak

Costmary

Costus root

Cubeb Currant, black, buds and leaves

Damiana leaves

Davana

Dill, Indian

Dittany (fraxinella) roots Dittany of Crete

Dragon's blood (dracorubin)

Elder tree leaves

Elecampane rhizome and roots

Elemi Erigeron

Eucalyptus globulus leaves

Fir ("pine")

Fir, balsam, needles and twigs

Galanga, greater Galbanum

Gambir

Genet flowers

Gentian rhizome and roots

Gentian, stemless Germander, chamaedrys

Germander, golden

Guaiac

Guarana

Haw, black, bark Hemlock needles and twigs

Hyacinth flowers

Iceland moss

Imperatoria

Iva Labdanum Lemon-verbena

Linaloe wood

Linden leaves

Lovage Lungmoss (lungwort)

Maidenhair fern

Maple, mountain

Mimosa (black wattle) flowers

Mullein flowers Myrrh

Myrtle leaves

Oak, English, wood

Oak, white, chips

Oak moss Olibanum

Opopanax (bisabolmyrrh)

Orris root

Pansy

Passion flower Patchouly

Peach leaves

Pennyroyal, American

Pennyroyal, European

Pine, dwarf, needles and twigs Pine, Scotch, needles and twigs

Pine, white, bark

Pine, white oil

Poplar buds

Quassia Quebracho bark

Quillaia (soapbark)

Red saunders (red sandalwood)

Rhatany root

Rhubarb, garden root Rhubarb root

Roselle

Rosin (colophony)

St. Johnswort leaves, flowers, and caulis

Sandalwood, white (yellow, or East Indian) Sandarac

Sarsaparilla

Sassafras leaves

Senna, Alexandria

Serpentaria (Virginia snakeroot) Simaruba bark

Snakeroot, Canadian (wild ginger)

Spruce needles and twigs

Storax (styrax)

Tagetes (marigold) Tansy Thistle, blessed (holy thistle) ToIu

Turpentine

Valerian rhizome and roots Veronica

Vervain, European Vetiver Violet, Swiss

Walnut husks (hulls), leaves, and green nuts Woodruff, sweet

Yarrow Yerba santa Yucca, Joshua-tree Yucca, Mohave

Natural Colorants

In addition to beta-carotene, the FDA has permitted many color additives for foods (21 CFR § § 73.1-73.615) derived from natural sources, such as annatto, carrot oil, oleo resins turmeric and paprika, corn gluten (endosperm) oil, saffron and the like. All of the preceding sections of the Code of Federal Regulations are hereby incorporated in their entirety by reference. In certain embodiments, a natural food colorant is or is derived from a fruit or vegetable extract, carmine, carotene, annatto, turmeric, curcumin, raspberry, cherry, blueberry or other natural food colors known in the art.

Selected Aloe Vera Gel-Containing Compositions of the Invention Naturally occurring antimicrobial agents — Echinacea, Goldenseal, and grapefruit seed extract — can be used to inhibit the growth of germs in the mouth. These antimicrobial agents are gentle and do not destroy healthy gum tissue. Other chemical-based mouth rinses use alcohol to effectively kill germs, but may dry the mouth or cause sloughing of gum tissue. Vegetable glycerin and aloe vera gel provide a soothing and anti-inflammatory effect on the gums. Vegetable glycerin acts as a protective barrier whereas aloe vera gel serves as a moisturizer. Xylitol also provides a soothing effect on the gums, as well as flavor and antiplaque properties. Echinacea can be used to treat inflammation of the mouth and pharynx. Echinacea is analgesic and has anti-inflammatory and anti-microbial properties. Echinacea angustifolia and Echinacea purpurea may be used. Goldenseal, such as Hydrastis canadensis is found in plant extracts and has antiseptic and antimicrobial properties. Calendula {Calendula officinalis flower) is used to treat inflammation of the oral and pharyngeal mucosa. Grapefruit seed extract has anti-fungal and antimicrobial properties. Citrus paradisi seed may be used. Witch hazel can be used in the mouth rinse to provide an astringent feel to the mouth. Sodium bicarbonate (baking soda) can also be added as a flavor agent and breath freshener.

In certain embodiments, the present invention relates to an oral hygiene composition, comprising water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate, grapefruit seed extract; at least one natural flavor; at least one natural colorant; and at least one natural betaine. In certain embodiments, the present invention relates to an oral hygiene composition, consisting essentially of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

In certain embodiments, the present invention relates to an oral hygiene composition, consisting of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

In certain embodiments, the present invention relates to an oral hygiene composition, comprising water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate, grapefruit seed extract; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one preservative.

In certain embodiments, the present invention relates to an oral hygiene composition, consisting essentially of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one preservative.

In certain embodiments, the present invention relates to an oral hygiene composition, consisting of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one preservative.

In certain embodiments, the present invention relates to an oral hygiene composition, comprising water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate, grapefruit seed extract; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine.

In certain embodiments, the present invention relates to an oral hygiene composition, consisting essentially of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine.

In certain embodiments, the present invention relates to an oral hygiene composition, consisting of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal;

Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine.

In certain embodiments, the present invention relates to an oral hygiene composition, comprising water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal;

Calendula; citric acid; potassium citrate, grapefruit seed extract; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one preservative. In certain embodiments, the present invention relates to an oral hygiene composition, consisting essentially of water; vegetable glycerin; aloe vera gel; Echinacea;

Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one preservative. In certain embodiments, the present invention relates to an oral hygiene composition, consisting of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal;

Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one preservative.

In certain embodiments, the present invention relates to an oral hygiene composition comprising water, vegetable glycerin, witch hazel, aloe vera gel, sodium bicarbonate, xylitol, at least one natural flavor; and at least one natural betaine.

In certain embodiments, the present invention relates to an oral hygiene composition consisting of water, vegetable glycerin, witch hazel, aloe vera gel, sodium bicarbonate, xylitol, at least one natural flavor; and at least one natural betaine. In certain embodiments, the present invention relates to an oral hygiene composition consisting essentially of water, vegetable glycerin, witch hazel, aloe vera gel, sodium bicarbonate, xylitol, at least one natural flavor; and at least one natural betaine. In certain embodiments, the present invention relates to an oral hygiene composition comprising water, vegetable glycerin, witch hazel, aloe vera gel, at least one natural flavor, at least one natural betaine; and ascorbic acid.

In certain embodiments, the present invention relates to an oral hygiene composition consisting of water, vegetable glycerin, witch hazel, aloe vera gel, at least one natural flavor, at least one natural betaine; and ascorbic acid.

In certain embodiments, the present invention relates to an oral hygiene composition consisting essentially of water, vegetable glycerin, witch hazel, aloe vera gel, at least one natural flavor, at least one natural betaine; and ascorbic acid. Selected Water Content Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 60-80% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 65-75% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 67-72% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 69% by weight of said composition.

