WO2009030705A2

WO2009030705A2 - Device for administration of medication in blister packs

Info

Publication number: WO2009030705A2
Application number: PCT/EP2008/061621
Authority: WO
Inventors: Alfred Von Schuckmann
Original assignee: Alfred Von Schuckmann
Priority date: 2007-09-04
Filing date: 2008-09-03
Publication date: 2009-03-12
Also published as: WO2009030705A3; DE102007041720A1

Abstract

The invention relates to a device (1) for administration of a medication in a blister pack, and to achieve a simple design suitable for administration on a massive scale, the invention provides for a bag (49) being pleated together on the broad side (41) of a plate (40) and with the boundary edge thereof tied to the edge of the base plate, said bag being inflatable by a dosing pump (2) the connecting tube section (53) of which contains a blister pack. The bag after being suctioned empty is disposed of with the plate.

Description

Device for administering a blister-packed medicament

The invention relates to a device for administering a blister packaged medicament.

Such devices are known. These are mainly used for the inhalation of medicinal, powdery masses, which are further portioned in cavities of a blister pack. The filled cavities are covered by a laminated aluminum foil. In this regard, in particular also known devices in the form of inhalers are known. In these is a blister, which is opened immediately before inhalation, for example, pierced. The inhalation process takes place while flowing through the cavity, wherein the stored medicament is discharged.

In view of the above-described prior art, a technical problem of the invention is seen in a structurally simple manner to design a device of the type in question so that a simple functionally reliable handling is given in particular in the course of the inhalation process.

This problem is solved initially and essentially by a folded on one broad side of a plate and bounded with its peripheral edge at the bottom plate edge bag, which bottom plate has a laterally projecting connecting pipe section for a metering pump, in which connecting pipe section is a deductible receiving chamber for the blister pack, which is obviously by means of a piercing needle, which sits in the connection pipe section of the metering pump. As a result of this embodiment, a simplified handling is achieved, in particular for the inhaling patient. Inhalation takes place in the simplest way by usual inhalation, without thereby achieving an excessively high air flow must, as is the case with the known devices, to clear the opened blister on the increased air flow. The emptying of the cavity of the present device is already achieved in the course of an inhalation preparation via the metering pump by first piercing the blister by means of the pump-side needle and thereafter flowing through and emptying it by actuating the pump. The air entraining the preferably powdered medicament expands the bag tied on the plate side, in order to offer an inhalable volume of air displaced with a powder cloud. In a preferred embodiment, an air volume of 100 to 400 ml, more preferably 200 ml is available for inhalation in the bag. The stated numerical range also includes all intermediate values, in particular in 1/10 steps, ie about 100.1 ml to 400 ml or 100 ml to 399.9 ml, 100.2 ml to 400 ml or 100 ml to 399, 8 ml or 101.1 ml to 399.9 ml or 100.2 ml to 399.8 ml etc. The air volume offered is particularly associated with the peelable receiving chamber for the blister pack, which further offers an enlarged flow channel cross-section for inhalation is sufficient for a usual inhalation without further effort. Thus, the device for inhalation is also suitable for weakened patients, and also for children, especially infants and babies. It takes to receive the drug to be inhaled only the usual inhalation, in the course of which the bag is emptied of the powder cloud under compression of the bag. For this purpose, in a preferred embodiment, the plate-side connecting pipe section at the same time a mouthpiece, which may be further equipped optionally after the pumping and prior to the actual inhalation with a mouth and nose covering mask, such as for use in infants.

After piercing the blister and after the pumping operation to clear the cavity and inflate the bag, the plate having the bag is removed from the metering pump. In the course of this process, the Removed receiving chamber with the pierced blister from the plate-side connecting pipe section and thereafter provided with the inflated bag plate to the patient. The powder cloud in the inflated bag or the volume of air built up in the bag will remain standing for about a minute even with the flow channel otherwise open to the outside for inhalation. There is enough time after preparation for the inhalation process.

Further features of the invention are explained below, also in the figure description, often in their preferred association with the subject matter of claim 1 or with features of further claims. But they can also be in an assignment to only individual features of claim 1 or the respective further claim or each independently of importance.

