WO2008150208A1 - Dispositif pour la distribution d'une substance et instrument de remplissage pour un tel dispositif - Google Patents

Dispositif pour la distribution d'une substance et instrument de remplissage pour un tel dispositif Download PDF

Info

Publication number
WO2008150208A1
WO2008150208A1 PCT/SE2008/000375 SE2008000375W WO2008150208A1 WO 2008150208 A1 WO2008150208 A1 WO 2008150208A1 SE 2008000375 W SE2008000375 W SE 2008000375W WO 2008150208 A1 WO2008150208 A1 WO 2008150208A1
Authority
WO
WIPO (PCT)
Prior art keywords
piston
mixing
substances
spout
cylinder
Prior art date
Application number
PCT/SE2008/000375
Other languages
English (en)
Inventor
Jan Svensson
Original Assignee
Jan Svensson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jan Svensson filed Critical Jan Svensson
Publication of WO2008150208A1 publication Critical patent/WO2008150208A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M2005/1787—Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3123—Details having air entrapping or venting means, e.g. purging channels in pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A61M5/31595—Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking

Definitions

  • a substance dispensing device and a filling instrument for such a device A substance dispensing device and a filling instrument for such a device
  • the present invention relates to a substance dispensing device, and a filling instrument for such a device according to the introductory portions of the independent claims.
  • it relates to such a device useable as a syringe
  • Multi chamber syringes are know and are applicable among other things for dispensing of several different substances in sequence.
  • One patent relating to this subject is JP2004344639 which discloses prefilled syringe with three or more chambers. Each of the chambers may contain different substances, and the syringe is intended to disperse the substances in sequence. The document does not disclose how to fill such a multi chamber syringe, and makes no reference to means for mixing substances stored in the syringe.
  • US2006142701 discloses a syringe with at least two pistons separating two or more volumes inside the syringe.
  • One of the pistons is provided with a rod, while the others are not attached to rods.
  • the document claims mixing of fluids in the syringe is made possible using differential pressure, but control of the rodless pistons using liquid pressure seems difficult. Further, such a device using differential pressure to control passage of fluid between chambers may allow leaks between chambers.
  • WO2006128915 discloses a syringe with an outer and an inner chamber.
  • the device is intended for mixing of substances within the syringe and may be used for sequential dispensing of the contents, but is not preferentially intended for this purpose.
  • the design makes use of the available volume in an inefficient way as the inner chamber is surrounded by unused space inside the outer chamber, and it is further a relatively complex construction making it unnecessarily expensive to produce.
  • An object of the invention is therefore to provide a substance dispensing device, and a filling instrument for such a device which allows both separate storing, mixing and dosing of substances.
  • the invention relates to a device for storing, mixing and dosing of substances, typically used as a syringe.
  • the device comprises a cylinder with an open end and an end provided with a spout, an end piston slideably arrangable in said cylinder closest to the open end and at least one mixing piston slideably arrangable between the end piston and the end provided with a spout.
  • At least a first and a second cylinder volume separated by the mixing piston are formed, where the end piston is provided with a end piston rod an at least one mixing piston is provided with a mixing piston rod, where the piston rods extends from the pistons towards the cylinder opening and beyond the opening.
  • the at least said mixing piston is provided with a valve device which, when open, allows substance to be exchanged between said first and second cylinder volumes, and where the mixing piston is slideable with respect to the end piston for mixing of substances between the first and second cylinder volumes.
  • a device according to the invention has the advantage that it may store two or more substances completely sealed and separate from each other.
  • many active substances are relatively chemically inert while dry, but rapidly starts to deteriorate while in liquid solution, so being able to store them separately is an important advantage.
  • the device further allows mixing of selected substances inside a sterile device that may be used as a syringe.
  • the same device also allows sequential dispensing of substances, or mixes of substances. Such a sequential dispensing may be advantageous in a number of different applications.
  • the invention further relates to a filling instrument for such a device for storing, mixing and dosing of substances.
  • Figs la-d shows schematic illustrations of a two chamber syringe according to the invention
  • Figs 2a-d shows schematic illustrations of a three chamber syringe according to the invention
