WO2009072654A1 - ケロイド及び肥厚性瘢痕根治治療剤 - Google Patents
ケロイド及び肥厚性瘢痕根治治療剤 Download PDFInfo
- Publication number
- WO2009072654A1 WO2009072654A1 PCT/JP2008/072279 JP2008072279W WO2009072654A1 WO 2009072654 A1 WO2009072654 A1 WO 2009072654A1 JP 2008072279 W JP2008072279 W JP 2008072279W WO 2009072654 A1 WO2009072654 A1 WO 2009072654A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- keloid
- therapeutic agent
- hypertrophic scar
- radical therapeutic
- agent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/746,653 US20110008312A1 (en) | 2007-12-07 | 2008-12-08 | Radical therapeutic agent for keloid and hypertrophic scar |
ES08857855.4T ES2523841T3 (es) | 2007-12-07 | 2008-12-08 | Agente terapéutico radical para queloide y cicatriz hipertrófica |
EP08857855.4A EP2223699B1 (en) | 2007-12-07 | 2008-12-08 | Radical therapeutic agent for keloid and hypertrophic scar |
JP2009544768A JP5560491B2 (ja) | 2007-12-07 | 2008-12-08 | ケロイド及び肥厚性瘢痕根治治療剤 |
CA2708062A CA2708062A1 (en) | 2007-12-07 | 2008-12-08 | Chondroitinase abc for keloid and hypertrophic scar therapy |
CN200880120686.0A CN101969986B (zh) | 2007-12-07 | 2008-12-08 | 瘢痕疙瘩和增生性瘢痕根治治疗药 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-317294 | 2007-12-07 | ||
JP2007317294 | 2007-12-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009072654A1 true WO2009072654A1 (ja) | 2009-06-11 |
Family
ID=40717831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/072279 WO2009072654A1 (ja) | 2007-12-07 | 2008-12-08 | ケロイド及び肥厚性瘢痕根治治療剤 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20110008312A1 (ja) |
EP (1) | EP2223699B1 (ja) |
JP (3) | JP5560491B2 (ja) |
KR (1) | KR20100098401A (ja) |
CN (2) | CN104940915A (ja) |
CA (1) | CA2708062A1 (ja) |
ES (1) | ES2523841T3 (ja) |
WO (1) | WO2009072654A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013039244A1 (ja) | 2011-09-15 | 2013-03-21 | 生化学工業株式会社 | 骨格筋再生促進剤 |
JP2017537934A (ja) * | 2014-12-07 | 2017-12-21 | ヴェッスル セラピューティクス リミテッド | ケロイド瘢痕を処置するためのフィビュリン−5の使用 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2223699B1 (en) * | 2007-12-07 | 2014-08-20 | Seikagaku Corporation | Radical therapeutic agent for keloid and hypertrophic scar |
US8877185B2 (en) | 2012-05-10 | 2014-11-04 | Stan S. Sastry | Managing and treating keloids |
US9796970B1 (en) | 2017-04-24 | 2017-10-24 | Advantek Serum Laboratories Ltd. | Production of high purity chondroitinase ABC |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06153947A (ja) | 1992-06-26 | 1994-06-03 | Seikagaku Kogyo Co Ltd | コンドロイチナーゼabc、その製造法及び医薬組成物 |
JPH10262660A (ja) | 1997-03-21 | 1998-10-06 | Seikagaku Kogyo Co Ltd | 新規コンドロイチン硫酸分解酵素 |
JP2002335968A (ja) | 2001-05-16 | 2002-11-26 | Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho | 新規転写因子、その遺伝子及びその結合dna配列 |
JP2004504262A (ja) | 1999-12-02 | 2004-02-12 | アイベックス テクノロジーズ, インコーポレイテッド | 線維芽細胞の増殖の弱毒化 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995029256A1 (en) * | 1994-04-22 | 1995-11-02 | American Cyanamid Company | Chondroitinases i and ii, methods of preparation, and use thereof |
