WO2009044531A1 - β－アミノ酸の製造方法 - Google Patents

β－アミノ酸の製造方法 Download PDF

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Publication number
WO2009044531A1
WO2009044531A1 PCT/JP2008/002724 JP2008002724W WO2009044531A1 WO 2009044531 A1 WO2009044531 A1 WO 2009044531A1 JP 2008002724 W JP2008002724 W JP 2008002724W WO 2009044531 A1 WO2009044531 A1 WO 2009044531A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
producing
aminomutase
synthesizing
precipitated
Prior art date
Application number
PCT/JP2008/002724
Other languages
English (en)
French (fr)
Inventor
Tomonori Hidesaki
Original Assignee
Mitsui Chemicals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals, Inc. filed Critical Mitsui Chemicals, Inc.
Priority to CN200880108775.3A priority Critical patent/CN101809159B/zh
Priority to US12/681,139 priority patent/US8895270B2/en
Priority to JP2009535964A priority patent/JP5307721B2/ja
Priority to EP08835248.9A priority patent/EP2216410B1/en
Publication of WO2009044531A1 publication Critical patent/WO2009044531A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/222—Phenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/225—Tyrosine; 3,4-Dihydroxyphenylalanine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　β－アミノ酸の製造方法は、アミノ酸アミノムターゼの存在下、α－アミノ酸からβ－アミノ酸を合成する工程を含み、反応液中でβ－アミノ酸を固体として析出させる。
PCT/JP2008/002724 2007-10-01 2008-09-30 β－アミノ酸の製造方法 WO2009044531A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN200880108775.3A CN101809159B (zh) 2007-10-01 2008-09-30 β-氨基酸的制造方法
US12/681,139 US8895270B2 (en) 2007-10-01 2008-09-30 Method for producing β-Phenylalanine
JP2009535964A JP5307721B2 (ja) 2007-10-01 2008-09-30 （Ｓ）−β−フェニルアラニンの製造方法
EP08835248.9A EP2216410B1 (en) 2007-10-01 2008-09-30 Method for producing (s)-beta-phenylalanine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-257425 2007-10-01
JP2007257425 2007-10-01

Publications (1)

Publication Number Publication Date
WO2009044531A1 true WO2009044531A1 (ja) 2009-04-09

Family

ID=40525963

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/002724 WO2009044531A1 (ja) 2007-10-01 2008-09-30 β－アミノ酸の製造方法

Country Status (5)

Country Link
US (1) US8895270B2 (ja)
EP (1) EP2216410B1 (ja)
JP (1) JP5307721B2 (ja)
CN (1) CN101809159B (ja)
WO (1) WO2009044531A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108707597A (zh) * 2018-06-06 2018-10-26 安徽工程大学 一种固化的苯丙氨酸变位酶及其固化方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62288A (ja) * 1985-03-09 1987-01-06 Sanraku Inc 発酵法によるｌ−アミノ酸の製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3660235A (en) * 1969-08-22 1972-05-02 Ajinomoto Kk Method for producing phenylalanine by fermentation
JP2958789B2 (ja) * 1990-01-22 1999-10-06 味の素株式会社 アミノ酸・核酸およびその誘導体の精製方法
FR2686898B1 (fr) * 1992-01-30 1996-09-20 Ajinomoto Kk Methode de production de la l-phenylalanine.
JP3753465B2 (ja) 1995-03-03 2006-03-08 三菱レイヨン株式会社 微生物によるアミノ酸の製造法
US7452701B2 (en) * 1998-11-24 2008-11-18 Wisconsin Alumni Research Foundation Methods for the preparation of β-amino acids
US6521748B2 (en) * 1999-08-06 2003-02-18 E. I. Du Pont De Nemours And Company Polynucleotide encoding a mutant Rhodotorula glutinis tyrosine ammonia lyase polypeptide
JP4599726B2 (ja) * 2001-02-20 2010-12-15 味の素株式会社 Ｌ−グルタミン酸の製造法
WO2008129873A1 (ja) * 2007-04-13 2008-10-30 Mitsui Chemicals, Inc. Ｓ体選択性フェニルアラニンアミノムターゼ、これをコードするＤＮＡ及び（Ｓ）－β－フェニルアラニンの製造方法並びに（Ｓ）－β－フェニルアラニン類似体の製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62288A (ja) * 1985-03-09 1987-01-06 Sanraku Inc 発酵法によるｌ−アミノ酸の製造方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY, vol. 42, 2003, pages 12708 - 12718
BIOCHEMISTRY, vol. 46, 2007, pages 9785 - 9794
CHRISTENSON S.D.: "Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis", BIOCHEMISTRY, vol. 42, no. 43, 4 November 2003 (2003-11-04), pages 12708 - 12718, XP008134704 *
FORTIN P.D. ET AL.: "A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines", NATURE, vol. 448, no. 7155, 16 August 2007 (2007-08-16), pages 824 - 827, XP008134706 *
J.AM.CHEM.SOC., vol. 129, 2007, pages 6988 - 6989
MUTATU W. ET AL.: "Unusual mechanism for an aminomutase rearrangement: retention of configuration at the migration termini", BIOCHEMISTRY, vol. 46, no. 34, 28 August 2007 (2007-08-28), pages 9785 - 9794, XP008134703 *
NATURE, vol. 448, 2007, pages 824 - 827

Also Published As

Publication number Publication date
CN101809159B (zh) 2014-11-26
CN101809159A (zh) 2010-08-18
EP2216410A4 (en) 2013-09-18
EP2216410B1 (en) 2018-04-18
US20100221793A1 (en) 2010-09-02
JPWO2009044531A1 (ja) 2011-02-03
EP2216410A1 (en) 2010-08-11
JP5307721B2 (ja) 2013-10-02
US8895270B2 (en) 2014-11-25

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