WO2009127808A3 - Dispositif de dissociation par transfert d'électrons - Google Patents

Dispositif de dissociation par transfert d'électrons Download PDF

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Publication number
WO2009127808A3
WO2009127808A3 PCT/GB2009/000902 GB2009000902W WO2009127808A3 WO 2009127808 A3 WO2009127808 A3 WO 2009127808A3 GB 2009000902 W GB2009000902 W GB 2009000902W WO 2009127808 A3 WO2009127808 A3 WO 2009127808A3
Authority
WO
WIPO (PCT)
Prior art keywords
electron transfer
transfer dissociation
dissociation device
ion guide
fragmentation
Prior art date
Application number
PCT/GB2009/000902
Other languages
English (en)
Other versions
WO2009127808A8 (fr
WO2009127808A2 (fr
Inventor
Jeffrey Mark Brown
Martin Raymond Green
Original Assignee
Micromass Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromass Uk Limited filed Critical Micromass Uk Limited
Priority to AT09732048T priority Critical patent/ATE526678T1/de
Priority to JP2011504520A priority patent/JP4808826B2/ja
Priority to US12/937,806 priority patent/US8283626B2/en
Priority to CA2721109A priority patent/CA2721109C/fr
Priority to EP09732048A priority patent/EP2277190B1/fr
Publication of WO2009127808A2 publication Critical patent/WO2009127808A2/fr
Publication of WO2009127808A3 publication Critical patent/WO2009127808A3/fr
Publication of WO2009127808A8 publication Critical patent/WO2009127808A8/fr
Priority to US13/645,910 priority patent/US8563921B2/en
Priority to US14/056,622 priority patent/US9111740B2/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/28—Static spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0072—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by ion/ion reaction, e.g. electron transfer dissociation, proton transfer dissociation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Particle Accelerators (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)

Abstract

L'invention porte sur un spectromètre de masse comportant un dispositif de dissociation par transfert d'électrons comprenant un guide d'ions. Un système de commande détermine le degré de fragmentation et de réduction de charge d'ions précurseurs à l'intérieur du guide d'ions et fait varier la vitesse à laquelle des ions sont transmis à travers le guide d'ions afin d'optimiser le processus de fragmentation et de réduction de charge.
PCT/GB2009/000902 2008-04-14 2009-04-03 Dispositif de dissociation par transfert d'électrons WO2009127808A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AT09732048T ATE526678T1 (de) 2008-04-14 2009-04-03 Elektronentransferdissoziierungsvorrichtung
JP2011504520A JP4808826B2 (ja) 2008-04-14 2009-04-03 電子移動解離デバイス
US12/937,806 US8283626B2 (en) 2008-04-14 2009-04-03 Electron transfer dissociation device
CA2721109A CA2721109C (fr) 2008-04-14 2009-04-03 Dispositif de dissociation par transfert d'electrons
EP09732048A EP2277190B1 (fr) 2008-04-14 2009-04-03 Dispositif de dissociation par transfert d'électrons
US13/645,910 US8563921B2 (en) 2008-04-14 2012-10-05 Electron transfer dissociation device
US14/056,622 US9111740B2 (en) 2008-04-14 2013-10-17 Electron transfer dissociation device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0806725.8 2008-04-14
GBGB0806725.8A GB0806725D0 (en) 2008-04-14 2008-04-14 Mass spectrometer
US4949508P 2008-05-01 2008-05-01
US61/049,495 2008-05-01

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/937,806 A-371-Of-International US8283626B2 (en) 2008-04-14 2009-04-03 Electron transfer dissociation device
US13/645,910 Continuation US8563921B2 (en) 2008-04-14 2012-10-05 Electron transfer dissociation device

Publications (3)

Publication Number Publication Date
WO2009127808A2 WO2009127808A2 (fr) 2009-10-22
WO2009127808A3 true WO2009127808A3 (fr) 2010-05-27
WO2009127808A8 WO2009127808A8 (fr) 2011-04-28

Family

ID=39433593

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/000902 WO2009127808A2 (fr) 2008-04-14 2009-04-03 Dispositif de dissociation par transfert d'électrons

Country Status (7)

Country Link
US (3) US8283626B2 (fr)
EP (1) EP2277190B1 (fr)
JP (1) JP4808826B2 (fr)
AT (1) ATE526678T1 (fr)
CA (1) CA2721109C (fr)
GB (2) GB0806725D0 (fr)
WO (1) WO2009127808A2 (fr)