Selected Vegetable Glycerin Percentages In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein vegetable glycerin is about 15-30% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein vegetable glycerin is about 17-25% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein vegetable glycerin is about 19-24% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein vegetable glycerin is about 24% by weight of said composition.

Selected Echinacea Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Echinacea is about 0.5-5% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Echinacea is about 0.5-3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Echinacea is about 0.5-2% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Echinacea is about 1.5 % by weight of said composition.

Selected Aloe Vera Gel Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein aloe vera gel is about 1-5% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein aloe vera gel is about 2-4% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein aloe vera gel is about 3 % by weight of said composition.

Selected Goldenseal Percentages In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Goldenseal is about 0.1-3 % by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Goldenseal is about 0.5-2 % by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Goldenseal is about 0.5-1 % by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Goldenseal is about 0.7 % by weight of said composition.

Selected Calendula Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Calendula is about 0.1 -3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Calendula is about 0.5-2% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Calendula is about 0.5-1 % by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Calendula is about 0.7 % by weight of said composition.

Selected Citric Acid Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein citric acid is about 0.1 -3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein citric acid is about 0.1-2% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein citric acid is about 0.5-1.5% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein citric acid is about 0.8% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein citric acid is about 0.6% by weight of said composition.

Selected Natural Flavor Percentages In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is about 0.01-2% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is about 0.01-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is about 0.01-0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is about 0.01-0.1% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is peppermint.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is peppermint in about 0.1-2% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is peppermint in about 0.1-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is peppermint in about 0.2-0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is peppermint in about 0.3% by weight of said composition. Selected Peppermint Twist Flavor Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Peppermint Twist Flavor (487929).

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.1 -2% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.1-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.2-0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.3% by weight of said composition. Selected Natural Flavor (Orange) Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is orange.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is orange in about 0.01-0.20% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is orange in about 0.01-0.10% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is orange in about 0.03-0.07% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is orange in about 0.05% by weight of said composition. Selected Orange Zest Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Orange Zest Flavor (487927).

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.01- 0.20% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.01- 0.10% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.03- 0.07% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.05% by weight of said composition. Selected Grapefruit Seed Extract Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein grapefruit seed extract is about 0.01-0.20% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein grapefruit seed extract is about 0.01-1.0% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein grapefruit seed extract is about 0.1-0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein grapefruit seed extract is about 0.2% by weight of said composition.

Selected Natural Colorant Percentages In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is about 0.01-3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is about 0.01-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is about 0.01-0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red in about 0.1-3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red in about 0.01-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red in about 0.05-0.5% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red in about 0.05-0.2% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red in about 0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red in about 0.09% by weight of said composition. Selected Natural Red Color Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B).

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B) in about 0.1-3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B) in about 0.01-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B) in about 0.05- 0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B) in about 0.05- 0.2% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B) in about 0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B) in about 0.08% by weight of said composition. Selected Natural Green Color Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Green Color (6004).

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Green Color (6004) in about 0.01- 3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Green Color (6004) in about 0.01- 1% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Green Color (6004) in about 0.025% by weight of said composition.

Selected Natural Betaine Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is about 0.01-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is about 0.01-0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is about 0.05-0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is about 0.05-0.1% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is about 0.14% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is about 0.07% by weight of said composition. Selected Natural Betaines

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is olivamidopropyl betaine.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is cocamidopropyl betaine.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is soyamidopropyl betaine.

Selected Preservative Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said preservative is about 0.01 -0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said preservative is about 0.02-0.3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said preservative is about 0.05-0.1% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said preservative is selected from the group consisting of sodium benzoate and potassium sorbate.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said preservative is 0.05-0.1% by weight sodium benzoate and 0.05- 0.1 % by weight potassium sorbate .

Selected Witch Hazel Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein witch hazel is about 0.1-5% by weight of said composition.

Selected Sodium Bicarbonate Percentages In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein sodium bicarbonate is about 0.1-5% by weight of said composition.

Selected Xylitol Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein xylitol is about 0.1-3% by weight of said composition. Selected Ascorbic Acid Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein ascorbic acid is about 0.1-2% by weight of said composition.

Selected Formulations In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; said at least one natural flavor is peppermint in about 0.1-2% by weight of said composition; grapefruit seed extract is about 0.01-0.2% by weight of said composition; said colorant is red in about 0.01-3% by weight of said composition; and said natural betaine is about 0.01- 1% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; said at least one natural flavor is peppermint in about 0.1-2% by weight of said composition; grapefruit seed extract is about 0.01-0.2% by weight of said composition; said natural colorant is red in about 0.01-3% by weight of said composition; said natural betaine is about 0.01-1% by weight of said composition; and said preservative is 0.01-0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 69% by weight of said composition; vegetable glycerin is about 21% by weight of said composition; Echinacea is about 1.5% by weight of said composition; aloe vera gel is about 3% by weight of said composition; Goldenseal is about 7% by weight of said composition; Calendula is about 0.7% by weight of said composition; citric acid is about 0.7% by weight of said composition; said natural flavor is Peppermint Twist Flavor (487929) in about 0.3% by weight of said composition; grapefruit seed extract is about 0.05% by weight of said composition; said natural colorant is Natural Red Color (2889B) in about 0.5% by weight of said composition; and said olivamidopropyl betaine is about 0.14% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; said natural flavor is orange in about 0.01-2% by weight of said composition; grapefruit seed extract is about 0.01-0.2% by weight of said composition; said natural colorant is red in about 0.01-3% by weight of said composition; and said natural betaine is about 0.01-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; said at least one natural flavor is orange in about 0.01-2% by weight of said composition; grapefruit seed extract is about 0.01-0.2% by weight of said composition; said natural colorant is red in about 0.01-3% by weight of said composition; said natural betaine is about 0.01-1% by weight of said composition and said at least one natural preservative is 0.01-0.5% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 69% by weight of said composition; vegetable glycerin is about 21% by weight of said composition; Echinacea is about 1.5% by weight of said composition; aloe vera gel is about 3% by weight of said composition; Goldenseal is about 0.7% by weight of said composition; Calendula is about 0.7% by weight of said composition; citric acid is about 0.9% by weight of said composition; said natural flavor is Orange Zest (487927) in about 0.05% by weight of said composition; grapefruit seed extract is about 0.05% by weight of said composition; said natural colorant is red in about 0.09% by weight of said composition; and olivamidoproyl betaine is about 0.07% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; witch hazel is about 0.1-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; sodium bicarbonate is about 0.1-5% by weight of said composition; xylitol is about 0.1-3% by weight of said composition; natural flavor is about 0.01-2% by weight of said composition; and natural betaine is about 0.01-1% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; witch hazel is about 0.1-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; natural flavor is about 0.01-2% by weight of said composition; natural betaine is about 0.01-1% by weight of said composition; and ascorbic acid is about 0.1-2% by weight of said composition.

