WO2009131752A3 - Programmed-release, nanostructured biological construct for stimulating cellular engraftment for tissue regeneration - Google Patents
Programmed-release, nanostructured biological construct for stimulating cellular engraftment for tissue regeneration Download PDFInfo
- Publication number
- WO2009131752A3 WO2009131752A3 PCT/US2009/036117 US2009036117W WO2009131752A3 WO 2009131752 A3 WO2009131752 A3 WO 2009131752A3 US 2009036117 W US2009036117 W US 2009036117W WO 2009131752 A3 WO2009131752 A3 WO 2009131752A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tissue regeneration
- construct
- therapeutic
- release
- biological
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
- A61L2300/61—Coatings having two or more layers containing two or more active agents in different layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/624—Nanocapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Abstract
A biologically engineered construct comprising of a polymeric biomatrix (100), designed with a nanophase texture (106), and a therapeutic agent (104 or 300) for the purpose of tissue regeneration and/or controlled delivery of regenerative factors and therapeutic substances after it is implanted into tissues, vessels, or luminal structures within the body. The therapeutic agent (104 or 300) may be a therapeutic substance (104) or a biological agent (300), such as antibodies, ligands, or living cells. The nanophase construct is designed to maximize lumen size, promote tissue remodeling, and ultimately make the implant more biologically compatible. The nano-textured polymeric biomatrix (100) may comprise one or more layers containing therapeutic substances (104) and/or beneficial biological agents (300) for the purpose of controlled, physiological, differential substance/drug delivery into the luminal and abluminal surfaces of the vessel or lumen, and the attraction of target molecules/cells that will regenerate functional tissue. The topographic and biocompatible features of this layered biological construct provides an optimal environment for tissue regeneration along with a pro grammed -release, drug delivery system to improve physiological tolerance of the implant, and to maximize the cellular survival, migration, and integration within the implanted tissues.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09734987A EP2282718A2 (en) | 2008-04-25 | 2009-03-05 | Programmed-release, nanostructured biological construct for stimulating cellular engraftment for tissue regeneration |
CN2009801240870A CN102083412A (en) | 2008-04-25 | 2009-03-05 | Programmed-release, nanostructured biological construct for stimulating cellular engraftment for tissue regeneration |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/150,329 | 2008-04-25 | ||
US12/150,329 US20080311172A1 (en) | 2007-04-25 | 2008-04-25 | Programmed-release, nanostructured biological construct |
US22113908A | 2008-07-31 | 2008-07-31 | |
US12/221,139 | 2008-07-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009131752A2 WO2009131752A2 (en) | 2009-10-29 |
WO2009131752A3 true WO2009131752A3 (en) | 2009-12-17 |
Family
ID=41217351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/036117 WO2009131752A2 (en) | 2008-04-25 | 2009-03-05 | Programmed-release, nanostructured biological construct for stimulating cellular engraftment for tissue regeneration |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2282718A2 (en) |
CN (1) | CN102083412A (en) |
WO (1) | WO2009131752A2 (en) |
Families Citing this family (30)
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JP5569398B2 (en) | 2008-02-29 | 2014-08-13 | フェッローサン メディカル ディバイス エー/エス | Device for promoting hemostasis and / or wound healing |
CN102905732A (en) * | 2010-03-15 | 2013-01-30 | 弗罗桑医疗设备公司 | A method for promotion of hemostasis and/or wound healing |
CN101927033B (en) * | 2010-08-09 | 2013-06-12 | 华南理工大学 | PHBV (Poly (HydroxyButyrate-hydroxyValerate)) nano fiber support material as well as preparation method and application thereof |
WO2012173555A1 (en) | 2011-06-13 | 2012-12-20 | Dentsply Ih Ab | Collagen coated article |
EP2731555B1 (en) * | 2011-07-13 | 2018-11-07 | Vivex Biomedical, Inc. | Spinal implants with stem cells |
CA2841336A1 (en) * | 2011-07-13 | 2012-01-19 | Cadorel, Catherine | Composite part for endosseous implantation, and method for manufacturing such a part |
