WO2009004164A9 - Derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDF

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Publication number
WO2009004164A9
WO2009004164A9 PCT/FR2008/000731 FR2008000731W WO2009004164A9 WO 2009004164 A9 WO2009004164 A9 WO 2009004164A9 FR 2008000731 W FR2008000731 W FR 2008000731W WO 2009004164 A9 WO2009004164 A9 WO 2009004164A9
Authority
WO
WIPO (PCT)
Prior art keywords
same
pharmaceutical compositions
compositions containing
preparing
diazeniumdiolate derivatives
Prior art date
Application number
PCT/FR2008/000731
Other languages
English (en)
Other versions
WO2009004164A3 (fr
WO2009004164A2 (fr
Inventor
Alexis Cordi
Laure Haberkorn
Tony Verbeuren
Christine Courchay
Serge Simonet
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of WO2009004164A2 publication Critical patent/WO2009004164A2/fr
Publication of WO2009004164A3 publication Critical patent/WO2009004164A3/fr
Publication of WO2009004164A9 publication Critical patent/WO2009004164A9/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Composés de formule (I) : G-(CH2)n-A-(CH2)m-(CR1R2)p-(CH2)o-R3 dans laquelle : n vaut 0, 1, 2 ou 3; m vaut 0, 1, 2 ou 3; p vaut 0 ou 1; o vaut 0, 1 ou 2; R1 et R2 représentent chacun un atome d'hydrogène ou un groupement alkyle; un des groupements -CH2- ou -CR1R2- peut également être remplacé par un groupement phénylène, -PhC(O)- ou -PhC(O)O-; A et G sont tels que définis dans la description; R3 représente un groupement (II) ou (III). Médicaments.
PCT/FR2008/000731 2007-05-30 2008-05-29 Derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent WO2009004164A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0703815 2007-05-30
FR0703815A FR2916757B1 (fr) 2007-05-30 2007-05-30 Nouveaux derives diazeniumdiolates,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (3)

Publication Number Publication Date
WO2009004164A2 WO2009004164A2 (fr) 2009-01-08
WO2009004164A3 WO2009004164A3 (fr) 2009-04-30
WO2009004164A9 true WO2009004164A9 (fr) 2010-03-18

Family

ID=39004844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/000731 WO2009004164A2 (fr) 2007-05-30 2008-05-29 Derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (3)

Country Link
AR (1) AR066776A1 (fr)
FR (1) FR2916757B1 (fr)
WO (1) WO2009004164A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2498605B1 (fr) * 2009-10-29 2014-08-27 Merck Sharp & Dohme Corp. Diurétiques
WO2012099770A2 (fr) * 2011-01-19 2012-07-26 Merck Sharp & Dohme Corp. Dérivés de diolate de diazénium
JO3350B1 (ar) 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
CA3028423A1 (fr) * 2016-06-22 2017-12-28 Medchem Partners, Llc. Donneurs d'oxyde nitrique
CN109608371B (zh) * 2019-01-16 2020-12-29 泰州学院 O2-4-(3-(4-胺磺酰基苯基)脲)苯基偶氮鎓二醇盐衍生物、制备方法及用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
CA2266908C (fr) * 1996-09-27 2010-07-20 Joseph E. Saavedra Diazen-1-ium-1,2-diolates 1-substitutes o2-aryles ou o2-glycosyles et 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates o2-subtitutes
US20070112050A1 (en) * 2005-04-12 2007-05-17 Psivida Inc. HMGCoA reductase inhibitor combinations and uses thereof

Also Published As

Publication number Publication date
FR2916757B1 (fr) 2009-07-17
AR066776A1 (es) 2009-09-09
FR2916757A1 (fr) 2008-12-05
WO2009004164A3 (fr) 2009-04-30
WO2009004164A2 (fr) 2009-01-08

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