WO2009056862A3 - Dépistage de la susceptibilité au cancer de la prostate - Google Patents
Dépistage de la susceptibilité au cancer de la prostate Download PDFInfo
- Publication number
- WO2009056862A3 WO2009056862A3 PCT/GB2008/003711 GB2008003711W WO2009056862A3 WO 2009056862 A3 WO2009056862 A3 WO 2009056862A3 GB 2008003711 W GB2008003711 W GB 2008003711W WO 2009056862 A3 WO2009056862 A3 WO 2009056862A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- prostate cancer
- genes
- snp
- individuals
- psp94
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Un panneau de marqueurs de la susceptibilité au cancer de la prostate permet le dépistage pour identifier des personnes à haut risque de développer le cancer de la prostate. On peut offrir à de telles personnes un suivi et une gestion cliniques plus rapprochés pour assurer un diagnostic et une intervention au moment opportun. On a observé qu'un nombre de polymorphismes simple nucléotide (SNP) se lient à des sites/gènes qui sont susceptibles de jouer des rôles fonctionnel/causal dans le cancer de la prostate. Le SNP les plus étroitement associés (rs 10993994) est le 2bp en amont du site de début de la transcription du gène MSMB. Le gène MSMB code pour le PSP94 qui est un facteur de liaison à l'immunoglobuline qui est produit par les cellules épithéliales de la prostate et sécrété dans le fluide séminal. Il a été établi que la perte de PSP94 est associée à la récurrence tumorale chez des patients suivant une prostatectomie. La seconde association en termes d'importance est pour le SNP rs2735839 qui se situe entre les gènes de la kallikréine-2 et -3. Ces gènes ont également été liés au cancer de la prostate et proposés comme marqueurs possibles. D'autres SNP sont associés de manière significative à la susceptibilité de personnes au cancer de la prostate.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0721605A GB0721605D0 (en) | 2007-11-02 | 2007-11-02 | Prostrate cancer susceptibility screening |
GB0721605.4 | 2007-11-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009056862A2 WO2009056862A2 (fr) | 2009-05-07 |
WO2009056862A3 true WO2009056862A3 (fr) | 2009-07-23 |
Family
ID=38834783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2008/003711 WO2009056862A2 (fr) | 2007-11-02 | 2008-10-31 | Dépistage de la susceptibilité au cancer de la prostate |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB0721605D0 (fr) |
WO (1) | WO2009056862A2 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2294086T3 (en) | 2008-06-04 | 2018-01-02 | Modiquest B V | ANTI-INFLAMMATORY AGENTS |
SG186940A1 (en) | 2010-07-27 | 2013-02-28 | Genomic Health Inc | Method for using gene expression to determine prognosis of prostate cancer |
WO2012029080A1 (fr) * | 2010-08-30 | 2012-03-08 | Decode Genetics Ehf | Variants de séquence associés à des taux d'antigène spécifique de la prostate |
EP2611943B1 (fr) * | 2010-09-03 | 2017-01-04 | Wake Forest University Health Sciences | Procédés et compositions pour la corrélation de marqueurs génétiques au risque de cancer de la prostate |
US9534256B2 (en) | 2011-01-06 | 2017-01-03 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with risk of aggressive prostate cancer |
CN103060434B (zh) * | 2012-10-19 | 2014-07-23 | 卫生部北京医院 | 一种预测前列腺癌易感性的试剂和方法 |
CN103060432B (zh) * | 2012-10-19 | 2014-07-23 | 卫生部北京医院 | 一种预测前列腺癌易感性的方法和检测试剂盒 |
CN103432593B (zh) * | 2013-08-01 | 2015-04-15 | 中山大学附属肿瘤医院 | 一种用于预防或治疗食管癌的药物组合物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003009814A2 (fr) * | 2001-07-25 | 2003-02-06 | Millennium Pharmaceuticals, Inc. | Nouveaux genes, compositions, trousses et methodes d'identification, evaluation, prevention, et traitement du cancer de la prostate |
WO2005007830A2 (fr) * | 2003-07-14 | 2005-01-27 | Mayo Foundation For Medical Education And Research | Procedes et compositions pour diagnostic, stadage et pronostic du cancer de la prostate |
-
2007
- 2007-11-02 GB GB0721605A patent/GB0721605D0/en not_active Ceased
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2008
- 2008-10-31 WO PCT/GB2008/003711 patent/WO2009056862A2/fr active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003009814A2 (fr) * | 2001-07-25 | 2003-02-06 | Millennium Pharmaceuticals, Inc. | Nouveaux genes, compositions, trousses et methodes d'identification, evaluation, prevention, et traitement du cancer de la prostate |
WO2005007830A2 (fr) * | 2003-07-14 | 2005-01-27 | Mayo Foundation For Medical Education And Research | Procedes et compositions pour diagnostic, stadage et pronostic du cancer de la prostate |
Non-Patent Citations (7)
Title |
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AMUNDADOTTIR L T ET AL: "A common variant associated with prostate cancer in European and African populations", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, vol. 38, no. 6, 7 May 2006 (2006-05-07), pages 652 - 658, XP002396336, ISSN: 1061-4036 * |
BEKE L ET AL: "The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2", ONCOGENE, vol. 26, no. 31, July 2007 (2007-07-01), pages 4590 - 4595, XP002513955, ISSN: 0950-9232 * |
BUCKLAND PAUL R ET AL: "Strong bias the location of functional promoter polymorphisms", HUMAN MUTATION, vol. 26, no. 3, September 2005 (2005-09-01), pages 214 - 223, XP002513954, ISSN: 1059-7794 * |
EELES ROSALIND A ET AL: "Multiple newly identified loci associated with prostate cancer susceptibility", NATURE GENETICS, vol. 40, no. 3, March 2008 (2008-03-01), pages 316 - 321, XP002513956, ISSN: 1061-4036 * |
NAM ET AL: "A Novel Serum Marker, Total Prostate Secretory Protein of 94 Amino Acids, Improves Prostate Cancer Detection and Helps Identify High Grade Cancers at Diagnosis", JOURNAL OF UROLOGY, BALTIMORE, MD, US, vol. 175, no. 4, 1 April 2006 (2006-04-01), pages 1291 - 1297, XP005363045, ISSN: 0022-5347 * |
SCHAID D J: "The complex genetic epidemiology of prostate cancer", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, vol. 13, no. REVIEW NR 1, 28 January 2004 (2004-01-28), pages R103 - R121, XP002396337, ISSN: 0964-6906 * |
THOMAS GILLES ET AL: "Multiple loci identified in a genome-wide association study of prostate cancer", NATURE GENETICS, vol. 40, no. 3, March 2008 (2008-03-01), pages 310 - 315, XP002513957, ISSN: 1061-4036 * |
Also Published As
Publication number | Publication date |
---|---|
GB0721605D0 (en) | 2007-12-12 |
WO2009056862A2 (fr) | 2009-05-07 |
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