WO2009033053A1 - Système distributeur de gouttes dosées à bouton-poussoir - Google Patents

Système distributeur de gouttes dosées à bouton-poussoir Download PDF

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Publication number
WO2009033053A1
WO2009033053A1 PCT/US2008/075443 US2008075443W WO2009033053A1 WO 2009033053 A1 WO2009033053 A1 WO 2009033053A1 US 2008075443 W US2008075443 W US 2008075443W WO 2009033053 A1 WO2009033053 A1 WO 2009033053A1
Authority
WO
WIPO (PCT)
Prior art keywords
valve assembly
flowable substance
delivery system
way valve
inner core
Prior art date
Application number
PCT/US2008/075443
Other languages
English (en)
Inventor
Greg Pardes
Stewart Swiss
Original Assignee
Reseal International Partnership Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reseal International Partnership Limited filed Critical Reseal International Partnership Limited
Priority to EP08829850A priority Critical patent/EP2190753A4/fr
Priority to JP2010524194A priority patent/JP2010537791A/ja
Priority to CA 2736180 priority patent/CA2736180A1/fr
Priority to US12/274,137 priority patent/US7874467B2/en
Publication of WO2009033053A1 publication Critical patent/WO2009033053A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/205—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure the valve being formed by a tubular flexible sleeve surrounding a rod-like element provided with at least one radial passageway which is normally closed by the sleeve
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/0055—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents
    • B65D83/0072—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents the contents of a flexible bag being expelled by a piston or a movable bottom or partition provided in the container or the package
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G01F11/025—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons
    • G01F11/027—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons of the syringe type
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W30/00—Technologies for solid waste management
    • Y02W30/50—Reuse, recycling or recovery technologies
    • Y02W30/80—Packaging reuse or recycling, e.g. of multilayer packaging

