WO2008156124A1 - Method for separation of immunoglobulin monomer - Google Patents

Method for separation of immunoglobulin monomer Download PDF

Info

Publication number
WO2008156124A1
WO2008156124A1 PCT/JP2008/061164 JP2008061164W WO2008156124A1 WO 2008156124 A1 WO2008156124 A1 WO 2008156124A1 JP 2008061164 W JP2008061164 W JP 2008061164W WO 2008156124 A1 WO2008156124 A1 WO 2008156124A1
Authority
WO
WIPO (PCT)
Prior art keywords
immunoglobulin
monomer
ultrafiltration membrane
immunoglobulin monomer
passing
Prior art date
Application number
PCT/JP2008/061164
Other languages
French (fr)
Japanese (ja)
Inventor
Fumihiko Yamaguchi
Hitoshi Mizomoto
Shinya Hamasaki
Takena Mochizuki
Original Assignee
Asahi Kasei Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Kabushiki Kaisha filed Critical Asahi Kasei Kabushiki Kaisha
Priority to US12/665,651 priority Critical patent/US8741600B2/en
Priority to JP2009520521A priority patent/JP5099930B2/en
Publication of WO2008156124A1 publication Critical patent/WO2008156124A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/26—Polyalkenes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/26—Polyalkenes
    • B01D71/261—Polyethylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/26—Polyalkenes
    • B01D71/262—Polypropylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/30—Polyalkenyl halides
    • B01D71/32—Polyalkenyl halides containing fluorine atoms
    • B01D71/34—Polyvinylidene fluoride
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B01D71/42—Polymers of nitriles, e.g. polyacrylonitrile
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B01D71/42—Polymers of nitriles, e.g. polyacrylonitrile
    • B01D71/421—Polyacrylonitrile
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/52—Polyethers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/52—Polyethers
    • B01D71/521—Aliphatic polyethers
    • B01D71/5211—Polyethylene glycol or polyethyleneoxide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
    • B01D71/68—Polysulfones; Polyethersulfones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/08—Polyethers derived from hydroxy compounds or from their metallic derivatives
    • C08L71/10—Polyethers derived from hydroxy compounds or from their metallic derivatives from phenols
    • C08L71/12—Polyphenylene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L81/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur with or without nitrogen, oxygen or carbon only; Compositions of polysulfones; Compositions of derivatives of such polymers
    • C08L81/06—Polysulfones; Polyethersulfones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/14—Pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/16—Flow or flux control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L25/00—Compositions of, homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Compositions of derivatives of such polymers
    • C08L25/02—Homopolymers or copolymers of hydrocarbons
    • C08L25/04—Homopolymers or copolymers of styrene
    • C08L25/08—Copolymers of styrene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
    • C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

Abstract

[PROBLEMS] To provide: a method for separating an immunoglobulin monomer with a high degree of accuracy by subjecting an immunoglobulin solution comprising at least the immunoglobulin monomer and an aggregate thereof to the cross-flow filtration through an ultrafiltration membrane; and an ultrafiltration membrane module and a cross-flow filtration apparatus for use in the method. [MEANS FOR SOLVING PROBLEMS] An immunoglobulin monomer can be separated by subjecting an immunoglobulin solution comprising at least the immunoglobulin monomer and an aggregate thereof and having an immunoglobulin concentration of 1 to 150 g/L to the cross-flow filtration through an ultrafiltration membrane having a cut-off molecular weight of not smaller than 100,000 and smaller than 500,000. In this manner, the immunoglobulin monomer can be passed at a passing rate of 80% or more and with such a fractionation performance that the ratio of the passing rate of an immunoglobulin dimer passing through the ultrafiltration membrane to the passing rate of the immunoglobulin monomer passing through the ultrafiltration membrane is 0.20 or less.
PCT/JP2008/061164 2007-06-19 2008-06-18 Method for separation of immunoglobulin monomer WO2008156124A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/665,651 US8741600B2 (en) 2007-06-19 2008-06-18 Method for separation of immunoglobulin monomers
JP2009520521A JP5099930B2 (en) 2007-06-19 2008-06-18 Method for separating immunoglobulin monomer

