WO2009106502A3 - Implantat und verfahren zu dessen herstellung - Google Patents

Implantat und verfahren zu dessen herstellung Download PDF

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Publication number
WO2009106502A3
WO2009106502A3 PCT/EP2009/052112 EP2009052112W WO2009106502A3 WO 2009106502 A3 WO2009106502 A3 WO 2009106502A3 EP 2009052112 W EP2009052112 W EP 2009052112W WO 2009106502 A3 WO2009106502 A3 WO 2009106502A3
Authority
WO
WIPO (PCT)
Prior art keywords
implant
well
coating
areas
manufacture
Prior art date
Application number
PCT/EP2009/052112
Other languages
English (en)
French (fr)
Other versions
WO2009106502A2 (de
Inventor
Matthias Schnabelrauch
Armin Rex Kautz
Falko Schlottig
Original Assignee
Thommen Medical Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thommen Medical Ag filed Critical Thommen Medical Ag
Priority to CA2716671A priority Critical patent/CA2716671A1/en
Priority to JP2010548087A priority patent/JP5492790B2/ja
Priority to CN2009801110133A priority patent/CN102089016A/zh
Priority to EP09714030A priority patent/EP2254606A2/de
Priority to AU2009218573A priority patent/AU2009218573A1/en
Priority to US12/919,678 priority patent/US8414958B2/en
Publication of WO2009106502A2 publication Critical patent/WO2009106502A2/de
Publication of WO2009106502A3 publication Critical patent/WO2009106502A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances

Abstract

Beschrieben wird ein Implantat, welches wenigstens bereichsweise im implantierten Zustand in den Oberflächenbereichen, die wenigstens mittelbar mit Hart-und /oder Weichgewebe in Kontakt stehen, eine Beschichtung aufweist. Das Implantat ist bevorzugtermassen dadurch gekennzeichnet, dass die Beschichtung sowohl ein Statin wie beispielsweise Simvastatin in der hydrolysierten oder unhydrolysierten Form oder pharmazeutisch verträgliche Salze davon als auch wenigstens eine weitere Komponente ausgewählt aus der Gruppe der verzweigten oder linearen, substituierten oder unsubstituierten, gesättigten oder teilweise ungesättigten C10-C30 Alkyl-, Alkenyl-, Alkylaryl-, Aryl-, Cycloalkyl-, Alkylcycloalkyl-, Alkylcycloaryl-Amine oder Mischungen davon und/oder wenigstens eine wasserlösliche ionische polymere Komponente enthält. Des weiteren wird ein Verfahren zur Herstellung eines derartigen Implantates beschrieben sowie eine Zusammensetzung, welche in einem derartigen Verfahren eingesetzt werden kann.
PCT/EP2009/052112 2008-02-27 2009-02-23 Implantat und verfahren zu dessen herstellung WO2009106502A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2716671A CA2716671A1 (en) 2008-02-27 2009-02-23 Implant and method for the manufacture thereof
JP2010548087A JP5492790B2 (ja) 2008-02-27 2009-02-23 インプラント及びその製造方法
CN2009801110133A CN102089016A (zh) 2008-02-27 2009-02-23 植入物及其制备方法
EP09714030A EP2254606A2 (de) 2008-02-27 2009-02-23 Implantat und verfahren zu dessen herstellung
AU2009218573A AU2009218573A1 (en) 2008-02-27 2009-02-23 Implant and method for the manufacture thereof
US12/919,678 US8414958B2 (en) 2008-02-27 2009-02-23 Implant and method for the manufacture thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00281/08 2008-02-27
CH2812008 2008-02-27

Publications (2)

Publication Number Publication Date
WO2009106502A2 WO2009106502A2 (de) 2009-09-03
WO2009106502A3 true WO2009106502A3 (de) 2010-07-01

Family

ID=39580199

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/052112 WO2009106502A2 (de) 2008-02-27 2009-02-23 Implantat und verfahren zu dessen herstellung

Country Status (8)

Country Link
US (1) US8414958B2 (de)
EP (1) EP2254606A2 (de)
JP (1) JP5492790B2 (de)
KR (1) KR20100125346A (de)
CN (1) CN102089016A (de)
AU (1) AU2009218573A1 (de)
CA (1) CA2716671A1 (de)
WO (1) WO2009106502A2 (de)

