WO2009109574A3 - Methode zum anti-inflammatorischen und anti-ödematösen schutz von explantiertem biologischen material bis zu seiner transplantation in patieten - Google Patents

Methode zum anti-inflammatorischen und anti-ödematösen schutz von explantiertem biologischen material bis zu seiner transplantation in patieten Download PDF

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Publication number
WO2009109574A3
WO2009109574A3 PCT/EP2009/052503 EP2009052503W WO2009109574A3 WO 2009109574 A3 WO2009109574 A3 WO 2009109574A3 EP 2009052503 W EP2009052503 W EP 2009052503W WO 2009109574 A3 WO2009109574 A3 WO 2009109574A3
Authority
WO
WIPO (PCT)
Prior art keywords
transplantation
edematous
inflammatory
patients
protection
Prior art date
Application number
PCT/EP2009/052503
Other languages
English (en)
French (fr)
Other versions
WO2009109574A2 (de
Inventor
Anke Esperester
Stephan Nees
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Priority to EP09717445A priority Critical patent/EP2249639A2/de
Priority to CA2718810A priority patent/CA2718810C/en
Priority to JP2010549126A priority patent/JP2011527985A/ja
Priority to US12/919,563 priority patent/US8795956B2/en
Publication of WO2009109574A2 publication Critical patent/WO2009109574A2/de
Publication of WO2009109574A3 publication Critical patent/WO2009109574A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Die vorliegende Erfindung betrifft eine Methode zum Schutz von Transplantaten, sowohl von Organen als auch von einzelnen Blutgefäßen, gegen entzündliche Reaktionen, die durch den mit der Explantation und Lagerung bis zur Transplantation verbundenen operativen Eingriff ausgelöst werden. Dies wird durch Behandlung der Transplantate via intraarterielle Applikation von Flavonolverbindungen, insbesondere mit Quercetinglucuronid und/oder Kämpferolglucuronid, erreicht.
PCT/EP2009/052503 2008-03-06 2009-03-03 Methode zum anti-inflammatorischen und anti-ödematösen schutz von explantiertem biologischen material bis zu seiner transplantation in patieten WO2009109574A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP09717445A EP2249639A2 (de) 2008-03-06 2009-03-03 Methode zum anti-inflammatorischen und anti-ödematösen schutz von explantiertem biologischen material bis zu seiner transplantation in patieten
CA2718810A CA2718810C (en) 2008-03-06 2009-03-03 Methods for the anti-inflammatory and anti-edematous protection of explanted biological material until the transplantation thereof in patients
JP2010549126A JP2011527985A (ja) 2008-03-06 2009-03-03 外植された生物学的材料を患者に移植するまで抗炎症性及び抗浮腫性保護するための方法
US12/919,563 US8795956B2 (en) 2008-03-06 2009-03-03 Method for the anti-inflammatory protection of transplants using quercetin glucuronide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008012908A DE102008012908A1 (de) 2008-03-06 2008-03-06 Methode zum anti-inflammatorischen und anti-ödematösen Schutz von explantiertem biologischen Material bis zu seiner Transplantation in Patienten
DE102008012908.9 2008-03-06

Publications (2)

Publication Number Publication Date
WO2009109574A2 WO2009109574A2 (de) 2009-09-11
WO2009109574A3 true WO2009109574A3 (de) 2010-09-23

Family

ID=40651377

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/052503 WO2009109574A2 (de) 2008-03-06 2009-03-03 Methode zum anti-inflammatorischen und anti-ödematösen schutz von explantiertem biologischen material bis zu seiner transplantation in patieten

Country Status (6)

Country Link
US (1) US8795956B2 (de)
EP (1) EP2249639A2 (de)
JP (1) JP2011527985A (de)
CA (1) CA2718810C (de)
DE (1) DE102008012908A1 (de)
WO (1) WO2009109574A2 (de)