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GB0705730D0 (en) 2007-03-26 2007-05-02 Micromass Ltd Mass spectrometer
GB0723183D0 (en) * 2007-11-23 2008-01-09 Micromass Ltd Mass spectrometer
GB0806725D0 (en) * 2008-04-14 2008-05-14 Micromass Ltd Mass spectrometer
GB0820308D0 (en) * 2008-11-06 2008-12-17 Micromass Ltd Mass spectrometer
US8389932B2 (en) * 2008-07-01 2013-03-05 Waters Technologies Corporation Stacked-electrode peptide-fragmentation device
US8604419B2 (en) * 2010-02-04 2013-12-10 Thermo Fisher Scientific (Bremen) Gmbh Dual ion trapping for ion/ion reactions in a linear RF multipole trap with an additional DC gradient
US8589084B2 (en) * 2010-10-08 2013-11-19 Massachusetts Institute Of Technology Detection of ethanol emission from a spark ignition engine operating on gasohols
GB201019337D0 (en) * 2010-11-16 2010-12-29 Micromass Ltd Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis
US9513232B2 (en) 2010-12-29 2016-12-06 Dh Technologies Development Pte. Ltd. Method for triggering dependent spectra for data acquisition
JP2015503745A (ja) * 2011-12-27 2015-02-02 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド イオン−イオン反応のための試薬イオンの発生
GB2503538B (en) * 2012-03-27 2015-09-09 Micromass Ltd A method of mass spectrometry and a mass spectrometer
WO2013150315A2 (fr) * 2012-04-05 2013-10-10 Micromass Uk Limited Analyse ms/ms utilisant une fragmentation ecd ou etd
GB201208733D0 (en) 2012-05-18 2012-07-04 Micromass Ltd Excitation of reagent molecules within a rf confined ion guide or ion trap to perform ion molecule, ion radical or ion-ion interaction experiments
US9337005B2 (en) * 2012-05-18 2016-05-10 Micromass Uk Limited Method of MS/MS mass spectrometry
CA2873125A1 (fr) * 2012-05-18 2013-11-21 Micromass Uk Limited Procede ameliore de spectrometrie de masse ms e
US9552970B2 (en) * 2013-03-06 2017-01-24 Micromass Uk Limited Time shift for improved ion mobility spectrometry or separation digitisation
US8624181B1 (en) 2013-03-15 2014-01-07 Agilent Technologies, Inc. Controlling ion flux into time-of-flight mass spectrometers
GB201317831D0 (en) * 2013-10-09 2013-11-20 Micromass Ltd MS/MS analysis using ECD or ETD fragmentation
US9905406B2 (en) * 2013-10-23 2018-02-27 Micromass Uk Limited Charge-stripping of multiply-charged ions
DE112015001457B4 (de) 2014-03-24 2020-01-02 Micromass Uk Limited Verfahren zum Erzeugen von Ionen mit einem Masse-/Ladungs-Verhältnis durch Ladungsverringerung
WO2015151160A1 (fr) * 2014-03-31 2015-10-08 株式会社島津製作所 Procédé de spectrométrie de masse et dispositif de spectrométrie de masse
DE112015002067T5 (de) * 2014-04-30 2017-01-19 Micromass Uk Limited Massenspektrometer mit einem verringerten potentialabfall
EP3155641B1 (fr) * 2014-06-10 2022-11-23 Micromass UK Limited Guide d'ions
WO2016011355A1 (fr) 2014-07-18 2016-01-21 Thermo Finnigan Llc Procédés de spectrométrie de masse de mélanges de protéines de polypeptides au moyen de réaction de transfert de protons
GB2541384B (en) * 2015-08-14 2018-11-14 Thermo Fisher Scient Bremen Gmbh Collision cell having an axial field
GB201516926D0 (en) * 2015-09-24 2015-11-11 Micromass Ltd Method of generating electron transfer dissociation reagent ions
CN106704095A (zh) * 2015-11-12 2017-05-24 曾建荣 涡轮装置
EP3193352A1 (fr) 2016-01-14 2017-07-19 Thermo Finnigan LLC Procédés de caractérisation basée sur la spectrométrie de masse de molécules biologiques
EP3460481B1 (fr) 2016-01-14 2020-09-02 Thermo Finnigan LLC Procédés d'analyse spectrale descendante de masse multiplexé de mélanges de protéines ou de polypeptides
CN109314037B (zh) * 2016-06-21 2022-04-19 Dh科技发展私人贸易有限公司 用于通过电子捕获解离分析蛋白质的方法和系统
DE102016124900B4 (de) * 2016-12-20 2019-12-12 Bruker Daltonik Gmbh Schaltelement in Ionenmobilitätsspektrometern
EP3343588A1 (fr) * 2016-12-29 2018-07-04 Thermo Finnigan LLC Procédés de photodissociation par ultraviolet pour la spectrométrie de masse
GB2570435B (en) 2017-11-20 2022-03-16 Thermo Fisher Scient Bremen Gmbh Mass spectrometer
GB2573485B (en) 2017-11-20 2022-01-12 Thermo Fisher Scient Bremen Gmbh Mass spectrometer
US10665441B2 (en) 2018-08-08 2020-05-26 Thermo Finnigan Llc Methods and apparatus for improved tandem mass spectrometry duty cycle
EP3844796A4 (fr) * 2018-08-29 2022-05-25 DH Technologies Development Pte. Ltd. Accumulation de précurseurs dans un état de charge unique en spectrométrie de masse
US11251029B2 (en) * 2018-08-29 2022-02-15 Dh Technologies Development Pte. Ltd. Method for top down proteomics using ExD and PTR
GB201914451D0 (en) * 2019-10-07 2019-11-20 Micromass Ltd Automatically standardising spectrometers
US11480544B2 (en) * 2020-02-05 2022-10-25 Battelle Memorial Institute Atmospheric pressure ion focusing device employing nonlinear DC voltage sequences

