WO2009047498A3 - Mutant enzymes - Google Patents
Mutant enzymes Download PDFInfo
- Publication number
- WO2009047498A3 WO2009047498A3 PCT/GB2008/003407 GB2008003407W WO2009047498A3 WO 2009047498 A3 WO2009047498 A3 WO 2009047498A3 GB 2008003407 W GB2008003407 W GB 2008003407W WO 2009047498 A3 WO2009047498 A3 WO 2009047498A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mutant enzymes
- enzymes
- mutant
- oxidation
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/14—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (1.14.14)
- C12Y114/14001—Unspecific monooxygenase (1.14.14.1)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Processing Of Solid Wastes (AREA)
- Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010527539A JP5770474B2 (en) | 2007-10-08 | 2008-10-08 | Mutant enzyme |
US12/681,868 US9133443B2 (en) | 2007-10-08 | 2008-10-08 | Mutant enzymes |
CN200880119582.8A CN101889080B (en) | 2007-10-08 | 2008-10-08 | Mutant enzyme |
EP08806547.9A EP2207877B1 (en) | 2007-10-08 | 2008-10-08 | Mutant enzymes |
US14/852,218 US9834759B2 (en) | 2007-10-08 | 2015-09-11 | Mutant enzymes |
US15/802,321 US10501727B2 (en) | 2007-10-08 | 2017-11-02 | Mutant enzymes |
US16/672,220 US11155790B2 (en) | 2007-10-08 | 2019-11-01 | Mutant enzymes |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0719620.7A GB0719620D0 (en) | 2007-10-08 | 2007-10-08 | Mutant Enzymes |
GB0719620.7 | 2007-10-08 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/681,868 A-371-Of-International US9133443B2 (en) | 2007-10-08 | 2008-10-08 | Mutant enzymes |
US14/852,218 Division US9834759B2 (en) | 2007-10-08 | 2015-09-11 | Mutant enzymes |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009047498A2 WO2009047498A2 (en) | 2009-04-16 |
WO2009047498A3 true WO2009047498A3 (en) | 2009-06-04 |
Family
ID=38739292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2008/003407 WO2009047498A2 (en) | 2007-10-08 | 2008-10-08 | Mutant enzymes |
Country Status (6)
Country | Link |
---|---|
US (4) | US9133443B2 (en) |
EP (3) | EP2207877B1 (en) |
JP (2) | JP5770474B2 (en) |
CN (3) | CN101889080B (en) |
GB (1) | GB0719620D0 (en) |
WO (1) | WO2009047498A2 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0719620D0 (en) * | 2007-10-08 | 2007-11-14 | Isis Innovation | Mutant Enzymes |
PL2773751T3 (en) * | 2011-11-01 | 2017-08-31 | Firmenich Sa | Cytochrome p450 and use thereof for the enzymatic oxidation of terpenes |
KR101401468B1 (en) * | 2011-11-15 | 2014-05-30 | 전남대학교산학협력단 | Novel preparation method of metabolites of atorvastatin using bacterial cytochrome P450 and composition therefor |
WO2013076258A2 (en) * | 2011-11-23 | 2013-05-30 | Dsm Ip Assets B.V. | P450 bm3 mutants and their use for regio- and stereoselective hydroxylation of alpha-and beta-ionone |
WO2013160365A1 (en) * | 2012-04-24 | 2013-10-31 | Dsm Ip Assets B.V. | Stereoselective hydroxylation of benzenes |
EP2906518A4 (en) | 2012-10-09 | 2016-07-27 | California Inst Of Techn | In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes |
