WO2009057790A1 - 骨及び軟骨形成タンパク質を含有する医薬品及び医療器具 - Google Patents
骨及び軟骨形成タンパク質を含有する医薬品及び医療器具 Download PDFInfo
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- WO2009057790A1 WO2009057790A1 PCT/JP2008/069980 JP2008069980W WO2009057790A1 WO 2009057790 A1 WO2009057790 A1 WO 2009057790A1 JP 2008069980 W JP2008069980 W JP 2008069980W WO 2009057790 A1 WO2009057790 A1 WO 2009057790A1
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- Prior art keywords
- bone
- repairing
- therapeutic agent
- jaw
- medicine
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/495—Transforming growth factor [TGF]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
Abstract
本発明は、生体内で強い炎症などの副作用を引き起こさず、骨芽細胞が存在するところでのみ作動し、軟骨形成を伴い自然治癒と同じ経過で骨形成を速やかに誘導する医薬の提供することを課題とする。本発明は、炎症を起こさずに骨を処置するための、NELL1を含む骨治療剤を提供することによって上記課題を解決した。本発明は、病巣掻爬もしくは切除後の骨欠損補填、骨折の治癒遷延、偽関節、仮骨延長術、人工関節置換術、脊椎固定術、軟骨移植、顎裂骨移植、外傷による骨欠損部補填、開頭術後骨欠損補填、歯槽提形成術、上顎洞底挙上術、歯槽骨再生、人工歯根周囲の顎骨再生等において用いられる。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-286810 | 2007-11-02 | ||
JP2007286810A JP2011016723A (ja) | 2007-11-02 | 2007-11-02 | 骨及び軟骨形成タンパク質を含有する医薬品及び医療器具 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009057790A1 true WO2009057790A1 (ja) | 2009-05-07 |
Family
ID=40591169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/069980 WO2009057790A1 (ja) | 2007-11-02 | 2008-10-31 | 骨及び軟骨形成タンパク質を含有する医薬品及び医療器具 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP2011016723A (ja) |
WO (1) | WO2009057790A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010016469A1 (ja) * | 2008-08-04 | 2010-02-11 | 片山化学工業株式会社 | Nell-1による組織・臓器異所再生制御技術 |
WO2016072396A1 (ja) * | 2014-11-04 | 2016-05-12 | 国立大学法人 東京医科歯科大学 | 骨形成因子安定保持剤、骨形成因子活性化剤、骨形成因子の安定保持方法、骨形成因子の活性化方法、医薬組成物、複合体の使用、及び骨の再生方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114010584B (zh) * | 2021-11-09 | 2023-10-20 | 华熙生物科技股份有限公司 | 一种抑菌创面修复凝胶及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999040220A2 (en) * | 1998-02-06 | 1999-08-12 | Glaxo Group Limited | Method of screening therapeutic agents |
WO2001056607A1 (fr) * | 2000-02-03 | 2001-08-09 | Eisai Co., Ltd. | Inhibiteurs de l'expression de l'integrine |
WO2004072100A2 (en) * | 2003-02-07 | 2004-08-26 | The Regents Of The University Of California | Nell peptide expression systems and bone formation activity of nell peptide |
WO2006089023A2 (en) * | 2005-02-16 | 2006-08-24 | The Regents Of The University Of California | Pharmaceutical compositions for treating or preventing bone conditions |
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2007
- 2007-11-02 JP JP2007286810A patent/JP2011016723A/ja not_active Withdrawn
-
2008
- 2008-10-31 WO PCT/JP2008/069980 patent/WO2009057790A1/ja active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999040220A2 (en) * | 1998-02-06 | 1999-08-12 | Glaxo Group Limited | Method of screening therapeutic agents |
WO2001056607A1 (fr) * | 2000-02-03 | 2001-08-09 | Eisai Co., Ltd. | Inhibiteurs de l'expression de l'integrine |
WO2004072100A2 (en) * | 2003-02-07 | 2004-08-26 | The Regents Of The University Of California | Nell peptide expression systems and bone formation activity of nell peptide |
WO2006089023A2 (en) * | 2005-02-16 | 2006-08-24 | The Regents Of The University Of California | Pharmaceutical compositions for treating or preventing bone conditions |
Non-Patent Citations (3)
Title |
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CHAE, H.J. ET AL.: "Mechanism of mitogenic effect of fluoride on fetal rat osteoblastic cells: evidence for Shc, Grb2 and P-CREB-dependent pathways", RES COMMUN MOL PATHOL PHARMACOL, vol. 105, no. 3, 1999, pages 185 - 99 * |
GE, C. ET AL.: "Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development", J CELL BIOL, vol. 176, no. 5, 2007, pages 709 - 18 * |
NOBUYUKI BOKUI ET AL.: "Mukessei Baiyo ni yori Tairyo Hatsugen Saseta Shinki Kotsukeisei Inshi NELL1 no Seikagakuteki Kaiseki", SEIKAGAKU, vol. 74, no. 8, 2002, pages 804 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010016469A1 (ja) * | 2008-08-04 | 2010-02-11 | 片山化学工業株式会社 | Nell-1による組織・臓器異所再生制御技術 |
WO2016072396A1 (ja) * | 2014-11-04 | 2016-05-12 | 国立大学法人 東京医科歯科大学 | 骨形成因子安定保持剤、骨形成因子活性化剤、骨形成因子の安定保持方法、骨形成因子の活性化方法、医薬組成物、複合体の使用、及び骨の再生方法 |
Also Published As
Publication number | Publication date |
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JP2011016723A (ja) | 2011-01-27 |
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