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JP2011512320A (ja) * 2007-08-31 2011-04-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 赤ブドウの葉の抽出物を含む噴霧可能な組成物
DE102008012908A1 (de) 2008-03-06 2009-09-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methode zum anti-inflammatorischen und anti-ödematösen Schutz von explantiertem biologischen Material bis zu seiner Transplantation in Patienten
WO2010033776A1 (en) 2008-09-18 2010-03-25 Surmodics Pharmaceuticals, Inc. Microencapsulation process with solvent and salt
WO2013047665A1 (ja) * 2011-09-29 2013-04-04 石原産業株式会社 生物材料の低温保存用の保存剤及び低温での生物材料の保存方法
WO2014010685A1 (ja) * 2012-07-11 2014-01-16 石原産業株式会社 生物材料の低温保存用の保存剤及び低温での生物材料の保存方法

Citations (4)

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EP1057405A1 (de) * 1999-06-02 2000-12-06 MG Pharmacy Ltd. Aufbewahrungsmittel zur Konservierung von tierischen Zellen, Geweben und Organen und entsprechendes Verfahren
WO2003099307A1 (en) * 2002-05-27 2003-12-04 Uy-Dong Sohn Process for preparing quercetin-3-o-¥â-d-glucuronide(qgc) isolated from rumex aquaticus
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EP1535514A1 (de) * 2002-08-30 2005-06-01 MG Pharmacy Inc. Zusammensetzung f r den schutz von organen, geweben oder zellen und ihre verwendung

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CA2414702C (en) 1999-06-30 2008-02-05 Silverbrook Research Pty Ltd Printhead support structure and assembly
JP2001122791A (ja) 1999-10-20 2001-05-08 Boehringer Ingelheim Internatl Gmbh 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤
JP2003267801A (ja) * 2002-03-12 2003-09-25 Pharmafoods Kenkyusho:Kk 保存剤用組成物及び該組成物を含有する動物の細胞または臓器の保存剤
US20040151769A1 (en) 2002-12-31 2004-08-05 Boehringer Ingelheim International Gmbh Film coated tablet containing an extract of red vine leaves
US20040151794A1 (en) 2002-12-31 2004-08-05 Boehringer Ingelheim International Gmbh Method of improvement of blood circulation
DE10326764A1 (de) * 2003-06-13 2004-12-30 Biotest Ag Endothel-protektive Perfusionslösung, eine Apparatur und Verfahren zur Konservierung des Endothels in isolierten Hohlorganen und biologischen Gefäßen
US20050053560A1 (en) 2003-09-05 2005-03-10 Pharmaton S.A Use of a composition containing extracts of Vitis vinifera and lycopersicum for protecting the skin
EP1550451A1 (de) 2003-12-29 2005-07-06 Boehringer Ingelheim International GmbH Behandlung von chronischer venöser Insuffizienz mit einem Extrakt aus Blättern von roten Weinreben und einem Diuretika
EP1550450A1 (de) 2003-12-29 2005-07-06 Boehringer Ingelheim International GmbH Behandlung von chronischer venöser Insuffizienz mit einem Extrakt aus Blättern von roten Weinreben und einem Blutumlauf verbesserndes Mittel
EP1550452A1 (de) 2003-12-29 2005-07-06 Boehringer Ingelheim International GmbH Behandlung von chronischer venöser Insuffizienz mit einem Extrakt aus Blättern von roten Weinreben und einem antithrombotischen Mittel
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JP2007226473A (ja) 2006-02-22 2007-09-06 Fuji Xerox Co Ltd 電子文書管理システム及び方法
JP2011512320A (ja) 2007-08-31 2011-04-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 赤ブドウの葉の抽出物を含む噴霧可能な組成物
DE102008012909A1 (de) 2008-03-06 2009-09-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Flavonoidverbindungen für die Prophylaxe und Therapie ischämischer oder entzündlicher Herz- und Kreislauferkrankungen
DE102008012908A1 (de) 2008-03-06 2009-09-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methode zum anti-inflammatorischen und anti-ödematösen Schutz von explantiertem biologischen Material bis zu seiner Transplantation in Patienten