WO2014058729A1 (en) * | 2012-10-09 | 2014-04-17 | California Institute Of Technology | In vivo and in vitro carbene insertion and nitrene transfer reactions catalyzed by heme enzymes |
WO2014070673A1 (en) | 2012-10-29 | 2014-05-08 | University Of Rochester | Artemisinin derivatives, methods for their preparation and their use as antimalarial agents |
US9399762B2 (en) | 2014-02-18 | 2016-07-26 | California Institute Of Technology | Methods and systems for sulfimidation or sulfoximidation of organic molecules |
US9708587B2 (en) | 2014-07-09 | 2017-07-18 | Codexis, Inc. | P450-BM3 variants with improved activity |
US9683220B2 (en) * | 2015-07-07 | 2017-06-20 | Codexis, Inc. | P450-BM3 variants with improved activity |
CN106701850B (en) * | 2016-11-10 | 2020-08-28 | 中国科学院成都生物研究所 | Function of novel cytochrome P450 oxidase |
MX2020008073A (en) * | 2018-01-31 | 2020-11-13 | Univ Michigan Regents | Biocatalyst and methods for synthesizing mixed disulfide conjugates of thienopyridine compounds. |
CN110628841B (en) * | 2018-06-25 | 2021-11-23 | 中国科学院天津工业生物技术研究所 | Novel method for synthesizing key intermediate of dextromethorphan through enzyme catalysis asymmetry |
CN110819641B (en) * | 2019-12-02 | 2021-04-06 | 河南农业大学 | Application of olefin hydratase in preparation of primary alcohol |
CN113106073B (en) * | 2020-01-20 | 2022-09-20 | 中国科学院青岛生物能源与过程研究所 | Mutant for synergistically and selectively catalyzing hydroxylation of toluene and analogue and application thereof |
EP3858986A1 (en) * | 2020-02-03 | 2021-08-04 | Bayer Aktiengesellschaft | P450 bm3 monooxygenase variants for c19-hydroxylation of steroids |
CN113774033B (en) * | 2021-06-11 | 2023-10-24 | 合肥生融生物科技有限公司 | Artificial biocatalyst for converting fatty acid into beta-hydroxy fatty acid |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0361490A (en) * | 1989-07-28 | 1991-03-18 | Sumitomo Chem Co Ltd | P450 reductase-fused oxidase |
WO2001007574A2 (en) * | 1999-07-27 | 2001-02-01 | Basf Aktiengesellschaft | Modified cytochrome p450 monooxygenases |
WO2005017106A2 (en) * | 2003-06-17 | 2005-02-24 | California Institute Of Technology | Libraries of optimized cytochrome p450 enzymes and the optimized p450 enzymes |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
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DE3629890A1 (en) | 1986-08-29 | 1988-03-10 | Schering Ag | MICROORGANISMS AND PLASMIDES FOR THE 2,4-DICHLORPHENOXYACETIC ACID (2,4-D) MONOOXIGENASE - FORMATION AND METHOD FOR PRODUCING THIS PLASMIDE AND STEM |
FR2693207B1 (en) | 1992-07-03 | 1994-09-30 | Orsan | Yeast strain allowing the co-expression of a heterogeneous cytochrome P450 monooxygenase activity and an endogenous or heterologous NADPH-cytochrome P450-reductase and its use for bioconversion purposes. |
JP3061490B2 (en) | 1992-11-30 | 2000-07-10 | 日本インテック株式会社 | Electrolytic ionic water generator |
GB9422205D0 (en) | 1994-11-03 | 1994-12-21 | British Gas Plc | Enzyme mutant and method |
CA2236381A1 (en) * | 1995-11-01 | 1997-05-09 | Bg Plc | Mutant mono-oxygenase cytochrome p450cam |
AU716583B2 (en) * | 1995-11-01 | 2000-03-02 | Bg Plc | Mutant mono-oxygenase cytochome P450cam |