Thus, in an embodiment of the subject invention, an overflow channel is provided in the receiving chamber. The air flow directed axially via the connecting pipe section via the metering pump into the receiving chamber for the blister pack is deflected out of the axial alignment via this overflow channel, so more preferably into an axially parallel alignment. This offers the advantage of a particularly tangential flow of the air flow mixed with the medicament powder into a vortex chamber upstream of the plate-side bag in the direction of flow, thus achieving a good distribution of the entrained powder in the air volume of the inflated bag. Accordingly, the powder cloud in the bag is evened.

In the ready state of the device, in particular the plate-shaped inhalation part and also after inhalation and corresponding sucking out of the bag comprising the powder cloud, the bag wall is in the compressed, ie folded state. For this one has a broadside the bottom plate a recess for receiving the folded bag wall, this recess may be formed by a peripheral edge of the bottom plate encircling, over the broad side projecting collar, which accordingly offers an inner space for receiving the folded bag. The bag is held in place in this recess, in particular in the delivery state in a protected position.

In a further preferred embodiment of the subject invention it is provided that the metering pump is designed as a over a single piston stroke the required amount of air metered dispensing hand pump. By the

Forming the pump as a hand pump is the preparation for inhalation as well as the inhalation process itself, regardless of any supply connections, such as power connections. The chamber volume of the pump corresponds to the volume of air received through the bag, so that the amount of air required to blow out the powdered medicament from the blister pack and to completely fill the bag is sufficient with only a single piston stroke. In order to prevent accidental multiple pumping, which may possibly lead to destruction of the bag, in particular the pump end position is secured, for example, rest assured. Also, the Pumpansaugstellung can also be secured in a corresponding manner.

The removable from the plate-side connecting pipe section before the inhalation process receiving chamber for the blister pack has in a further embodiment, a plug-like, insertable in the connecting pipe section cylinder portion. This sits sealing in the connection pipe section. At this cylinder section is followed by a flat, projecting into the receiving chamber guide tongue, with frontal concave concavity and medium-sized window. The guide tongue also forms, in cooperation with the connecting tube section which receives the guide tongue. Cross-section of the overflow, this continues with a total of substantially matching cross-sectional configuration of the guide tongue receiving portion of the connecting pipe section. The front concave cavity of the guide tongue forms inserted into the connecting pipe section a wall portion of the vortex chamber into which the overflow opens. In order to prevent or at least minimize a negative pressure effect on the inflated bag when the receiving chamber is removed from the connecting pipe section, the opening cross section of the connecting pipe section receiving the guide tongue is widened at a distance from the sealed swirling chamber. In the course of the removal of the receiving chamber, the sealing region of the receiving chamber assigned to the frontal concave cavity reaches, after a displacement of approximately 1 to 2 mm, this cross-sectional widened area which is in communication with the environment, whereby any negative pressure that may be built up via this minimal displacement path is torn off. The mediocre trained in the guide tongue window may support this effect.

The bag attachment side is associated with a flow-through in the plate. The latter is seated in the flow direction in the course of the inflating of the bag behind the vortex chamber, via which throughflow opening the particle-laden air flows into the bag. This flow-through opening is enclosed by a circumferential, raised against the plate broad side collar. Next, this circumferential collar has openings radially aligned with the flow opening. With strong suction in the course of the inhalation process, the bag wall can be sucked in almost sealingly against the end edge of the peripheral collar. Particulate residual air in the bag radially outside of the annular collar can be further sucked through the openings. The invention is explained in more detail below with reference to the attached drawing, which represents only one exemplary embodiment. It shows:

Figure 1 is a perspective view of the device, consisting of a pump and an inhaler, regarding the standby position.

2 shows the inhalation part in an exploded view;

3 shows a side view against the inhalation part;

4 shows the plan view for this purpose;

5 shows the front view with a view of a connection pipe section of the inhalation part;

6 shows the longitudinal section along the line VI - VI in Fig. 4.