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
EP1057405A1 (de) * 1999-06-02 2000-12-06 MG Pharmacy Ltd. Aufbewahrungsmittel zur Konservierung von tierischen Zellen, Geweben und Organen und entsprechendes Verfahren
WO2003099307A1 (en) * 2002-05-27 2003-12-04 Uy-Dong Sohn Process for preparing quercetin-3-o-¥â-d-glucuronide(qgc) isolated from rumex aquaticus
EP1535514A1 (de) * 2002-08-30 2005-06-01 MG Pharmacy Inc. Zusammensetzung f r den schutz von organen, geweben oder zellen und ihre verwendung
EP1435242A1 (de) * 2002-12-31 2004-07-07 Pharmaton S.A. Blutströmung Verbesserungsverfahren

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DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2004, MOCHIZUKI MIKA ET AL: "Effect of quercetin conjugates on vascular permeability and expression of adhesion molecules", XP002589354, Database accession no. PREV200500205124 *
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ESPERESTER ANKE ET AL: "Quercetin-glucuronide (QG) prevents microcirculatory complications acutely caused by simultaneously activated PMN and platelets (P) in the human heart", CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 110, no. 17, Suppl. S, 1 October 2004 (2004-10-01), pages 126, XP009117017, ISSN: 0009-7322 *
FANTINELLI JULIANA C ET AL: "Cardioprotective effects of a non-alcoholic extract of red wine during ischaemia and reperfusion in spontaneously hypertensive rats", CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, WILEY-BLACKWELL PUBLISHING ASIA, AU LNKD- DOI:10.1111/J.1440-1681.2007.04567.X, vol. 34, no. 3, 1 March 2007 (2007-03-01), pages 166 - 169, XP009117257, ISSN: 0305-1870 *
KIESEWETTTER H ET AL: "EFFICACY OF ORALLY ADMINISTERED EXTRACT OF RED VINE LEAF AS 195 (FOLIA VITIS VINIFERAE) IN CHRONIC VENOUS INSUFFICIENCY (STAGES I-II) A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL", ARZNEIMITTEL FORSCHUNG. DRUG RESEARCH, ECV EDITIO CANTOR VERLAG, AULENDORF, DE, vol. 50, no. 2, 1 January 2000 (2000-01-01), pages 109 - 117, XP001146699, ISSN: 0004-4172 *
LODI FEDERICA ET AL: "Protective effects of quercetin and its metabolites on endothelial dysfunction in rat aorta", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, US, vol. 21, no. 6, 1 April 2007 (2007-04-01), pages A1172, XP009116966, ISSN: 0892-6638 *
NEES STEPHAN ET AL: "Protective effects of flavonoids contained in the red vine leaf on venular endothelium against the attack of activated blood components in vitro", ARZNEIMITTEL FORSCHUNG. DRUG RESEARCH, ECV EDITIO CANTOR VERLAG, AULENDORF, DE, vol. 53, no. 5, 1 January 2003 (2003-01-01), pages 330 - 341, XP001539346, ISSN: 0004-4172 *
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TRIBOLO ET AL: "Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells", ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, IE LNKD- DOI:10.1016/J.ATHEROSCLEROSIS.2007.07.040, vol. 197, no. 1, 21 February 2008 (2008-02-21), pages 50 - 56, XP022493932, ISSN: 0021-9150 *

Also Published As

Publication number Publication date
CA2718810A1 (en) 2009-09-11
WO2009109574A2 (de) 2009-09-11
DE102008012908A1 (de) 2009-09-10
EP2249639A2 (de) 2010-11-17
US20110129809A1 (en) 2011-06-02
JP2011527985A (ja) 2011-11-10
US8795956B2 (en) 2014-08-05
CA2718810C (en) 2017-06-20

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