WO2009073941A3 - Ternary liposomal composition containing a polynucleotide - Google Patents

Ternary liposomal composition containing a polynucleotide Download PDF

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Publication number
WO2009073941A3
WO2009073941A3 PCT/BR2008/000387 BR2008000387W WO2009073941A3 WO 2009073941 A3 WO2009073941 A3 WO 2009073941A3 BR 2008000387 W BR2008000387 W BR 2008000387W WO 2009073941 A3 WO2009073941 A3 WO 2009073941A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotides
vaccination
liposomal configuration
ternary
polynucleotide
Prior art date
Application number
PCT/BR2008/000387
Other languages
French (fr)
Other versions
WO2009073941A2 (en
Inventor
Maria Helena Andrade Santana
Rogério SILVA ROSADA
Arlete A. M. Coelho Castelo
Célio LOPES SILVA
Lucimara Gaziola De La Torre
Original Assignee
Universidade Estadual De Campinas-Unicamp
Universidade De São Paulo-Usp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Estadual De Campinas-Unicamp, Universidade De São Paulo-Usp filed Critical Universidade Estadual De Campinas-Unicamp
Publication of WO2009073941A2 publication Critical patent/WO2009073941A2/en
Publication of WO2009073941A3 publication Critical patent/WO2009073941A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Abstract

This invention provides a product for therapy and vaccination, constituted by a functional liposomal configuration containing complexed polynucleotides preferably on the outer surface of dehydrated-rehydrated liposomes (DRV), and the production process thereof. This functional liposomal configuration containing polynucleotides has mucoadhesion properties which allow administration by non-invasive routes, such as the nasal route, and is able to efficiently carry the polynucleotides to the interior of cells, releasing them in the cytoplasm. These properties allows for higher in vivo action efficiency of the carried polynucleotides, reduced concentration and dose frequency, and, in the case of vaccination, give protection against the specific disease. The present technology also develops a liposomal configuration carrying polynucleotides, which encode the protein HSP65, for prevention and treatment of tuberculosis.
PCT/BR2008/000387 2007-12-12 2008-12-12 Ternary liposomal composition containing a polynucleotide WO2009073941A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BRC10705630A BRPI0705630F8 (en) 2007-12-12 2007-12-12 Production process of liposomal gene vaccine, liposomal gene vaccine and use thereof
BRPI0705630-3 2007-12-12
BRC10705630-3 2008-08-29

Publications (2)

Publication Number Publication Date
WO2009073941A2 WO2009073941A2 (en) 2009-06-18
WO2009073941A3 true WO2009073941A3 (en) 2009-08-27

Family

ID=40755920

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2008/000387 WO2009073941A2 (en) 2007-12-12 2008-12-12 Ternary liposomal composition containing a polynucleotide

Country Status (2)

Country Link
BR (1) BRPI0705630F8 (en)
WO (1) WO2009073941A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2661253B1 (en) * 2011-01-04 2017-04-19 Archivel Farma, SL Liposome formulation suitable for treating or preventing tuberculosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110745A (en) * 1997-07-24 2000-08-29 Inex Pharmaceuticals Corp. Preparation of lipid-nucleic acid particles using a solvent extraction and direct hydration method
US20040043954A1 (en) * 1999-05-14 2004-03-04 Gregory Gregoriadis Liposomes
WO2006086330A2 (en) * 2005-02-08 2006-08-17 Id Biomedical Corporation Of Quebec C.O.B. As Glaxosmithkline Biologicals North America Pharmaceutical compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110745A (en) * 1997-07-24 2000-08-29 Inex Pharmaceuticals Corp. Preparation of lipid-nucleic acid particles using a solvent extraction and direct hydration method
US20040043954A1 (en) * 1999-05-14 2004-03-04 Gregory Gregoriadis Liposomes
WO2006086330A2 (en) * 2005-02-08 2006-08-17 Id Biomedical Corporation Of Quebec C.O.B. As Glaxosmithkline Biologicals North America Pharmaceutical compositions

Also Published As

Publication number Publication date
BRPI0705630E2 (en) 2011-03-09
BRPI0705630B8 (en) 2021-05-25
BRPI0705630F1 (en) 2021-03-30
BRPI0705630B1 (en) 2020-09-24
BRPI0705630A2 (en) 2010-12-28
WO2009073941A2 (en) 2009-06-18
BRPI0705630F8 (en) 2022-01-18

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