WO2009102820A3 - Modified sugar substrates and methods of use - Google Patents
Modified sugar substrates and methods of use Download PDFInfo
- Publication number
- WO2009102820A3 WO2009102820A3 PCT/US2009/033842 US2009033842W WO2009102820A3 WO 2009102820 A3 WO2009102820 A3 WO 2009102820A3 US 2009033842 W US2009033842 W US 2009033842W WO 2009102820 A3 WO2009102820 A3 WO 2009102820A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- modified sugar
- sugar substrates
- sugars
- substrates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
The invention relates generally to functionalized sugars and methods of making and using such sugars. The novel sugars described herein are used as substrates to make glyco conjugates with therapeutic and diagnostic applications.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2778208P | 2008-02-11 | 2008-02-11 | |
US61/027,782 | 2008-02-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009102820A2 WO2009102820A2 (en) | 2009-08-20 |
WO2009102820A3 true WO2009102820A3 (en) | 2009-10-22 |
Family
ID=40957483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/033842 WO2009102820A2 (en) | 2008-02-11 | 2009-02-11 | Modified sugar substrates and methods of use |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009102820A2 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE038285T2 (en) | 2012-10-23 | 2018-10-29 | Synaffix Bv | Modified antibody, antibody-conjugate and process for the preparation thereof |
SI2991683T1 (en) | 2013-05-02 | 2020-01-31 | Glykos Finland Oy | Conjugates of a glycoprotein or a glycan with a toxic payload |
EP3058083B1 (en) | 2013-10-14 | 2018-04-11 | SynAffix B.V. | Modified glycoprotein, protein-conjugate and process for the preparation thereof |
CN105829543B (en) | 2013-10-14 | 2021-06-01 | 西纳福克斯股份有限公司 | Glycosylated antibodies, antibody-conjugates and methods of making the same |
CN105814213B (en) | 2013-10-14 | 2021-05-04 | 西纳福克斯股份有限公司 | Modified glycoproteins, protein-conjugates and methods of making the same |
EP3057618B1 (en) | 2013-10-14 | 2022-12-14 | SynAffix B.V. | Glycoengineered antibody, antibody-conjugate and methods for their preparation |
EP3925951A1 (en) | 2014-01-24 | 2021-12-22 | SynAffix B.V. | Process for the cycloaddition of a(hetero)aryl 1,3-dipole compound with a (hetero)cycloalkyne |
SI3116887T1 (en) | 2014-03-13 | 2021-06-30 | Universitaet Basel | Carbohydrate ligands that bind to igm antibodies against myelin-associated glycoprotein |
CN108026134A (en) | 2015-09-16 | 2018-05-11 | 巴塞尔大学 | With reference to the carbohydrate ligand of anti-glycosphingolipid glycoprotein epitope antibodies |
WO2017137457A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
EP3413916A1 (en) | 2016-02-08 | 2018-12-19 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
US10738284B2 (en) * | 2017-06-05 | 2020-08-11 | Regeneron Pharmaceuticals, Inc. | B4GALT1 cDNA variants and compositions comprising the same |
WO2020094670A1 (en) | 2018-11-05 | 2020-05-14 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing trop-2 |
CN115884793A (en) | 2020-01-09 | 2023-03-31 | 梅尔莎纳医疗公司 | Site-specific antibody-drug conjugates with peptide-containing linkers |
AU2022205057A1 (en) | 2021-01-04 | 2023-07-13 | Mersana Therapeutics, Inc. | B7h4-targeted antibody-drug conjugates and methods of use thereof |
GB202116442D0 (en) | 2021-11-15 | 2021-12-29 | Actome Gmbh | High-efficacy labeling of antibodies with oligonucleotide labels |
WO2023161296A1 (en) | 2022-02-22 | 2023-08-31 | Adc Therapeutics Sa | Conjugation method involving a transglutaminase at the fc region comprising a trimmed n-glycan |
WO2023180484A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing ptk7 |
WO2023180485A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing trop-2 |
WO2023180489A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen |
WO2023180490A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing nectin-4 |
WO2024038065A1 (en) | 2022-08-15 | 2024-02-22 | Synaffix B.V. | Anthracyclins and conjugates thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005051429A2 (en) * | 2003-11-19 | 2005-06-09 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Targeted conjugates with a modified saccharide linker |