EP1839671A3 (en) * | 1999-12-02 | 2007-10-31 | BioMarin Pharmaceutical Inc. | Attenuation of fibroblast proliferation |
EP2223699B1 (en) * | 2007-12-07 | 2014-08-20 | Seikagaku Corporation | Radical therapeutic agent for keloid and hypertrophic scar |
-
2008
- 2008-12-08 EP EP08857855.4A patent/EP2223699B1/en not_active Not-in-force
- 2008-12-08 WO PCT/JP2008/072279 patent/WO2009072654A1/ja active Application Filing
- 2008-12-08 CA CA2708062A patent/CA2708062A1/en not_active Abandoned
- 2008-12-08 US US12/746,653 patent/US20110008312A1/en not_active Abandoned
- 2008-12-08 JP JP2009544768A patent/JP5560491B2/ja active Active
- 2008-12-08 KR KR1020107013497A patent/KR20100098401A/ko not_active Application Discontinuation
- 2008-12-08 CN CN201510430761.5A patent/CN104940915A/zh active Pending
- 2008-12-08 CN CN200880120686.0A patent/CN101969986B/zh not_active Expired - Fee Related
- 2008-12-08 ES ES08857855.4T patent/ES2523841T3/es active Active
-
2014
- 2014-05-22 JP JP2014106132A patent/JP2014156482A/ja active Pending
-
2015
- 2015-07-17 JP JP2015142855A patent/JP2015227355A/ja active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06153947A (ja) | 1992-06-26 | 1994-06-03 | Seikagaku Kogyo Co Ltd | コンドロイチナーゼabc、その製造法及び医薬組成物 |
JPH10262660A (ja) | 1997-03-21 | 1998-10-06 | Seikagaku Kogyo Co Ltd | 新規コンドロイチン硫酸分解酵素 |
JP2004504262A (ja) | 1999-12-02 | 2004-02-12 | アイベックス テクノロジーズ, インコーポレイテッド | 線維芽細胞の増殖の弱毒化 |
JP2002335968A (ja) | 2001-05-16 | 2002-11-26 | Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho | 新規転写因子、その遺伝子及びその結合dna配列 |
Non-Patent Citations (29)
Title |
---|
ABERGEL, R. P.; PIZZURRO, D.; MEEKER, C. A. ET AL.: "Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures", J. INVEST. DERMATOL., vol. 84, 1985, pages 384 - 390 |
COSTA AM ET AL.: "Mechanical Force Induce Scar", REMODELING: AM J PATHOL, vol. 155, 1999, pages 1671 - 1679 |
H. MIYAZONO; H. KIKUCHI; K. YOSHIDA; K. MORIKAWA; K. TOKUYASU, J. BIOCHEM., vol. 61, 1989, pages 1023 |
K. HIYAMA; S. OKADA, J. BIOCHEM. (TOKYO), vol. 80, 1976, pages 1201 |
K. HIYAMA; S. OKADA, J. BIOL.CHEM., vol. 250, 1975, pages 1824 |
K. MAEYAMA; A. TAWADA; A. UENO; K. YOSHIDA, J. BIOCHEM., vol. 57, 1985, pages 1189 |
K.S BHANGOO; J.K. QUINLIVAN; J.R. CONNELLY: "Elastin fibers in scar tissue", PLAST. RECONSTR. SURG., vol. 57, 1976, pages 308 - 13 |
MAGUIRE H C: "Treatment of keloids with triamcinolone acetonide injected intralesionnally", JAMA, vol. 192, 1956, pages 325 - 329 |
MIKA IKEDA ET AL.: "Keloid ni Okeru Dansei Sen'i no Ijo to Glycosaminoglycan no Kajo Chikuseki", DAI 14 KAI JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY KISO GAKUJUTSU SHUKAI PROGRAM SHOROKUSHU, 2005, pages 93, XP008128533 * |
N.V. KAMATH; A. ORMSBY; W.F. BERGFELD; N.S. HOUSE: "A light microscopic and immunohistochemical evaluation of scars", J CUTAN PATHOL, vol. 29, 2002, pages 27 - 32 |
NAITOH, M.; HOSOKAWA, N.; KUBOTA, H. ET AL.: "Upregulation of HSP47 and collagen type III in the dermal fibrotic disease, keloid.", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 280, 2001, pages 1316 - 1322 |