  • Figs 3a-e shows schematic illustrations of a four chamber syringe according to the invention
  • Figs 4a-e shows schematic illustrations of a five chamber syringe according to the invention
  • Fig. 5 shows a two chamber syringe in partial cross section
  • Figs 6a-c shows illustrations of a three chamber syringe in partial cross section
  • Figs 7a-b shows a mixing piston and mixing rod
  • Fig. 8 shows a mixing piston and a filling instrument
  • Figs 9a-d shows how remaining air may be removed from the syringe
  • Figs 10a-d shows an embodiment of the syringe having a separate top portion
  • Figs la-d shows schematic illustrations of a two chamber syringe according to the invention in a sequence of storage, mixing and dosing stages.
  • Fig. Ia shows the syringe in its storage state.
  • the syringe is comprised of a cylindrical outer casing 1 with an open end and one end with a spout 2.
  • Two pistons are slideably mounted inside the cylindrical casing, and end piston U and a mixing piston Ml.
  • the end piston U is arranged near the open end of the cylindrical casing 1 while the mixing piston M is arranged near the spout.
  • the interior volume delimited by the lower surface of the mixing piston Ml and the interior surface of the cylindrical casing extending to the spout defines a first storage volume, or chamber, containing a first substance Xl.
  • a second storage volume extends from the upper surface of the mixing piston Ml to the lower surface of the end piston U and is delimited by the interior surface of the cylindrical casing.
  • the second storage volume contains a second substance X2.
  • the mixing piston Ml From the mixing piston Ml extends a mixing rod Rl towards the open end of the cylindrical casing.
  • the mixing rod Rl extends through the end piston U and beyond the open end of the cylindrical casing.
  • An end rod RU extends from the end piston U in the same direction as the mixing rod.
  • the mixing rod Rl and the end rod RU may travel independently of each other, within the limits set by locking arrangements described further below.
  • the mixing piston has been pushed towards the end piston by the user forcing the mixing rod Rl upwards.
  • the mixing piston comprises valves that allow liquid substances to pass through it.
  • the first substance Xl may be a solid in the form of a powder or a granulate, which makes it possible to store the substance longer periods than what would be possible in a liquid solution.
  • the second substance X2 would in such an example be a liquid into which the second substance is soluble.
  • the second substance is preferably a chemically inert substance, which in itself is little deteriorated during storage. Mixing the two substances dissolves the first substance in the second substance, allowing the solution to enter the bloodstream, while storage and mixing is done in a enclosed, sterile environment.
  • a device according to the invention allows for completely sealed, separate storage of different substances that, during storage, are kept out of contact with each other.
  • many active substances are relatively chemically inert while dry, but rapidly starts to deteriorate while in liquid solution, so being able to store them separately is an important advantage.
  • the device further allows mixing of substances inside a sterile device that may be used as a syringe.
  • the device according to the invention allows sequential dispensing of substances, or mixes of substances. Such a sequential dispensing may be advantageous in a number of different applications.
  • Figs 2a-d shows schematic illustrations of a three chamber syringe according to the invention in a sequence of storage, mixing and dosing stages.
  • Fig. 2a shows the syringe in its storage state, with three pistons, an end piston U 3 a first mixing piston Ml and a second mixing piston M2.
  • the end piston U is arranged near the open end of the cylindrical outer casing 1
  • the first mixing piston Ml is arranged nearest the spout
  • the second mixing piston M2 is arranged between the end piston U and the first mixing piston Ml.
  • the three pistons define three storage volumes containing three different substances X1-X3.
  • the first storage volume extends inside the cylindrical casing from the spout to the lower surface of the first mixing piston Ml and contains the first substance Xl.
  • the second storage volume extends from the upper surface of the first mixing piston Ml to the lower surface of the second mixing piston Ml and contains the second substance X2.
  • the third storage volume extends from the upper surface of the second mixing piston M2 to the lower surface of the end piston U and contains the third substance X3.
  • a device according to the invention may allow for sequential dispensing of three different substances, without mixing of substances.
  • the different pistons are still denoted mixing pistons, whether actually used for mixing or not.
  • Figs 3a-e shows schematic illustrations of a four chamber syringe according to the invention in a sequence of storage, mixing and dosing stages.
  • Fig. 3a shows the syringe in its storage state, with four pistons, an end piston U, a first mixing piston Ml, a second mixing piston M2 and a third mixing piston M3.
