WO2008146680A1 - Méthode de production de l-lysine - Google Patents

Méthode de production de l-lysine Download PDF

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Publication number
WO2008146680A1
WO2008146680A1 PCT/JP2008/059348 JP2008059348W WO2008146680A1 WO 2008146680 A1 WO2008146680 A1 WO 2008146680A1 JP 2008059348 W JP2008059348 W JP 2008059348W WO 2008146680 A1 WO2008146680 A1 WO 2008146680A1
Authority
WO
WIPO (PCT)
Prior art keywords
lysine
producing
culture medium
bacterial cells
ycdo
Prior art date
Application number
PCT/JP2008/059348
Other languages
English (en)
Japanese (ja)
Inventor
Yousuke Nishio
Yohei Yamada
Yuri Nagai
Yoshihiro Usuda
Kazuhiko Matsui
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Publication of WO2008146680A1 publication Critical patent/WO2008146680A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention porte sur une méthode de production de L-lysine consistant: à cultiver une bactérie de la famille des Enterobacteriaceae, capable de produire la L-lysine et ayant été modifiée pour accroître l'activité d'au moins la N-acétyl-anhydromuramyl-L-alanine amidase, et une protéine codée par le gène efeO (ycdO); à produire et accumuler la L-lysine dans le milieu de culture ou dans les cellules bactériennes; et à recueillir la L-lysine dans le milieu de culture ou les cellules bactériennes.
PCT/JP2008/059348 2007-05-29 2008-05-21 Méthode de production de l-lysine WO2008146680A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-141905 2007-05-29
JP2007141905A JP2010187541A (ja) 2007-05-29 2007-05-29 Ｌ−リジンの製造法

Publications (1)

Publication Number Publication Date
WO2008146680A1 true WO2008146680A1 (fr) 2008-12-04

Family

ID=40316826

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/059348 WO2008146680A1 (fr) 2007-05-29 2008-05-21 Méthode de production de l-lysine

Country Status (2)

Country Link
JP (1) JP2010187541A (fr)
WO (1) WO2008146680A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107937376A (zh) * 2017-10-19 2018-04-20 浙江工业大学 一种泛生菌酰胺酶突变体、基因、工程菌及其应用
CN111154746A (zh) * 2020-01-13 2020-05-15 浙江工业大学 酰胺酶突变体及其在催化合成2-氯烟酸中的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5414636B2 (ja) 2010-08-24 2014-02-12 本田技研工業株式会社 車両用駆動装置
WO2016012607A1 (fr) * 2014-07-25 2016-01-28 Delphi Genetics Cellule hôte améliorée pour la production de protéines

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005237379A (ja) * 2004-01-30 2005-09-08 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117082A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117076A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117077A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005237379A (ja) * 2004-01-30 2005-09-08 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117082A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117076A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
JP2007117077A (ja) * 2005-09-27 2007-05-17 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
IMAIZUMI A. ET AL.: "Improved Production of L-Lysine by Disruption of Stationary Phase-specific rmf Gene in Escherichia coli", J. BIOTECHNOL., vol. 117, no. 1, 2005, pages 111 - 118 *
JACOBS C. ET AL.: "AmpD, Essential for both Beta-lactamase Regulation and Cell Wall Recycling, is a Novel Cytosolic N-Acetylmuramyl-L-Alanine Amidase", MOL. MICROBIOL., vol. 15, no. 3, 1995, pages 553 - 559 *
STANCIK L.M. ET AL.: "pH-Dependent Expression of Periplasmic Proteins and Amino Acid Catabolism in Escherichia coli", J. BACTERIOL., vol. 184, no. 15, 2002, pages 4246 - 4258 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107937376A (zh) * 2017-10-19 2018-04-20 浙江工业大学 一种泛生菌酰胺酶突变体、基因、工程菌及其应用
CN107937376B (zh) * 2017-10-19 2020-10-02 浙江工业大学 一种泛生菌酰胺酶突变体、基因、工程菌及其应用
CN111154746A (zh) * 2020-01-13 2020-05-15 浙江工业大学 酰胺酶突变体及其在催化合成2-氯烟酸中的应用
CN111154746B (zh) * 2020-01-13 2021-10-08 浙江工业大学 酰胺酶突变体及其在催化合成2-氯烟酸中的应用

Also Published As

Publication number Publication date
JP2010187541A (ja) 2010-09-02

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