WO2007120638A2 (en) * | 2006-04-12 | 2007-10-25 | President And Fellows Of Harvard College | Methods and compositions for modulating glycosylation |
WO2008143944A2 (en) * | 2007-05-14 | 2008-11-27 | Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Methods of glycosylation and bioconjugation |
WO2009025646A1 (en) * | 2007-08-22 | 2009-02-26 | Government Of The U.S.A, As Represented By The Secretary, Department Of Health & Human Services | Alpha 1-3 n-galactosyltransferase with altered donor specificities |
-
2009
- 2009-02-11 WO PCT/US2009/033842 patent/WO2009102820A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005051429A2 (en) * | 2003-11-19 | 2005-06-09 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Targeted conjugates with a modified saccharide linker |
WO2007120638A2 (en) * | 2006-04-12 | 2007-10-25 | President And Fellows Of Harvard College | Methods and compositions for modulating glycosylation |
WO2008143944A2 (en) * | 2007-05-14 | 2008-11-27 | Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Methods of glycosylation and bioconjugation |
WO2009025646A1 (en) * | 2007-08-22 | 2009-02-26 | Government Of The U.S.A, As Represented By The Secretary, Department Of Health & Human Services | Alpha 1-3 n-galactosyltransferase with altered donor specificities |
Non-Patent Citations (9)
Title |
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BOEGGEMAN ELIZABETH ET AL: "Direct identification of nonreducing GlcNAc residues on N-glycans of glycoproteins using a novel chemoenzymatic method", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 18, no. 3, 1 May 2007 (2007-05-01), pages 806 - 814, XP002474455, ISSN: 1043-1802 * |
BOIX ESTER ET AL: "Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-Galactosyltransferase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, vol. 277, no. 31, 2 August 2002 (2002-08-02), pages 28310 - 28318, XP002491823, ISSN: 0021-9258, [retrieved on 20020514] * |
HANG HOWARD C ET AL: "Probing glycosyltransferase activities with the Staudinger ligation", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC. US, vol. 126, no. 1, 14 January 2004 (2004-01-14), pages 6 - 7, XP002491764, ISSN: 0002-7863, [retrieved on 20031210] * |
KHIDEKEL N ET AL: "A CHEMOENZYMATIC APPROACH TOWARD THE RAPID AND SENSITIVE DETECTION OF O-GLCNAC POSTTRANSLATIONAL MODIFICATIONS", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC. US, vol. 125, no. 52, 31 December 2003 (2003-12-31), pages 16162/16163, XP008055588, ISSN: 0002-7863 * |
LAZAREVIC D ET AL: "Syntheses of unnatural N-substituted UDP-galactosamines as alternative substrates for N-acetylgalactosaminyl transferases", CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol. 337, no. 21-23, 19 November 2002 (2002-11-19), pages 2187 - 2194, XP004392212, ISSN: 0008-6215 * |
QASBA P K ET AL: "Substrate-induced conformational changes in glycosyltransferases", TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER, HAYWARDS, GB, vol. 30, no. 1, 1 January 2005 (2005-01-01), pages 53 - 62, XP004710941, ISSN: 0968-0004 * |
QASBA P K: "Involvement of sugars in protein-protein interactions", CARBOHYDRATE POLYMERS, APPLIED SCIENCE PUBLISHERS, LTD. BARKING, GB, vol. 41, no. 3, 1 March 2000 (2000-03-01), pages 293 - 309, XP004244362, ISSN: 0144-8617 * |
QASBA PRADMAN K ET AL: "Mutant glycosyltransferases assist in the development of a targeted drug delivery system and contrast agents for MRI", AAPS JOURNAL, AMERICAN ASSOCIATION OF PHARMACEUTICAL SCIENTISTS, US, vol. 8, no. 1, 1 January 2006 (2006-01-01), pages E190 - E195, XP002491763, ISSN: 1550-7416, [retrieved on 20060324] * |
TANIGUCHI N ET AL: "UDP N ACETYL GALACTOSAMINE GLOBOSIDE ALPHA-3-N ACETYL GALACTOSAMINYL TRANSFERASE EC-2.4.1.88 PURIFICATION CHARACTERIZATION AND SOME PROPERTIES", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, vol. 257, no. 18, 1 January 1982 (1982-01-01), pages 10631 - 10637, XP002491762, ISSN: 0021-9258 * |
Also Published As
Publication number | Publication date |
---|---|
WO2009102820A2 (en) | 2009-08-20 |
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