Applications Claiming Priority (30)

Application Number Priority Date Filing Date Title
JP2007-161048 2007-06-19
JP2007161048 2007-06-19
JP2008-021079 2008-01-31
JP2008021068 2008-01-31
JP2008-021068 2008-01-31
JP2008-021080 2008-01-31
JP2008021080 2008-01-31
JP2008021079 2008-01-31
JP2008022363 2008-02-01
JP2008-022471 2008-02-01
JP2008022358 2008-02-01
JP2008022349 2008-02-01
JP2008022471 2008-02-01
JP2008-022358 2008-02-01
JP2008-022346 2008-02-01
JP2008022346 2008-02-01
JP2008-022349 2008-02-01
JP2008022472 2008-02-01
JP2008022473 2008-02-01
JP2008-022472 2008-02-01
JP2008-022363 2008-02-01
JP2008-022473 2008-02-01
JP2008042380 2008-02-25
JP2008-042381 2008-02-25
JP2008-042380 2008-02-25
JP2008042381 2008-02-25
JP2008-053148 2008-03-04
JP2008053148 2008-03-04
JP2008-066676 2008-03-14
JP2008066676 2008-03-14

Publications (1)

Publication Number Publication Date
WO2008156124A1 true WO2008156124A1 (en) 2008-12-24

Family

ID=40156283

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061164 WO2008156124A1 (en) 2007-06-19 2008-06-18 Method for separation of immunoglobulin monomer

Country Status (2)

Country Link
JP (1) JP5099930B2 (en)
WO (1) WO2008156124A1 (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009141965A1 (en) * 2008-05-22 2009-11-26 旭化成メディカル株式会社 Filtration method
WO2010109920A1 (en) * 2009-03-27 2010-09-30 旭化成メディカル株式会社 Method for removing viruses in high-concentration monoclonal antibody solution
WO2011111679A1 (en) * 2010-03-09 2011-09-15 東洋紡績株式会社 Porous, hollow fiber membrane for liquid treatment containing protein
EP2377599A1 (en) * 2008-12-25 2011-10-19 Toyo Boseki Kabushiki Kaisha Porous hollow fiber membrane and porous hollow fiber membrane for processing protein-containing liquid
JP2012006989A (en) * 2010-06-22 2012-01-12 Nok Corp Method of manufacturing fiber strengthening porous film
JP2012006988A (en) * 2010-06-22 2012-01-12 Nok Corp Method of manufacturing fiber strengthening polyvinylidene fluoride porous film
WO2013077341A1 (en) * 2011-11-21 2013-05-30 東レ株式会社 Method for producing cellulase, and apparatus for said method
JP2013534540A (en) * 2010-07-19 2013-09-05 ラボラトワール、フランセ、デュ、フラクショヌマン、エ、デ、ビオテクノロジ Concentrated human immunoglobulin composition
JP2014526371A (en) * 2011-09-01 2014-10-06 中外製薬株式会社 Method for preparing a composition comprising an antibody highly concentrated by ultrafiltration
WO2014181796A1 (en) 2013-05-07 2014-11-13 株式会社日立製作所 Purification device, and purification method
WO2016031834A1 (en) * 2014-08-25 2016-03-03 旭化成メディカル株式会社 Porous membrane
JP2017515664A (en) * 2014-05-01 2017-06-15 サビック グローバル テクノロジーズ ベスローテン フェンノートシャップ Porous asymmetric polyphenylene ether membrane and related separation modules and methods
JP2018011530A (en) * 2016-07-19 2018-01-25 株式会社日立製作所 Separation apparatus, culture apparatus, and separation method
JP2020513308A (en) * 2016-12-09 2020-05-14 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング Hollow fiber membranes with improved separation efficiency and production of hollow fiber membranes with improved separation efficiency
WO2022118943A1 (en) * 2020-12-04 2022-06-09 旭化成メディカル株式会社 Porous hollow-fiber membrane and method for testing integrity
JP7467481B2 (en) 2019-01-18 2024-04-15 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング Dialyzers containing fluorine-containing hollow fiber membranes - Patents.com