Compositions according to the invention may be presented for use as a conventional gargle or may be packaged in a suitable delivery device for use as a mouth spray.

Compositions according to the invention have a pH from about 3.0 to about 10.5. In certain embodiments, compositions according to the invention have a pH from about 3.0 to about 7.0. In certain embodiments, compositions according to the invention have a pH from about 3.0 to about 5.0. In certain embodiments, compositions according to the invention have a pH from about 3.0 to about 4.0. In certain embodiments, compositions according to the invention have a pH from about 3.0 to about 3.5. In certain embodiments, compositions according to the invention have a pH of about 3.2.

Selected Aloe Vera Gel Powder-Containing Compositions of the Invention

In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, comprising water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, consisting essentially of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, consisting of water; vegetable glycerin; aloe vera gel powder;

Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, comprising water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one natural preservative.

In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, consisting essentially of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one natural preservative.

In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, consisting of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one natural preservative.

In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, comprising water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine.

In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, consisting essentially of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine. In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, consisting of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine. In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, comprising water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one natural preservative. In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, consisting essentially of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one natural preservative. In certain embodiments, the present invention relates to an anti-gingivitis or anti- plaque composition, consisting of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one natural preservative. Selected Water Content Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 65-75% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 67-75% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 72% by weight of said composition. Selected Vegetable Glycerin Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein vegetable glycerin is about 15-30% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein vegetable glycerin is about 17-27% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein vegetable glycerin is about 19-25% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein vegetable glycerin is about 24% by weight of said composition. Selected Aloe Vera Gel Powder Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein aloe vera gel powder is about 0.01-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein aloe vera gel powder is about 0.05-0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein aloe vera gel powder is about 0.1 % by weight of said composition.

Selected Echinacea Percentages In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Echinacea is about 0.5-5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Echinacea is about 0.5-3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Echinacea is about 0.5-2% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Echinacea is about 1.5 % by weight of said composition. Selected Aloe Vera Gel Powder Concentrations

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein aloe vera gel powder is concentrated to about 50X-500X.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein aloe vera gel powder is concentrated to about 100X-300X.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein aloe vera gel powder is concentrated to about 150X-250X.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein aloe vera gel powder is concentrated to about 200X. Selected Goldenseal Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Goldenseal is about 0.1-3 % by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Goldenseal is about 0.5-2 % by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Goldenseal is about 0.5-1 % by weight of said composition.

Selected Calendula Percentages In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Calendula is about 0.1-3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Calendula is about 0.5-1 % by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein Calendula is about 0.7 % by weight of said composition. Selected Grapefruit Seed Extract Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein grapefruit seed extract is about 0.01-1% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein grapefruit seed extract is about 0.1-1% by weight of said composition.

Selected Citric Acid Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein citric acid is about 0.1-1.5% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein citric acid is about 0.8% by weight of said composition.

Selected Potassium Citrate Percentages In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein potassium citrate is about 0.01-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein potassium citrate is about 0.01-0.5% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein potassium citrate is about 0.05-0.15% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein potassium citrate is about 0.05% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein potassium citrate is about 0.13% by weight of said composition.

Selected Natural Flavor Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is about 0.01-2% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is about 0.01-0.1% by weight of said composition.

Selected Natural Flavor (Orange) Percentages In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is orange.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is orange in about 0.03-0.07% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is orange in about 0.05% by weight of said composition.

Selected Orange Zest Flavor (487927) Percentages In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Orange Zest Flavor (487927).

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.01- 0.2% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.01- 0.1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.05% by weight of said composition.

Selected Natural Flavor (Peppermint) Percentages In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is peppermint.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is peppermint in about 0.2-0.5% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is peppermint in about 0.3% by weight of said composition.

Selected Peppermint Twist Flavor Percentages (487929) In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Peppermint Twist Flavor (487929).

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.1-2% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.1-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is about 0.01-0.5% by weight of said composition. Selected Natural (Red) Colorant Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red in about 0.01-3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red in about 0.01-1% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red in about 0.05-0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red in about 0.05-0.2% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is red in about 0.09% by weight of said composition.

Selected Natural Red Color (2889B) Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B). In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B) in about 0.1-3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B) in about 0.01-1% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B) in about 0.05- 0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B) in about 0.05- 0.2% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Red Color (2889B) in about 0.09% by weight of said composition. Selected Natural (Green) Colorant Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is green.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is green in about 0.01-3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is green in about 0.01-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is green in about 0.01-0.5% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is green in about 0.01-0.2% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is green in about 0.025% by weight of said composition.

Selected Natural Green Color (6064) Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Green Color (6064). In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Green Color (6064) in about 0.01- 3% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Green Color (6064) in about 0.01- 1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Green Color (6064) in about 0.01- 0.5% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Green Color (6064) in about 0.01- 0.2% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural colorant is Natural Green Color (6064) in about 0.025% by weight of said composition.

Selected Natural Betaine Percentages

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is about 0.05-0.5% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is about 0.1-0.15% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said natural betaine is about 0.14% by weight of said composition. Selected Olivamidopropyl Betaine Percentages

Selected Preservatives

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein said preservative is selected from the group consisting of sodium benzoate and potassium sorbate.

Selected Formulations

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; aloe vera gel powder is about 0.01-1% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; potassium citrate is about 0.01-1% by weight of said composition; at least one natural flavor is Peppermint Twist Flavor (487929) in about 0.1 -2% by weight of said composition; grapefruit seed extract is about 0.01-0.2% by weight of said composition; said colorant is green in about 0.01-3% by weight of said composition; and said natural betaine is about 0.01-1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; aloe vera gel powder is about 0.01-1% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; potassium citrate is about 0.01-1% by weight of said composition; at least one natural flavor is Orange Zest (487927) in about 0.01-0.2% by weight of said composition; grapefruit seed extract is about 0.01-0.2% by weight of said composition; said colorant is red in about 0.01-3% by weight of said composition; and said natural betaine is about 0.01- 1% by weight of said composition.

In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 72% by weight of said composition; vegetable glycerin is about 24% by weight of said composition; aloe vera gel powder is about 0.1% by weight of said composition; Echinacea is about 1.5% by weight of said composition; Goldenseal is about 0.7% by weight of said composition; Calendula is about 0.7% by weight of said composition; citric acid is about 0.6% by weight of said composition; said natural flavor is Peppermint Twist Flavor (487929) in about 0.3% by weight of said composition; grapefruit seed extract is about 0.2% by weight of said composition; said natural colorant is Natural Green Color (6004) in about 0.025% by weight of said composition; and said olivamidopropyl betaine is about 0.14% by weight of said composition. In certain embodiments, the invention relates to any one of the aforementioned compositions, wherein water is about 72% by weight of said composition; vegetable glycerin is about 21% by weight of said composition; aloe vera gel powder is about 0.1% by weight of said composition; Echinacea is about 1.5% by weight of said composition; Goldenseal is about 0.7% by weight of said composition; Calendula is about 0.7% by weight of said composition; citric acid is about 0.8% by weight of said composition; said natural flavor is Orange Zest Flavor (487927) in about 0.05% by weight of said composition; grapefruit seed extract is about 0.2% by weight of said composition; said natural colorant is Natural Red Color (2889B) in about 0.086% by weight of said composition; and said olivamidopropyl betaine is about 0.14% by weight of said composition.