  • the end piston U is arranged near the open end of the cylindrical outer casing 1
  • the first mixing piston Ml is arranged nearest the spout
  • the second M2 and the third mixing pistons M3 are arranged in numeral order between the end piston U and the first mixing piston Ml.
  • the four pistons define four storage volumes containing four different substances Xl -X4, each substance initially in its corresponding storage volume, with storage volumes denoted according to its numeral order, starting with the first storage volume at the spout.
  • a device according to the invention may allow for mixing of two substances, followed by sequential dispensing of the mixed substances and two unmixed substances.
  • Figs 4a-e shows schematic illustrations of a five chamber syringe according to the invention in a sequence of storage, mixing and dosing stages.
  • Fig. 4a shows the syringe in its storage state, with five pistons, an end piston U, a first mixing piston Ml, a second mixing piston M2, a third mixing piston M3 and a fourth mixing piston M4.
  • the end piston U is arranged near the open end of the cylindrical outer casing 1
  • the first mixing piston Ml is arranged nearest the spout
  • the second M2, third M3 and the fourth M4 mixing pistons are arranged in numeral order between the end piston U and the first mixing piston Ml .
  • the five pistons define five storage volumes containing five different substances Xl -X5, each substance initially in its corresponding storage volume, with storage volumes denoted according to its numeral order, starting with the first storage volume at the spout.
  • a device may allow for mixing of two pairs of substances. This is then followed by sequential dispensing of the first mixed pair of substances Xl, X2, a second mixed pair of substances X3, X4 and finally a single unmixed substance X5.
  • Fig. 5 shows, in partial cross section, a two chamber syringe illustrated as it looks when used for storage of substances.
  • the syringe is comprised of a cylindrical outer casing 1 with a spout 2.
  • Two pistons are slideably mounted inside the cylindrical casing, and end piston U and a mixing piston Ml.
  • the end piston U is arranged near the open end of the cylindrical casing 1 while the mixing piston M is arranged near the spout.
  • the interior volume has a first storage volume containing a first substance Xl and a second storage volume containing a second substance X2.
  • the mixing piston Ml From the mixing piston Ml extends a thinner mixing rod Rl towards the open end of the cylindrical casing and a hollow, end rod RU extends from the end piston U.
  • the mixing rod Rl is arranged inside the end rod RU and extends through the end piston U which is provided with a gasket for preventing leakage.
  • Figs 6a-c shows illustrations of a three chamber syringe in partial cross section, illustrating three steps of a mixing and dispensing using the syringe.
  • the three chamber syringe has three pistons, an end piston U, a first Ml and a second M2 mixing piston.
  • the three pistons define three storage volumes containing three different substances Xl -X3, extending as illustrated in fig. 2a.
  • the syringe comprises two piston rods, a mixing rod Rl arranged inside an end rod RU.
  • the mixing rod is fixedly arranged on the first mixing piston Ml, but extends slideably through the second mixing piston M2.
  • the first Ml and a second M2 mixing pistons comprises check valves V that allow flow of substance towards the spout but not in the opposite direction.
  • the mixing rod Rl is provided with a handle portion P.
  • the handle portion P receives in its hollow interior the mixing rod Rl top.
  • the mixing rod Rl top is provided with resilient barbs B extending outwards.
  • the interior diameter of the handle portion P is sufficient to allow the barbs of the mixing rod Rl top to slide inside it, but narrows at its bottom, preventing the barbs from leaving the interior of the handle portion P.
  • the mixing rod Rl and the first mixing piston Ml are pulled up with is as the three parts are connected to each other. Substance then flows through the check valves of the first mixing piston Ml and the substances in first and second storage volumes are mixed.
  • a locking device L fixes the handle portion P with respect to the end rod RU, and as the handle portion P is forced towards the spout, all three pistons move with it. In fig. 6c all the pistons have moved towards the spout until the first mixing piston Ml has reached the spout area. As the handle is pusher further towards the spout, the second storage volume is dispensed through the spout and then the third storage volume is dispensed through the spout.
  • Fig. 7a-b shows a mixing piston M and a mixing rod Rl with its barbs B.
  • the barbs in opposite directions from a groove at the end of the rod and may resiliently bend inwards if pressure is applied.
  • the barbs extends from the rod with, in cross section, an essentially triangular shape.
  • the side of the triangle facing upwards is angled at a smaller angle from the direction of the rod than the side of the triangle facing in the opposite direction. This allows the barbs to enter the handle portion, but lock into the handle portion when retracting from it.
