WO2009007827A3 - Novel diclofenac esters and uses thereof - Google Patents

Novel diclofenac esters and uses thereof Download PDF

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Publication number
WO2009007827A3
WO2009007827A3 PCT/IB2008/001781 IB2008001781W WO2009007827A3 WO 2009007827 A3 WO2009007827 A3 WO 2009007827A3 IB 2008001781 W IB2008001781 W IB 2008001781W WO 2009007827 A3 WO2009007827 A3 WO 2009007827A3
Authority
WO
WIPO (PCT)
Prior art keywords
esters
diclofenac
novel
novel diclofenac
compositions
Prior art date
Application number
PCT/IB2008/001781
Other languages
French (fr)
Other versions
WO2009007827A2 (en
WO2009007827A9 (en
Inventor
Hans Hitz
Rolf Schaefer
Original Assignee
Schaefer Chem Inst
Hans Hitz
Rolf Schaefer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schaefer Chem Inst, Hans Hitz, Rolf Schaefer filed Critical Schaefer Chem Inst
Publication of WO2009007827A2 publication Critical patent/WO2009007827A2/en
Publication of WO2009007827A3 publication Critical patent/WO2009007827A3/en
Publication of WO2009007827A9 publication Critical patent/WO2009007827A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention relates to novel cycloalkyl alkyl and fluoroalkyl esters of diclofenac that more readily penetrate membrane systems than diclofenac (acid) or prior art esters of diclofenac. Pharmaceutical compositions comprising these esters as well as methods for treating inflammatory conditions using the latter compositions are also disclosed.
PCT/IB2008/001781 2007-07-10 2008-07-03 Novel diclofenac esters and uses thereof WO2009007827A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92971807P 2007-07-10 2007-07-10
US60/929,718 2007-07-10

Publications (3)

Publication Number Publication Date
WO2009007827A2 WO2009007827A2 (en) 2009-01-15
WO2009007827A3 true WO2009007827A3 (en) 2009-03-19
WO2009007827A9 WO2009007827A9 (en) 2009-09-11

Family

ID=40139370

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/001781 WO2009007827A2 (en) 2007-07-10 2008-07-03 Novel diclofenac esters and uses thereof

Country Status (1)

Country Link
WO (1) WO2009007827A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632866B2 (en) 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
WO2009037707A2 (en) 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
WO2009037705A2 (en) * 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. Esters of n-phenylanthranilic acid for use in the treatment of cancer and inflammation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1132318A (en) * 1966-03-30 1968-10-30 Geigy Ag J R New substituted phenylacetic esters, their production and compositions containing them
AU514991B2 (en) * 1976-05-26 1981-03-12 Commonwealth Of Australia, The Pharmaceutical compositions containing antiinflammatory analgesic compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1132318A (en) * 1966-03-30 1968-10-30 Geigy Ag J R New substituted phenylacetic esters, their production and compositions containing them
AU514991B2 (en) * 1976-05-26 1981-03-12 Commonwealth Of Australia, The Pharmaceutical compositions containing antiinflammatory analgesic compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DOH, HEA-JEONG ET AL: "Rat skin permeation of diclofenac and its prodrugs", YAKCHE HAKHOECHI , 31(2), 95-100 CODEN: YAHAEX; ISSN: 0259-2347, 2001, XP009110345 *
WHITEHOUSE, M. W. ET AL: "Esterification of acidic antiinflammatory drugs suppresses their gastrotoxicity without adversely affecting their antiinflammatory activity in rats", JOURNAL OF PHARMACY AND PHARMACOLOGY , 32(11), 795-6 CODEN: JPPMAB; ISSN: 0022-3573, 1980, XP009110344 *

Also Published As

Publication number Publication date
WO2009007827A2 (en) 2009-01-15
WO2009007827A9 (en) 2009-09-11

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