WO2013076682A1 - Buse de distributeur multidose - Google Patents

Buse de distributeur multidose Download PDF

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Publication number
WO2013076682A1
WO2013076682A1 PCT/IB2012/056633 IB2012056633W WO2013076682A1 WO 2013076682 A1 WO2013076682 A1 WO 2013076682A1 IB 2012056633 W IB2012056633 W IB 2012056633W WO 2013076682 A1 WO2013076682 A1 WO 2013076682A1
Authority
WO
WIPO (PCT)
Prior art keywords
membrane
shutter
head according
dispenser head
chamber
Prior art date
Application number
PCT/IB2012/056633
Other languages
English (en)
Inventor
Massimo Ronchetti
Alfredo PULPITO
Original Assignee
Luso Pharma Sagl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luso Pharma Sagl filed Critical Luso Pharma Sagl
Publication of WO2013076682A1 publication Critical patent/WO2013076682A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0062—Outlet valves actuated by the pressure of the fluid to be sprayed
    • B05B11/0064—Lift valves
    • B05B11/0067—Lift valves having a valve seat located downstream the valve element (take precedence)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/30—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages
    • B05B1/3033—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages the control being effected by relative coaxial longitudinal movement of the controlling element and the spray head
    • B05B1/304—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages the control being effected by relative coaxial longitudinal movement of the controlling element and the spray head the controlling element being a lift valve
    • B05B1/3046—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages the control being effected by relative coaxial longitudinal movement of the controlling element and the spray head the controlling element being a lift valve the valve element, e.g. a needle, co-operating with a valve seat located downstream of the valve element and its actuating means, generally in the proximity of the outlet orifice
    • B05B1/306—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to control volume of flow, e.g. with adjustable passages the control being effected by relative coaxial longitudinal movement of the controlling element and the spray head the controlling element being a lift valve the valve element, e.g. a needle, co-operating with a valve seat located downstream of the valve element and its actuating means, generally in the proximity of the outlet orifice the actuating means being a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0062—Outlet valves actuated by the pressure of the fluid to be sprayed
    • B05B11/0072—A valve member forming part of an outlet opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1001—Piston pumps
    • B05B11/1016—Piston pumps the outlet valve having a valve seat located downstream a movable valve element controlled by a pressure actuated controlling element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes

