WO2009025852A2 - Methods of using mirna for detection of in vivo cell death - Google Patents
Methods of using mirna for detection of in vivo cell death Download PDFInfo
- Publication number
- WO2009025852A2 WO2009025852A2 PCT/US2008/009991 US2008009991W WO2009025852A2 WO 2009025852 A2 WO2009025852 A2 WO 2009025852A2 US 2008009991 W US2008009991 W US 2008009991W WO 2009025852 A2 WO2009025852 A2 WO 2009025852A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mirna
- urine
- specific
- disorder
- body fluid
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
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Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08795523.3A EP2195450B2 (en) | 2007-08-22 | 2008-08-22 | Methods of using mirna for detection of in vivo cell death |
AU2008289447A AU2008289447B2 (en) | 2007-08-22 | 2008-08-22 | Methods of using miRNA for detection of in vivo cell death |
JP2010521887A JP5416110B2 (en) | 2007-08-22 | 2008-08-22 | Methods of using miRNA to detect in vivo cell death |
CN200880113585.0A CN101861399B (en) | 2007-08-22 | 2008-08-22 | Use the method for miRNA detection bodies inner cell death condition |
DK08795523.3T DK2195450T4 (en) | 2007-08-22 | 2008-08-22 | Methods of using miRNA FOR DETECTION IN VIVO cell death |
ES08795523.3T ES2415245T5 (en) | 2007-08-22 | 2008-08-22 | Methods of using miRNA for the detection of cell death in vivo |
PL08795523T PL2195450T3 (en) | 2007-08-22 | 2008-08-22 | Methods of using mirna for detection of in vivo cell death |
CA2696403A CA2696403C (en) | 2007-08-22 | 2008-08-22 | Methods of using mirna for detection of in vivo cell death |
SI200830987T SI2195450T1 (en) | 2007-08-22 | 2008-08-22 | Methods of using mirna for detection of in vivo cell death |
HRP20130618AT HRP20130618T1 (en) | 2007-08-22 | 2013-07-02 | Methods of using mirna for detection of in vivo cell death |
AU2014210676A AU2014210676B2 (en) | 2007-08-22 | 2014-08-11 | Methods of Using miRNA for Detection of In Vivo Cell Death |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96587107P | 2007-08-22 | 2007-08-22 | |
US60/965,871 | 2007-08-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009025852A2 true WO2009025852A2 (en) | 2009-02-26 |
WO2009025852A3 WO2009025852A3 (en) | 2009-05-07 |
Family
ID=40378881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/009991 WO2009025852A2 (en) | 2007-08-22 | 2008-08-22 | Methods of using mirna for detection of in vivo cell death |
Country Status (17)
Country | Link |
---|---|
US (4) | US8486626B2 (en) |
EP (2) | EP2195450B2 (en) |
JP (1) | JP5416110B2 (en) |
CN (2) | CN101861399B (en) |
AU (2) | AU2008289447B2 (en) |
CA (1) | CA2696403C (en) |
CY (1) | CY1114111T1 (en) |
DK (2) | DK2195450T4 (en) |
ES (2) | ES2660785T3 (en) |
HK (1) | HK1218767A1 (en) |
HR (1) | HRP20130618T1 (en) |
HU (1) | HUE019019T5 (en) |
NO (1) | NO2612926T3 (en) |
PL (2) | PL2195450T3 (en) |
PT (2) | PT2195450E (en) |
TR (1) | TR201802758T4 (en) |
WO (1) | WO2009025852A2 (en) |
Cited By (18)
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WO2010004562A2 (en) * | 2008-07-09 | 2010-01-14 | Rosetta Genomics Ltd. | Methods and compositions for detecting colorectal cancer |
WO2010009398A1 (en) * | 2008-07-18 | 2010-01-21 | Xenomics, Inc. | Methods for pcr-based detection of "ultra short" nucleic acid sequences |
WO2011057003A3 (en) * | 2009-11-04 | 2011-07-21 | Samuil Umansky | Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
EP2733220A1 (en) * | 2012-11-16 | 2014-05-21 | Siemens Aktiengesellschaft | Novel miRNAs as diagnostic markers |
WO2014075822A1 (en) * | 2012-11-16 | 2014-05-22 | Siemens Aktiengesellschaft | New diagnostic mirna markers for parkinson disease |
EP2759602A1 (en) * | 2013-01-25 | 2014-07-30 | Charité - Universitätsmedizin Berlin | Non-invasive prenatal genetic diagnostic methods |
AU2013211850A1 (en) * | 2012-01-27 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiling and quantitating cell-free RNA |