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020166958A1 (en) * 2001-04-23 2002-11-14 Afeyan Noubar B. Tailored waveform/charge reduction mass spectrometry
US20030155498A1 (en) * 2002-02-20 2003-08-21 Yoshiaki Kato Mass spectrometer system
US20040026612A1 (en) * 2002-05-30 2004-02-12 Bateman Robert Harold Mass spectrometer
US20060255261A1 (en) * 2005-04-04 2006-11-16 Craig Whitehouse Atmospheric pressure ion source for mass spectrometry
WO2007060437A2 (fr) * 2005-11-23 2007-05-31 Micromass Uk Limited Spectrometre de masse
WO2009066087A2 (fr) * 2007-11-23 2009-05-28 Micromass Uk Limited Dispositif de réaction ion-ion

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CA2391140C (fr) * 2001-06-25 2008-10-07 Micromass Limited Spectrometre de masse
JP3951741B2 (ja) 2002-02-27 2007-08-01 株式会社日立製作所 電荷調整方法とその装置、および質量分析装置
US6794641B2 (en) * 2002-05-30 2004-09-21 Micromass Uk Limited Mass spectrometer
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US7026613B2 (en) 2004-01-23 2006-04-11 Thermo Finnigan Llc Confining positive and negative ions with fast oscillating electric potentials
DE05727506T1 (de) * 2004-03-12 2007-09-06 The University Of Virginia Patent Foundation Elektronentransferdissoziation zur biopolymer-sequenzanalyse
JP4654087B2 (ja) 2005-03-18 2011-03-16 株式会社日立ハイテクノロジーズ 質量分析計及び質量分析方法
US7385185B2 (en) * 2005-12-20 2008-06-10 Agilent Technologies, Inc. Molecular activation for tandem mass spectroscopy
US7829851B2 (en) 2006-12-01 2010-11-09 Purdue Research Foundation Method and apparatus for collisional activation of polypeptide ions
US7842917B2 (en) 2006-12-01 2010-11-30 Purdue Research Foundation Method and apparatus for transmission mode ion/ion dissociation
GB0705730D0 (en) 2007-03-26 2007-05-02 Micromass Ltd Mass spectrometer
GB0806725D0 (en) * 2008-04-14 2008-05-14 Micromass Ltd Mass spectrometer
GB0820308D0 (en) 2008-11-06 2008-12-17 Micromass Ltd Mass spectrometer
US8389932B2 (en) * 2008-07-01 2013-03-05 Waters Technologies Corporation Stacked-electrode peptide-fragmentation device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020166958A1 (en) * 2001-04-23 2002-11-14 Afeyan Noubar B. Tailored waveform/charge reduction mass spectrometry
US20030155498A1 (en) * 2002-02-20 2003-08-21 Yoshiaki Kato Mass spectrometer system
US20040026612A1 (en) * 2002-05-30 2004-02-12 Bateman Robert Harold Mass spectrometer
US20060255261A1 (en) * 2005-04-04 2006-11-16 Craig Whitehouse Atmospheric pressure ion source for mass spectrometry
WO2007060437A2 (fr) * 2005-11-23 2007-05-31 Micromass Uk Limited Spectrometre de masse
WO2009066087A2 (fr) * 2007-11-23 2009-05-28 Micromass Uk Limited Dispositif de réaction ion-ion

Also Published As

Publication number Publication date
US9111740B2 (en) 2015-08-18
US20140042314A1 (en) 2014-02-13
US20130026358A1 (en) 2013-01-31
CA2721109A1 (fr) 2009-10-22
CA2721109C (fr) 2016-11-22
EP2277190A2 (fr) 2011-01-26
EP2277190B1 (fr) 2011-09-28
ATE526678T1 (de) 2011-10-15
GB0905905D0 (en) 2009-05-20
WO2009127808A8 (fr) 2011-04-28
JP4808826B2 (ja) 2011-11-02
GB2460506A (en) 2009-12-09
WO2009127808A2 (fr) 2009-10-22
JP2011517052A (ja) 2011-05-26
GB0806725D0 (en) 2008-05-14
US20110062323A1 (en) 2011-03-17
US8283626B2 (en) 2012-10-09
US8563921B2 (en) 2013-10-22
GB2460506B (en) 2011-06-22

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