Definitions

  • the present invention relates to a controlled-dosage dispenser, also known as multidose dispenser or metering device, in particular for medical or cosmetic applications.
  • a controlled-dosage dispenser i.e. a dispenser which is able to supply a predetermined and constant quantity of product, for each single use.
  • Dispensers of this type which are also known as multidose dispensers, are widely used, for example, for pharmaceutical products for topical use and requiring a precise dosage, such as ophthalmic solutions.
  • a known multidose dispenser comprises a prefilling volume, or prefilling chamber, which has dimensions such as to contain exactly the quantity of product intended for the single dispensing operation (for example 50 microlitres). Dispensing is performed by operating a movable element of a dispensing system, such as a pushbutton which is opposed by a spring.
  • a technical problem which arises in multidose dispensers is that of avoiding contamination of the product by external agents, in particular the external air. Contact with the external air is damaging not only owing to the possible presence of pathogenic agents, but also because contact with oxygen is often harmful for the product.
  • Another solution consists in dispensers provided with a nozzle having a protective filter, but this is likewise not satisfactory because the barrier effect of the filter is limited by the size of the pores, and in particular a filter is absolutely ineffective against viruses and also because a small quantity of product remaining downstream of the filter - and therefore in contact with the outside - may in any case contaminate the quantity dispensed.
  • dispensers of the type considered here to maintain the sterility of the product without using preservatives and therefore of effectively insulating the container from the external environment.
  • Other requisites of a multidose dispenser are reliability over time, a constant quantity supplied and the compatibility with different products both in terms of state (liquids of varying density, sprays, etc.) and composition.
  • the economic aspect must also be taken into account.
  • These dispensers in fact consist of devices which cannot be reused and therefore there is an incentive to reduce as far as possible the complexity, the number of parts and their cost.
  • a multidose dispenser for liquid products without preservatives is known, for example, from EP 2152599.
  • Said dispenser consists of a bottle provided with a dropper nozzle and a flexible sleeve for sealing the nozzle.
  • it is substantially suitable only for liquid products to be dispensed in the form of droplets, i.e. substantially for aqueous solutions, and is not very suitable, for example, for gel preparations; moreover it requires a relatively complex design of the nozzle which comprises sections of varying conicity and also comprises the aforementioned sleeve.
  • a dispenser comprising a rigid body, for example a cylindrical body, and a dispensing head which is screwed or fixed in some other manner to the top of the cylindrical body.
  • the cylindrical body contains a reservoir, the bottom of which is formed by a sealingly slidable piston which is pressed by a contact spring against the bottom of the cylindrical body itself, so as to pressurize the product.
  • the dispensing head comprises a cylinder communicating with the reservoir. Said cylinder also communicates with a chamber from which a dispensing nozzle extends. The nozzle is closed by a needle valve which is housed slidably inside the said chamber and is normally closed by the action of a spring.
  • a dispensing pushbutton is connected to the stem of the piston sliding inside the cylinder and, when displaced, compresses the product contained in the said cylinder and at the same time closes the opening communicating with the reservoir, essentially isolating said cylinder from said reservoir. Consequently, the advancing movement of the piston has the effect of increasing significantly the pressure inside the cylinder and inside the chamber communicating therewith.
  • the force exerted by the product on the needle valve overcomes the thrust of the spring, thus opening the valve and allowing dispensing.
  • the quantity of product dispensed essentially depends on the travel of the piston inside the cylinder and may be adjusted. At the end of operation a new quantity of product is recalled into the cylinder from the container, without any contact with the external environment. In fact, immediate closure of the needle valve, as soon as the pressure drops at the end of the piston travel, prevents the entry of air into the chamber and into the storage cylinder.
  • This dispenser has a series of advantages, including the possibility of using liquid products of any density, as well as oily solutions, protecting the product from contact with the air. There still exists, however, room for improvement.
  • the needle valve requires a sliding seal on the walls of the chamber, adjacent to the nozzle, where said valve is housed.
  • the sliding seal may be formed by a small O-ring or gasket, but requires a good dimensional precision of the components.
  • the valve must be guided with great precision inside the sliding seat and the same seat of the seal must be made with minimum tolerances. Moreover it is required to insert a small metallic spring which is compressed between the head of the needle valve and a suitable contact surface.
  • a movable shutter which is housed inside said chamber so as to close said nozzle and which can be opened by the effect of the pressure inside said chamber; characterized in that the means for housing the shutter comprise an elastically deformable membrane which is arranged so as to sealingly close a section of said chamber, in a zone where the shutter is housed, and is connected to the shutter so as to react elastically to an opening movement of said shutter.
  • Said membrane acts both as an elastic recall element for the shutter and as a sealing element.
  • Said membrane in other words, may replace both a conventional return spring and the seal (O-ring or the like) between the shutter and a related guide.
