WO2008155777A3 - Procédé de préparation de l'efletrizine - Google Patents

Procédé de préparation de l'efletrizine Download PDF

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Publication number
WO2008155777A3
WO2008155777A3 PCT/IN2008/000279 IN2008000279W WO2008155777A3 WO 2008155777 A3 WO2008155777 A3 WO 2008155777A3 IN 2008000279 W IN2008000279 W IN 2008000279W WO 2008155777 A3 WO2008155777 A3 WO 2008155777A3
Authority
WO
WIPO (PCT)
Prior art keywords
efletrizine
preparing
piperazinyl
ethoxy
bis
Prior art date
Application number
PCT/IN2008/000279
Other languages
English (en)
Other versions
WO2008155777A2 (fr
Inventor
Rajendra Gokalbhai Chavda
Ketan Ambalal Doshi
Shriprakash Dhar Dwivedi
Original Assignee
Cadila Healthcare Ltd
Rajendra Gokalbhai Chavda
Ketan Ambalal Doshi
Shriprakash Dhar Dwivedi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd, Rajendra Gokalbhai Chavda, Ketan Ambalal Doshi, Shriprakash Dhar Dwivedi filed Critical Cadila Healthcare Ltd
Publication of WO2008155777A2 publication Critical patent/WO2008155777A2/fr
Publication of WO2008155777A3 publication Critical patent/WO2008155777A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Abstract

L'invention concerne un nouveau procédé de préparation de l'Efletrizine ou de ses sels acceptables d'un point de vue pharmaceutique. La présente invention concerne également un procédé de préparation d'un nouvel intermédiaire de celle-ci sous forme cristalline, ainsi qu'un procédé de préparation du dihydrochlorure d'acide 2-{-2-[4-(bis(4-fiourophenyl-)methyl)-1-piperazinyl]ethoxy} acétique pratiquement pur. L'acide 2-{-2-[4-(bis(4-flourophenyl-)methyl)-1-piperazinyl]ethoxy} acétique est connu habituellement sous le nom d'Efletrizine et est représenté par la formule (I). L'Efletrizine est utile comme agent thérapeutique dans le traitement de maladies allergiques et d'autres troubles.
PCT/IN2008/000279 2007-06-18 2008-05-02 Procédé de préparation de l'efletrizine WO2008155777A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1164MU2007 2007-06-18
IN1164/MUM/2007 2007-06-18

Publications (2)

Publication Number Publication Date
WO2008155777A2 WO2008155777A2 (fr) 2008-12-24
WO2008155777A3 true WO2008155777A3 (fr) 2009-07-23

Family

ID=40156778

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000279 WO2008155777A2 (fr) 2007-06-18 2008-05-02 Procédé de préparation de l'efletrizine

Country Status (1)

Country Link
WO (1) WO2008155777A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0919550A1 (fr) * 1997-11-26 1999-06-02 Ucb, S.A. Formes pseudopolymorphiques de l'acide 2-2-4-bis(4-fluorophényl)méthyl -1-pipérazinyl-éthoxy acétique dihydrochloride
WO2003009849A1 (fr) * 2001-07-26 2003-02-06 Ucb, S.A. Procede de fabrication de derives d'acides 2-(2-(4-(bis(4-fluorophenyl)methyl)-piperazine-1-yl)ethoxy)acetiques ou de sels de ces composes et intermediaires correspondants
EP1535922A1 (fr) * 2002-07-11 2005-06-01 Takeda Pharmaceutical Company Limited Derive de pyrrolopyridine et utilisation de ce dernier
EP1714961A1 (fr) * 2004-02-12 2006-10-25 Mitsubishi Pharma Corporation Compos indazole et utilisation pharmaceutique de celui-ci

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0919550A1 (fr) * 1997-11-26 1999-06-02 Ucb, S.A. Formes pseudopolymorphiques de l'acide 2-2-4-bis(4-fluorophényl)méthyl -1-pipérazinyl-éthoxy acétique dihydrochloride
US20010021712A1 (en) * 1997-11-26 2001-09-13 Monique Berwaer Pseudopolymorphic forms of 2-[2-[4-[Bis (4-fluorophenyl) methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
WO2003009849A1 (fr) * 2001-07-26 2003-02-06 Ucb, S.A. Procede de fabrication de derives d'acides 2-(2-(4-(bis(4-fluorophenyl)methyl)-piperazine-1-yl)ethoxy)acetiques ou de sels de ces composes et intermediaires correspondants
EP1535922A1 (fr) * 2002-07-11 2005-06-01 Takeda Pharmaceutical Company Limited Derive de pyrrolopyridine et utilisation de ce dernier
EP1714961A1 (fr) * 2004-02-12 2006-10-25 Mitsubishi Pharma Corporation Compos indazole et utilisation pharmaceutique de celui-ci

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NARENDRA SHARATH CHANDRA J N ET AL: "Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-[bis(4-fluorophenyl)-me thyl]piperazine", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 14, no. 19, 1 October 2006 (2006-10-01), pages 6621 - 6627, XP025133573, ISSN: 0968-0896, [retrieved on 20061001] *
SASSE A ET AL: "(Partial)Agonist/antagonist properities of novel diarylalkyl carbamates on histamine H3 receptors", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 8, 5 May 2000 (2000-05-05), pages 1139 - 1149, XP002196518, ISSN: 0968-0896 *

Also Published As

Publication number Publication date
WO2008155777A2 (fr) 2008-12-24

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