  • the figures illustrate more clearly the two check valves V on the mixing piston M, and also show penetrable, self closing membrane elements 4.
  • the self closing membrane elements 4 may be used as a substitute for check valves, but are in this embodiment used for filling the syringe using a filling instrument.
  • Fig. 8 shows a mixing piston Ml and a filling instrument 5 constituted by a tubular element which penetrates the self closing membrane element 4.
  • the self closing membrane elements 4 are preferably used in pairs, cooperating with corresponding pairs of tubular filling elements, one for inserting substance into a storage volume and the other one to prevent over pressure from occurring and for removing gas bubbles remaining after the filling process has completed.
  • the penetrable membranes appear on all pistons and the membranes are aligned along a straight line such that all of the storage volumes may be filled using the filling instrument.
  • Figs 9a-d shows how remaining air may be removed from the syringe using a filling instrument 5.
  • the syringe is illustrated in fig. 9a, embodied as a two chamber syringe and one of the pistons is illustrated in greater detail in the sequence of figs 9b-d showing how the filling instrument cooperates with the self closing membrane element of the piston.
  • the filling instrument 5 is pushed towards the piston.
  • the filling instrument has a pointy central portion 6 extending around the central rod, the pointy portion having two conduits 7a, b.
  • the filling instrument also has an outer rim part facing the rim of the piston, limiting how far the pointy portion may extend through the membrane element of the piston.
  • the filling instrument 5 engages the piston, and the pointy portion has pushed the resilient membrane element away, such that the conduits may be used to remove air from the second storage volume.
  • the membrane elements are resilient, except for the conduits, the second storage volume remains disconnected to the exterior such that its contents may remain sterile.
  • the piston is pushed towards the rod and the filling instrument 5 is pushed towards the piston.
  • the piston may engage the rod with the filling instrument engaging the piston, such that as the two are pushed in, air may leave the second storage volume through the conduits.
  • Figs 10a-d shows an embodiment of the syringe having a separate top portion 9 allowing the syringe to be filled from the end to which a spout is attachable.
  • the spout is provided on the separate top portion 9.
  • This embodiment has the particular advantage that the substance in the top portion 9 and the substances in the other storage volumes may be sterilised in different way.
  • the substance in the top portion 9 may for example be sterilised by heat treatment, without affecting the temperature of the substances in the other storage volumes.
  • the piston closest to the top portion is illustrated in greater detail in the sequence of figs lOb-d showing how the filling instrument cooperates with the self closing membrane element of the piston.
  • fig. 10b the piston is pushed towards the rod and the filling instrument 5 is pushed towards the piston.
  • fig. 10c the piston engages the rod with the filling instrument engaging the piston, such that as the two are pushed in, air may leave the second storage volume through the conduits.
  • the filling instrument disengages the piston and the self closing membrane element has closed, leaving the substance in the second storage volume free of air.
  • the top portion may then be attached to the syringe.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif pour le stockage, le mélange et le dosage de substances, utilisé généralement comme seringue. Le dispositif comprend un cylindre à bec, un piston d'extrémité et au moins un piston de mélange. Au moins des premier et second volumes de cylindres séparés par le piston de mélange sont formés. Le piston de mélange comprend un dispositif de valve qui, lorsqu'il est ouvert, permet l'échange de substances entre ledit premier et ledit second volume cylindrique, le piston de mélange pouvant coulisser par rapport au piston d'extrémité pour mélanger les substances entre le premier et le second volume cylindrique. Un tel dispositif peut stocker une ou plusieurs substances de manière complètement indépendante et étanche les unes par rapport aux autres. Le dispositif permet également de mélanger des substances sélectionnées dans un dispositif stérile qui peut être utilisé comme seringue. Enfin, le même dispositif permet également une distribution séquentielle de substances ou de mélanges de substances. L'invention concerne également un instrument de remplissage pour un tel dispositif pour le stockage, le mélange et le dosage de substances.
PCT/SE2008/000375 2007-06-08 2008-06-02 Dispositif pour la distribution d'une substance et instrument de remplissage pour un tel dispositif WO2008150208A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0701343A SE0701343L (sv) 2007-06-08 2007-06-08 Enhet för separerad lagring, separerad blandning och separerad injicering av olika läkemedelssubstanser
SE0701343-6 2007-06-08