  • the presence of a further means for recalling the shutter is not excluded; however, in the preferred versions, the membrane acts as the sole elastic recall element.
  • the shutter is fixed directly to a portion of said membrane, for example to a central portion surrounded by a sealing region. More preferably said membrane has a surface portion communicating with the product storage chamber, i.e. directly exposed to the pressure of the product during the use.
  • the pressure induced by the actuator means acts directly on the membrane, deforming it and causing opening of the shutter.
  • said membrane comprises a region for supporting the shutter, for example in the central part of the membrane itself, and a sealing region around said supporting region.
  • the sealing region is clamped against a contact surface of the body, for example by means of a ring or equivalent means; clamping of said membrane region has both the effect of fixing the membrane itself, and consequently also the movable shutter associated with it, and of providing a sealing zone.
  • the membrane comprises at least one wave or bellows portion which connects said- region supporting the shutter to said fixing and sealing region.
  • Said wave acts essentially as a suspension element for the movable shutter, between a membrane portion which is substantially fixed, for example being clamped by the above mentioned ring, and a membrane portion movable together with the shutter itself.
  • the membrane has substantially the form of a disc and the sealing and fixing region is substantially an annular edge or peripheral rim of said disc.
  • the membrane is made of plastic or rubber or elastomer resistant to wear caused by the use of oxidising or saline substances.
  • the shutter is for example formed by a needle valve, with or without a seal in the region of the nozzle, depending on requirements.
  • the needle is guided by a fixed sleeve, which is mounted inside said chamber; the head of the needle comprises a blind threaded hole, and the needle is fixed to said membrane by means of a screw passing inside a central hole of the membrane itself and engaged inside said blind hole.
  • the shutter consists of a needle valve which is integral with said membrane.
  • a membrane with a shutter formed as one piece advantageously may be made by means of die-casting and using a suitable material, for example polyethylene. This reduces the production and assembly costs.
  • the nozzle may have a passage cross-section which is substantially constant or diverges towards the outlet. Moreover, the nozzle may be aligned in the axial sliding direction of the needle valve or inclined at a suitable angle.
  • the actuator means advantageously comprise a sliding piston, the advancing movement of which compresses the product inside the chamber and at the same time sealingly obstructs the product inlet opening, thus obtaining compression and subsequent dispensing of a controlled volume of product.
  • said piston is provided with a lip-type sealing ring which replaces a conventional sealing means such as an O-ring.
  • Said ring is advantageously integrally formed with the piston, for example a piston with an integrated sealing ring may be obtained by means of a die- casting operation.
  • the dispenser head according to the invention is connected to a product container, thus forming a multidose dispenser.
  • Said container in accordance with various embodiments, may be rigid or also flexible.
  • a dispenser may comprise a dual system comprising two reservoirs for the components of a dual-component product; two dispensing heads operated simultaneously by a single actuating pushbutton; a common output nozzle where the individual components of the product are mixed.
  • An advantage of the invention consists in the significant constructional simplification. Owing to the membrane, which acts both as an elastic recall element and as a sealing element, neither a precise nor a sealed assembly of the shutter and associated guide is required; nor is a sliding seal associated with the shutter itself necessary. Since less precise machining operations are employed, a considerable reduction in costs may be achieved without adversely affecting the reliability.
  • Another advantage is that the needle valve is substantially not affected by jamming problems. Since less rigid tolerances may be adopted, the unit is less prone to jamming caused by micro bodies or crystals, for example when a highly saline product is present and local precipitation and the formation of solid micro granules may occur. Since the risk of jamming (seizing) of the shutter is practically eliminated, the design may be simplified, avoiding the need for a further connection channel between nozzle head and reservoir and associated non-return valve.
  • the invention is applicable to a wide range of pharmaceutical, cosmetic or other products, independently of their composition and their physical state (density, viscosity, etc.).
  • the invention is applicable, among other things, to products which take the form of aqueous solutions, gels or sprays.
  • An example of preferred application consists in multidose dispensers of ophthalmic products in gel form.
  • the product container may also be flexible, for example made of PE, and not necessarily rigid.
  • pressurization of the product is caused entirely by the actuator means, advantageously formed by a piston, with which the nozzle head is equipped.
  • the dispenser head according to the invention more specifically is defined as being isobaric, the pressure being generated by the actuator means, and does not require a product which is pressurized or contains a propellant, as in certain embodiments of the prior art. This constitutes a further advantage.
  • Operation occurs in a gentle and gradual manner owing to the elastic reaction effect of the membrane to the pressure exerted by the product.
  • Fig. 1 is a cross-sectional view of a dispenser head according to a first preferred embodiment of the present invention.
