WO2009044846A1 - 薬物誘発性リン脂質症の予測方法 - Google Patents
薬物誘発性リン脂質症の予測方法 Download PDFInfo
- Publication number
- WO2009044846A1 WO2009044846A1 PCT/JP2008/068034 JP2008068034W WO2009044846A1 WO 2009044846 A1 WO2009044846 A1 WO 2009044846A1 JP 2008068034 W JP2008068034 W JP 2008068034W WO 2009044846 A1 WO2009044846 A1 WO 2009044846A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- induced phospholipidosis
- amount
- predicting drug
- drug
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
- G01N2333/918—Carboxylic ester hydrolases (3.1.1)
- G01N2333/92—Triglyceride splitting, e.g. by means of lipase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009536096A JP5062578B2 (ja) | 2007-10-04 | 2008-10-03 | 薬物誘発性リン脂質症の予測方法 |
CA2697988A CA2697988A1 (en) | 2007-10-04 | 2008-10-03 | Method of predicting drug-induced phospholipidosis |
US12/674,771 US20110117588A1 (en) | 2007-10-04 | 2008-10-03 | Method of predicting drug-induced phospholipidosis |
EP08835363A EP2194141A4 (en) | 2007-10-04 | 2008-10-03 | METHOD FOR PREDICTING MEDICINE-INDUCED PHOSPHOLIPIDOSIS |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-261125 | 2007-10-04 | ||
JP2007261125 | 2007-10-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009044846A1 true WO2009044846A1 (ja) | 2009-04-09 |
Family
ID=40526268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/068034 WO2009044846A1 (ja) | 2007-10-04 | 2008-10-03 | 薬物誘発性リン脂質症の予測方法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20110117588A1 (ja) |
EP (1) | EP2194141A4 (ja) |
JP (1) | JP5062578B2 (ja) |
CA (1) | CA2697988A1 (ja) |
WO (1) | WO2009044846A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013114233A (ja) * | 2011-11-30 | 2013-06-10 | Olympus Corp | 画像処理装置、顕微鏡システム、画像処理方法、及び画像処理プログラム |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9841426B2 (en) * | 2009-03-11 | 2017-12-12 | Marker Gene Technologies, Inc | Intracellular organelle peptide targeted enzyme substrates |
US20200147070A1 (en) * | 2017-05-17 | 2020-05-14 | Nextcea Inc. | Inducing phospholipidosis for enhancing therapeutic efficacy |
CN108929373A (zh) * | 2017-05-22 | 2018-12-04 | 苏州偶领生物医药有限公司 | 一种共价键修饰哺乳动物atg8 同源物的方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006112947A (ja) | 2004-10-15 | 2006-04-27 | Sumitomo Chemical Co Ltd | 物質が有するホスホリピドーシス誘発能力の検定方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2434445A (en) * | 2006-01-13 | 2007-07-25 | Cytokinetics Inc | Assay for phospholipidosis |
-
2008
- 2008-10-03 CA CA2697988A patent/CA2697988A1/en not_active Abandoned
- 2008-10-03 JP JP2009536096A patent/JP5062578B2/ja not_active Expired - Fee Related
- 2008-10-03 EP EP08835363A patent/EP2194141A4/en not_active Withdrawn
- 2008-10-03 WO PCT/JP2008/068034 patent/WO2009044846A1/ja active Application Filing
- 2008-10-03 US US12/674,771 patent/US20110117588A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006112947A (ja) | 2004-10-15 | 2006-04-27 | Sumitomo Chemical Co Ltd | 物質が有するホスホリピドーシス誘発能力の検定方法 |
Non-Patent Citations (24)
Title |
---|
"Dai 35 Kai Annual Meeting of the Japanese Society of Toxicology", 25 June 2008, article KAZUHIKO IKEDA ET AL.: "Shinki in vitro Phospholipidosis Screening-kei no Kochiku" * |
"Meth. Enzymol.", vol. 70, article "Immunochemical Techniques" |
ANDERSON N. ET AL: "Drug-induced phospholipidosis.", FEBS LETT., vol. 580, September 2006 (2006-09-01), pages 5533 - 5540, XP025232693 * |
ATIENZAR F. ET AL: "Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells.", TOXICOL. SCI., vol. 96, no. 1, March 2007 (2007-03-01), pages 101 - 114, XP003026555 * |
BARITUSSIO A. ET AL: "Amiodarone inhibits lung degradation of SP-A and perturbs the distribution of lysosomal enzymes.", AM. J. PHYSIOL. LUNG CELL. MOL. PHYSIOL., vol. 281, November 2001 (2001-11-01), pages 1189 - 1199, XP003026552 * |
BIOCHEM. PHARMACOL., vol. 53, 1997, pages 1521 - 32 |
BIOCHEM. PHARMACOL., vol. 62, 2001, pages 1661 - 73 |
BIOCHIM. BIOPHYS. ACTA, vol. 1631, 2003, pages 136 - 46 |
CELL BIOL. TOXICOL., vol. 19, 2003, pages 161 - 76 |
FUJIMURA H. ET AL: "Cell-based fluorescence assay for evaluation of new-drugs potential for phospholipidosis in an early stage of drug development.", EXP. TOXICOL. PATHOL., vol. 58, August 2007 (2007-08-01), pages 375 - 382, XP022155499 * |
J. BIOCHEM, vol. 125, 1999, pages 1137 - 1143 |
KASAHARA T. ET AL: "Establishment of an in vitro high-throughput screening assay for detecting phospholipidosis-inducing potential.", TOXICOL. SCI., vol. 90, no. 1, December 2005 (2005-12-01), pages 133 - 141, XP003026554 * |
METHODS IN ENZYMOLOGY, vol. 80, 1981, pages 535 - 561 |
NIOI P. ET AL: "vitro detection of drug- induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies.", TOXICOL. SCI., vol. 99, no. 1, September 2007 (2007-09-01), pages 162 - 173, XP003026556 * |
PROCEEDING OF THE SOCIETY FOR THE BIOLOGICAL MEDICINE, vol. 73, 1950, pages 1 |
PROG. NEUROBIOL., vol. 60, 2000, pages 501 - 12 |
SCIENCE, vol. 122, 1952, pages 501 |
See also references of EP2194141A4 * |
SEWELL R. B. ET AL: "Perhexilene: effects on hepatic lysosomal function in rats.", CLIN. EXP. PHARMACOL. PHYSIOL., vol. 16, January 1989 (1989-01-01), pages 25 - 32, XP003026553 * |
THE EMBO JOURNAL, vol. 12, 1993, pages 5219 - 5223 |
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 199, 1967, pages 519 |
TOXICOL. SCI., vol. 83, 2005, pages 282 - 92 |
TOXICOL. SCI., vol. 90, 2006, pages 133 - 41 |
VIROLOGY, vol. 8, 1959, pages 396 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013114233A (ja) * | 2011-11-30 | 2013-06-10 | Olympus Corp | 画像処理装置、顕微鏡システム、画像処理方法、及び画像処理プログラム |
US9632300B2 (en) | 2011-11-30 | 2017-04-25 | Olympus Corporation | Image processing apparatus, microscope system, image processing method, and computer-readable recording medium |
Also Published As
Publication number | Publication date |
---|---|
EP2194141A1 (en) | 2010-06-09 |
JPWO2009044846A1 (ja) | 2011-02-10 |
EP2194141A4 (en) | 2010-10-20 |
JP5062578B2 (ja) | 2012-10-31 |
CA2697988A1 (en) | 2009-04-09 |
US20110117588A1 (en) | 2011-05-19 |
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