7 shows the section along the line VII - VII in Fig. 3;

8 shows a cross section through the inhaler according to the line VIII - VIII in Fig. 3;

9 shows a further cross section according to the line IX - IX in Fig. 3;

10 shows a perspective cutout view, showing the region of a pump-side connection section with a needle;

11 shows a longitudinal section through the pump with attached inhaler;

FIG. 12 shows the enlargement of the area denoted by XII in FIG. 11; FIG. FIG. 13 shows a longitudinal sectional illustration according to FIG. 11 after the dosage has been taken; FIG.

FIG. 14 is a perspective view according to FIG. 1, but after a metering and subsequent removal of the inhalation part; FIG.

Fig. 15 is a longitudinal sectional view of FIG. 6, the ready position of the inhalation for inhalation concerning and

FIG. 16 shows a cross-sectional view according to FIG. 8 concerning the ready position according to FIG. 15.

Shown and described is first with reference to the illustration in Figure 1, a device 1 for the administration of a blisterverpackten drug, which consists essentially of a hand-operated pump 2 and a separate inhaler 3.

The hand-operated pump 2 initially has an annular in cross section pump cylinder 4. This is closed at one end by a cylinder bottom 5. The cylindrical top 6 opposite the cylinder bottom 5 has a passage opening 7 oriented coaxially to the cylinder axis x-x, which is remote from the limited cylinder space 9 by an annular collar 8 integrally formed with the cylinder cover 6.

In the cylinder chamber 9, a piston 10 is guided along the axis x. This is by means of a circumferential lip seal 11 sealingly against the inner wall of the pump cylinder 4.

The piston 10 is supported on a tubular piston rod 12 which receives centrally the axis x and the cylinder space 9 in the longitudinal extent durch- passing through the passage opening 7 is guided. The piston 10 facing the free end of the piston rod 12 passes through the piston 10 centrally, so that the defined by the piston rod 12 pump flow channel 13 opens freely to the piston rod 12 facing away from the piston surface 14.

Facing the piston rear side facing away from the piston surface 14, the piston rod 12 carries a radial collar 15 which is supported on the piston rear side. This forms the bottom of a cylinder section 16 which concentrically surrounds the piston rod 12 and has a diameter-reduced cross-section relative to the cylinder chamber inner diameter 16 corresponds to about twice the outer diameter of the piston rod 12th

The cylinder section 16 which surrounds the piston rod 12 extends approximately over the entire axial length of the piston rod 12 and, in the end region remote from the radial collar 15, merges into a circular disc-shaped cover 17, which is penetrated centrally by the piston rod 12.

The axial length of the cylinder portion 16 is further selected so that in a piston stop position on the cylinder chamber side bottom 5 as shown in Figure 10, the outwardly facing surface of the ceiling 17 in a plane to the free edge of the cylindrical portion 16 comprehensive annular collar 8 extends. Taking into account a relative displacement to the annular collar 8, the outer diameter of the cylinder section 16 is adapted to the inner diameter of the annular collar 8. Accordingly, the annular collar 8 provides guidance of the piston rod 12 via the cylinder section 16 in the course of the displacement of the piston rod 12 along the cylinder axis x.

The projecting beyond the ceiling 17 end portion of the piston rod 12 further carries an actuating handle 18 in the form of an annular disc-shaped Radial extension. This connects directly to the ceiling 17 and has a relation to the pump cylinder side annular collar 8 enlarged diameter, so that the actuating handle 18 circumferentially protrudes radially beyond the annular collar 8. The actuating handle 18 serves at the same time in the pump end position according to FIG. 10 in cooperation with the facing end face of the annular collar 8 as a stop for the piston rod 12.

On the ceiling 17 facing away from the wide area of the actuating handle 18 coaxially aligned with the axis x connecting pipe section 19 is formed. This is formed in a first, emanating from the actuating handle 18 portion hollow cylindrical. The further portion of the connecting pipe section 19, so on about two-thirds of the total length of the connecting pipe section 19 is designed shell-shaped, opening upwards. As a result, a support portion 20 is formed, with an outer diameter corresponding to the outer diameter of the hollow cylindrical coupling portion 21.

The valley of the half-shell-shaped support section 20 is provided with an axis-parallel, longitudinal slot-like opening 22.

