WO2009038659A3 - Nanoparticules de silice organiquement modifiées avec des photosensibilisateurs incorporés par covalence pour l'administration de médicaments lors d'une thérapie photodynamique - Google Patents

Nanoparticules de silice organiquement modifiées avec des photosensibilisateurs incorporés par covalence pour l'administration de médicaments lors d'une thérapie photodynamique Download PDF

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Publication number
WO2009038659A3
WO2009038659A3 PCT/US2008/010608 US2008010608W WO2009038659A3 WO 2009038659 A3 WO2009038659 A3 WO 2009038659A3 US 2008010608 W US2008010608 W US 2008010608W WO 2009038659 A3 WO2009038659 A3 WO 2009038659A3
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WO
WIPO (PCT)
Prior art keywords
photosensitizers
nanoparticles
imaging agents
covalently linked
photosensitizer
Prior art date
Application number
PCT/US2008/010608
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English (en)
Other versions
WO2009038659A2 (fr
Inventor
Ravindra Pandey
Lalit Goswami
Allan Oseroff
Janet Morgan
Paras Prasad
Earl Bergey
Tymish Ohulchanskyy
Indrajit Roy
Original Assignee
Health Research, Inc.
The Research Foundation Of State University Of New York
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Application filed by Health Research, Inc., The Research Foundation Of State University Of New York filed Critical Health Research, Inc.
Publication of WO2009038659A2 publication Critical patent/WO2009038659A2/fr
Publication of WO2009038659A3 publication Critical patent/WO2009038659A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des nanoparticules contenant des photosensibilisateurs liés par covalence qui remédient au problème de la libération prématurée et améliorent donc le résultat de la PDT. L'invention concerne des nanoparticules à base de silice qui contiennent au moins un photosensibilisateur lié par covalence. Le photosensibilisateur est de préférence constitué de composés à base de tétrapyrrole de types porphyrines, chlorines, bactériochlorines, benzochlorines, dérivés de benzoporphyrine, phéophorbides, notamment pyrophéophorbides, et phthalocyanines, naphthanocyanines avec et sans systèmes de cycles condensés et dérivés de tous les composés ci-dessus. La nanoparticule peut également comprendre des agents d'imagerie liés par covalence, par exemple radionucléides, agents d'imagerie par résonance magnétique (RM) et fluorescence. Les agents d'imagerie et les photosensibilisateurs peuvent se trouver à la périphérie (surface) des nanoparticules pour augmenter leur efficacité. Des nanoparticules spécifiques d'une cible peuvent être obtenues en incorporant des molécules de ciblage biologique, comme des anticorps spécifiques sur la surface, qui réagissent avec des ligands particuliers pour obtenir une spécificité de cible. Des agents de diagnostic peuvent être présents dans l'anticorps en plus d'agents d'imagerie et de photosensibilisateurs spécifiques d'une tumeur.
PCT/US2008/010608 2007-09-14 2008-09-11 Nanoparticules de silice organiquement modifiées avec des photosensibilisateurs incorporés par covalence pour l'administration de médicaments lors d'une thérapie photodynamique WO2009038659A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99380707P 2007-09-14 2007-09-14
US60/993,807 2007-09-14

Publications (2)

Publication Number Publication Date
WO2009038659A2 WO2009038659A2 (fr) 2009-03-26
WO2009038659A3 true WO2009038659A3 (fr) 2009-09-03

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PCT/US2008/010608 WO2009038659A2 (fr) 2007-09-14 2008-09-11 Nanoparticules de silice organiquement modifiées avec des photosensibilisateurs incorporés par covalence pour l'administration de médicaments lors d'une thérapie photodynamique

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WO (1) WO2009038659A2 (fr)

Cited By (1)

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CN110718966B (zh) * 2019-10-25 2020-12-25 云南电网有限责任公司信息中心 一种电力设备数据采集及管理方法

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GB2464958A (en) * 2008-10-31 2010-05-05 Univ Muenster Wilhelms A method for the manufacture of a photosensitising nano-material
AU2009347929A1 (en) * 2009-06-12 2012-01-19 Amrita Vishwa Vidyapeetham University Targeted nano-photomedicines for photodynamic therapy of cancer
FR2956109B1 (fr) * 2010-02-11 2012-04-20 Commissariat Energie Atomique Procede de preparation par voie stober de particules de silice contenant un derive de phtalocyanine, lesdites particules et leurs utilisations.
US8609837B2 (en) 2010-07-06 2013-12-17 Health Research, Inc. Metallation enhancements in tumor-imaging and PDT therapy
EP2484388A1 (fr) * 2011-02-05 2012-08-08 MaRVis Technologies GmbH Dispositif médical implantable ou insérable détectable par IRM doté d'un revêtement comportant des ions paramagnétiques et son procédé de préparation
CN103827126B (zh) * 2011-11-18 2017-05-17 株式会社艾迪科 新型化合物和担载该新型化合物的担载体
EP2692365A1 (fr) 2012-08-03 2014-02-05 MaRVis Medical GmbH Dispositif médical implantable ou insérable détectable par IRM doté dýun revêtement comportant des ions paramagnétiques et son procédé de préparation
KR102237799B1 (ko) 2012-11-14 2021-04-08 더블유.알. 그레이스 앤드 캄파니-콘. 생물학적 활성 물질 및 비-정렬된 무기 산화물을 함유하는 조성물
US9119875B2 (en) 2013-03-14 2015-09-01 International Business Machines Corporation Matrix incorporated fluorescent porous and non-porous silica particles for medical imaging
PT107125B (pt) * 2013-08-23 2019-02-13 Inst Superior Tecnico Nanossistema multifuncional superparamagnético como agente de contraste para imagem por ressonância magnética e seu método de produção
WO2016094991A1 (fr) * 2014-12-16 2016-06-23 Universidade Estadual De Campinas - Unicamp Procédé d'obtention de nanoparticules de silice pégylées transporteuses d'agences pharmaceutiques hydrophobes, nanoparticules ainsi obtenues et leurs utilisations
CN113546042A (zh) * 2021-07-22 2021-10-26 中国药科大学 一种基于切伦科夫效应的酸响应纳米胶束及其制备方法和应用
CN115364211B (zh) * 2022-08-02 2023-12-22 北京大学 超小酞菁共轭介孔二氧化硅纳米粒子及其作为声敏剂的应用

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US5648485A (en) * 1994-10-26 1997-07-15 University Of British Columbia β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
US20030157021A1 (en) * 1995-02-02 2003-08-21 Jo Klaveness Light imaging contrast agents
US20040180096A1 (en) * 2003-01-24 2004-09-16 Paras Prasad Ceramic based nanoparticles for entrapping therapeutic agents for photodynamic therapy and method of using same

Patent Citations (3)

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US5648485A (en) * 1994-10-26 1997-07-15 University Of British Columbia β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
US20030157021A1 (en) * 1995-02-02 2003-08-21 Jo Klaveness Light imaging contrast agents
US20040180096A1 (en) * 2003-01-24 2004-09-16 Paras Prasad Ceramic based nanoparticles for entrapping therapeutic agents for photodynamic therapy and method of using same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110718966B (zh) * 2019-10-25 2020-12-25 云南电网有限责任公司信息中心 一种电力设备数据采集及管理方法

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Publication number Publication date
WO2009038659A2 (fr) 2009-03-26

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