Publications (1)

Publication Number Publication Date
WO2008150208A1 true WO2008150208A1 (fr) 2008-12-11

Family

ID=40093910

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2008/000375 WO2008150208A1 (fr) 2007-06-08 2008-06-02 Dispositif pour la distribution d'une substance et instrument de remplissage pour un tel dispositif

Country Status (2)

Country Link
SE (1) SE0701343L (fr)
WO (1) WO2008150208A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102784426A (zh) * 2011-05-16 2012-11-21 吴振文 注射器
JP2014041123A (ja) * 2012-08-21 2014-03-06 Astrium Gmbh 少なくとも十分に分離して物質を保管及び送出するための、特に宇宙空間における保管及び送出のための容器
WO2014155114A1 (fr) * 2013-03-26 2014-10-02 Consort Medical Plc Ensemble seringue de mélange amélioré
WO2016109339A1 (fr) * 2014-12-30 2016-07-07 3M Innovative Properties Company Récipient pour mélanger et distribuer des composants de médicament liquides
US9731076B2 (en) 2012-06-29 2017-08-15 Ethicon, Inc. Multi-compartment pre-filled mixing syringes with bypass
KR20170100626A (ko) * 2014-12-30 2017-09-04 쓰리엠 이노베이티브 프로퍼티즈 컴파니 성분들을 혼합 및 분배하기 위한 용기
CN108087614A (zh) * 2017-12-11 2018-05-29 郑州莉迪亚医药科技有限公司 一种曲柄连杆式混液阀
CN110177588A (zh) * 2016-11-18 2019-08-27 Om有限公司 用于混合药物物质的封装和设备
US10507286B2 (en) 2014-12-30 2019-12-17 3M Innovative Properties Company Container for mixing and dispensing two components

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511239A (en) * 1967-01-21 1970-05-12 Penicillin Ges Dauelsberg & Co Multi-chamber syringe
US4371094A (en) * 1980-07-31 1983-02-01 Products Research & Chemical Corporation Barrier two part pairing and dispensing cartridge
WO1988009679A1 (fr) * 1987-06-04 1988-12-15 The Boc Group, Inc. Seringue hypodermique
JP2004344639A (ja) * 2003-03-04 2004-12-09 Fukoku Co Ltd プレフィルドシリンジ及びこれに用いる仕切用ガスケット
US20050245880A1 (en) * 2004-05-03 2005-11-03 Howlett Michael W Multi-chamber, sequential dose dispensing syringe
WO2006128915A1 (fr) * 2005-06-02 2006-12-07 Schwoebel Eckhard Seringue a plusieurs cylindres

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511239A (en) * 1967-01-21 1970-05-12 Penicillin Ges Dauelsberg & Co Multi-chamber syringe
US4371094A (en) * 1980-07-31 1983-02-01 Products Research & Chemical Corporation Barrier two part pairing and dispensing cartridge
WO1988009679A1 (fr) * 1987-06-04 1988-12-15 The Boc Group, Inc. Seringue hypodermique
JP2004344639A (ja) * 2003-03-04 2004-12-09 Fukoku Co Ltd プレフィルドシリンジ及びこれに用いる仕切用ガスケット
US20050245880A1 (en) * 2004-05-03 2005-11-03 Howlett Michael W Multi-chamber, sequential dose dispensing syringe
WO2006128915A1 (fr) * 2005-06-02 2006-12-07 Schwoebel Eckhard Seringue a plusieurs cylindres

