BRPI0705630B8 - functional liposomal configuration and process of obtaining functional liposomal configuration - Google Patents

functional liposomal configuration and process of obtaining functional liposomal configuration

Info

Publication number
BRPI0705630B8
BRPI0705630B8 BRPI0705630A BRPI0705630A BRPI0705630B8 BR PI0705630 B8 BRPI0705630 B8 BR PI0705630B8 BR PI0705630 A BRPI0705630 A BR PI0705630A BR PI0705630 A BRPI0705630 A BR PI0705630A BR PI0705630 B8 BRPI0705630 B8 BR PI0705630B8
Authority
BR
Brazil
Prior art keywords
functional liposomal
liposomal configuration
functional
polynucleotides
configuration
Prior art date
Application number
BRPI0705630A
Other languages
Portuguese (pt)
Inventor
A M Coelho Castelo Arlete
Lopes Silva Célio
Gaziola De La Torre Lucimara
Helena Andrade Santana Maria
Silva Rosada Rogério
Original Assignee
Univ Estadual Campinas Unicamp
Univ Sao Paulo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Estadual Campinas Unicamp, Univ Sao Paulo filed Critical Univ Estadual Campinas Unicamp
Priority to BRC10705630A priority Critical patent/BRPI0705630F8/en
Priority to PCT/BR2008/000387 priority patent/WO2009073941A2/en
Publication of BRPI0705630A2 publication Critical patent/BRPI0705630A2/en
Publication of BRPI0705630E2 publication Critical patent/BRPI0705630E2/en
Publication of BRPI0705630B1 publication Critical patent/BRPI0705630B1/en
Publication of BRPI0705630F1 publication Critical patent/BRPI0705630F1/pt
Publication of BRPI0705630B8 publication Critical patent/BRPI0705630B8/en
Publication of BRPI0705630F8 publication Critical patent/BRPI0705630F8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

configuração lipossomal funcional e processo de obtenção de configuração lipossomal funcional a invenção apresenta um produto para terapia e vacinação, constituído de uma configuração lipossomal funcional contendo polinucleotídeos complexados preferencialmente na superfície externa de lipossomas do tipo drvs, e o seu processo de produção. essa configuração lipossomal funcional contendo polinucleotídeos possui propriedades de mucoadesão que permite a administração através de vias não invasivas como a via nasal, e é capaz de carrear eficientemente os polinucleotídeos até o interior das células, liberando- os no citoplasma. essas propriedades potencializam maior eficiência de ação in vivo dos polinucleotídeos carreados, redução da concentração e freqüência de doses, e, no caso da vacinação produz proteção contra a doença específicafunctional liposomal configuration and process for obtaining functional liposomal configuration the invention presents a product for therapy and vaccination, consisting of a functional liposomal configuration containing polynucleotides preferentially complexed on the external surface of liposomes of the drvs type, and its production process. this functional liposomal configuration containing polynucleotides has mucoadhesion properties that allow administration through non-invasive routes such as the nasal route, and is capable of efficiently carrying polynucleotides into cells, releasing them into the cytoplasm. these properties enhance the efficiency of the in vivo action of the carried polynucleotides, reduce the concentration and frequency of doses, and, in the case of vaccination, it produces protection against the specific disease

BRC10705630A 2007-12-12 2007-12-12 Production process of liposomal gene vaccine, liposomal gene vaccine and use thereof BRPI0705630F8 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRC10705630A BRPI0705630F8 (en) 2007-12-12 2007-12-12 Production process of liposomal gene vaccine, liposomal gene vaccine and use thereof
PCT/BR2008/000387 WO2009073941A2 (en) 2007-12-12 2008-12-12 Ternary liposomal composition containing a polynucleotide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRC10705630A BRPI0705630F8 (en) 2007-12-12 2007-12-12 Production process of liposomal gene vaccine, liposomal gene vaccine and use thereof

Publications (6)

Publication Number Publication Date
BRPI0705630A2 BRPI0705630A2 (en) 2010-12-28
BRPI0705630E2 BRPI0705630E2 (en) 2011-03-09
BRPI0705630B1 BRPI0705630B1 (en) 2020-09-24
BRPI0705630F1 BRPI0705630F1 (en) 2021-03-30
BRPI0705630B8 true BRPI0705630B8 (en) 2021-05-25
BRPI0705630F8 BRPI0705630F8 (en) 2022-01-18

Family

ID=40755920

Family Applications (1)

Application Number Title Priority Date Filing Date
BRC10705630A BRPI0705630F8 (en) 2007-12-12 2007-12-12 Production process of liposomal gene vaccine, liposomal gene vaccine and use thereof

Country Status (2)

Country Link
BR (1) BRPI0705630F8 (en)
WO (1) WO2009073941A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX341918B (en) * 2011-01-04 2016-09-07 Archivel Farma Sl Liposome formulation suitable for treating or preventing tuberculosis.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7384923B2 (en) * 1999-05-14 2008-06-10 Lipoxen Technologies Limited Liposomes
AU8428998A (en) * 1997-07-24 1999-02-16 Inex Pharmaceuticals Corporation Preparation of lipid-nucleic acid particles using a solvent extraction and direct hydration method
CA2597170A1 (en) * 2005-02-08 2006-08-17 Id Biomedical Corporation Of Quebec C.O.B. As Glaxosmithkline Biological S North America Pharmaceutical compositions

Also Published As

Publication number Publication date
WO2009073941A3 (en) 2009-08-27
BRPI0705630A2 (en) 2010-12-28
BRPI0705630F8 (en) 2022-01-18
BRPI0705630B1 (en) 2020-09-24
BRPI0705630E2 (en) 2011-03-09
BRPI0705630F1 (en) 2021-03-30
WO2009073941A2 (en) 2009-06-18

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Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: ADDITIONAL INVENTOR'S CERTIFICATE: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

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