About halfway along the extension length of the entire connecting pipe section 19, an annular step 23 is formed on the inside of the supporting section 20, on which the free end of the connecting pipe section 19 is approximately half the material thickness dimension of the pipe Connecting pipe section 19 reduced diameter connects.

The piston rod 12 or the pump flow channel 13 opens within the coupling portion 21 under closure of the mouth cross-section through a molded-on cover 24. The latter has a central opening 25 into which a needle 26 is inserted in the form of a hollow needle. This may be welded to the cover 24. Alternatively, in the case of a general configuration of the pump parts, plastic injection-molded parts can at the same time be encapsulated by the covering material in the course of production.

The needle 26 is composed essentially of two cross-shaped in cross-section aligned knives, the socket side pass into a cover 24 passing through the hollow body. Facing away from the cover 24, the cutting edges are pointed.

By the selected arrangement of the needle 26 forming cutting results in a central flow opening 27 and each associated with the floor plan a gusset of the cross-shaped arranged cutting a further flow-through opening 28th

The length of the needle 26 is further selected so that its tip slightly, that is further protrudes with a measure of a few mm (1 to 3 mm) over the plane defined by the end edge of the coupling portion 21, perpendicular to the x axis aligned plane.

The protruding into this support section 20 end portion of the piston rod 12 forms a base, the outer wall carries a circumferential annular seal 29.

The two Pumpendstellung are rest assured. For this purpose, the cylinder section 16 surrounding the piston rod 12 has a longitudinal slot 30 along its length. Whose ends are provided with keyhole-like extensions 31, 32. The annular collar 8 has a radial bore 33 through which a spring-loaded pin 34 radially inward for engagement in the longitudinal slot 30th attacks. The diameter of the pin 34 is adapted to the width dimension of the longitudinal slot 30 which is considered transversely to the axis x.

At the end, the pin 34 carries an end section 35 which is enlarged in diameter relative to the pin 34. The latter is adapted to the opening cross-section of the extensions 31 and 32.

Radially outside the pin 34 is provided with an example thumb-operable handle 36. The pin 34 is loaded radially outward (relative to the axle x) via a spring 37 surrounding the pin 34.

To displace the piston rod 12, first the handle 36 is to be pressed down against the force of the spring 37 so that the end section 35 passes radially inward out of the associated extension 31 or 32. Thereafter, the piston rod 12 is displaceable, wherein the longitudinal slot 30 is the pin 34 receivingly guided along the pin 34, this up to the other end position, then spring assisted in the pin-side end portion 35 automatically to achieve the safety catch in the corresponding extension 31 and 32nd the longitudinal slot 30 again invades.

The pump 2 is also designed as a tabletop device or the like. For this purpose, the pump cylinder 4 is further provided on the outside wall with two adjustable feet 38. These have different lengths, so that an alignment of the pump 2 sets when stopping on a horizontal surface 39 at an acute angle of about 15 ° between the cylinder axis x and the surface 39, this with increasing piston rod 12 in the direction of the connecting pipe section 19th

The inhalation part 3 initially has a circular disk-shaped plate 40 with an upper broad side 41 and a lower broad side 42. Assigned to the upper one Broadside 41 edge-round a segmented axial collar 43 is formed. As a result of this embodiment, a depression 44 is formed in the interior of the axial collar 43, bounded below by the upper broad side 41.

The plate 40 is interspersed centrally by a circular flow opening 45. This is associated with the upper broad side 41 surrounded by a circumferential, opposite the plate broad side raised collar 46. The axial height of the collar 46 corresponds approximately to a quarter of the axial height of the circumferential in the edge region of the plate 40 Axialkragens 43. Next, the collar 46 is provided with radially to the flow opening 45 aligned openings 47.

On the underside of the plate 40, that is to say associated with the lower broad side 42, the inhalation part 43 is provided at the edge with two diametrically opposite wall sections 48 which are part-circular in plan. By means of this, the inhalation part 3 can be placed on a flat surface.

The plate 40 is further a carrier of a bag 49. This is with its opening edge 50 undetachably supported by overlapping the Axialkragens 43 on the plate 40, so in particular by welding, to which further the bag 49 is peripherally circumferentially provided with a reinforcing ring 51.