US5763237A (en) * | 1996-05-21 | 1998-06-09 | Board Of Trustees Operating Michigan State University | Method for production of monoterpene derivatives of limonene |
GB9825421D0 (en) | 1998-11-19 | 1999-01-13 | Isis Innovation | Process for oxidising terpenes |
GB9914373D0 (en) * | 1999-06-18 | 1999-08-18 | Isis Innovation | Process for oxidising aromatic compounds |
AU5805400A (en) | 1999-07-09 | 2001-01-30 | Novo Nordisk A/S | A process for preparing an enzyme containing granule |
MY126592A (en) * | 1999-07-27 | 2006-10-31 | Basf Ag | Novel cytochrome p450 monooxygenases and their use for the oxidation of organic compounds |
AU2002307340A1 (en) | 2001-04-16 | 2002-10-28 | California Institute Of Technology | Peroxide-driven cytochrome p450 oxygenase variants |
JP3548168B2 (en) * | 2001-06-11 | 2004-07-28 | 株式会社永田農業研究所 | How to grow nitrogen-free fertilizer rice |
US7777097B2 (en) * | 2001-06-22 | 2010-08-17 | Syngenta Participations Ag | Plant disease resistance genes |
WO2003008563A2 (en) | 2001-07-20 | 2003-01-30 | California Institute Of Technology | Improved cytochrome p450 oxygenases |
EP1570407A2 (en) * | 2002-10-28 | 2005-09-07 | Commissariat A L'energie Atomique | A method for performing restrained dynamics docking of one or multiple substrates on multi-specific enzymes |
US7524664B2 (en) | 2003-06-17 | 2009-04-28 | California Institute Of Technology | Regio- and enantioselective alkane hydroxylation with modified cytochrome P450 |
DK1660646T3 (en) | 2003-08-11 | 2015-03-09 | California Inst Of Techn | Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use |
GB0403992D0 (en) | 2004-02-23 | 2004-03-31 | Isis Innovation | Oxidation by hydrogen peroxide |
EP1899471A4 (en) * | 2005-03-28 | 2009-11-25 | California Inst Of Techn | Alkane oxidation by modified hydroxylases |
US8252559B2 (en) * | 2006-08-04 | 2012-08-28 | The California Institute Of Technology | Methods and systems for selective fluorination of organic molecules |
JP4532450B2 (en) | 2006-09-06 | 2010-08-25 | 株式会社デンソー | Engine control data processing apparatus and engine control apparatus |
GB0719620D0 (en) * | 2007-10-08 | 2007-11-14 | Isis Innovation | Mutant Enzymes |
EP3674414A1 (en) | 2015-08-12 | 2020-07-01 | CeMM - Forschungszentrum für Molekulare Medizin GmbH | Methods for studying nucleic acids |
-
2007
- 2007-10-08 GB GBGB0719620.7A patent/GB0719620D0/en not_active Ceased
-
2008
- 2008-10-08 WO PCT/GB2008/003407 patent/WO2009047498A2/en active Application Filing
- 2008-10-08 EP EP08806547.9A patent/EP2207877B1/en active Active
- 2008-10-08 EP EP12184552.3A patent/EP2548952B1/en active Active
- 2008-10-08 JP JP2010527539A patent/JP5770474B2/en active Active
- 2008-10-08 US US12/681,868 patent/US9133443B2/en active Active
- 2008-10-08 CN CN200880119582.8A patent/CN101889080B/en active Active
- 2008-10-08 CN CN202110384963.6A patent/CN113293150A/en active Pending
- 2008-10-08 CN CN201510867081.XA patent/CN105441397B/en active Active
- 2008-10-08 EP EP16163352.4A patent/EP3061811B1/en active Active
-
2015
- 2015-07-01 JP JP2015132299A patent/JP6165198B2/en active Active
- 2015-09-11 US US14/852,218 patent/US9834759B2/en active Active