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Publication number Priority date Publication date Assignee Title
WO2011157758A1 (de) * 2010-06-15 2011-12-22 Innotere Gmbh Knochenimplantat, enthaltend einen magnesiumhaltigen metallischen werkstoff mit verminderter korrosionsrate und verfahren und set zu dessen herstellung
US20120239131A1 (en) * 2011-03-15 2012-09-20 Medtronic Vascular, Inc. Methods and apparatus for treatment of aneurysmal tissue
EP2753594B1 (de) 2011-09-06 2017-03-22 Vita Zahnfabrik H. Rauter GmbH & Co. KG Verfahren zur herstellung von keramischen implantaten für medizinische zwecke
DE102013201885A1 (de) * 2013-02-05 2014-08-07 Urs Brodbeck Keramikkörper, insbesondere zur Verwendung in einem Knochenimplantat, insbesondere als Dentalimplantat
KR20160061991A (ko) 2013-09-27 2016-06-01 비타 찬파브릭 하. 라우터 게엠베하 & 코.카게 분해가능한 코팅을 포함하는 임플란트
DE112015003446T5 (de) * 2014-08-22 2017-04-20 Cummins, Inc. System und Verfahren zur Verbesserung von Nachbehandlung in einem Verbrennungsmotor
CN105214140B (zh) * 2015-09-22 2018-02-09 重庆大学 协同调控骨质疏松症中局部骨重建及愈合的钛合金的功能化界面构建方法
CN106729964A (zh) * 2016-12-02 2017-05-31 江苏师范大学 一种兼具促进骨形成和抑制骨吸收作用的二氧化钛纳米管及其制备方法
ES2901421T3 (es) 2017-04-11 2022-03-22 Straumann Holding Ag Implante dental
WO2018213221A1 (en) 2017-05-15 2018-11-22 University Of Cincinnati Compositions and methods for treating defects in avascular cartilaginous tissue by directly administering one or more metabolites of simvastatin
CN113368314A (zh) * 2021-05-20 2021-09-10 沈阳理工大学 一种镁基金属高分子复合骨引导再生膜及其制备方法

Citations (8)

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Publication number Priority date Publication date Assignee Title
EP1159934A2 (de) * 2000-06-01 2001-12-05 Terumo Kabushiki Kaisha Implantierbare Schlauchvorrichtung (Stent)
WO2003105731A1 (en) * 2002-06-13 2003-12-24 Neuropro Technologies, Inc. Bone growth compositions and methods
WO2004091626A1 (en) * 2003-04-07 2004-10-28 Osteoscreen, Inc. Bone growth stimulation with no/statin and other no modulating combinations
US20040247673A1 (en) * 2003-06-09 2004-12-09 Fergione Michael B. Pharmaceutical compositions of atorvastatin
WO2006082500A1 (en) * 2005-02-03 2006-08-10 Pfizer Products Inc. Dosage forms providing controlled and immediate release of cholesteryl ester transfer protein inhibitors and immediate release of hmg-coa reductase inhibitors
DE20122679U1 (de) * 2000-06-27 2007-03-01 Shire Holdings Ag Behandlung von Knochenerkrankungen
US20070048351A1 (en) * 2005-09-01 2007-03-01 Prescient Medical, Inc. Drugs coated on a device to treat vulnerable plaque
WO2007048264A1 (de) * 2005-10-27 2007-05-03 Thommen Medical Ag Dentalimplantat und verfahren zu dessen herstellung

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US4916239A (en) * 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
EP1228057A2 (de) * 1999-10-27 2002-08-07 Merck & Co., Inc. Laktonbildungsverfahren
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US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
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Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1159934A2 (de) * 2000-06-01 2001-12-05 Terumo Kabushiki Kaisha Implantierbare Schlauchvorrichtung (Stent)
DE20122679U1 (de) * 2000-06-27 2007-03-01 Shire Holdings Ag Behandlung von Knochenerkrankungen
WO2003105731A1 (en) * 2002-06-13 2003-12-24 Neuropro Technologies, Inc. Bone growth compositions and methods
WO2004091626A1 (en) * 2003-04-07 2004-10-28 Osteoscreen, Inc. Bone growth stimulation with no/statin and other no modulating combinations
US20040247673A1 (en) * 2003-06-09 2004-12-09 Fergione Michael B. Pharmaceutical compositions of atorvastatin
WO2006082500A1 (en) * 2005-02-03 2006-08-10 Pfizer Products Inc. Dosage forms providing controlled and immediate release of cholesteryl ester transfer protein inhibitors and immediate release of hmg-coa reductase inhibitors
US20070048351A1 (en) * 2005-09-01 2007-03-01 Prescient Medical, Inc. Drugs coated on a device to treat vulnerable plaque
WO2007048264A1 (de) * 2005-10-27 2007-05-03 Thommen Medical Ag Dentalimplantat und verfahren zu dessen herstellung

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ISMAIL FATMA A: "Design and in vitro evaluation of polymeric formulae of simvastatin for local bone induction", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, NEW YORK, NY, US LNKD- DOI:10.1080/03639040600751886, vol. 32, no. 10, 1 November 2006 (2006-11-01), pages 1199 - 1206, XP009090743, ISSN: 0363-9045 *

Also Published As

Publication number Publication date
JP5492790B2 (ja) 2014-05-14
US8414958B2 (en) 2013-04-09
JP2011512921A (ja) 2011-04-28
CA2716671A1 (en) 2009-09-03
AU2009218573A1 (en) 2009-09-03
US20110053113A1 (en) 2011-03-03
EP2254606A2 (de) 2010-12-01
CN102089016A (zh) 2011-06-08
WO2009106502A2 (de) 2009-09-03
KR20100125346A (ko) 2010-11-30

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