This is in cross-section elongated rectangular shaped with a longitudinal extent transverse to the extension direction of the channel portion 52. The side wall of the channel portion 52 includes the flow opening 45 on the underside semicircular, further the width dimension of the channel portion 52nd measured transversely to the longitudinal extent of the channel portion 52 and the diameter of the semicircular, coaxial to the flow-through opening 45 aligned channel section wall approximately twice the diameter of the flow-through 45 corresponds.

The channel section 52 opens into a connection pipe section 53 of the inhalation part 3 which adjoins the plate 40 radially outside, this under conical widening. The connecting pipe section 53 is designed as a hollow cylinder with an annular cross-section. The outer diameter of the connecting pipe section 53 corresponds approximately to the inner diameter of the pump-side connecting pipe section 19 in the region of the supporting section 20.

In the connecting pipe section 53 of the inhalation part 3, a receiving chamber 54 is received pluggable. This first has a plug-like, in the connecting pipe section 53 insertable cylinder portion 55, to which a flat, projecting into the channel section 52 leading tongue 56 connects. The latter is cross-sectionally adapted to the open cross-section of the channel section 52.

At the front, the guide tongue 56 forms a concave hollow 57 running transversely to the channel extension. This is assigned in plug connection of the receiving chamber 54 in the connecting pipe section 53 to the flow-through opening 45, in the plan semicircular end portion of the channel section 52, whereby a circular disk-shaped, coaxial with the flow opening 45 aligned and radially limited swirl space 58 is created. The wall of the concave cavity 57 correspondingly forms a partial wall section of the swirling space 58.

The accommodated in the connecting pipe section 53 cylinder portion 55 of the receiving chamber 54 has a radially inwardly projecting, circumferential step 59. At this stage 59 is supported in a plan circular disc-shaped blister 60, the powdered drug receiving cavity 64th directed towards the guide tongue 56 projects into a central flow channel 61 of the receiving chamber 54. At the rear, the blister 60 is bound by an annular collar 62 in the axial direction, for clamping between annular collar 62 and step 59. The annular collar 62 is achieved, for example, by plastic deformation.

The cylindrical portion 55 of the receiving chamber 54 faces away from the guide tongue 56 in a radially outwardly flared support collar 63. This lies on the facing frontal edge surface of the connecting pipe section 53 and is compared to the connecting pipe section 53 enlarged diameter, further has a diameter, the corresponds to the pump-side connecting pipe section 19 in the region of the coupling portion 21.

The guide tongue 56 is initially designed as a solid component, with a channel section 52 adapted cross-section. In the middle, that is to say viewed in the direction of extension between the cylinder section 55 and the end-side cavity 57, a window 65 passing through the broad sides of the guide tongue 56 is formed.

Narrow edge side, the guide tongue 56 is further provided with a longitudinal extent of the guide tongue 56 aligned laterally projecting rib 66. This occurs in association with the receiving chamber 54 to the channel portion 52 in a correspondingly aligned in the longitudinal direction of the channel portion 52 guide groove 67 a. As a result, a position-oriented allocation of the receiving chamber 54 to the inhalation part 3 is given.

Opposite the rib 56 extends along the transversely directed to the broad sides of the guide tongue 56 narrow edge surface slit-like in cross-section, the side wall of the guide tongue 56 towards open Überströmka- In allocation position of the receiving chamber 54 in the channel section 52, the overflow channel 68 is closed by the associated side wall of the channel section 52 in cross section.

At one end, the overflow channel 68 merges into a branch channel 69 connecting this overflow channel 68 with the central flow channel 61.

Due to the axially parallel lateral arrangement of the overflow channel 68, it faces away from the flow channel 61 tangentially into the swirling space 58.