Citations (5)

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JPS5659716A (en) * 1979-10-22 1981-05-23 Toyo Soda Mfg Co Ltd Separating method of gamma-globulin aggregate with membrane
JPH10265406A (en) * 1997-03-19 1998-10-06 Green Cross Corp:The Immunoglobulin preparation
WO2002013859A1 (en) * 2000-08-10 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Method of inhibiting antibody-containing solution from coagulating or becoming turbid
JP2003012693A (en) * 2000-11-03 2003-01-15 Millipore Corp Method of removing protein aggregate and virus from protein solution
WO2007018284A1 (en) * 2005-08-09 2007-02-15 Asahi Kasei Kabushiki Kaisha Separation membrane for use in treatment of liquid comprising aromatic ether polymer which is hydrophilized with hydrophilizing agent

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
JPS5659716A (en) * 1979-10-22 1981-05-23 Toyo Soda Mfg Co Ltd Separating method of gamma-globulin aggregate with membrane
JPH10265406A (en) * 1997-03-19 1998-10-06 Green Cross Corp:The Immunoglobulin preparation
WO2002013859A1 (en) * 2000-08-10 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Method of inhibiting antibody-containing solution from coagulating or becoming turbid
JP2003012693A (en) * 2000-11-03 2003-01-15 Millipore Corp Method of removing protein aggregate and virus from protein solution
WO2007018284A1 (en) * 2005-08-09 2007-02-15 Asahi Kasei Kabushiki Kaisha Separation membrane for use in treatment of liquid comprising aromatic ether polymer which is hydrophilized with hydrophilizing agent

Non-Patent Citations (1)

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Title
LITZEN A. ET AL.: "Separation and quantitation of monoclonal antibody aggregates by asymmetrical flow field-flow fractionation and comparison to gel permeation chromatography", ANAL. BIOCHEM., vol. 212, no. 2, 1993, pages 469 - 480, XP024763578 *