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102784426A (zh) * 2011-05-16 2012-11-21 吴振文 注射器
US9731076B2 (en) 2012-06-29 2017-08-15 Ethicon, Inc. Multi-compartment pre-filled mixing syringes with bypass
US10456526B2 (en) 2012-06-29 2019-10-29 Ethicon, Inc. Multi-compartment pre-filled mixing syringes with bypass
JP2014041123A (ja) * 2012-08-21 2014-03-06 Astrium Gmbh 少なくとも十分に分離して物質を保管及び送出するための、特に宇宙空間における保管及び送出のための容器
EP2700393A3 (fr) * 2012-08-21 2015-09-23 Airbus DS GmbH Récipient pour le logement et la distribution au moins majoritairement séparés de substances, notamment pour un logement et une distribution dans l'espace
US9238543B2 (en) 2012-08-21 2016-01-19 Airbus Ds Gmbh Container for the at least substantially separate storage and release of substances, in particular for storage and release in outer space
AU2014242674B2 (en) * 2013-03-26 2018-11-22 Consort Medical Plc Improved mixing syringe assembly
WO2014155114A1 (fr) * 2013-03-26 2014-10-02 Consort Medical Plc Ensemble seringue de mélange amélioré
US11185637B2 (en) 2013-03-26 2021-11-30 Consort Medical Plc Mixing syringe assembly
CN107469198B (zh) * 2013-03-26 2020-09-18 和谐医疗有限公司 改进的混合注射器组件
CN107469198A (zh) * 2013-03-26 2017-12-15 和谐医疗有限公司 改进的混合注射器组件
US10507286B2 (en) 2014-12-30 2019-12-17 3M Innovative Properties Company Container for mixing and dispensing two components
US10327990B2 (en) 2014-12-30 2019-06-25 3M Innovative Properties Company Container for mixing and dispensing fluid medication components
KR20170101281A (ko) * 2014-12-30 2017-09-05 쓰리엠 이노베이티브 프로퍼티즈 컴파니 유체 약제 성분들을 혼합 및 분배하기 위한 용기
US10744265B2 (en) 2014-12-30 2020-08-18 Kindeva Drug Delivery L.P. Container for mixing and dispensing components
KR20170100626A (ko) * 2014-12-30 2017-09-04 쓰리엠 이노베이티브 프로퍼티즈 컴파니 성분들을 혼합 및 분배하기 위한 용기
WO2016109339A1 (fr) * 2014-12-30 2016-07-07 3M Innovative Properties Company Récipient pour mélanger et distribuer des composants de médicament liquides
KR102450956B1 (ko) 2014-12-30 2022-10-04 쓰리엠 이노베이티브 프로퍼티즈 컴파니 성분들을 혼합 및 분배하기 위한 용기
KR102450955B1 (ko) 2014-12-30 2022-10-04 쓰리엠 이노베이티브 프로퍼티즈 컴파니 유체 약제 성분들을 혼합 및 분배하기 위한 용기
CN110177588A (zh) * 2016-11-18 2019-08-27 Om有限公司 用于混合药物物质的封装和设备
CN108087614A (zh) * 2017-12-11 2018-05-29 郑州莉迪亚医药科技有限公司 一种曲柄连杆式混液阀

Also Published As

Publication number Publication date
SE0701343L (sv) 2008-12-09

Similar Documents

Publication Publication Date Title
WO2008150208A1 (fr) Dispositif pour la distribution d'une substance et instrument de remplissage pour un tel dispositif
CA2980585C (fr) Appareil et procede de transfert et de remise en suspension de medicament alimente par gaz sous pression
US7101354B2 (en) Mixing syringe with and without flush
US20050177100A1 (en) Dual chamber mixing syringe and method for use
CN107771093A (zh) 用于混合两种组分和用于在存储条件下保持真空的注射器
JP2016519598A5 (fr)
JP5718885B2 (ja) カートリッジ内に変位可能なクロージャを有するマルチコンポーネント・カートリッジ・システム
EP2994086A1 (fr) Valve d'aiguille et connecteurs pour utilisation dans des appareils de transfert de liquide
JP2002524213A (ja) 無針注射器カートリッジ
EP2403565B1 (fr) Système de réservoir sous pression pour le stockage et la distribution de liquides
US20130060203A1 (en) Syringe with yielding element
CN112638446A (zh) 具有真空辅助混合及/或递送的多容积药物递送系统
US20140296791A1 (en) Pre-filled multi-chamber device for sequential delivery
JP2019069036A (ja) 液体供給システム
US20070185438A1 (en) Multi-chamber mixing ampoule
RU2704016C2 (ru) Система и способ для подготовки инъекции
JPWO2017057659A1 (ja) ２種類の物質を連通するためのシリンジ装置及びその方法
WO2009019673A2 (fr) Ampoule de mélange multichambre
CA2676248A1 (fr) Seringue de melange avec et sans rincage
RU2236873C1 (ru) Многокамерный шприц
RU2237495C1 (ru) Многокамерный шприц
JP2003144544A (ja) 医療用低速駆動装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08767048

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08767048

Country of ref document: EP

Kind code of ref document: A1