  • Fig. 2 is a view, on a larger scale, of a detail of Fig. 1.
  • Fig. 3 is a cross-sectional view of a dispenser head according to another preferred embodiment of the present invention.
  • Fig. 4 is a plan view of the internal membrane of the dispenser head according to Fig. 1 or Fig. 3.
  • Fig. 5 is cross-sectional view of the membrane according to Fig. 4.
  • Fig. 6 shows an example of a dispenser comprising a dispenser head according to the invention.
  • Fig. 7 shows an example of a dispenser for a dual-component product according to another application of the invention.
  • Fig. 8 shows another particularly preferred form for the internal membrane of the dispenser head.
  • Fig. 9 shows an example of an assembly comprising a dispenser head combined with a flexible container for the product.
  • this shows a cross-section of a dispenser head according to a preferred embodiment of the invention.
  • the head comprises a body denoted generally by 30 which is preferably made of plastic and which, in the example, is formed essentially by joining together a half-body 1 and a half-body 2.
  • the dispenser head has an inlet opening for the product, which communicates with a chamber 23 via a duct 20.
  • the dispenser head shown in Fig. 1 during the use, is mounted on a product container, not shown in Fig. 1 , communicating with said opening 22.
  • the container may be rigid or flexible. An example of a flexible product container is shown in Fig. 9.
  • Said chamber 23 communicates with a dispensing nozzle 21 which is closed by a movable shutter, which is represented here by a needle valve 10 housed inside the chamber 23.
  • the nozzle 21 in the figure is a diverging duct suitable for the dispensing of sprays, but in other embodiments, which are entirely equivalent, the dispensing nozzle may have a constant cross-section.
  • the orientation of the nozzle may also vary according to the needs, depending on the type of product, the mode of use, etc., for example being aligned axially with the needle valve 10, or inclined.
  • the end of the dispensing nozzle 21 and the needle 10, in some embodiments of the invention, may undergo a silver-coating process in order to ensure improved sterility.
  • the needle valve 10 may be provided with a seal 13 (Fig. 2) for sealing against an inlet seat of the nozzle 21 ; this seal is optional and may be omitted in other embodiments of the invention.
  • the shutter may comprise a zone lined with deformable material, such as silicone material, with a sealing effect.
  • the needle valve 10 may comprise a silicone-lined tip instead of said seal 3.
  • the needle valve 10 is intended to open (moving from right to left in the figure) following a pressure increase inside the chamber 23.
  • the pressure increase is caused by an operating pushbutton 3 which acts against a piston 4 housed inside the half-body 1 and slidable inside a cylindrical portion 20a of said duct 20 connecting the opening 22 and said chamber 23.
  • the piston 4 is opposed by a coaxial spring 6 and is provided with at least one seal 5 for sealing against the wall of the duct part 20a.
  • the seal 5 is located on the opposite side to the section 20 for connection to the chamber 23, relative to the product inlet opening 22.
  • the seal 5 is a double seal formed by two O-rings.
  • the O-ring seals present on the actuator piston 4 may be dispensed with or replaced by forming an elastic sealing ring (of the "herringbone” type) on the piston itself.
  • a screw 7 acts as adjusting element for the end of travel of the button 3 and the piston 4.
  • valve 10 is slidable inside a guide sleeve 8 which is fixed inside a suitable seat of the half- body 2, inside the chamber 23.
  • the needle valve 10 is fixed to an elastically deformable membrane 9 by means of a screw 12.
  • Said membrane 9 operates substantially both as an elastic suspension and recall element, keeping the valve closed against the closing seat of the nozzle 21 , and as a sealing element for sealing the chamber 23 from the exterior by means of a clamping ring 11 which compresses the edge of the membrane.
  • the ring in greater detail is mounted, for example screwed, into a seat 15 of the half-body 2, closing the chamber 23 on the opposite side to the dispensing nozzle 21.
  • the membrane 9 is substantially a disc with a peripheral portion 9a and a central portion 9b connected by a wave 9c which acts as a suspension element.
  • the part 9a as can be seen is compressed by the ring 11 against a surface 16 of the half-body 2, thus sealing the chamber 23 with respect to the mounting seat 15 of the ring (Fig. 2).
  • the needle 10, which is slidable inside the guide 8, is fixed to the central membrane portion 9b, by means of said screw 12 which engages a threaded blind hole 14 formed in the head of the needle 10.
  • said screw 12 passes through a central hole 9e in the membrane 9; however, another hermetic seal is created by means of compression of the membrane zone 9b, between the head of the needle 10, on one side, and the head of the screw 12, on the opposite side. In this way, the chamber 23 remains perfectly sealed.
  • the needle valve 10 slides with a sufficient precision inside the guide, sleeve 8; however, the coupling arrangement is not sealed and has a certain play, visible in Fig. 2, such that the region 24 between the front end of the guide 8 and the membrane 9 communicates with the chamber 23. Consequently the membrane surface indicated as 9d is substantially exposed to the pressure of the product contained in the chamber 23 or in the region 24 communicating therewith.
  • the movable assembly formed by the needle 10 and screw 12 is able to move, elastically opposed by the membrane 9, With respect to the fixed guide 8, with a hermetic sealing action being ensured by the same membrane 9 sealingly compressed between ring 11 and contact surface 16 and also clamped by the screw 12 in the region where the needle 10 is fixed.
  • Fig. 3 shows another preferred embodiment in which the details are indicated by the same reference numbers as in Figs. 1 and 2.
