WO2009131486A3 - Photosensitiser and a method for the production thereof - Google Patents

Photosensitiser and a method for the production thereof Download PDF

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Publication number
WO2009131486A3
WO2009131486A3 PCT/RU2008/000715 RU2008000715W WO2009131486A3 WO 2009131486 A3 WO2009131486 A3 WO 2009131486A3 RU 2008000715 W RU2008000715 W RU 2008000715W WO 2009131486 A3 WO2009131486 A3 WO 2009131486A3
Authority
WO
WIPO (PCT)
Prior art keywords
photosensitiser
chlorine
cryostabiliser
glucamine
methyl
Prior art date
Application number
PCT/RU2008/000715
Other languages
French (fr)
Russian (ru)
Other versions
WO2009131486A2 (en
Inventor
Виктор Александрович БОРИСОВ
Гелий Васильевич ПОНОМАРЁВ
Валентин Иванович ДЕРНОВСКИЙ
Original Assignee
Borisov Viktor Aleksandrovich
Ponomarev Gely Vasilievich
Dernovsky Valentin Ivanovich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Borisov Viktor Aleksandrovich, Ponomarev Gely Vasilievich, Dernovsky Valentin Ivanovich filed Critical Borisov Viktor Aleksandrovich
Publication of WO2009131486A2 publication Critical patent/WO2009131486A2/en
Publication of WO2009131486A3 publication Critical patent/WO2009131486A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The inventions relate to pharmacology, in particular, to the production of biologically active chlorine compounds. The inventive photosensitiser for photodynamic therapy exhibits long storage- stability, increased operational properties and consumer characteristics and has an extended storage life as a medicinal preparation. The photosensitiser contains e6 chlorine with N-methyl-D-glucamine and sodium at a molar ratio of 1:2:1, and a cryostabiliser, wherein the photosensitiser structure corresponds to structural formula (I). According to the second invention, the method for producing a photosensitiser for photodynamic therapy involves suspending e6 chlorine in apyrogenic water, adding, while agitating, a calculated quantity of N-methyl-D-glucamine and sodium hydroxide (NaOH), filtering the thus produced e6 chlorine salt solution, adding a calculated quantity of cryostabiliser therein and lyophilizing it.
PCT/RU2008/000715 2008-04-22 2008-11-21 Photosensitiser and a method for the production thereof WO2009131486A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2008115234 2008-04-22
RU2008115234/15A RU2367434C1 (en) 2008-04-22 2008-04-22 Photosensitiser and method for preparing thereof

Publications (2)

Publication Number Publication Date
WO2009131486A2 WO2009131486A2 (en) 2009-10-29
WO2009131486A3 true WO2009131486A3 (en) 2009-12-17

Family

ID=41167767

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2008/000715 WO2009131486A2 (en) 2008-04-22 2008-11-21 Photosensitiser and a method for the production thereof

Country Status (2)

Country Link
RU (1) RU2367434C1 (en)
WO (1) WO2009131486A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101332319B1 (en) * 2011-05-04 2013-11-22 다이아텍코리아 주식회사 Methods for Preparing Powder Chlorophyll a and Photosensitizer from Spirulina
KR101138437B1 (en) * 2011-08-05 2012-04-26 다이아텍코리아 주식회사 Methods for Preparing Powder Chlorophyll a and Photosensitizer from Spirulina
RU2523380C1 (en) * 2013-05-21 2014-07-20 Общество с ограниченной ответственностью "ГЕЛИОХЛОРИН" Photosensitiser and method of its obtaining
RU2548726C2 (en) * 2013-12-25 2015-04-20 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Photosensitiser for photodynamic therapy
RU2576025C1 (en) * 2014-07-30 2016-02-27 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича" Российской академии медицинских наук (ФГБУ "ИБМХ" РАМН) Method for producing composition for photodynamic therapy in form of phospholipid nanoparticles based on glucamine chlorine e6 salt, maltose and phosphatidylcholine
RU2568597C1 (en) * 2014-11-27 2015-11-20 Общество с ограниченной ответственностью "РЕВИКСАН" (ООО "РЕВИКСАН") Photosensitiser and method for producing it
RU2646477C1 (en) * 2017-04-05 2018-03-05 Елена Вячеславовна Филоненко Photosensitiser for treatment of cancer diseases and method of its obtaining

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002962A (en) * 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
RU2144538C1 (en) * 1998-01-22 2000-01-20 Закрытое акционерное общество "Вета" Method of preparing water-soluble chlorines
RU2152790C1 (en) * 1999-05-12 2000-07-20 Мещерякова Аделия Леонидовна Agent for photodynamic diagnosis and therapy of oncological diseases
RU2183956C1 (en) * 2001-03-30 2002-06-27 Общество с ограниченной ответственностью "РАДА-ФАРМА" Photosensibilizer agent and method for producing it
WO2002083097A2 (en) * 2001-04-11 2002-10-24 Qlt Inc. Drug delivery system for hydrophobic drugs
RU2276976C2 (en) * 2004-08-10 2006-05-27 Открытое акционерное общество "Группа компаний "ГРАНД" Photosensibilizator and method for its preparing

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002962A (en) * 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
RU2144538C1 (en) * 1998-01-22 2000-01-20 Закрытое акционерное общество "Вета" Method of preparing water-soluble chlorines
RU2152790C1 (en) * 1999-05-12 2000-07-20 Мещерякова Аделия Леонидовна Agent for photodynamic diagnosis and therapy of oncological diseases
RU2183956C1 (en) * 2001-03-30 2002-06-27 Общество с ограниченной ответственностью "РАДА-ФАРМА" Photosensibilizer agent and method for producing it
WO2002083097A2 (en) * 2001-04-11 2002-10-24 Qlt Inc. Drug delivery system for hydrophobic drugs
RU2276976C2 (en) * 2004-08-10 2006-05-27 Открытое акционерное общество "Группа компаний "ГРАНД" Photosensibilizator and method for its preparing

Also Published As

Publication number Publication date
WO2009131486A2 (en) 2009-10-29
RU2367434C1 (en) 2009-09-20

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