Definitions

  • the collapsible reservoir can be, for example, a bellows type reservoir, a collapsible tube, an internal bag or other type of suitable reservoir designed to dispense practically all of its contents.
  • the dispensing delivery system has a normally closed controllable outlet orifice for dispensing a controlled amount of the flowable substance out of the valve assembly.
  • the reservoir is in sealed contact with the valve assembly so that its contents do not receive any contaminants when the flowable substance is dispensed.
  • Dispensation of the flowable substance is effected by applying pressure to a reservoir directly or through a pump so that its contents flow to and through the valve assembly.
  • Fig. 7 is an axially extending view of a metered push button dispenser system according to an exemplary embodiment of the present invention.
  • the end of the valve cover 14 adjacent the reservoir 2 has a radially outwardly extending flange 14a bearing against the flange at the end of the flexible membrane effecting the seal for the valve assembly at the opening from the reservoir 2.
  • the opening or neck area of reservoir 2 seals against flange 14a, for example, by way of a screw thread which mates with the collar 8.
  • the collar 8 and the opening or neck area of the reservoir 2 are designed with locking features that permit the override of the collar 8 during assembly but subsequently prevent the unscrewing and disassembly of the collar 8 and the opening of the system. This prevents any unintended contamination by the consumer and also eliminates the possibility of refilling the system.
  • a pump assembly 16 is joined to a valve assembly 3a and to a reservoir 2 and bottle 6b.
  • the collar 8 surrounds the connection between the pump assembly 16 and valve assembly 3a.
  • the pump assembly 16 is connected to the bottle 6 by screw threads.
  • the opening or neck area of bottle 6 seals against pump assembly 16, for example, by way of a screw thread which mates with the pump assembly 16 sealing flange 2c of reservoir 2 between the bottle 6 and the pump assembly 16.
  • the collar 8 and the opening or neck area of the reservoir 2 are designed with locking features that permit the override of the pump assembly 16 during assembly but subsequently prevent the unscrewing and disassembly of the pump assembly 16 and the opening of the system. This prevents any unintended contamination by the consumer and also eliminates the possibility of refilling the system.
  • the pump assembly 16 is thus connected to a valve assembly 3 a having an actuator 17, an inner core 10, an axially extending blind passageway 11, ports 12, a flexible membrane 13, a valve cover 14 with a flange 14a, and a soft cover 7 with a controllable outlet orifice 7a (further described below in connection with the descriptions of Figs. 4A-D).
  • the actuator 17 may be connected to or include an atomizer. In operation the actuator 17 serves to transfer force via a check valve of the pump assembly 16 to draw flowable substance from the reservoir 2, thus providing the force necessary to dispense flowable substance.
  • conventional pumps may be utilized in this manner.
  • the reservoir 2 can be disposed within a bottle 6 whose open end is sealed by a plug 2c.
  • Plug 2c serves to protect the reservoir 2 from damage, rupture or inadvertent application of feree on the reservoir 2.
  • the controllable outlet orifice 7a can be formed as desired to provide a spray or a stream of the flowable substance. Alternatively, by selectively dimensioning the controllable outlet orifice 7a, a drop-like amount of the flowable substance can be dispensed, for example if an eye care solution is being dispensed. If a greater amount of the flowable substance is to be dispensed, the controllable outlet orifice 7a can be formed for dispensing a larger quantity of the flowable substance, for example, a eye or nasal solution and/or gel.
  • the inner core 10 and the flexible membrane 13 are constructed such that they fit tightly together, for example having very close tolerances which allow for an air-tight seal to be formed between the flexible membrane 13 and the inner core 10.
  • the molding process for the flexible membrane 13 and the inner core 10, as well as other components described above as sealing against one another is an asymmetric molding process which creates a surface substantially free of defects or seam lines at the areas of contact where sealing occurs. Accordingly, in an exemplary embodiment, very close tolerances between the parts, for example the inner core 10 and flexible membrane 13 and the other parts, are used to provide an optimal seal and operation of the valve assembly.
  • valve cover 14 encircles the flexible membrane 13 and, as shown in the rest position in Fig. 2a, is spaced radially outwardly from the outer surface of the flexible membrane.
  • the end of the valve cover 14 adjacent the reservoir 2 has a radially outwardly extending flange 14a bearing against the flange at the end of the flexible membrane effecting the seal for the valve assembly at the opening from the reservoir 2.
  • a valve assembly having a flat topped soft cover 7 is provided.
  • the soft cover 7 has a flattened top, which allows for less flowable substance to adhere to the controllable outlet orifice 7a because the flattened top results in a shorter controllable outlet orifice 7a.
  • the soft cover 7 has a controllable outlet orifice 7a which can be formed as desired to provide a spray or a stream of the flowable substance.
  • the controllable outlet orifice 7a can be a cross-slit as shown in Fig. 3.