Selected Methods of the Invention

The invention provides a method of treating or preventing dental caries, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition according to the invention. The invention provides a method of treating or preventing oral microbial infections, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition according to the invention.

The invention provides a method of treating or preventing oral inflammation, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition according to the invention.

The invention also provides a method of treating dentine hypersensitivity, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition according to the invention. The invention provides a method of treating or preventing dental caries and oral microbial infections, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition according to the invention.

The invention provides a method of treating or preventing dental caries and oral inflammation, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition according to the invention.

The invention provides a method of treating or preventing oral microbial infections and oral inflammation, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition according to the invention.

The invention provides a method of treating or preventing dental caries, oral microbial infections and oral inflammation, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition according to the invention.

In certain embodiments, the invention relates to any of the aforementioned methods, wherein said mammal is a primate, bovine, ovine, caprine, equine, porcine, rodent, feline, or canine.

In certain embodiments, the invention relates to any of the aforementioned methods, wherein said mammal is a primate, equine, feline, or canine.

In certain embodiments, the invention relates to any of the aforementioned methods, wherein said mammal is a human.

Selected Kits of the Invention

This invention also provides kits for conveniently and effectively implementing the methods of the invention. Such kits comprise at least one composition of the invention; and instructions for use thereof. In certain embodiments, a kit further comprises a means for facilitating the use of said composition consistent with a method of this invention. Such kits provide a convenient and effective means for assuring that the methods are practiced in an effective manner. The compliance means of such kits includes any means which facilitates practicing a method of this invention. Such compliance means include instructions, packaging, and dispensing means, and combinations thereof. Kit components may be packaged for either manual or partially or wholly automated practice of the foregoing methods.

EXAMPLES

The invention now being generally described, it will be more readily understood by reference to the following examples, which are included merely for purposes of illustration of certain aspects and embodiments of the present invention, and are not intended to limit the invention. Example 1

Natural Dentist Inc. has discovered an effective natural oral rinse containing herbs having anti-inflammatory and antimicrobial properties and does not contain emulsifiers or surfactants derived from petroleum products. The natural oral rinse contains emulsifiers derived from olives and is equally as effective in dispersing natural flavor oils as petroleum-based products. Many adults who undergo oral surgery, or periodontal procedures would benefit from the rinse. Below is the formulation for orange zest natural oral rinse and peppermint twist natural oral rinse and the composition of unflavored concentrate 8339G.

f Citric acid is added to the formulation in the Unflavored Concentrate 8339G and individually. * Ingredients added as 30 % by weight Unflavored Concentrate 8339G, the composition of which is listed below.

Example 2

Manufacturing

The natural mouth rinse can be formulated by following the steps listed below. The batch procedure consists of the steps as listed below. The ingredients of the Peppermint Twist and Orange Zest formulations are listed above in Example 1.

Table 1 : Instructions for manufacturing natural mouth rinse formulation Peppermint Twist.

Table 2: Instructions for manufacturing natural mouth rinse formulation Orange Zest.

Example 3 An in vitro antimicrobial study to demonstrate the effectiveness of the new mouth rinse against a series of oral pathogen was performed by Dr. Anne Haffajee. To permit comparisons of efficacy among test agents, the data are usually expressed as minimum inhibitory concentrations (MICs) of the test agent(s) against a range of microbial species of interest. The MIC is usually performed using the broth or agar dilution techniques; i.e., serial dilutions of the agent(s) are incorporated in agar (or broth) media and the lowest concentration of the agent that completely inhibits growth of a given strain is recorded as the MIC.

While the methods are routine, occasionally one encounters "pitfalls" for some agents or combinations of agents. These include: a) insolubility of the agent(s) in the test medium, b) unforeseen interaction of a medium constituent with one or more of the test agents (e.g., precipitation) or c) volatility of an important ingredient of the test mixture (such as alcohol).

Another important consideration is the range of expected minimum inhibitory concentrations. For antibiotics this would typically be in the microgram or sub microgram per mL range, for other antibacterials the range might be much higher leading to difficulty in dissolving the test product. Nonetheless, if possible to perform on a given formulation, the MIC is the most reliable and easily interpreted method of comparison of formulations in use today. Methods

An agar dilution method was employed to assess the inhibitory effect of the test agents. All MICs were performed in duplicate. Strains employed

The strains employed are summarized in the accompanying Table. The numbers next to each species indicate the strain designation and an asterisk symbol indicates that the component was added after autoclaving. The basal medium is composed of the following constituents:

Final concentration in

Constituent medium (g/L)

Trypticase soy agar 40.0

Hemin 0.005

N acetyl muramic acid* 0.010

Menadione* 0.0005

Sheep blood* 50.0 mL

Table 2: The composition of basil medium

The basal medium was sterilized in individual tubes (1 per agar plate) by autoclaving at 121 C for 15 min and then placed in a 50 ⁰C water bath. The volume in each tube was adjusted so that the final volume of about 20 mL was obtained when the filter- sterilized test agents were added.

Preparation of test media The test agents supplied by Natural Dentist were filter-sterilized by passage through a 0.22 μm Nalgene filter. Dilutions of each agent were prepared to provide final concentrations of 1, 2, 4, 8, 16, 32, 64, 128, 256 and 512 μg/mL.

The media was aseptically dispensed in a total of 20 mL in 100 mm plastic petri plates, allowed to set and used the next day. Preparation of inoculum

The organisms were grown on blood agar plates under an atmosphere of 80% N₂, 10% H₂ and 10% CO₂ at 35 ⁰C for 3 days. Growth was aseptically harvested from the plate and suspended in 1 mL of sterile Mycoplasma broth. Each suspension was adjusted to an optical density approximating a MacFarland #0.5 standard. Inoculation of test media

100 μL of each strain suspension were placed in the wells of a sterile microtiter plate. A MIC 2000 inoculator (Dynatech) was used to transfer 1.5 μL of inoculum to the surface of the prepared plates. Control plates, without the test agents, were inoculated at the beginning and end of the series of inoculations. These plates were used to indicate that the inoculum is present and viable throughout the series.

Reading of plates and interpretation of data

The plates were incubated under an atmosphere of 80% N₂, 10% H₂ and 10% CO₂ at 35 ⁰C and evaluated daily. The MIC was interpreted as the lowest concentration of the agent that completely inhibits the growth of the test species.