EP2822474B1 (en) | 2012-03-06 | 2018-05-02 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
AU2013275758B2 (en) | 2012-06-12 | 2015-03-12 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
CN103055302B (en) * | 2013-01-08 | 2014-05-14 | 福建医科大学附属协和医院 | Ultrasonic biological effect mediated recombinant human endostatin controlled release preparation |
AU2014283170B2 (en) | 2013-06-21 | 2017-11-02 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
CN103598927A (en) * | 2013-10-17 | 2014-02-26 | 上海交通大学 | Degradable magnesium alloy nerve conduit for nerve defect repair and preparation method of nerve conduit |
CN103656750B (en) * | 2013-12-07 | 2014-12-24 | 西南交通大学 | Method for improving various bionic functions on surface of cardiovascular implant material |
JP6489485B2 (en) | 2013-12-11 | 2019-03-27 | フェロサン メディカル デバイシーズ エイ/エス | Dry composition containing an extrusion enhancing factor |
CN103893826A (en) * | 2014-03-03 | 2014-07-02 | 重庆大学 | Titanium alloy surface modification method for regulating and controlling stem cell differentiation and promoting in-vivo bone formation |
BR112017007466B1 (en) | 2014-10-13 | 2021-03-02 | Ferrosan Medical Devices A/S | method for preparing a dry composition, method for reconstituting the dry composition, paste, dry composition, container, homeostatic kit, and, using a dry composition |
US10653837B2 (en) | 2014-12-24 | 2020-05-19 | Ferrosan Medical Devices A/S | Syringe for retaining and mixing first and second substances |
CN104707180B (en) * | 2015-02-06 | 2017-01-25 | 福州大学 | BMP loaded silk fibroin/collagen scaffold material and preparation method thereof |
US10918796B2 (en) | 2015-07-03 | 2021-02-16 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
CN109735434B (en) * | 2016-09-14 | 2022-09-23 | 四川蓝光英诺生物科技股份有限公司 | Artificial tissue precursors and methods of making the same |
AU2017317607B2 (en) * | 2016-10-19 | 2018-05-17 | Beta Cell Technologies Pty Ltd | Cell population seeding in dermal matrices for endocrine |
US20200385666A1 (en) * | 2018-01-24 | 2020-12-10 | Yokogawa Electric Corporation | Cell culture carrier and cell culture container |
US20210369918A1 (en) * | 2018-04-25 | 2021-12-02 | Sapporo Medical University | Cell sheet for transplantation into living body and method for producing same |
AU2019266529A1 (en) | 2018-05-09 | 2020-12-03 | Ethicon Inc. | Method for preparing a haemostatic composition |
CN110755608A (en) * | 2018-07-27 | 2020-02-07 | 上海微创医疗器械(集团)有限公司 | Application of specific antibody, implanted medical instrument and preparation method thereof |
US20210353831A1 (en) * | 2018-10-03 | 2021-11-18 | Establishment Labs S.A. | Scaffolding for implantable medical devices and methods of use thereof |
CN109172037B (en) * | 2018-10-22 | 2023-09-12 | 上海交通大学医学院附属上海儿童医学中心 | Design and application of multi-layer tissue engineering tracheal stent based on 3D printing and electrostatic spinning technology |
AU2018453854B2 (en) * | 2018-12-20 | 2023-03-16 | Bio-Recell Ltd. | Membrane for separation of stem cells from biological samples, production process of said membrane, and process and device for separation, comprising said membrane |
CN109938875A (en) * | 2019-03-07 | 2019-06-28 | 宁波光远致信生物科技有限公司 | A kind of nerve prosthesis and its preparation method and application |
MX2021011780A (en) * | 2019-03-29 | 2021-11-12 | Tdbt Ip Inc | Tissue and organ replacements and methods of making thereof. |
EP4100071A1 (en) | 2020-02-07 | 2022-12-14 | King's College London | Tissue regeneration patch |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2007018647A2 (en) * | 2005-05-02 | 2007-02-15 | Emory University | Multifunctional nanostructures, methods of synthesizing thereof, and methods of use thereof |
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2009
- 2009-03-05 CN CN2009801240870A patent/CN102083412A/en active Pending
- 2009-03-05 WO PCT/US2009/036117 patent/WO2009131752A2/en active Application Filing
- 2009-03-05 EP EP09734987A patent/EP2282718A2/en not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007018647A2 (en) * | 2005-05-02 | 2007-02-15 | Emory University | Multifunctional nanostructures, methods of synthesizing thereof, and methods of use thereof |
Non-Patent Citations (10)
Also Published As
Publication number | Publication date |
---|---|
WO2009131752A2 (en) | 2009-10-29 |
EP2282718A2 (en) | 2011-02-16 |
CN102083412A (en) | 2011-06-01 |
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