NAMBA, Y. ET AL.: "Clinical evaluation of tranilast on keloid and hypertrophic scar", JAPANESE JOURNAL OF BURN INJURIES, vol. 18, 1992, pages 30 - 45 |
OOURA, T. ET AL.: "Definition and Classification of Keloid Hypertrophic Scar", JAPANESE JOURNAL OF PLASTIC SURGERY, vol. 36, 1993, pages 265 - 274 |
OOURA, T. ET AL.: "Results of Experimental Use of Silicone Gel Sheet for Treatment of Hypertrophic Scar and Keloid", JOURNAL OF CLINICAL THERAPEUTICS AND MEDICINES, vol. 14, 1998, pages 2921 - 2937 |
PELTONEN, J.; HSIAO, L. L.; JAAKKOLA, S. ET AL.: "Activation of collagen gene expression in keloids: co-localization of type I and VI collagen and transforming growth factor-beta 1 mRNA", J. INVEST. DERMATOL., vol. 97, 1991, pages 240 - 248 |
PERKINS K ET AL.: "Silicone gel: a new treatment for burn scars and contractures", BURNS, vol. 9, 1983, pages 201 - 204 |
R. FUJIMORI: "Pressure therapy of keloids", J. OF OPERATION, vol. 44, 1990, pages 3 - 13 |
ROBLES DT; MOORE E; DRAZNIN M; BERG D. KELOIDS: "Pathology and management", DERMATOLOGY ONLINE JOURNAL, vol. 13, no. 3, 2007, pages 9 |
S. SUZUKI; H. SAITO; T. YAMAGATA; K. ANNO; N. SENO; Y. KAWAI; T. FURUHASHI, J. BIOL. CHEM., vol. 243, 1968, pages 1543 |
See also references of EP2223699A4 * |
SEIKAGAKU JITEN: "Kabushiki Kaisha Tokyo Kagaku Dojin", 20 November 1998, pages: 556, XP008128534 * |
SUZUKI, S., OPERATION: OPERATION OF KELOID AND/OR HYPERTROPHIC SCAR, vol. 50, 1996, pages 1557 - 1561 |
SUZUKI, S.: "Treatment of cicatricial keloid", MB DERMA, vol. 67, 2002, pages 134 - 138 |
SUZUKI, S.; FUJIMORI R.: "Treatment of itching of hypertrophic scar and keloid", MB DERMA, vol. 30, 1999, pages 14 - 19 |
SUZUKI, S.; NAITO, M.: "Treatment of keloids and hypertrophic scars", JAPAN MEDICAL JOURNAL, vol. 4516, 2003, pages 29 - 32 |
T. YAMAGATA, H.; SAITO, O.; HABUCHI, S. SUZUKI, J. BIOL. CHEM., vol. 243, 1968, pages 1523 |
T. YAMAGATA; H. SAITO; O. HABUCHI; S. SUZUKI, J. BIOL. CHEM., vol. 243, 1968, pages 1523 |
Y. M. MICHELACCI; C. P. DIETRICH, BIOCHEM. J., vol. 151, 1975, pages 121 |
Y. M. MICHELACCI; C. P.DIETRICH, BIOCHEM. BIOPHYS. RES. COMMUN., vol. 56, 1974, pages 973 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013039244A1 (ja) | 2011-09-15 | 2013-03-21 | 生化学工業株式会社 | 骨格筋再生促進剤 |
US9144601B2 (en) | 2011-09-15 | 2015-09-29 | Seikagaku Corporation | Skeletal muscle regeneration promoter |
JP2017537934A (ja) * | 2014-12-07 | 2017-12-21 | ヴェッスル セラピューティクス リミテッド | ケロイド瘢痕を処置するためのフィビュリン−5の使用 |
Also Published As
Publication number | Publication date |
---|---|
EP2223699A4 (en) | 2011-02-09 |
CN101969986B (zh) | 2015-08-19 |
JP2015227355A (ja) | 2015-12-17 |
EP2223699B1 (en) | 2014-08-20 |
CN101969986A (zh) | 2011-02-09 |
JP2014156482A (ja) | 2014-08-28 |
CA2708062A1 (en) | 2009-06-11 |
KR20100098401A (ko) | 2010-09-06 |
CN104940915A (zh) | 2015-09-30 |
JP5560491B2 (ja) | 2014-07-30 |
ES2523841T3 (es) | 2014-12-02 |
US20110008312A1 (en) | 2011-01-13 |
JPWO2009072654A1 (ja) | 2011-04-28 |
EP2223699A1 (en) | 2010-09-01 |
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