Results

The following table compares the lowest concentration of the agent that completely inhibits the growth of a given strain for Listerine and the Peppermint Twist natural mouth rinse. The test was performed using the method presented in Example 2. The results indicate that the new natural mouth rinse requires lower concentrations of the agents to inhibit the growth of a number of given species, such as A. israelii, F. nuc. Nucleatum, S. salivarius, and is much more potent compared to the Listerine. Overall, this study shows that the new natural mouth rinse is highly effective at killing the microorganisms that cause bad breath.

Example 4 Additional Natural Oral Rinse Formulations (Prophetic Example)

Additional natural oral rinse formulations with anti-inflammatory and antimicrobial properties will be investigated. Examples of additional formulations are listed below, along with a range of estimated weight percentages for the individual ingredients. The weight percent of all the ingredients should total 100 percent of the composition. Additional ingredients may be added to the proposed formulations such as zinc chloride for tartar control, fluoride to prevent tooth decay, preservatives, antioxidants, and stabilizers.

Example 5

We have discovered an effective natural oral rinse containing herbs having antigingivitis/antiplaque properties which does not contain emulsifϊers or surfactants derived from petroleum products. Rather, the natural oral rinse contains emulsifϊers derived from olives and is equally as effective in dispersing natural flavor oils as petroleum-based products. Below is the formulation for peppermint twist antigingivitis/antiplaque oral rinse and orange zest antigingivitis/antiplaque oral rinse and the composition of unflavored concentrate 8339G.

^Citric acid is added to the formulation in the Unflavored Concentrate 8339G and individually.

Ingredients added as 30 % by weight Unflavored Concentrate 8339G, the composition of which is listed below.

Incorporation by Reference

All of the U.S. patents and U.S. patent application publications cited herein are hereby incorporated by reference.

Equivalents

Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims.

Claims

We claim:

1. An anti-gingivitis or anti-plaque composition comprising water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

2. An anti-gingivitis or anti-plaque composition consisting essentially of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

3. An anti-gingivitis or anti-plaque composition consisting of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

4. An anti-gingivitis or anti-plaque composition comprising water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one natural preservative.

5. An anti-gingivitis or anti-plaque composition consisting essentially of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one natural preservative.

6. An anti-gingivitis or anti-plaque composition consisting of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one natural preservative.

7. An anti-gingivitis or anti-plaque composition comprising water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine.

8. An anti-gingivitis or anti-plaque composition consisting essentially of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine.

9. An anti-gingivitis or anti-plaque composition consisting of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine.

10. An anti-gingivitis or anti-plaque composition comprising water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one natural preservative.

11. An anti-gingivitis or anti-plaque composition consisting essentially of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one natural preservative.

12. An anti-gingivitis or anti-plaque composition consisting of water; vegetable glycerin; aloe vera gel powder; Echinacea; Goldenseal; Calendula; grapefruit seed extract; citric acid; potassium citrate; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one natural preservative.

13. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein water is about 60-80% by weight of said composition.

14. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein water is about 65-75% by weight of said composition.

15. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein water is about 67-75% by weight of said composition.

16. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein water is about 72% by weight of said composition.

17. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein vegetable glycerin is about 15-30% by weight of said composition.

18. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein vegetable glycerin is about 17-27% by weight of said composition.

19. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein vegetable glycerin is about 19-25% by weight of said composition.

20. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein vegetable glycerin is about 24% by weight of said composition.

21. The anti-gingivitis or anti-plaque or anti-plaque composition of any one of claims 1 ■ 12, wherein aloe vera gel powder is about 0.01-1% by weight of said composition.

22. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein aloe vera gel powder is about 0.05-0.5% by weight of said composition.

23. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein aloe vera gel powder is about 0.1 % by weight of said composition.

24. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Echinacea is about 0.5-5% by weight of said composition.

25. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Echinacea is about 0.5-3% by weight of said composition.

26. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Echinacea is about 0.5-2% by weight of said composition.

27. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Echinacea is about 1.5 % by weight of said composition.

28. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein aloe vera gel powder is concentrated to about 50X-500X.

29. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein aloe vera gel powder is concentrated to about 100X-300X.

30. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein aloe vera gel powder is concentrated to about 200X.

31. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Goldenseal is about 0.1-3 % by weight of said composition.

32. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Goldenseal is about 0.5-2 % by weight of said composition.

33. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Goldenseal is about 0.5-1 % by weight of said composition.

34. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Goldenseal is about 0.7 % by weight of said composition.

35. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Calendula is about 0.1-3% by weight of said composition.

36. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Calendula is about 0.5-2% by weight of said composition.

37. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Calendula is about 0.5-1 % by weight of said composition.

38. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein Calendula is about 0.7 % by weight of said composition.

39. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein grapefruit seed extract is about 0.01-1% by weight of said composition.

40. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein grapefruit seed extract is about 0.1-1% by weight of said composition.

41. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein grapefruit seed extract is about 0.1-0.5% by weight of said composition.

42. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein grapefruit seed extract is about 0.2% by weight of said composition.

43. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein citric acid is about 0.1-3% by weight of said composition.

44. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein citric acid is about 0.1-2% by weight of said composition.

45. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein citric acid is about 0.1-1.5% by weight of said composition.

46. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein citric acid is about 0.8% by weight of said composition.

47. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein citric acid is about 0.6% by weight of said composition.

48. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein potassium citrate is about 0.01-1% by weight of said composition.

49. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein potassium citrate is about 0.01-0.5% by weight of said composition.

50 The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein potassium citrate is about 0.05-0.15% by weight of said composition.

51. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein potassium citrate is about 0.05% by weight of said composition.

52. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein potassium citrate is about 0.13% by weight of said composition.

53. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural flavor is Orange Zest Flavor (487927).

54. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.01-0.2% by weight of said composition.

55. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.01-0.1% by weight of said composition.

56. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.03-0.07% by weight of said composition.

57. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.05% by weight of said composition.

58. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural flavor is Peppermint Twist Flavor (487929).

59. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.1-2% by weight of said composition.

60. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.1 - 1 % by weight of said composition.

61. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.2-0.5% by weight of said composition.

62. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.3% by weight of said composition.

63. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is red.

64. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is red in about 0.01-3% by weight of said composition.

65. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is red in about 0.01-1% by weight of said composition.

66. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is red in about 0.05-0.5% by weight of said composition.

67. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is red in about 0.05-0.2% by weight of said composition.

68. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is red in about 0.09% by weight of said composition.

69. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Red Color (2889B).

70. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Red Color (2889B) in about 0.1-3% by weight of said composition.

71. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Red Color (2889B) in about 0.01-1% by weight of said composition.

72. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Red Color (2889B) in about 0.05-0.5% by weight of said composition.

73. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Red Color (2889B) in about 0.05-0.2% by weight of said composition.

74. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Red Color (2889B) in about 0.09% by weight of said composition.

75. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is green.

76. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is green in about 0.01-3% by weight of said composition.

77. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is green in about 0.01-1% by weight of said composition.

78. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is green in about 0.01 -0.5% by weight of said composition.

79. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is green in about 0.01-0.2% by weight of said composition.

80. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is green in about 0.025% by weight of said composition.

81. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Green Color (6064).

82. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Green Color (6064) in about 0.01-3% by weight of said composition.

83. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Green Color (6064) in about 0.01-1% by weight of said composition.

84. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Green Color (6064) in about 0.01-0.5% by weight of said composition.

85. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Green Color (6064) in about 0.01-0.2% by weight of said composition.

86. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural colorant is Natural Green Color (6064) in about 0.025% by weight of said composition.

87. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural betaine is about 0.01-1% by weight of said composition.

88. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural betaine is about 0.01-0.5% by weight of said composition.

89. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural betaine is about 0.05-0.5% by weight of said composition.

90. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural betaine is about 0.1-0.15% by weight of said composition.

91. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural betaine is about 0.14% by weight of said composition.

92. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural betaine is olivamidopropyl betaine.

93. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural betaine is cocamidopropyl betaine.

94. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein said natural betaine is soyamidopropyl betaine.

95. The anti-gingivitis or anti-plaque composition of any one of claims 4-6 and 10-12, wherein said preservative is selected from the group consisting of sodium benzoate and potassium sorbate.

96. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; aloe vera gel powder is about 0.01-1% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; potassium citrate is about 0.01-1% by weight of said composition; at least one natural flavor is Peppermint Twist Flavor (487929) in about 0.1-2% by weight of said composition; grapefruit seed extract is about 0.01-0.2% by weight of said composition; said colorant is green in about 0.01-3% by weight of said composition; and said natural betaine is about 0.01-1% by weight of said composition.

97. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; aloe vera gel powder is about 0.01-1% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; potassium citrate is about 0.01-1% by weight of said composition; at least one natural flavor is Orange Zest (487927) in about 0.01-0.2% by weight of said composition; grapefruit seed extract is about 0.01-0.2% by weight of said composition; said colorant is red in about 0.01-3% by weight of said composition; and said natural betaine is about 0.01-1% by weight of said composition.

98. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein water is about 72% by weight of said composition; vegetable glycerin is about 24% by weight of said composition; aloe vera gel powder is about 0.1% by weight of said composition; Echinacea is about 1.5% by weight of said composition; Goldenseal is about 0.7% by weight of said composition; Calendula is about 0.7% by weight of said composition; citric acid is about 0.6% by weight of said composition; said natural flavor is Peppermint Twist Flavor (487929) in about 0.3% by weight of said composition; grapefruit seed extract is about 0.2% by weight of said composition; said natural colorant is Natural Green Color (6004) in about 0.025% by weight of said composition; and said olivamidopropyl betaine is about 0.14% by weight of said composition.

99. The anti-gingivitis or anti-plaque composition of any one of claims 1-12, wherein water is about 72% by weight of said composition; vegetable glycerin is about 21% by weight of said composition; aloe vera gel powder is about 0.1% by weight of said composition; Echinacea is about 1.5% by weight of said composition; Goldenseal is about 0.7% by weight of said composition; Calendula is about 0.7% by weight of said composition; citric acid is about 0.8% by weight of said composition; said natural flavor is Orange Zest Flavor (487927) in about 0.05% by weight of said composition; grapefruit seed extract is about 0.2% by weight of said composition; said natural colorant is Natural Red Color (2889B) in about 0.086% by weight of said composition; and said olivamidopropyl betaine is about 0.14% by weight of said composition.

100. An oral hygiene composition comprising water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate, grapefruit seed extract; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

101. An oral hygiene composition, consisting essentially of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

102. An oral hygiene composition, consisting of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; and at least one natural betaine.

103. An oral hygiene composition, comprising water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate, grapefruit seed extract; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one preservative.

104. An oral hygiene composition, consisting essentially of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one preservative.

105. An oral hygiene composition, consisting of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; at least one natural betaine; and at least one preservative.

106. An oral hygiene composition, comprising water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate, grapefruit seed extract; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine.

107. An oral hygiene composition, consisting essentially of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine.

108. An oral hygiene composition, consisting of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; and olivamidopropyl betaine.

109. An oral hygiene composition, comprising water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate, grapefruit seed extract; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one preservative.

110. An oral hygiene composition, consisting essentially of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one preservative.

111. An oral hygiene composition, consisting of water; vegetable glycerin; aloe vera gel; Echinacea; Goldenseal; Calendula; citric acid; potassium citrate; grapefruit seed extract; at least one natural flavor; at least one natural colorant; olivamidopropyl betaine; and at least one preservative.

112. An oral hygiene composition comprising water, vegetable glycerin, witch hazel, aloe vera gel, sodium bicarbonate, xylitol, at least one natural flavor; and at least one natural betaine.

113. An oral hygiene composition consisting of water, vegetable glycerin, witch hazel, aloe vera gel, sodium bicarbonate, xylitol, at least one natural flavor; and at least one natural betaine.

114. An oral hygiene composition consisting essentially of water, vegetable glycerin, witch hazel, aloe vera gel, sodium bicarbonate, xylitol, at least one natural flavor; and at least one natural betaine.

115. An oral hygiene composition comprising water, vegetable glycerin, witch hazel, aloe vera gel, at least one natural flavor, at least one natural betaine; and ascorbic acid.

116. An oral hygiene composition consisting of water, vegetable glycerin, witch hazel, aloe vera gel, at least one natural flavor, at least one natural betaine; and ascorbic acid.

117. An oral hygiene composition consisting essentially of water, vegetable glycerin, witch hazel, aloe vera gel, at least one natural flavor, at least one natural betaine; and ascorbic acid.

118. The oral hygiene composition of any one of claims 100- 117, wherein water is about 60-80% by weight of said composition.

119. The oral hygiene composition of any one of claims 100-117, wherein water is about 65-75% by weight of said composition.

120. The oral hygiene composition of any one of claims 100-117, wherein water is about 67-72% by weight of said composition.

121. The oral hygiene composition of any one of claims 100- 117, wherein water is about 69% by weight of said composition.

122. The oral hygiene composition of any one of claims 100-117, wherein vegetable glycerin is about 15-30% by weight of said composition.

123. The oral hygiene composition of any one of claims 100- 117, wherein vegetable glycerin is about 17-25% by weight of said composition.

124. The oral hygiene composition of any one of claims 100-117, wherein vegetable glycerin is about 19-25% by weight of said composition.

125. The oral hygiene composition of any one of claims 100- 117, wherein vegetable glycerin is about 24% by weight of said composition.

