WO2009048039A1 - 分子・細胞イメージング方法及び半導体ナノ粒子 - Google Patents

分子・細胞イメージング方法及び半導体ナノ粒子 Download PDF

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Publication number
WO2009048039A1
WO2009048039A1 PCT/JP2008/068155 JP2008068155W WO2009048039A1 WO 2009048039 A1 WO2009048039 A1 WO 2009048039A1 JP 2008068155 W JP2008068155 W JP 2008068155W WO 2009048039 A1 WO2009048039 A1 WO 2009048039A1
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WIPO (PCT)
Prior art keywords
molecule
cell
imaging method
semiconductor nanoparticle
cell imaging
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PCT/JP2008/068155
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English (en)
French (fr)
Inventor
Kazuya Tsukada
Takuji Aimiya
Original Assignee
Konica Minolta Medical & Graphic, Inc.
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Publication date
Application filed by Konica Minolta Medical & Graphic, Inc. filed Critical Konica Minolta Medical & Graphic, Inc.
Publication of WO2009048039A1 publication Critical patent/WO2009048039A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

　細胞本来の挙動に関する精度の高い情報等が得られ、かつ細胞障害性が少ない分子・細胞イメージング方法及びそれに用いる半導体ナノ粒子を提供する。本発明の分子・細胞イメージング方法は、標的細胞にレーザーを照射することにより細胞内に蛍光標識物質を導入し、当該蛍光標識物質が発する蛍光により標的細胞内の分子を可視化する分子・細胞イメージング方法において、当該蛍光標識物質が半導体ナノ粒子からなることを特徴とする。
PCT/JP2008/068155 2007-10-12 2008-10-06 分子・細胞イメージング方法及び半導体ナノ粒子 WO2009048039A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007266310 2007-10-12
JP2007-266310 2007-10-12

Publications (1)

Publication Number Publication Date
WO2009048039A1 true WO2009048039A1 (ja) 2009-04-16

Family

ID=40549183

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068155 WO2009048039A1 (ja) 2007-10-12 2008-10-06 分子・細胞イメージング方法及び半導体ナノ粒子

Country Status (1)

Country Link
WO (1) WO2009048039A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021039592A1 (ja) * 2019-08-29 2021-03-04 コニカミノルタ株式会社 創薬支援方法、創薬支援装置及びプログラム

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004077389A (ja) * 2002-08-21 2004-03-11 Hitachi Software Eng Co Ltd 半導体ナノ粒子を含む機能性蛍光試薬
JP2005074552A (ja) * 2003-08-29 2005-03-24 Japan Science & Technology Agency コア・シェル構造体からなる発光体、それを用いた分子マーカー、光記録媒体並びにそれらの調製方法
JP2005168495A (ja) * 2003-11-17 2005-06-30 Japan Science & Technology Agency 細胞外物質の細胞内への導入方法
JP2005172429A (ja) * 2003-12-05 2005-06-30 Sony Corp 生体物質蛍光標識剤及び生体物質蛍光標識方法、並びにバイオアッセイ方法及び装置
JP2005287419A (ja) * 2004-03-31 2005-10-20 Hokkaido Univ レーザインジェクション方法および装置
JP2006000016A (ja) * 2004-06-15 2006-01-05 Fujitsu Ltd 物質注入装置および物質注入方法
WO2006096835A2 (en) * 2005-03-08 2006-09-14 Molecular Probes, Inc. Monitoring and manipulating cellular transmembrane potentials using nanostructures
WO2007086198A1 (ja) * 2006-01-27 2007-08-02 Konica Minolta Medical & Graphic, Inc. 半導体ナノ粒子蛍光体
WO2007086501A1 (ja) * 2006-01-27 2007-08-02 Konica Minolta Medical & Graphic, Inc. 生体物質の蛍光標識物質および生体物質の蛍光標識方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004077389A (ja) * 2002-08-21 2004-03-11 Hitachi Software Eng Co Ltd 半導体ナノ粒子を含む機能性蛍光試薬
JP2005074552A (ja) * 2003-08-29 2005-03-24 Japan Science & Technology Agency コア・シェル構造体からなる発光体、それを用いた分子マーカー、光記録媒体並びにそれらの調製方法
JP2005168495A (ja) * 2003-11-17 2005-06-30 Japan Science & Technology Agency 細胞外物質の細胞内への導入方法
JP2005172429A (ja) * 2003-12-05 2005-06-30 Sony Corp 生体物質蛍光標識剤及び生体物質蛍光標識方法、並びにバイオアッセイ方法及び装置
JP2005287419A (ja) * 2004-03-31 2005-10-20 Hokkaido Univ レーザインジェクション方法および装置
JP2006000016A (ja) * 2004-06-15 2006-01-05 Fujitsu Ltd 物質注入装置および物質注入方法
WO2006096835A2 (en) * 2005-03-08 2006-09-14 Molecular Probes, Inc. Monitoring and manipulating cellular transmembrane potentials using nanostructures
WO2007086198A1 (ja) * 2006-01-27 2007-08-02 Konica Minolta Medical & Graphic, Inc. 半導体ナノ粒子蛍光体
WO2007086501A1 (ja) * 2006-01-27 2007-08-02 Konica Minolta Medical & Graphic, Inc. 生体物質の蛍光標識物質および生体物質の蛍光標識方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021039592A1 (ja) * 2019-08-29 2021-03-04 コニカミノルタ株式会社 創薬支援方法、創薬支援装置及びプログラム

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