EP2742155A4 (en) * | 2011-08-08 | 2015-06-10 | Advanced Genomic Technology Llc | Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof |
EP2758538A4 (en) * | 2011-09-22 | 2015-08-26 | Lineage Biosciences Inc | Compositions and methods for analyzing heterogeneous samples |
US9556487B2 (en) | 2011-04-18 | 2017-01-31 | Diamir, Llc | Methods of using miRNA from bodily fluids for early detection and monitoring of mild cognitive impairment (MCI) and alzheimer's disease (AD) |
US9771617B2 (en) | 2011-06-27 | 2017-09-26 | Eisai R&D Management Co., Ltd. | Microrna biomarkers indicative of alzheimer's disease |
US10138520B2 (en) | 2012-11-16 | 2018-11-27 | Siemens Aktiengesellschaft | Diagnostic miRNA markers for Alzheimer |
US10722858B2 (en) | 2013-03-15 | 2020-07-28 | Lineage Biosciences, Inc. | Methods and compositions for tagging and analyzing samples |
US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
US11098362B2 (en) | 2013-11-18 | 2021-08-24 | Diamir, Llc | Methods of using miRNAs from bodily fluids for detection and monitoring of Parkinson's disease (PD) |
US11149313B2 (en) | 2016-03-21 | 2021-10-19 | Diamir, Llc | Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases |
US11845988B2 (en) | 2019-02-14 | 2023-12-19 | Mirvie, Inc. | Methods and systems for determining a pregnancy-related state of a subject |
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EP2271931A4 (en) * | 2008-04-25 | 2011-10-12 | Merck Sharp & Dohme | Microrna biomarkers of tissue injury |
US20120034608A1 (en) * | 2009-04-14 | 2012-02-09 | Merck Sharp & Dohme Corp. | Microrna as a biomarker of pancreatic islet beta-cell engagement |
WO2011006119A2 (en) | 2009-07-09 | 2011-01-13 | The Scripps Research Institute | Gene expression profiles associated with chronic allograft nephropathy |
PT2496720T (en) | 2009-11-06 | 2020-10-12 | Univ Leland Stanford Junior | Non-invasive diagnosis of graft rejection in organ transplant patients |
US20140227691A1 (en) * | 2010-05-14 | 2014-08-14 | Fluidigm, Inc. | Nucleic acid isolation methods |
CN102188719B (en) * | 2011-05-12 | 2012-12-19 | 南方医科大学 | Application of EB virus miR-BART3 antisense oligonucleotides in preparing medicament for treating nasopharyngeal darcinoma |
ITRM20110685A1 (en) | 2011-12-23 | 2013-06-24 | Internat Ct For Genetic En Gineering And | MICRORNA FOR CARDIAC REGENERATION THROUGH THE INDUCTION OF THE PROLIFERATION OF CARDIAC MYCYCLES |
US20140087964A1 (en) * | 2012-09-24 | 2014-03-27 | University Of Virginia Patent Foundation | Compositions and methods for detecting aberrant regulation, expression, and levels of hgh |
CN103045736B (en) * | 2012-12-20 | 2014-09-17 | 徐勇 | Down syndrome 21 chromosome miRNA differential expression map model, modeling method and application |
CN103045596A (en) * | 2012-12-20 | 2013-04-17 | 徐勇 | Down syndrome 21 chromosome-related miRNA, gene, screening method and application |
US10443100B2 (en) | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
US11104951B2 (en) | 2014-05-22 | 2021-08-31 | The Scripps Research Institute | Molecular signatures for distinguishing liver transplant rejections or injuries |
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AU2016264102A1 (en) | 2015-05-18 | 2017-12-21 | Karius, Inc. | Compositions and methods for enriching populations of nucleic acids |
WO2017019751A1 (en) | 2015-07-27 | 2017-02-02 | The Johns Hopkins University | Method to use viral and host methylation markers for cervical cancer screening and triage in liquid prep, serum/plasma, and urine: pcr and sequencing based process methods |
WO2017044710A1 (en) * | 2015-09-11 | 2017-03-16 | Corning Incorporated | Compositions and methods for nucleic acid purification from blood samples |
WO2018045359A1 (en) * | 2016-09-02 | 2018-03-08 | Karius, Inc. | Detection and treatment of infection during pregnancy |
CA3043709A1 (en) | 2016-11-14 | 2018-05-17 | Berg Llc | Methods for treating parkinson's disease |
CN109983134A (en) | 2016-11-30 | 2019-07-05 | 香港中文大学 | The analysis of Cell-free DNA in urine and other samples |