126. The oral hygiene composition of any one of claims 100-111, wherein Echinacea is about 0.5-5% by weight of said composition.

127. The oral hygiene composition of any one of claims 100-111, wherein Echinacea is about 0.5-3% by weight of said composition.

128. The oral hygiene composition of any one of claims 100- 111, wherein Echinacea is about 0.5-2% by weight of said composition.

129. The oral hygiene composition of any one of claims 100-111, wherein Echinacea is about 1.5 % by weight of said composition.

130. The oral hygiene composition of any one of claims 100- 117, wherein aloe vera gel is about 1-5% by weight of said composition.

131. The oral hygiene composition of any one of claims 100- 117, wherein aloe vera gel is about 2-4% by weight of said composition.

132. The oral hygiene composition of any one of claims 100-117, wherein aloe vera gel is about 3 % by weight of said composition.

133. The oral hygiene composition of any one of claims 100-111, wherein Goldenseal is about 0.1-3 % by weight of said composition.

134. The oral hygiene composition of any one of claims 100-111, wherein Goldenseal is about 0.5-2 % by weight of said composition.

135. The oral hygiene composition of any one of claims 100-111, wherein Goldenseal is about 0.5-1 % by weight of said composition.

136. The oral hygiene composition of any one of claims 100-111, wherein Goldenseal is about 0.7 % by weight of said composition.

137. The oral hygiene composition of any one of claims 100-111, wherein Calendula is about 0.1-3% by weight of said composition.

138. The oral hygiene composition of any one of claims 100-111, wherein Calendula is about 0.5-2% by weight of said composition.

139. The oral hygiene composition of any one of claims 100-111, wherein Calendula is about 0.5-1 % by weight of said composition.

140. The oral hygiene composition of any one of claims 100-111, wherein Calendula is about 0.7 % by weight of said composition.

141. The oral hygiene composition of any one of claims 100-111, wherein citric acid is about 0.1-3% by weight of said composition.

142. The oral hygiene composition of any one of claims 100-111, wherein citric acid is about 0.1-2% by weight of said composition.

143. The oral hygiene composition of any one of claims 100-111, wherein citric acid is about 0.5-1.5% by weight of said composition.

144. The oral hygiene composition of any one of claims 100-111, wherein citric acid is about 0.8% by weight of said composition.

145. The oral hygiene composition of any one of claims 100-111, wherein citric acid is about 0.6% by weight of said composition.

146. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is about 0.01-2% by weight of said composition.

147. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is about 0.01-1% by weight of said composition.

148. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is about 0.01-0.5% by weight of said composition.

149. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is about 0.01 -0.1 % by weight of said composition.

150. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is peppermint.

151. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is peppermint in about 0.1-2% by weight of said composition.

152. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is peppermint in about 0.1-1% by weight of said composition.

153. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is peppermint in about 0.2-0.5% by weight of said composition.

154. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is peppermint in about 0.3% by weight of said composition.

155. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is Peppermint Twist Flavor (487929).

156. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.1-2% by weight of said composition.

157. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.1-1% by weight of said composition.

158. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.2-0.5% by weight of said composition.

159. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is Peppermint Twist Flavor (487929) in about 0.3% by weight of said composition.

160. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is orange.

161. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is orange in about 0.01-0.20% by weight of said composition.

162. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is orange in about 0.01-0.10% by weight of said composition.

163. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is orange in about 0.03-0.07% by weight of said composition.

164. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is orange in about 0.05% by weight of said composition.

165. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is Orange Zest Flavor (487927).

166. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.01-0.20% by weight of said composition.

167. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.01-0.10% by weight of said composition.

168. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.03-0.07% by weight of said composition.

169. The oral hygiene composition of any one of claims 100-117, wherein said natural flavor is Orange Zest Flavor (487927) in about 0.05% by weight of said composition.

170. The oral hygiene composition of any one of claims 100-111, wherein grapefruit seed extract is about 0.01-2.0% by weight of said composition.

171. The oral hygiene composition of any one of claims 100-111, wherein grapefruit seed extract is about 0.01-1.0% by weight of said composition.

172. The oral hygiene composition of any one of claims 100-111, wherein grapefruit seed extract is about 0.05-0.5% by weight of said composition.

173. The oral hygiene composition of any one of claims 100-111, wherein grapefruit seed extract is about 0.2% by weight of said composition.

174. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is about 0.01-3% by weight of said composition.

175. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is about 0.01-1% by weight of said composition.

176. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is about 0.01-0.5% by weight of said composition.

177. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is red.

178. The oral hygiene composition of any one of claims 100- 111, wherein said natural colorant is red in about 0.1-3% by weight of said composition.

179. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is red in about 0.01-1% by weight of said composition.

180. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is red in about 0.05-0.5% by weight of said composition.

181. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is red in about 0.05-0.2% by weight of said composition.

182. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is red in about 0.5% by weight of said composition.

183. The oral hygiene composition of any one of claims 100- 111, wherein said natural colorant is red in about 0.09% by weight of said composition.

184. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is Natural Red Color (2889B).

185. The oral hygiene composition of any one of claims 100- 111, wherein said natural colorant is Natural Red Color (2889B) in about 0.1-3% by weight of said composition.

186. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is Natural Red Color (2889B) in about 0.01-1% by weight of said composition.

187. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is Natural Red Color (2889B) in about 0.05-0.5% by weight of said composition.

188. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is Natural Red Color (2889B) in about 0.05-0.2% by weight of said composition.

189. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is Natural Red Color (2889B) in about 0.5% by weight of said composition.

190. The oral hygiene composition of any one of claims 100-111, wherein said natural colorant is Natural Red Color (2889B) in about 0.08% by weight of said composition.

191. The oral hygiene composition of any one of claims 100-117, wherein said natural betaine is about 0.01 - 1 % by weight of said composition.

192. The oral hygiene composition of any one of claims 100-117, wherein said natural betaine is about 0.01-0.5% by weight of said composition.

193. The oral hygiene composition of any one of claims 100-117, wherein said natural betaine is about 0.05-0.5% by weight of said composition.

194. The oral hygiene composition of any one of claims 100-117, wherein said natural betaine is about 0.05-0.1% by weight of said composition.

195. The oral hygiene composition of any one of claims 100-117, wherein said natural betaine is about 0.14% by weight of said composition.

196. The oral hygiene composition of any one of claims 100-117, wherein said natural betaine is about 0.07% by weight of said composition.

197. The oral hygiene composition of any one of claims 100-117, wherein said natural betaine is about 0.01-1% by weight of said composition.

198. The oral hygiene composition of any one of claims 100-117, wherein said natural betaine is olivamidopropyl betaine.

199. The oral hygiene composition of any one of claims 100-117, wherein said natural betaine is cocamidopropyl betaine.

200. The oral hygiene composition of any one of claims 100-117, wherein said natural betaine is soyamidopropyl betaine.

201. The oral hygiene composition of any one of claims 100-111, wherein said preservative is about 0.01-0.5% by weight of said composition.