  • controllable outlet orifice 7a by selectively dimensioning the controllable outlet orifice 7a, a drop-like amount of the flowable substance can be dispensed, for example if an eye care solution or other solution typically delivered in droplet form, is being dispensed. If a greater amount of the flowable substance is to be dispensed, the controllable outlet orifice 7a can be formed for dispensing a larger quantity of the flowable substance, for example by having a larger diameter opening.
  • a valve assembly having a flat cover 7 which has an enlarged version of controllable outlet orifice 7a is provided.
  • the enlarged version of controllable outlet orifice 7a is able to accommodate the inner core 10 and flexible membrane 13 and is suitable for dispensing viscous flowable substances such as lotions, creams and emollients, but may also be used for any flowable substance.
  • the enlarged version of controllable outlet orifice 7a allows flowable substance to be dispensed without having to move through two openings - namely the opening at the end of the flexible elastomer 13 and the controllable outlet orifice 7a, since these are now flush.
  • flowable substance flows through a single port 12 in inner core 10 and expands the flexible membrane 13, swirling around the exterior of inner core 10, and exiting via an outlet port 12a as shown in Figs. 6A and 6B.
  • additional ports 12 may be located through the inner core 10.
  • an actuator 17 serves to transfer force to the pump assembly 16 when it is depressed. This in turn compress the reservoir 2, thus providing the force necessary to open the valve assembly and in certain embodiments described above, controllable outlet port 7a, to dispense flowable substance.
  • Adjustment of the piston 21 and chamber 19 can provide for the dispensing of various volumes of flowable substance. Adjustment of the spring force and the angle of the cam flanges of the piston 21 provide variation of the force required to depress the button 17. Furthermore, adjustment of the spring force and the angle of the cam flanges of the piston provide variation of the force required to depress the button 17.
  • the check valve 18 prevents the flowable substance from reversing back into the reservior 2.
  • the reservoir 2 can be, for example, a collapsible container such as a tube or bellows.
  • a dynamic seal is maintained internally between the piston 21 and chamber 19 which prevents leakage and entry of solid, gas or liquid contaminants, including, for example, bacteria.
  • Elastomers suitable to form the soft cover 7, the flexible membrane 13 and the valve cover 14 in exemplary embodiments of the present invention include thermoplastic elastomers such as Dynaflex manufactured by GLS Corp., C-Flex manufactured by CPT Inc., or Santoprene manufactured by Advanced Elastomer Systems, Inc.
  • the elastomers, and the materials comprising any of the other components of the device may have integrated, impregnated, otherwise placed within them anti-microbial ingredients such as silver ions contained within a ceramic carrier, such as those supplied by AgION, or sustained-release ionic silver compounds, such as those supplied by Westlake Plastic Technologies which are known to be used in the making of anti-microbial plastics.
  • anti-microbial ingredients such as silver ions contained within a ceramic carrier, such as those supplied by AgION, or sustained-release ionic silver compounds, such as those supplied by Westlake Plastic Technologies which are known to be used in the making of anti-microbial plastics.
  • other anti-microbial suitable for compounding with or coating plastics may be used.
  • the soft cover 7 or the flexible membrane 13 or both could, for example, be positively charged to repel residual flowable substance, coated in for example, Teflon type-plastics, have increased surface tension or be anti-wetting, or any combination of the above so as to repel flowable substance.
  • the durometer of the elastomers can be varied in relation to the viscosity of the flowable substance.
  • assemblies containing substances with comparatively higher viscosities would utilize softer, i.e. lower durometer elastomers, in order to reduce the cracking force needed to dispense flowable substance, whereas lower viscosity flowable substances would utilized harder, i.e. higher durometer elastomers to maintain a strong seal.
  • flowable substances containing lubricants would also utilize harder, i.e. higher durometer elastomers to maintain a strong seal.
  • the parts of the dispending and delivery device, including the valve assembly may be manufactured to close tolerances such that they form airtight seals and are close fitting ensuring optimal seals and operation of the device.
  • a variety of pharmaceuticals, cosmetics, food stuffs and other flowable materials can be dispensed where it is important to maintain them free of contaminants from the ambient atmosphere.
  • the flowable characteristics of the material being dispensed determines or at least may affect the type and dimension of the valve assembly.
  • the material forming the controllable outlet orifice 7a does not absorb the flowable substance.
  • any substance entering the outlet orifice 7 is ejected from the dispenser and does not return into the space between the inner core and the flexible membrane, thereby maintaining the purity or sterility of the product remaining in the reservoir.
  • the various embodiments of the valve assembly described above can each be used in the various embodiments of the continuously sealing one way valve assembly device.