US10907211B1 (en) | 2017-02-16 | 2021-02-02 | Quantgene Inc. | Methods and compositions for detecting cancer biomarkers in bodily fluids |
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US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
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2008
- 2008-08-22 CN CN200880113585.0A patent/CN101861399B/en not_active Expired - Fee Related
- 2008-08-22 ES ES13161985.0T patent/ES2660785T3/en active Active
- 2008-08-22 HU HUE08795523A patent/HUE019019T5/en unknown
- 2008-08-22 DK DK08795523.3T patent/DK2195450T4/en active
- 2008-08-22 PT PT87955233T patent/PT2195450E/en unknown
- 2008-08-22 US US12/229,378 patent/US8486626B2/en not_active Expired - Fee Related
- 2008-08-22 ES ES08795523.3T patent/ES2415245T5/en active Active
- 2008-08-22 EP EP08795523.3A patent/EP2195450B2/en not_active Not-in-force
- 2008-08-22 PL PL08795523T patent/PL2195450T3/en unknown
- 2008-08-22 WO PCT/US2008/009991 patent/WO2009025852A2/en active Application Filing
- 2008-08-22 CA CA2696403A patent/CA2696403C/en not_active Expired - Fee Related
- 2008-08-22 AU AU2008289447A patent/AU2008289447B2/en not_active Ceased
- 2008-08-22 NO NO13161985A patent/NO2612926T3/no unknown
- 2008-08-22 EP EP13161985.0A patent/EP2612926B1/en active Active
- 2008-08-22 JP JP2010521887A patent/JP5416110B2/en not_active Expired - Fee Related
- 2008-08-22 DK DK13161985.0T patent/DK2612926T3/en active
- 2008-08-22 TR TR2018/02758T patent/TR201802758T4/en unknown
- 2008-08-22 PT PT131619850T patent/PT2612926T/en unknown
- 2008-08-22 CN CN201510649676.8A patent/CN105400868B/en not_active Expired - Fee Related
- 2008-08-22 PL PL13161985T patent/PL2612926T3/en unknown
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2013
- 2013-07-02 HR HRP20130618AT patent/HRP20130618T1/en unknown
- 2013-07-03 CY CY20131100546T patent/CY1114111T1/en unknown
- 2013-07-16 US US13/942,706 patent/US20150197805A1/en not_active Abandoned
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2014
- 2014-08-11 AU AU2014210676A patent/AU2014210676B2/en not_active Ceased
-
2016
- 2016-06-13 HK HK16106720.6A patent/HK1218767A1/en unknown
-
2017
- 2017-01-06 US US15/400,157 patent/US20180135126A1/en not_active Abandoned
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2018
- 2018-09-21 US US16/138,338 patent/US20200283851A1/en not_active Abandoned
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Cited By (41)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2010004562A2 (en) * | 2008-07-09 | 2010-01-14 | Rosetta Genomics Ltd. | Methods and compositions for detecting colorectal cancer |
WO2010004562A3 (en) * | 2008-07-09 | 2010-04-01 | Rosetta Genomics Ltd. | Methods and compositions for detecting colorectal cancer |
WO2010009398A1 (en) * | 2008-07-18 | 2010-01-21 | Xenomics, Inc. | Methods for pcr-based detection of "ultra short" nucleic acid sequences |
EP2853601B1 (en) | 2008-07-18 | 2016-09-21 | TrovaGene, Inc. | Methods for PCR-based detection of "ultra short" nucleic acid sequences |
US9816148B2 (en) | 2008-07-18 | 2017-11-14 | Trovagene, Inc. | Amplification and sequencing of transrenal nucleic acids |
EP2853601A1 (en) * | 2008-07-18 | 2015-04-01 | TrovaGene, Inc. | Methods for PCR-based detection of "ultra short" nucleic acid sequences |
WO2011057003A3 (en) * | 2009-11-04 | 2011-07-21 | Samuil Umansky | Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
US8648017B2 (en) | 2009-11-04 | 2014-02-11 | Diamir, Llc | Methods of using small RNA from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
EP3118334A1 (en) * | 2009-11-04 | 2017-01-18 | DiamiR, LLC | Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
US9803242B2 (en) | 2011-04-18 | 2017-10-31 | Diamir, Llc | miRNA-based universal screening test (UST) |
US9556487B2 (en) | 2011-04-18 | 2017-01-31 | Diamir, Llc | Methods of using miRNA from bodily fluids for early detection and monitoring of mild cognitive impairment (MCI) and alzheimer's disease (AD) |
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