-
2017
- 2017-11-02 US US15/802,321 patent/US10501727B2/en active Active
-
2019
- 2019-11-01 US US16/672,220 patent/US11155790B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0361490A (en) * | 1989-07-28 | 1991-03-18 | Sumitomo Chem Co Ltd | P450 reductase-fused oxidase |
WO2001007574A2 (en) * | 1999-07-27 | 2001-02-01 | Basf Aktiengesellschaft | Modified cytochrome p450 monooxygenases |
WO2005017106A2 (en) * | 2003-06-17 | 2005-02-24 | California Institute Of Technology | Libraries of optimized cytochrome p450 enzymes and the optimized p450 enzymes |
Non-Patent Citations (6)
Title |
---|
CHANG Y-T ET AL: "Homology modeling and substrate binding study of human CYP4A11 enzyme", PROTEINS: STRUCTURE, FUNCTION AND GENETICS, JOHN WILEY & SONS, INC, US, vol. 34, no. 3, 15 February 1999 (1999-02-15), pages 403 - 415, XP002380990, ISSN: 0887-3585 * |
LI HUIYING ET AL: "THE STRUCTURE OF THE CYTOCHROME P450BM-3 HAEM DOMAIN COMPLEXED WITH THE FATTY ACID SUBSTRATE, PALMITOLEIC ACID", NATURE STRUCTURAL BIOLOGY, NEW YORK, NY, US, vol. 4, no. 2, 1 January 1997 (1997-01-01), pages 140 - 146, XP008071368, ISSN: 1072-8368 * |
MUNRO ET AL: "Cytochrome P450-redox partner fusion enzymes", BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 1770, no. 3, 25 January 2007 (2007-01-25), pages 345 - 359, XP005858786, ISSN: 0304-4165 * |
WHITEHOUSE C. ET AL.: "Desaturation of Alkylbenzenes by Cytochrome P450BM3 (CYP102A1)", CHEM. EUR. J., vol. 14, 10 November 2008 (2008-11-10), pages 10905 - 10908, XP002507287, Retrieved from the Internet <URL:http://www3.interscience.wiley.com/cgi-bin/fulltext/121506354/PDFSTART> [retrieved on 20081208] * |
WHITEHOUSE CHRISTOPHER J C ET AL: "Evolved CYP102A1 (P450BM3) variants oxidise a range of non-natural substrates and offer new selectivity options.", CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND) 28 FEB 2008, no. 8, 28 February 2008 (2008-02-28), pages 966 - 968, XP002507286, ISSN: 1359-7345 * |
YUN ET AL: "The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 25, no. 7, 14 June 2007 (2007-06-14), pages 289 - 298, XP022116339, ISSN: 0167-7799 * |
Also Published As
Publication number | Publication date |
---|---|
US10501727B2 (en) | 2019-12-10 |
JP6165198B2 (en) | 2017-07-19 |
US20150376580A1 (en) | 2015-12-31 |
EP3061811B1 (en) | 2018-03-28 |
CN105441397A (en) | 2016-03-30 |
JP2010539967A (en) | 2010-12-24 |
EP2548952A3 (en) | 2013-09-18 |
GB0719620D0 (en) | 2007-11-14 |
JP5770474B2 (en) | 2015-08-26 |
US9834759B2 (en) | 2017-12-05 |
US20200056163A1 (en) | 2020-02-20 |
CN113293150A (en) | 2021-08-24 |
CN101889080B (en) | 2016-01-20 |
EP2207877A2 (en) | 2010-07-21 |
CN101889080A (en) | 2010-11-17 |
EP2207877B1 (en) | 2016-01-13 |
JP2016000037A (en) | 2016-01-07 |
WO2009047498A2 (en) | 2009-04-16 |
CN105441397B (en) | 2021-03-30 |
US20180148695A1 (en) | 2018-05-31 |
EP2548952B1 (en) | 2017-12-06 |
EP3061811A1 (en) | 2016-08-31 |
US9133443B2 (en) | 2015-09-15 |
US20100240106A1 (en) | 2010-09-23 |
US11155790B2 (en) | 2021-10-26 |
EP2548952A2 (en) | 2013-01-23 |
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