  • the flowable substance may be a pharmaceutical cosmeceutical, or nutraceautical, an eye care solution, other ophthalmological product, otorhinolarygology product, dermatological product, gynecological product, or product for treating or preventing anorectal, dermatological or pulmonary disorders or any formulation administered to the body through the mucus membranes; a food stuff, such as dairy products, beverages or juices; a cosmetic, such as a skin care solution or toiletries; and liquid vitamins, all of which are intended to be maintained free of contaminants from the ambient atmosphere and of preservatives during storage within the reservoir 2.
  • many existing commercial products that contain preservatives can be reformulated into preservative free versions and provided for multiple dose dispensing with the valve assembly and delivery system of the present invention.
  • preservatives emollients, eye drops, nasal sprays, cosmetic creams that currently require preservatives, notably parabens and benzalkonium chloride that have proved to be deleterious to tissue
  • preservatives notably parabens and benzalkonium chloride that have proved to be deleterious to tissue
  • these preservative free products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention because they are preservative free formulations.
  • Preservative-free storage and delivery of formulations also can be accomplished by providing, for example, multi-dose metered, high barrier and for preservative-free systems as described in U.S. Patent No. RE 34,243, incorporated by reference above and U.S. Patent Nos. 5,092,855; 5,305,783; 5,279,447; 5,305,786; and 5,353,961 all of which are hereby incorporated by reference in their entirety.
  • preservative free ophthalmological products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
  • eye drops and preferably those eye drops involved in chronic care, for example, dry eye, glaucoma, allergies and NSAIDs, and also those eye drops intended for acute care, for example during ocular surgery, are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
  • preservative-free otorhinolarygological products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
  • nasalia medicines and preferably nasal sprays, external ear creams, ear drops, steroid ear drops, antibiotic ear drops, nose drops, and nose drops comprising phenylephrine 0.25% and pseudoephedrine 30mg, are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
  • preservative free dermatological products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
  • preservative free skin preparations; scalp preparations; corticosteroid creams, lotions and ointments; topical antibiotics and topical anti-fungal agents are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
  • these preservative free dermatological products are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention because they are preservative free formulations.
  • preservative free products for the treatment or prevention of dermato logic disorders are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
  • preservative free skin preparations; scalp preparations; corticosteroid creams, lotions and ointments; topical antibiotics; topical anti-fungal agents; therapeutic skin creams including anti-bacterial, anti-fungal/parasitic, allergic and nonspecific dermatitis creams and emollients and all cosmetic dermatologic compounds used for dermatologic disorders are amendable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
  • preservative free products for the treatment or prevention of pulmonary disorders are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
  • preservative free formulations of products for chronic obstruction disorder for example, aerosol nebulizers using B-adrenergic, anticholinergic, corticosteroid and theophyline derivatives requiring multi-dose application are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.
  • preservative free eye wash products e.g. irrigation solutions
  • eye wash products used to clear the eye of environmental contamination are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly described herein.
  • eye wash products used to clear the eye of environmental contamination such as pollen or dirt are amenable to storage and dispensing from reservoirs using the continuously sealing one way valve assembly and delivery system of the present invention.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un ensemble de soupape unidirectionnel à scellage continu réutilisable et un système d'apport qui font circuler une substance fluide stérile d'une source à un orifice de refoulement et empêche tout contre-courant de contaminants à travers l'ensemble de soupape unidirectionnel à scellage continu lorsque la substance fluide cesse de s'écouler. L'ensemble de soupape comprend une membrane élastomère qui aide à empêcher un contre-courant quelconque de contaminants lorsque la distribution de la substance fluide est arrêtée. Un dosage multiple d'une substance fluide sans conservateur est proposé.
PCT/US2008/075443 2005-11-03 2008-09-05 Système distributeur de gouttes dosées à bouton-poussoir WO2009033053A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08829850A EP2190753A4 (fr) 2007-09-07 2008-09-05 Système distributeur de gouttes dosées à bouton-poussoir
JP2010524194A JP2010537791A (ja) 2007-09-07 2008-09-05 連続的にシールする一方向バルブアセンブリおよび送達システム
CA 2736180 CA2736180A1 (fr) 2007-09-07 2008-09-05 Systeme distributeur de gouttes dosees a bouton-poussoir
US12/274,137 US7874467B2 (en) 2005-11-03 2008-11-19 Metered drop push button dispenser system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97058807P 2007-09-07 2007-09-07
US60/970,588 2007-09-07