In each case on the wide side, the channel portion 52 extends cross-sectionally in a subsection, this by extending in the axial direction, bead-shaped recesses 70. These extend starting from the circular cross-section connecting pipe section 53 linearly in the direction of the flow opening 45, this at a distance ending with the receiving chamber 54 formed Whirling space 58, so that in the region of the cavity 57 of the receiving chamber 54 used a sealing chamber cross-section remains. The recesses 70 are still in projection to the receiving chamber side window 65 and open freely in the connecting pipe section 53rd

The function of the proposed device 1 is as follows: The inhalation part 3 is present with inserted and equipped with the blister 60 receiving chamber 54, this with compressed, that is folded bag 49th

The pump 2 is in the ready position, in which the piston 10 is moved via the piston rod 12 by means of the actuating handle 18 into a pumping space 71 filling the extract position. The sucked into the pump chamber 71 in this case air passes through radial openings 72, the cylinder chamber 9 and enforcing the lip seal 11 of the piston 10 overflowing. This pump preparation position is locked in place via the longitudinal slot-pin arrangement.

Due to the unopened blister 60, the inhalation part 3 is closed like a plug. An attempted sucking or blowing on or in the connecting pipe section 53 does not lead to a change in the situation; can not lead accordingly later to a mishalation.

The inhalation part 3 is associated with its connection pipe section 53 to the connection pipe section 19 of the pump 2, the free end section of the inhalation-side connection pipe section 53 engaging in the coupling section 21 of the pump 2. In the course of this assignment, the needle 26 dives through the cylinder portion 55 of the receiving chamber 54 for the final piercing of the blister 60, this from the foil-backed back through the cavity 64 in the direction of the flow channel 61st

The pierced Kavitätswandung is divided over the cross-knife-like needle 26 into four wall sections, which respectively in the piercing direction of the needle 26 into the flow channel 61 overlap.

For further inhalation preparation, the piston 10 is displaced via the actuating handle 18 in the direction of the cylinder bottom 5 after the inhalation part 3 has been attached to the pump 2 after the pump-side latching has been discontinued. The air displaced in this case flows via the hollow piston rod 12 and the needle-side through-flow openings 27 and 28 through the opened cavity 64 of the blister 60, for evacuation of the powdery medicament stored in the cavity 64. The wall sections of the cavity 64 that flatten out in the direction of flow optionally lead to a first pre-turbulence of the air flow and of the entrained medicament. About the puncture channel 69 and the axis-parallel overflow channel 68, the powder-laden air enters tangentially into the swirling space 58 and thereafter via the flow-through opening 45 in the sealed and consequently erecting bag 59th

The piston 10 is moved to the stop against the cylinder bottom 5 for almost complete emptying of the pump chamber 71. The asked in the pump chamber 71 available air volume is thereafter fully transferred into the bag 59. This volume of air is sufficient for complete emptying of the blister 60 and for transferring the contained medicament into the bag 49, in which finally an air column with a powder cloud P is established, which is self-holding for a sufficient period of time, for example 1 to 2 minutes.

After completion of the inhalation preparation by pumping the inhaled, medication-displaced air into the inhalation part 3, the latter is withdrawn from the pump 2 in the axial extension direction. In the course of this removal process, the support collar 63 of the receiving chamber 54 projecting radially beyond the inhalation-side connection tube section 53 comes against the pump-side annular step 23, which results in further withdrawal of the inhalation part 3 from the pump 2 resulting in removal of the receiving chamber 54 from the connection tube section 53. The receiving chamber 54 having the destroyed blister 60 is lost corresponding to the inhalation part 3. The latter is then available to the patient for inhalation.

A in the course of pulling the receiving chamber 54 from the connecting pipe section 53 optionally adjusting suction is torn off after a displacement of a few millimeters, preferably 1 to 2 mm, this due to the adjusting this short displacement cross-sectional enlargement of the channel portion 52 through the Recesses 70. By removing the receiving chamber 54, the user is offered the full cross section of the channel portion 52 for inhalation. The inhalation part 3 is guided to the mouth, wherein the connecting pipe section 53 also represents the mouthpiece. By usual inhalation standing in the bag 49 powder cloud P is sucked. The resulting negative pressure causes the folding of the bag 49 back into the recess 44 of the inhaler 3, this further optionally under sealing contact the bag wall on the end face of the collar 46. About the radial openings 47 of the collar 46 can also be a radially outwardly of the collar 46 are recessed in the recess 44 still adjusting residual air cushion.

