WO2009022477A1 - 生理活性物質を結合したノルボルネン系高分子重合体、その製法及び用途 - Google Patents

生理活性物質を結合したノルボルネン系高分子重合体、その製法及び用途 Download PDF

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Publication number
WO2009022477A1
WO2009022477A1 PCT/JP2008/053758 JP2008053758W WO2009022477A1 WO 2009022477 A1 WO2009022477 A1 WO 2009022477A1 JP 2008053758 W JP2008053758 W JP 2008053758W WO 2009022477 A1 WO2009022477 A1 WO 2009022477A1
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WO
WIPO (PCT)
Prior art keywords
biologically active
proces
production
same
active substances
Prior art date
Application number
PCT/JP2008/053758
Other languages
English (en)
French (fr)
Inventor
Yasuo Wakatsuki
Takashi Iida
Shojiro Ogawa
Shigenaga Takano
Original Assignee
Nihon University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon University filed Critical Nihon University
Priority to JP2009528042A priority Critical patent/JPWO2009022477A1/ja
Publication of WO2009022477A1 publication Critical patent/WO2009022477A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/02—Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes
    • C08G61/04—Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms
    • C08G61/06—Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds
    • C08G61/08—Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

【課題】生理活性物質を高密度で均一に分布している高分子重合体を提供すること。 【解決手段】高分子重合体にポリノルボルネンを選択して用いることで、上記課題が解決できた。
PCT/JP2008/053758 2007-08-10 2008-03-03 生理活性物質を結合したノルボルネン系高分子重合体、その製法及び用途 WO2009022477A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009528042A JPWO2009022477A1 (ja) 2007-08-10 2008-03-03 生理活性物質を結合したノルボルネン系高分子重合体、その製法及び用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007208756 2007-08-10
JP2007-208756 2007-08-10

Publications (1)

Publication Number Publication Date
WO2009022477A1 true WO2009022477A1 (ja) 2009-02-19

Family

ID=40350535

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053758 WO2009022477A1 (ja) 2007-08-10 2008-03-03 生理活性物質を結合したノルボルネン系高分子重合体、その製法及び用途

Country Status (2)

Country Link
JP (1) JPWO2009022477A1 (ja)
WO (1) WO2009022477A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016539206A (ja) * 2013-10-07 2016-12-15 ユニバーシティー オブ コネチカット 薬物送達用の自己集積ブラシブロックコポリマーナノ粒子
JP2017532417A (ja) * 2014-10-15 2017-11-02 ユニバーシティー オブ コネチカット 薬物送達のための生還元性（ｂｉｏ−ｒｅｄｕｃｉｂｌｅ）自己組織化液晶ブロックコポリマー

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001048964A (ja) * 1999-05-28 2001-02-20 Hitachi Chem Co Ltd 樹脂粒子の製造法
JP2003502488A (ja) * 1999-06-17 2003-01-21 ウィスコンシン・アラムナイ・リサーチ・ファウンデイション 多価アレイおよび多価アレイのコンビナトリアルライブラリーを作製する方法および試薬
WO2006024184A1 (en) * 2004-08-31 2006-03-09 Givaudan Sa Romp polymer particles comprising active ingredients

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001048964A (ja) * 1999-05-28 2001-02-20 Hitachi Chem Co Ltd 樹脂粒子の製造法
JP2003502488A (ja) * 1999-06-17 2003-01-21 ウィスコンシン・アラムナイ・リサーチ・ファウンデイション 多価アレイおよび多価アレイのコンビナトリアルライブラリーを作製する方法および試薬
WO2006024184A1 (en) * 2004-08-31 2006-03-09 Givaudan Sa Romp polymer particles comprising active ingredients

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. AM. CHEM. SOC., vol. 116, 1994, pages 12053 - 12054, XP002000244 *
SANDERS WILLIAM J ET AL: "Inhibition of L-selectin-mediated Leukocyte by Synthetic Glycoprotein Mimics", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 9, pages 5271 - 5278, XP000882907 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016539206A (ja) * 2013-10-07 2016-12-15 ユニバーシティー オブ コネチカット 薬物送達用の自己集積ブラシブロックコポリマーナノ粒子
US11103523B2 (en) 2013-10-07 2021-08-31 University Of Connecticut Self-assembled brush block copolymer-nanoparticles for drug delivery
JP2017532417A (ja) * 2014-10-15 2017-11-02 ユニバーシティー オブ コネチカット 薬物送達のための生還元性（ｂｉｏ−ｒｅｄｕｃｉｂｌｅ）自己組織化液晶ブロックコポリマー

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