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/949,154 Continuation-In-Part US7513396B2 (en) 2005-11-03 2007-12-03 One way valve assembly

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/274,137 Continuation-In-Part US7874467B2 (en) 2005-11-03 2008-11-19 Metered drop push button dispenser system

Publications (1)

Publication Number Publication Date
WO2009033053A1 true WO2009033053A1 (fr) 2009-03-12

Family

ID=40429374

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/075443 WO2009033053A1 (fr) 2005-11-03 2008-09-05 Système distributeur de gouttes dosées à bouton-poussoir

Country Status (5)

Country Link
EP (1) EP2190753A4 (fr)
JP (1) JP2010537791A (fr)
KR (1) KR20100076967A (fr)
CA (1) CA2736180A1 (fr)
WO (1) WO2009033053A1 (fr)

Cited By (6)

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Publication number Priority date Publication date Assignee Title
WO2011131483A1 (fr) * 2010-04-19 2011-10-27 Sulzer Mixpac Ag Cartouche pouvant être tenue verticalement, dispositif de décharge pour celle-ci et procédé d'utilisation de la cartouche
CN102448421A (zh) * 2009-04-01 2012-05-09 维拉Ip有限公司 多剂量包装体、用于递送预定多剂量的药物的治疗过程和方法
US8444019B2 (en) 2009-08-07 2013-05-21 Ecolab Usa Inc. Wipe and seal product pump
US11213480B1 (en) 2015-08-06 2022-01-04 Hikma Pharmaceuticals International Limited Phenylephrine hydrochloride ready-to-use solution
US20230042231A1 (en) * 2021-08-09 2023-02-09 Rife Plus (Shanghai) Co., Ltd Environment-friendly press bottle integrated with a bellows spring and equipped with an outer shell
US12116198B2 (en) 2022-08-16 2024-10-15 International Business Machines Corporation Sterile storage, transport and delivery of fluids

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Publication number Priority date Publication date Assignee Title
FR3011826B1 (fr) * 2013-10-10 2015-12-25 Karine Courtin Dispositif de distribution et de protection de fluide comportant un obturateur a fente
JP5893204B1 (ja) * 2015-02-23 2016-03-23 参天製薬株式会社 防腐効果のある医薬の組合せ
JP7235303B2 (ja) * 2019-05-28 2023-03-08 大成化工株式会社 用時混合装置

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US5092855A (en) 1990-01-22 1992-03-03 Reseal International Limited Partnership Enclosing sleeve for one-way valve
USRE34243E (en) 1987-07-13 1993-05-04 Reseal International Limited Partnership Valve assembly
US5279447A (en) 1992-08-12 1994-01-18 Reseal International Limited Partnership Fluid dispensing unit with metered outflow
US5305783A (en) 1991-12-31 1994-04-26 Reseal International Limited Partnership Elastomeric sleeve and method for assembling the sleeve on a one-way valve body
US5305786A (en) 1993-01-14 1994-04-26 Reseal International Limited Partnership One-way valve assembly
US5353961A (en) 1993-01-15 1994-10-11 Reseal International Limited Partnership Dual chamber dispenser
US6533145B2 (en) * 2000-12-19 2003-03-18 Kimberly-Clark Worldwide, Inc. Self-contained viscous liquid dispenser
WO2007056131A2 (fr) 2005-11-03 2007-05-18 Reseal International Limited Partnership Ensemble a soupape unidirectionnelle a etancheite en continu et systeme de distribution de fluide, et formulations pour l'utilisation

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GB9619445D0 (en) * 1996-09-18 1996-10-30 Boots Co Plc Fluid dispenser
US7874467B2 (en) * 2005-11-03 2011-01-25 Reseal International Limited Partnership Metered drop push button dispenser system

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USRE34243E (en) 1987-07-13 1993-05-04 Reseal International Limited Partnership Valve assembly
US5092855A (en) 1990-01-22 1992-03-03 Reseal International Limited Partnership Enclosing sleeve for one-way valve
US5305783A (en) 1991-12-31 1994-04-26 Reseal International Limited Partnership Elastomeric sleeve and method for assembling the sleeve on a one-way valve body
US5279447A (en) 1992-08-12 1994-01-18 Reseal International Limited Partnership Fluid dispensing unit with metered outflow
US5305786A (en) 1993-01-14 1994-04-26 Reseal International Limited Partnership One-way valve assembly
US5353961A (en) 1993-01-15 1994-10-11 Reseal International Limited Partnership Dual chamber dispenser
US6533145B2 (en) * 2000-12-19 2003-03-18 Kimberly-Clark Worldwide, Inc. Self-contained viscous liquid dispenser
WO2007056131A2 (fr) 2005-11-03 2007-05-18 Reseal International Limited Partnership Ensemble a soupape unidirectionnelle a etancheite en continu et systeme de distribution de fluide, et formulations pour l'utilisation

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Cited By (12)

* Cited by examiner, † Cited by third party
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CN102448421A (zh) * 2009-04-01 2012-05-09 维拉Ip有限公司 多剂量包装体、用于递送预定多剂量的药物的治疗过程和方法
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JP2010537791A (ja) 2010-12-09
EP2190753A4 (fr) 2011-07-13
CA2736180A1 (fr) 2009-03-12
KR20100076967A (ko) 2010-07-06

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