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5403827B2 (en) * 2008-05-22 2014-01-29 旭化成メディカル株式会社 Filtration method
WO2009141965A1 (en) * 2008-05-22 2009-11-26 旭化成メディカル株式会社 Filtration method
US9272245B2 (en) 2008-05-22 2016-03-01 Asahi Kasei Medical Co., Ltd. Filtration method
US9795932B2 (en) 2008-12-25 2017-10-24 Toyo Boseki Kabushiki Kaisha Porous hollow fiber membrane and a porous hollow fiber membrane for the treatment of a protein-containing liquid
EP2377599A1 (en) * 2008-12-25 2011-10-19 Toyo Boseki Kabushiki Kaisha Porous hollow fiber membrane and porous hollow fiber membrane for processing protein-containing liquid
EP2377599A4 (en) * 2008-12-25 2013-05-01 Toyo Boseki Porous hollow fiber membrane and porous hollow fiber membrane for processing protein-containing liquid
WO2010109920A1 (en) * 2009-03-27 2010-09-30 旭化成メディカル株式会社 Method for removing viruses in high-concentration monoclonal antibody solution
EP2412817B1 (en) 2009-03-27 2016-05-04 Asahi Kasei Medical Co., Ltd. Method for removing viruses in high-concentration monoclonal antibody solution
US9056896B2 (en) 2009-03-27 2015-06-16 Asahi Kasei Medical Co., Ltd. Method for removing viruses from high concentration monoclonal antibody solution
US9492794B2 (en) 2010-03-09 2016-11-15 Toyobo Boseki Kabushiki Kaisha Porous hollow fiber membrane for treatment of protein-containing liquid
WO2011111679A1 (en) * 2010-03-09 2011-09-15 東洋紡績株式会社 Porous, hollow fiber membrane for liquid treatment containing protein
JP5754654B2 (en) * 2010-03-09 2015-07-29 東洋紡株式会社 Porous hollow fiber membrane for protein-containing liquid treatment
AU2011225316B2 (en) * 2010-03-09 2014-04-17 Toyobo Co., Ltd. Porous, hollow fiber membrane for liquid treatment containing protein
JP2012006988A (en) * 2010-06-22 2012-01-12 Nok Corp Method of manufacturing fiber strengthening polyvinylidene fluoride porous film
JP2012006989A (en) * 2010-06-22 2012-01-12 Nok Corp Method of manufacturing fiber strengthening porous film
JP2013534540A (en) * 2010-07-19 2013-09-05 ラボラトワール、フランセ、デュ、フラクショヌマン、エ、デ、ビオテクノロジ Concentrated human immunoglobulin composition
JP2014526371A (en) * 2011-09-01 2014-10-06 中外製薬株式会社 Method for preparing a composition comprising an antibody highly concentrated by ultrafiltration
US9630988B2 (en) 2011-09-01 2017-04-25 Chugai Seiyaku Kabushiki Kaisha Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration
US10590164B2 (en) 2011-09-01 2020-03-17 Chugai Seiyaku Kabushiki Kaisha Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration
AU2012341519B2 (en) * 2011-11-21 2018-04-19 Toray Industries, Inc. Method for producing cellulase, and apparatus for said method
WO2013077341A1 (en) * 2011-11-21 2013-05-30 東レ株式会社 Method for producing cellulase, and apparatus for said method
US11253818B2 (en) 2011-11-21 2022-02-22 Toray Industries, Inc. Method for producing cellulase and apparatus for said method
US9981205B2 (en) 2013-05-07 2018-05-29 Hitachi, Ltd. Purification device, and purification method
WO2014181796A1 (en) 2013-05-07 2014-11-13 株式会社日立製作所 Purification device, and purification method
JP2017515662A (en) * 2014-05-01 2017-06-15 サビック グローバル テクノロジーズ ベスローテン フェンノートシャップ Porous asymmetric polyphenylene ether membrane and related separation modules and methods
JP2017515664A (en) * 2014-05-01 2017-06-15 サビック グローバル テクノロジーズ ベスローテン フェンノートシャップ Porous asymmetric polyphenylene ether membrane and related separation modules and methods
WO2016031834A1 (en) * 2014-08-25 2016-03-03 旭化成メディカル株式会社 Porous membrane
JPWO2016031834A1 (en) * 2014-08-25 2017-06-15 旭化成メディカル株式会社 Porous membrane
US11338248B2 (en) 2014-08-25 2022-05-24 Asahi Kasei Medical Co., Ltd. Porous membrane
JP2018011530A (en) * 2016-07-19 2018-01-25 株式会社日立製作所 Separation apparatus, culture apparatus, and separation method
JP2020513308A (en) * 2016-12-09 2020-05-14 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング Hollow fiber membranes with improved separation efficiency and production of hollow fiber membranes with improved separation efficiency
US11478759B2 (en) 2016-12-09 2022-10-25 Fresenius Medical Care Deutschland Gmbh Hollow fibre membrane with improved separating efficiency, and production of a hollow fibre membrane with improved separating efficiency
JP7187455B2 (en) 2016-12-09 2022-12-12 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング Hollow fiber membranes with improved separation efficiency and the production of hollow fiber membranes with improved separation efficiency
JP7467481B2 (en) 2019-01-18 2024-04-15 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング Dialyzers containing fluorine-containing hollow fiber membranes - Patents.com
WO2022118943A1 (en) * 2020-12-04 2022-06-09 旭化成メディカル株式会社 Porous hollow-fiber membrane and method for testing integrity

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JPWO2008156124A1 (en) 2010-08-26
JP5099930B2 (en) 2012-12-19

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