  • the duct 20 follows a different path with an "elbow" curve and that the nozzle 21 has a cross-section which is constant and not diverging.
  • the nozzle 21 is coaxial with the needle 10, but in other embodiments the nozzle 21 may be "tangential", i.e. inclined with respect to the axis of the needle. The choice of nozzle and/or the inclination depend on the product and use.
  • Figs. 4 and 5 show in greater detail the membrane 9 and the respective sealing part 9a and part 9b for fixation of the needle 10, connected by the suspension part 9c.
  • the hole 9e for the screw 12 shown in Figs. 1 and 2 may also be noted.
  • Fig. 6 shows a dispenser head according to the invention, for example with the embodiment of Fig. 3, forming part of a multidose dispenser 100 comprising a product reservoir 01 with an opening 102 which communicates with the above- described product inlet opening in the head.
  • Fig. 7 shows an example of application to a dispenser for a dual-component product.
  • the dispenser 200 comprises two reservoirs 201 and 202 for two components of a product, each with an opening 203, 204 which communicates with a dispensing unit according to the invention and, for example, of the type shown in Figs. 1 and 2 or Fig. 3.
  • Each of the units 31 , 32 comprises a respective shutter 10 and membrane 9; preferably the units 31 , 32 are operated simultaneously by the pressure of a single button 3 and the respective nozzles dispense a predetermined quantity of the component.
  • the components are mixed at the common outlet nozzle 33.
  • Fig. 8 shows another embodiment of the membrane 9, indicating the sealing portion 9a, the portion 9b for fixing the needle 10, the suspension part 9c and the hole 9e for the screw 12.
  • a preferred embodiment is shown where the sealing portion 9a has a protrusion 9f.
  • Fig. 9 shows a dispenser 300 comprising a head substantially similar to the head 30 described above.
  • the dispenser 300 comprises a product container formed by a flexible bag 40 fixed to a rigid support 41.
  • the product inlet opening 22 in the dispensing head is sealed by a breakable membrane; the rupture of said membrane is caused by screwing of the support 41 onto the head, thus connecting the aforementioned opening 22 with the inside of the product-containing bag 40.
  • operation takes place as follows.
  • a certain quantity of product is present inside the duct 20 and the chamber 23, which communicate via the opening 22 with the product container.
  • the piston 4 slides inside the guide section 20a and intercepts and substantially closes the opening 22, thus isolating the duct 20 and the chamber 23. While advancing to the end of its travel path, as shown in Fig. 1 , the piston 4 acts as a piston pump, compressing the product.
  • the pressure inside the propagation chamber 23 spreads into the zone 24 in contact with the membrane 9 and acts on the face 9d of the membrane.
  • the membrane is deformed with a displacement (towards the right in the figures) of the portion 9b, which is substantially suspended to the edge 9a by means of the suspension part 9c. Together with the membrane, the needle 10 fixed thereto is displaced, thus opening the product dispensing path through the nozzle 21.
  • the dimensions of the duct 20, the chamber 23 and the piston 4 determine the quantity supplied.
  • the outflow of the product causes a drop in the pressure and, consequently, closure of the needle 10 owing to the elasticity of the membrane, which returns to the original shape.
  • the division of the body into the parts 1 and 2 allows easy assembly of the guide 8, the needle 10 and the membrane 9.
  • the components may be easily inserted from the side of the opening 15, and the whole assembly is then closed and sealed by the ring 11.
  • the guide 8 is glued to the body 2 in the region of the contact surface 17 shown in Fig. 2; gluing is possible since the components are usually made of plastic.
  • the . needle 10 is inserted into the guide 8, followed by the membrane 9 to which the needle is screwed by means of the screw 12 (which may be for example an M1 screw); finally the ring 11 is screwed until tight compression of the edge 9a of the membrane.
  • the invention not only reduces the number of components, but also facilitates assembly compared to a design which has very precise tolerances, metal springs, etc.
  • a dual-component dispenser of the type shown in Fig. 7 is used for products which must be mixed together only at the moment of use, for example a carbonate salt with an acid, which cannot coexist in the same reservoir (generation of carbon dioxide).
  • This dispenser structure is suitable also for administering certain drugs which are soluble or stable in an acid environment, for example fluoroquinolones, but the acidity of the environment in which they are stable is incompatible with the human body; for example with the eyes, into which a slightly basic solution must be injected.
  • Other examples are hydrophilic substances or solutions with lipophilic substances; these substances require the use of a stabilization surfactant which however is damaging for the ocular surface or the mucous membranes.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mechanical Engineering (AREA)
  • Biophysics (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne une tête de distributeur multidose, en particulier pour des produits pharmaceutiques, qui comprend une buse de distribution (21) avec un obturateur (10) logé à l'intérieur d'une chambre sous pression (23), caractérisée en ce que les moyens pour loger l'obturateur comprennent une membrane élastiquement déformable (9) qui est agencée de manière à fermer de façon étanche ladite chambre (23) et qui est connectée à l'obturateur de manière à agir en tant qu'élément de suspension élastique de l'obturateur lui-même.
PCT/IB2012/056633 2011-11-24 2012-11-22 Buse de distributeur multidose WO2013076682A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH01879/11A CH705799A1 (it) 2011-11-24 2011-11-24 Testa di erogazione multi-dose con otturatore a membrana elastica. originale: Testa di erogazione multi-dose perfezionata.
CH01879/11 2011-11-24

