WO2009009381A1 - Améliorations du débit pour l'administration de substances biologiques et de médicaments par l'intermédiaire d'une aiguille hypodermique - Google Patents

Améliorations du débit pour l'administration de substances biologiques et de médicaments par l'intermédiaire d'une aiguille hypodermique Download PDF

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Publication number
WO2009009381A1
WO2009009381A1 PCT/US2008/069044 US2008069044W WO2009009381A1 WO 2009009381 A1 WO2009009381 A1 WO 2009009381A1 US 2008069044 W US2008069044 W US 2008069044W WO 2009009381 A1 WO2009009381 A1 WO 2009009381A1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
solution
needle
ultrasonic transducer
nozzle
Prior art date
Application number
PCT/US2008/069044
Other languages
English (en)
Inventor
Bart Lipkens
Walter M. Presz Jr
Stanley Kowalski Iii
Original Assignee
Flodesign, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flodesign, Inc. filed Critical Flodesign, Inc.
Publication of WO2009009381A1 publication Critical patent/WO2009009381A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/3131—Syringe barrels specially adapted for improving sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
    • A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall

Definitions

  • FIG. 7, including FIGs. (7(a)-7(b), are various views of another embodiment of a flow delivery system of the present invention having an ultrasonic transducer disposed within the syringe body;
  • FIG. 4 there illustrated are various views of portions of another embodiment of a syringe and nozzle flow delivery system according to the present invention.
  • This embodiment includes a contoured or streamlined nozzle 32 separate from the syringe 12 that, when connected with the syringe 12, allows for a smooth and continuous reduction of the internal cross-sectional diameter (ID) of the syringe 12 from the wider section fitting the plunger 14 to the smaller section with preferably an identical ID as that of the needle 20.
  • ID internal cross-sectional diameter
  • the needle 20 fits flush against the nozzle 32, thereby allowing for a smooth and continuous transition from the syringe 12 to the needle 20.

Abstract

La présente invention concerne un système d'administration d'une solution aqueuse à base d'une substance biologique et d'un médicament comprenant une seringue et une aiguille. Un ajutage profilé relie la seringue à l'aiguille et réduit la force de piston nécessaire pour expulser la solution hors de l'aiguille. Un transducteur à ultrasons génère des impulsions et des ondes de pression acoustique dans la solution. La force de radiation acoustique du champ acoustique aligne les particules dans la solution dans la direction de l'axe de la seringue et facilite l'expulsion. Aussi, la force de radiation acoustique modifie la forme de la substance biologique et du médicament en formes allongées, de ce fait réduisant la force d'expulsion nécessaire. En outre, l'excitation vibratoire de la substance biologique et du médicament par le champ d'ultrasons facilite l'expulsion de la solution. Des impulsions de forte pression peuvent délivrer des gouttes de la solution hors de l'ouverture de l'aiguille. Un capteur peut être utilisé pour exercer une régulation afin de permettre qu'une force constante soit opérée sur le système.
PCT/US2008/069044 2007-07-11 2008-07-02 Améliorations du débit pour l'administration de substances biologiques et de médicaments par l'intermédiaire d'une aiguille hypodermique WO2009009381A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94904107P 2007-07-11 2007-07-11
US60/949,041 2007-07-11

Publications (1)

Publication Number Publication Date
WO2009009381A1 true WO2009009381A1 (fr) 2009-01-15

Family

ID=40228987

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/069044 WO2009009381A1 (fr) 2007-07-11 2008-07-02 Améliorations du débit pour l'administration de substances biologiques et de médicaments par l'intermédiaire d'une aiguille hypodermique

Country Status (1)

Country Link
WO (1) WO2009009381A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110245799A1 (en) * 2010-03-31 2011-10-06 Erickson Signe R System and method for delivery of suspensions and other microparticle compositions
ITNA20100056A1 (it) * 2010-11-24 2012-05-25 Leasemedica Di Paolo Lamanna Manipolo per trattamenti estetici e sottocutanei in ultrasuono
CN104645489A (zh) * 2015-02-27 2015-05-27 苏州贝尔一锋医疗器械有限公司 微量弹水滴液器

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3569870A (en) * 1968-08-21 1971-03-09 Rca Corp Feed system
US5249584A (en) * 1990-05-18 1993-10-05 Karkar Maurice N Syringe for hematocrit and oxygen saturation blood analyzer
US20020052574A1 (en) * 1998-04-10 2002-05-02 Mark Hochman Pressure/force computer controlled drug delivery system with automated charging
US20020082518A1 (en) * 2000-12-22 2002-06-27 David Weiss Control systems for biopsy devices
US20040191275A1 (en) * 2003-01-09 2004-09-30 Henry Milner Ultrasonic dispersion apparatus, system, and method
US20050163716A1 (en) * 1993-11-30 2005-07-28 Bristol-Myers Squibb Medical Imaging, Inc. Methods of preparing gaseous precursor-filled microspheres
US20060241524A1 (en) * 2005-03-11 2006-10-26 Qi Yu Intravascular ultrasound catheter device and method for ablating atheroma
US20060252141A1 (en) * 2003-09-08 2006-11-09 Coakley William T Apparatus for ultrasonic microbial disruption

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3569870A (en) * 1968-08-21 1971-03-09 Rca Corp Feed system
US5249584A (en) * 1990-05-18 1993-10-05 Karkar Maurice N Syringe for hematocrit and oxygen saturation blood analyzer
US20050163716A1 (en) * 1993-11-30 2005-07-28 Bristol-Myers Squibb Medical Imaging, Inc. Methods of preparing gaseous precursor-filled microspheres
US20020052574A1 (en) * 1998-04-10 2002-05-02 Mark Hochman Pressure/force computer controlled drug delivery system with automated charging
US20020082518A1 (en) * 2000-12-22 2002-06-27 David Weiss Control systems for biopsy devices
US20040191275A1 (en) * 2003-01-09 2004-09-30 Henry Milner Ultrasonic dispersion apparatus, system, and method
US20060252141A1 (en) * 2003-09-08 2006-11-09 Coakley William T Apparatus for ultrasonic microbial disruption
US20060241524A1 (en) * 2005-03-11 2006-10-26 Qi Yu Intravascular ultrasound catheter device and method for ablating atheroma

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110245799A1 (en) * 2010-03-31 2011-10-06 Erickson Signe R System and method for delivery of suspensions and other microparticle compositions
WO2011123651A3 (fr) * 2010-03-31 2012-02-23 Surmodics, Inc. Système et procédé pour la délivrance de suspensions et d'autres compositions microparticulaires
EP2552515A2 (fr) * 2010-03-31 2013-02-06 Evonik Degussa Corporation Système et procédé pour la délivrance de suspensions et d'autres compositions microparticulaires
CN103140250A (zh) * 2010-03-31 2013-06-05 赢创有限公司 用于递送混悬液和其它微粒组合物的系统及方法
EP2552515A4 (fr) * 2010-03-31 2014-08-20 Evonik Corp Système et procédé pour la délivrance de suspensions et d'autres compositions microparticulaires
ITNA20100056A1 (it) * 2010-11-24 2012-05-25 Leasemedica Di Paolo Lamanna Manipolo per trattamenti estetici e sottocutanei in ultrasuono
CN104645489A (zh) * 2015-02-27 2015-05-27 苏州贝尔一锋医疗器械有限公司 微量弹水滴液器

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