WO2009022632A1 - 新規肝癌マーカー - Google Patents

新規肝癌マーカー Download PDF

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Publication number
WO2009022632A1
WO2009022632A1 PCT/JP2008/064248 JP2008064248W WO2009022632A1 WO 2009022632 A1 WO2009022632 A1 WO 2009022632A1 JP 2008064248 W JP2008064248 W JP 2008064248W WO 2009022632 A1 WO2009022632 A1 WO 2009022632A1
Authority
WO
WIPO (PCT)
Prior art keywords
liver cancer
cancer marker
novel liver
patient
novel
Prior art date
Application number
PCT/JP2008/064248
Other languages
English (en)
French (fr)
Inventor
Hideji Nakamura
Youichi Yabuuchi
Yasukazu Ohmoto
Toyoki Mori
Masahiro Muraguchi
Keiko Oga
Fusako Iwata
Kaori Murata
Original Assignee
Hyogo College Of Medicine
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyogo College Of Medicine, Otsuka Pharmaceutical Co., Ltd. filed Critical Hyogo College Of Medicine
Priority to JP2009528108A priority Critical patent/JP5553603B2/ja
Priority to ES08827455T priority patent/ES2392312T3/es
Priority to EP08827455A priority patent/EP2187216B1/en
Priority to CN200880102963.5A priority patent/CN101796415B/zh
Priority to US12/673,346 priority patent/US20110281284A1/en
Publication of WO2009022632A1 publication Critical patent/WO2009022632A1/ja

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

　本発明は、慢性肝疾患患者の血液中のHDGFを測定することにより、肝癌かどうかを診断する。または、該診断のための測定キットを提供する。
PCT/JP2008/064248 2007-08-10 2008-08-07 新規肝癌マーカー WO2009022632A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2009528108A JP5553603B2 (ja) 2007-08-10 2008-08-07 新規肝癌マーカー
ES08827455T ES2392312T3 (es) 2007-08-10 2008-08-07 Nuevo marcador del cáncer de hígado
EP08827455A EP2187216B1 (en) 2007-08-10 2008-08-07 Novel liver cancer marker
CN200880102963.5A CN101796415B (zh) 2007-08-10 2008-08-07 新型肝癌标志物
US12/673,346 US20110281284A1 (en) 2007-08-10 2008-08-07 Novel liver cancer marker

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007209544 2007-08-10
JP2007-209544 2007-08-10

Publications (1)

Publication Number Publication Date
WO2009022632A1 true WO2009022632A1 (ja) 2009-02-19

Family

ID=40350685

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/064248 WO2009022632A1 (ja) 2007-08-10 2008-08-07 新規肝癌マーカー

Country Status (7)

Country Link
US (1) US20110281284A1 (ja)
EP (1) EP2187216B1 (ja)
JP (1) JP5553603B2 (ja)
KR (1) KR20100040964A (ja)
CN (1) CN101796415B (ja)
ES (1) ES2392312T3 (ja)
WO (1) WO2009022632A1 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103245787B (zh) * 2012-02-01 2016-01-20 浙江大学 一种肝癌衍生生长因子检测试剂盒的制备方法
MY179845A (en) * 2014-07-02 2020-11-18 Dragon Victory Dev Ltd Specific biomarker set for non-invasive diagnosis of liver cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01500188A (ja) * 1986-04-08 1989-01-26 ザ、ゼネラル、ホスピタル、コーポレーション ヘパトーム由来成長因子
JP2003180368A (ja) * 2001-12-19 2003-07-02 Pharma Design Inc 癌患者に対する放射線治療の有効性の予測方法
JP2006526405A (ja) * 2003-06-04 2006-11-24 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 示差的調節された肝細胞癌遺伝子およびその利用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1978985A2 (en) * 2005-12-23 2008-10-15 Board Of Regents Of The University Of Texas System Anti-hyperproliferative therapies targeting hdgf

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01500188A (ja) * 1986-04-08 1989-01-26 ザ、ゼネラル、ホスピタル、コーポレーション ヘパトーム由来成長因子
JP2003180368A (ja) * 2001-12-19 2003-07-02 Pharma Design Inc 癌患者に対する放射線治療の有効性の予測方法
JP2006526405A (ja) * 2003-06-04 2006-11-24 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 示差的調節された肝細胞癌遺伝子およびその利用

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
HU TSUNG-HUI: "Expression of hepatoma-derived growth factor in hepatocellular carcinoma A novel prognostic factor", CANCER, vol. 98, no. 7, 2003, pages 1444 - 1456, XP009109915 *
KEN'YA YOSHIDA: "Kangan Oyobi Kanhatsugan ni Okeru Kangan Yurai Zoshoku Inshi HDGF no Yakuwari", MED J OSAKA UNIV, vol. 46, no. 1-4, 2003, pages 51 - 61, XP008130120 *
MASAHIKO WATANABE: "Gan no Soki Shindan Oyobi Chiryoho no Sentaku ni Yakudatsu Shuyo Marker no Kaihatsu", KOSEI RODOSHO GAN KENKYU JOSEIKIN NI YORU KENKYU HOKOKUSHU, vol. 2001, 2002, pages 336 - 341, XP008130117 *
MASATO MAEKAWA: "Suigan no Soki Shindan eno Approach Suigan no Shuyo Marker", SUIZO, vol. 19, no. 6, 2004, pages 579 - 583, XP003012959 *
REN HENING: "Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small- cell lung cancer.", JOURNAL OF CLINICAL ONCOLOGY, vol. 22, no. 16, 2004, pages 3230 - 3237, XP008129885 *
See also references of EP2187216A4 *
SHUJI NAKAMURA: "Kangan Shikkan Kesshochu no Kangan Yurai Zoshoku Inshi HDGF Nodo no Sokutei", ACTA HEPATOLOGICA JAPONICA, vol. 48, no. Supplemnet 2, 15 September 2007 (2007-09-15), pages A446, XP008130119 *
TERUO IWASAKI: "Hishosaibo Haigan Setsujorei ni Okeru Kangan Yurai Zoshoku Inshi HDGF no Hatsugen to sono Yogo Inshi to shite no Igi ni Tsuite", THE JOURNAL OF THE JAPANESE RESPIRATORY SOCIETY, vol. 18, no. 3, 2004, pages 482 P-581 *
TOSHIRO KAGESHITA: "Melanoma 'Shinki Kogen ni yoru Melanoma Kessei Shindan -glypican-3. SPARC", THE CELL, vol. 38, no. 14, 2006, pages 584 - 586, XP008130116 *
YASUSHI MIDORIKAWA: "Genpatsusei Kansaibogan ni Oite Kohatsugen suru Glypican 3 ni yoru Kessei Shindan to FGF2 Oyobi BMP-7 no Signal Dentatsu Yokusei", JOURNAL OF JAPAN SURGICAL SOCIETY, vol. 104, 2003, XP008130121 *

Also Published As

Publication number Publication date
ES2392312T3 (es) 2012-12-07
US20110281284A1 (en) 2011-11-17
EP2187216B1 (en) 2012-09-26
KR20100040964A (ko) 2010-04-21
EP2187216A4 (en) 2011-03-02
CN101796415B (zh) 2014-03-12
EP2187216A1 (en) 2010-05-19
JP5553603B2 (ja) 2014-07-16
CN101796415A (zh) 2010-08-04
JPWO2009022632A1 (ja) 2010-11-18

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