202. The oral hygiene composition of any one of claims 100-111, wherein said preservative is about 0.02-0.3% by weight of said composition.

203. The oral hygiene composition of any one of claims 100-111, wherein said preservative is about 0.05-0.1% by weight of said composition.

204. The oral hygiene composition of any one of claims 100-111, wherein said preservative is selected from the group consisting of sodium benzoate and potassium sorbate.

205. The oral hygiene composition of any one of claims 100-111, wherein said preservative is 0.05-0.1% by weight sodium benzoate and 0.05-0.1% by weight potassium sorbate.

206. The oral hygiene composition of any one of claims 100-111, wherein said preservative is selected from the group consisting of sodium benzoate and potassium sorbate.

207. The oral hygiene composition of any one of claims 112-117, wherein witch hazel is about 0.1-5% by weight of said composition.

208. The oral hygiene composition of any one of claims 112-117, wherein sodium bicarbonate is about 0.1-5% by weight of said composition.

209. The oral hygiene composition of any one of claims 112-117, wherein xylitol is about 0.1-3% by weight of said composition.

210. The oral hygiene composition of any one of claims 112-117, wherein ascorbic acid is about 0.1-2% by weight of said composition.

211. The oral hygiene composition of any one of claims 100-111, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; said at least one natural flavor is peppermint in about 0.1-2% by weight of said composition; grapefruit seed extract is about 0.01-2.0% by weight of said composition; said colorant is red in about 0.01-3% by weight of said composition; and said natural betaine is about 0.01-1% by weight of said composition.

212. The oral hygiene composition of any one of claims 100-111, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; said at least one natural flavor is peppermint in about 0.1 -2% by weight of said composition; grapefruit seed extract is about 0.01 -2.0% by weight of said composition; said natural colorant is red in about 0.01-3% by weight of said composition; said natural betaine is about 0.01-1% by weight of said composition; and said preservative is 0.01-0.5% by weight of said composition.

213. The oral hygiene composition of any one of claims 100-111, wherein water is about 69% by weight of said composition; vegetable glycerin is about 24% by weight of said composition; Echinacea is about 1.5% by weight of said composition; aloe vera gel is about 3% by weight of said composition; Goldenseal is about 0.7% by weight of said composition; Calendula is about 0.7% by weight of said composition; citric acid is about 0.6% by weight of said composition; said natural flavor is Peppermint Twist Flavor (487929) in about 0.3% by weight of said composition; grapefruit seed extract is about

0.2% by weight of said composition; said natural colorant is Natural Red Color (2889B) in about 0.5% by weight of said composition; and said olivamidopropyl betaine is about 0.14% by weight of said composition.

214. The oral hygiene composition of any one of claims 100-111, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; said natural flavor is orange in about 0.01-2% by weight of said composition; grapefruit seed extract is about 0.01-2.0% by weight of said composition; said natural colorant is red in about 0.01-3% by weight of said composition; and said natural betaine is about 0.01-1% by weight of said composition.

215. The oral hygiene composition of any one of claims 100-111, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; Echinacea is about 0.5-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; Goldenseal is about 0.1-3% by weight of said composition; Calendula is about 0.1-3% by weight of said composition; citric acid is about 0.1-3% by weight of said composition; said at least one natural flavor is orange in about 0.01-2% by weight of said composition; grapefruit seed extract is about 0.01-2.0% by weight of said composition; said natural colorant is red in about 0.01-3% by weight of said composition; said natural betaine is about 0.01-1% by weight of said composition and said at least one natural preservative is 0.01-0.5% by weight of said composition.

216. The oral hygiene composition of any one of claims 100-111, wherein water is about 69% by weight of said composition; vegetable glycerin is about 24% by weight of said composition; Echinacea is about 1.5% by weight of said composition; aloe vera gel is about 3% by weight of said composition; Goldenseal is about 0.7% by weight of said composition; Calendula is about 0.7% by weight of said composition; citric acid is about 0.8% by weight of said composition; said natural flavor is Orange Zest (487927) in about 0.05% by weight of said composition; grapefruit seed extract is about 0.2% by weight of said composition; said natural colorant is red in about 0.09% by weight of said composition; and olivamidoproyl betaine is about 0.14% by weight of said composition.

217. The oral hygiene composition of any one of claims 112-117, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; witch hazel is about 0.1-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; sodium bicarbonate is about 0.1-5% by weight of said composition; xylitol is about 0.1-3% by weight of said composition; natural flavor is about 0.01-2% by weight of said composition; and natural betaine is about 0.01- 1 % by weight of said composition.

218. The oral hygiene composition of any one of claims 100- 117, wherein water is about 60-80% by weight of said composition; vegetable glycerin is about 15-30% by weight of said composition; witch hazel is about 0.1-5% by weight of said composition; aloe vera gel is about 1-5% by weight of said composition; natural flavor is about 0.01-2% by weight of said composition; natural betaine is about 0.01-1% by weight of said composition; and ascorbic acid is about 0.1-2% by weight of said composition.

219. The oral hygiene composition of any one of claims 100-117, wherein the pH ranges from about 3.0 to about 10.5.

220. The oral hygiene composition of any one of claims 100- 117, wherein the pH ranges from about 3.0 to about 7.0.

221. The oral hygiene composition of any one of claims 100- 117, wherein the pH ranges from about 3.0 to about 5.0.

222. The oral hygiene composition of any one of claims 100-117, wherein the pH ranges from about 3.0 to about 4.0.

223. The oral hygiene composition of any one of claims 100- 117, wherein the pH ranges from about 3.0 to about 3.5.

224. The oral hygiene composition of any one of claims 100-117, wherein the pH is about 3.1.

225. A method of treating or preventing dental caries, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition of any one of claims 1-224.

226. A method of treating or preventing oral microbial infections, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition of any one of claims 1-224.

227. A method of treating or preventing oral inflammation, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition of any one of claims 1-224.

228. A method of treating dentine hypersensitivity, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition of any one of claims 1-224.

229. A method of treating or preventing dental caries and oral microbial infections, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition of any one of claims 1-224.

230. A method of treating or preventing dental caries and oral inflammation, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition of any one of claims 1-224.

231. A method of treating or preventing oral microbial infections and oral inflammation, comprising applying to the oral cavity of a mammal in need thereof a therapeutically effective amount of a composition of any one of claims 1 -224.

232. The method of any one of claims 225-231 , wherein said mammal is a primate, bovine, ovine, caprine, equine, porcine, rodent, feline, or canine.

233. The method of any one of claims 225-231 , wherein said mammal is a primate, equine, feline, or canine.

234. The method of any one of claims 225-231 , wherein said mammal is a human.

235. A kit, comprising : a container comprising a composition of any one of claims 1-224; and instructions for use thereof.