In preparation for a next inhalation part 3, the pump 2 is displaced again under suction of air in its piston extraction basic position.

While the inhalation member 3 is designed for single use as a disposable part, the pump 2 is reusable.

According to the proposed device, targeted single dosing of blister-packaged medicaments is also suitable for elderly or weak patients, moreover also for children, in particular infants. The application of the device 1 is simple and self-explanatory. A double dose is not possible since each patient is assigned an inhalation part 3. This also avoids the danger of infection. The handling of the inhalation part 3 prepared for inhalation also proves to be simple and, moreover, hygienic, since, after delivery of the inhalation part 3 after removal from the pump 2, this is detected at a distance from the mouthpiece formed by the connection pipe section 53, in particular in FIG Area of the plate 40. Since the powder cloud P remains in the inflated bag 49 for a sufficient time, there is also the possibility of temporarily stopping the prepared inhalation part 3 on a flat surface, to which the wall sections 48 serve.

All disclosed features are essential to the invention. The disclosure of the associated / attached priority documents (copy of the prior application) is hereby also incorporated in full in the disclosure of the application, also for the purpose of including features of these documents in claims of the present application.

LIST OF REFERENCE NUMBERS

1 device

2 pump 3 inhaler

4 pump cylinders

5 cylinder bottom

6 cylinder ceiling

7 passage opening 8 ring collar

9 cylinder space

10 pistons

11 lip seal

12 piston rod 13 pump flow channel

14 piston area

15 radial collars

16 cylinder section

17 ceiling 18 actuating handle

19 connecting pipe section

20 support section

21 coupling section

22 Breakthrough 23 Ring Level

24 cover

25 opening

26 needle

27 flow-through opening 28 flow-through openings 29 ring seals

30 longitudinal slot

31 extension

32 Extension 33 Radial bore

34 pen

35 end section

36 handle

37 spring 38 leveling feet

39 area

40 plate

41 upper broadside

42 lower broad side 43 axial collar

44 deepening

45 flow opening

46 collar

47 opening 48 wall sections

49 bags

50 opening edge

51 reinforcing ring

52 Channel section 53 Connecting pipe section

54 receiving chamber

55 cylinder section

56 guide tongue

57 Excavation 58 Spinal room 59 level

60 blisters

61 flow channel

62 ring collar 63 support collar

64 cavity

65 windows

66 rib

67 guide groove 68 overflow channel

69 stitch channel

70 recess

71 pump room

72 radial openings

P powder cloud

x cylinder axis

Claims

1. A device (1) for administering a blister-packed medicament, characterized by a bag (49) folded on one broad side (41) of a plate (40) and bounded by its marginal edge at the bottom plate edge, which bottom plate (40) has a laterally projecting connecting tube section (FIG. 53) for a metering pump (2), in which connecting pipe section (53) there is a detachable receiving chamber (54) for the blister pack, which by means of a piercing needle (26) in the connecting pipe section (19) of the metering pump (2 ), obviously.

2. Device according to claim 1 or in particular according thereto, characterized by an overflow channel (68) in the receiving chamber (54).

3. Device according to one or more of the preceding claims or in particular according thereto, characterized in that the one broad side (41) of the bottom plate (40) has a recess (44) for receiving the folded bag wall.

4. Device according to one or more of the preceding claims or in particular according thereto, characterized in that the metering pump (2) is designed as a dispensed over a single piston stroke the necessary amount of air dispensing hand pump.

5. Device according to one or more of the preceding claims or in particular according thereto, characterized in that the receiving chamber (54) has a plug-like, in the connecting pipe section (53) insertable cylinder portion (55) on which a flat, in the connecting pipe section (53 ) leading guide tongue (56) connects, with front concave cavity (57) and middle window (65).

6. Device according to one or more of the preceding claims or in particular according thereto, characterized by a bag attachment side associated flow opening (45) which is surrounded by a circumferential, opposite the plate broad side (41) raised collar (46).

7. Device according to one or more of the preceding claims or in particular according thereto, characterized in that the peripheral collar (46) radially to the flow-through opening (45) aligned openings (47).