Publications (1)

Publication Number Publication Date
WO2013076682A1 true WO2013076682A1 (fr) 2013-05-30

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Application Number Title Priority Date Filing Date
PCT/IB2012/056633 WO2013076682A1 (fr) 2011-11-24 2012-11-22 Buse de distributeur multidose

Country Status (2)

Country Link
CH (1) CH705799A1 (fr)
WO (1) WO2013076682A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015004227A1 (fr) * 2013-07-12 2015-01-15 Liita Holdings Ltd. Inhalateur
US20200281768A1 (en) * 2019-03-06 2020-09-10 Kedalion Therapeutics, Inc. Multi-dose ocular fluid delivery system
US20210137732A1 (en) * 2019-03-06 2021-05-13 Kedalion Therapeutics, Inc. Vented Multi-dose Ocular Fluid Delivery System
WO2021127535A1 (fr) * 2019-12-20 2021-06-24 Kedalion Therapeutics, Inc. Système d'administration multi-dose de fluide oculaire à évent
US11819453B2 (en) 2015-01-12 2023-11-21 Novartis Ag Micro-droplet delivery device and methods
US11925577B2 (en) 2020-04-17 2024-03-12 Bausch + Lomb Ireland Limted Hydrodynamically actuated preservative free dispensing system
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system

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WO2015004227A1 (fr) * 2013-07-12 2015-01-15 Liita Holdings Ltd. Inhalateur
CN105492056A (zh) * 2013-07-12 2016-04-13 利塔控股有限公司 吸入器
JP2016539677A (ja) * 2013-07-12 2016-12-22 リイタ ホールディングス リミテッド 吸入器
CN105492056B (zh) * 2013-07-12 2019-06-18 利塔控股有限公司 吸入器
US10583261B2 (en) 2013-07-12 2020-03-10 Liita Holdings Ltd Inhaler
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US20210137732A1 (en) * 2019-03-06 2021-05-13 Kedalion Therapeutics, Inc. Vented Multi-dose Ocular Fluid Delivery System
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US20200281768A1 (en) * 2019-03-06 2020-09-10 Kedalion Therapeutics, Inc. Multi-dose ocular fluid delivery system
WO2021127535A1 (fr) * 2019-12-20 2021-06-24 Kedalion Therapeutics, Inc. Système d'administration multi-dose de fluide oculaire à évent
EP4076303A4 (fr) * 2019-12-20 2024-01-17 Novartis Ag Système d'administration multi-dose de fluide oculaire à évent
US11925577B2 (en) 2020-04-17 2024-03-12 Bausch + Lomb Ireland Limted Hydrodynamically actuated preservative free dispensing system
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system

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