WO2009013972A1 - 免疫アジュバント及びIgA抗体測定方法 - Google Patents
免疫アジュバント及びIgA抗体測定方法 Download PDFInfo
- Publication number
- WO2009013972A1 WO2009013972A1 PCT/JP2008/061810 JP2008061810W WO2009013972A1 WO 2009013972 A1 WO2009013972 A1 WO 2009013972A1 JP 2008061810 W JP2008061810 W JP 2008061810W WO 2009013972 A1 WO2009013972 A1 WO 2009013972A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- immunoadjuvant
- intended
- extent
- plate
- inoculating
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- General Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
本発明は、分泌型IgAの産生能を高めることができ、かつ、安全性が高い免疫アジュバント及びその接種方法を提供する。具体的には、キトサン微粒子を含む免疫アジュバント、カチオン化キトサンを含む免疫アジュバント及びそれらの分散液又は水溶液を霧状として動物の肺内に噴霧することを特徴とする免疫アジュバントの接種方法を提供する。又、本発明は、ELISA法に用いるブロッキング後のプレートについて、非特異的反応の発生の程度を評価する方法を提供する。具体的には、ELISAプレートの一部のウェルを抗原でコーティングした後、プレート全体にブロッキング剤、免疫グロブリン、2次抗体、酵素標識した3次抗体を作用させ、次いで、酵素の基質を添加して、抗原をコーティングしたウェルとコーティングしていないウェルの酵素反応の程度を比較することを特徴とするELISAプレートにおける非特異的反応の発生の程度を評価する方法を提供する。
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-192364 | 2007-07-24 | ||
JP2007192364A JP2009031001A (ja) | 2007-07-24 | 2007-07-24 | IgA抗体測定方法 |
JP2007-192362 | 2007-07-24 | ||
JP2007192362A JP5259997B2 (ja) | 2007-07-24 | 2007-07-24 | 免疫アジュバント分散液 |
JP2007192363A JP5297009B2 (ja) | 2007-07-24 | 2007-07-24 | 免疫アジュバント水溶液 |
JP2007-192363 | 2007-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009013972A1 true WO2009013972A1 (ja) | 2009-01-29 |
Family
ID=40281231
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/061810 WO2009013972A1 (ja) | 2007-07-24 | 2008-06-30 | 免疫アジュバント及びIgA抗体測定方法 |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009013972A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014067976A1 (en) * | 2012-10-30 | 2014-05-08 | Nestec S.A. | Compositions comprising microparticles and probiotics to deliver a synergistic immune effect |
WO2015022907A1 (ja) | 2013-08-13 | 2015-02-19 | 生化学工業株式会社 | カチオン化キトサンを含有する医薬 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0649725B2 (ja) * | 1984-08-31 | 1994-06-29 | ライオン株式会社 | カチオン性キトサン誘導体の製造方法 |
JP2000501381A (ja) * | 1995-10-18 | 2000-02-08 | バンダービルト ユニバーシティー | 粘膜免疫応答のホルモン免疫調節誘導 |
JP2004502653A (ja) * | 2000-06-19 | 2004-01-29 | キャンディヴァクス・プロプライエタリー・リミテッド | カンジダ症の治療のための組成物および方法 |
WO2005121790A1 (ja) * | 2004-06-11 | 2005-12-22 | Toyo Boseki Kabushiki Kaisha | 測定感度を向上させるための組成物 |
WO2006107097A1 (ja) * | 2005-04-01 | 2006-10-12 | Riken | 経鼻ワクチン |
JP2007002123A (ja) * | 2005-06-24 | 2007-01-11 | Dainichiseika Color & Chem Mfg Co Ltd | キトサン微粒子 |
-
2008
- 2008-06-30 WO PCT/JP2008/061810 patent/WO2009013972A1/ja active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0649725B2 (ja) * | 1984-08-31 | 1994-06-29 | ライオン株式会社 | カチオン性キトサン誘導体の製造方法 |
JP2000501381A (ja) * | 1995-10-18 | 2000-02-08 | バンダービルト ユニバーシティー | 粘膜免疫応答のホルモン免疫調節誘導 |
JP2004502653A (ja) * | 2000-06-19 | 2004-01-29 | キャンディヴァクス・プロプライエタリー・リミテッド | カンジダ症の治療のための組成物および方法 |
WO2005121790A1 (ja) * | 2004-06-11 | 2005-12-22 | Toyo Boseki Kabushiki Kaisha | 測定感度を向上させるための組成物 |
WO2006107097A1 (ja) * | 2005-04-01 | 2006-10-12 | Riken | 経鼻ワクチン |
JP2007002123A (ja) * | 2005-06-24 | 2007-01-11 | Dainichiseika Color & Chem Mfg Co Ltd | キトサン微粒子 |
Non-Patent Citations (2)
Title |
---|
ISHIKAWA K.: "7. IgA Yudogata HIV-1 Vaccine Kaihatsu no Tame no Adjuvant Oyobi DDS no Kento", HIV KANSEN YOBO NI KANSURU KENKYUHAN HEISEI 17 NENDO SOKATSU.BUNTAN KENKYU HOKOKUSHO, March 2006 (2006-03-01), pages 39 - 42 * |
ISHIKAWA K.: "Vaccine Adjuvant Kaihatsu to Dobutsu Jikken", HIV NO KANSEN YOBO NI KANSURU KENKYU HEISEI 18 NENDO SOKATSU.BUNTAN KENKYU HOKOKUSHO, March 2007 (2007-03-01), pages 63 - 66 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014067976A1 (en) * | 2012-10-30 | 2014-05-08 | Nestec S.A. | Compositions comprising microparticles and probiotics to deliver a synergistic immune effect |
WO2015022907A1 (ja) | 2013-08-13 | 2015-02-19 | 生化学工業株式会社 | カチオン化キトサンを含有する医薬 |
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